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Cited by 1,064

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

The Spleen in Local and Systemic Regulation of Immunity

Open access
Bronte, Vincenzo, Pittet, Mikael J.·2013·Immunity

Abstract

Summary The spleen is the main filter for blood-borne pathogens and antigens, as well as a key organ for iron metabolism and erythrocyte homeostasis. However, immune and hematopoietic functions have been recently unveiled for the mouse spleen, suggesting additional roles for this secondary lymphoid organ. Here we discuss the integration of the spleen in the regulation of immune responses locally and in the whole body and present the relevance of findings for our understanding of inflammatory and degenerative diseases and their treatments. We also consider whether equivalent activities in humans are known, as well as initial therapeutic attempts to target the spleen for modulating innate and adaptive immunity.

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Crossref · 10.1016/j.immuni.2013.10.010

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Metadata

Authors
Bronte, V., & Pittet, M. J.
Venue
Immunity
Publisher
Elsevier BV
Published
2013-11
Volume
39
Issue
5
Pages
806-818
ISSN
1074-7613 (ISSN-L)
OpenAlex
W2101957891
Cited by
1,064
References
19
FWCI
12.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Spleen in Local and Systemic Regulation of Immunity. https://app.cochat.ai/papers/10.1016/j.immuni.2013.10.010
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Bronte, V., & Pittet, M. J. (2013). The Spleen in Local and Systemic Regulation of Immunity. Immunity. https://doi.org/10.1016/j.immuni.2013.10.010

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.