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Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha
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SUMMARY Vitamin A and its metabolite, retinoic acid (RA), have recently been implicated in the regulation of immune homeostasis via the peripheral induction of regulatory T cells. Here we show that RA is also required to elicit proinflammatory CD4+ helper T cell responses to infection and mucosal vaccination. Retinoic acid receptor alpha (RARα) is the critical mediator of these effects. Strikingly, antagonism of RAR signaling and deficiency in RARα(Rara−/−) results in a cell autonomous CD4+ T cell activation defect. Altogether, these findings reveal a fundamental role for the RA/RARα axis in the development of both regulatory and inflammatory arms of adaptive immunity and establish nutritional status as a broad regulator of adaptive T cell responses.
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Metadata
- Authors
- Hall, J. A., Cannons, J. L., Grainger, J. R., Dos Santos, L. M., Hand, T. W., Naik, S., Wohlfert, E. A., Chou, D. B., Oldenhove, G., Robinson, M., Grigg, M. E., Kastenmayer, R., Schwartzberg, P. L., & Belkaid, Y.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 34
- Issue
- 3
- Pages
- 435-447
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2040307290
- Cited by
- 377
- References
- 8
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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