The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha
Open accessAbstract
SUMMARY Vitamin A and its metabolite, retinoic acid (RA), have recently been implicated in the regulation of immune homeostasis via the peripheral induction of regulatory T cells. Here we show that RA is also required to elicit proinflammatory CD4+ helper T cell responses to infection and mucosal vaccination. Retinoic acid receptor alpha (RARα) is the critical mediator of these effects. Strikingly, antagonism of RAR signaling and deficiency in RARα(Rara−/−) results in a cell autonomous CD4+ T cell activation defect. Altogether, these findings reveal a fundamental role for the RA/RARα axis in the development of both regulatory and inflammatory arms of adaptive immunity and establish nutritional status as a broad regulator of adaptive T cell responses.
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A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 2×
“The best characterized are RA receptors (RAR) a, b and g, which transcriptionally regulate gene expression in partnership with retinoid X receptors (Chambon, 1996).”
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982
Vitamin effects on the immune system: Vitamins A and D take centre stage
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A role for mammalian target of rapamycin in regulating T cell activation versus anergy
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Quantitative Profiling of Endogenous Retinoic Acid in Vivo and in Vitro by Tandem Mass Spectrometry
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Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Self-citationMetabolic Pathways in Immune Cell Activation and Quiescence
Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Constantinides, M. G., Link, V. M., Tamoutounour, S., Wong, A. C., Perez-Chaparro, P. J., Han, S.-J., Chen, Y. E., Li, K., Farhat, S., Weckel, A., et al. (2019) · Science · doi:10.1126/science.aax6624 · Cited by 567
Self-citationInduced CD4+Foxp3+Regulatory T Cells in Immune Tolerance
Bilate, A. M., & Lafaille, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075043 · Cited by 569
Metadata
- Authors
- Hall, J. A., Cannons, J. L., Grainger, J. R., Dos Santos, L. M., Hand, T. W., Naik, S., Wohlfert, E. A., Chou, D. B., Oldenhove, G., Robinson, M., Grigg, M. E., Kastenmayer, R., Schwartzberg, P. L., & Belkaid, Y.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 34
- Issue
- 3
- Pages
- 435-447
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2040307290
- Cited by
- 377
- References
- 8
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hall, J. A., Cannons, J. L., Grainger, J. R., Dos Santos, L. M., Hand, T. W., Naik, S., Wohlfert, E. A., Chou, D. B., Oldenhove, G., Robinson, M., Grigg, M. E., Kastenmayer, R., Schwartzberg, P. L., & Belkaid, Y. (2011). Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha. Immunity. https://doi.org/10.1016/j.immuni.2011.03.003
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