Evidence that Meningeal mast cells can worsen stroke pathology in mice.
Open accessAbstract
Stroke is the leading cause of adult disability and the fourth most common cause of death in the United States. Inflammation is thought to play an important role in stroke pathology, but the factors that promote inflammation in this setting remain to be fully defined. An understudied but important factor is the role of meningeal-located immune cells in modulating brain pathology. Although different immune cells traffic through meningeal vessels en route to the brain, mature mast cells do not circulate but are resident in the meninges. With the use of genetic and cell transfer approaches in mice, we identified evidence that meningeal mast cells can importantly contribute to the key features of stroke pathology, including infiltration of granulocytes and activated macrophages, brain swelling, and infarct size. We also obtained evidence that two mast cell-derived products, interleukin-6 and, to a lesser extent, chemokine (C-C motif) ligand 7, can contribute to stroke pathology. These findings indicate a novel role for mast cells in the meninges, the membranes that envelop the brain, as potential gatekeepers for modulating brain inflammation and pathology after stroke.
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Meningeal immune cells play an important role in the brain injury response.
“numerous studies show that meningeal immune cells play an important role in the brain injury response”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Arac et al., 2014
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Follicle on the Roof: Tertiary Lymphoid Structures in Central Nervous System Autoimmunity
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Immunomodulatory contribution of mast cells to the regenerative biomaterial microenvironment
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Meningeal Multipotent Cells: A Hidden Target for CNS Repair?
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An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System
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- Authors
- Arac, A., Grimbaldeston, M. A., Nepomuceno, A. R. B., Olayiwola, O., Pereira, M. P., Nishiyama, Y., Tsykin, A., Goodall, G. J., Schlecht, U., Vogel, H., Tsai, M., Galli, S. J., Bliss, T. M., & Steinberg, G. K.
- Affiliations
- Stanford Medicine (US)
- South Australia Pathology (AU)
- Corresponding author
- Grimbaldeston, Michele A.
- Galli, Stephen J.
- Bliss, Tonya M.
- Steinberg, Gary K.
- ORCID
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 184
- Issue
- 9
- Pages
- 2493-2504
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC4188278
- OpenAlex
- W2157668990
- Cited by
- 74
- References
- 65
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- National Institutes of Health (NS37520-08, CA072074, NS080062, AI070813, AI023990)
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- stroke, meninges, neuroinflammation, granulocyte infiltration, macrophage activation, cerebral edema, infarct size, interleukin-6, CCL7, cell transfer
- MeSH terms
- Animals, Brain, Disease Models, Animal, Flow Cytometry, Magnetic Resonance Imaging, Male, Mast Cells, Meninges, Mice, Inbred C57BL, Mice, Knockout, Stroke, Mice, Gene Knock-In Techniques
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