Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
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Th17 cells accrue in the intestine in response to particular microbes. In rodents, segmented filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously functioning microbes in humans remain undefined. Here, we identified human symbiont bacterial species, in particular Bifidobacterium adolescentis, that could, alone, induce Th17 cells in the murine intestine. Similar to SFB, B. adolescentis was closely associated with the gut epithelium and engendered cognate Th17 cells without attendant inflammation. However, B. adolescentis elicited a transcriptional program clearly distinct from that of SFB, suggesting an alternative mechanism of promoting Th17 cell accumulation. Inoculation of mice with B. adolescentis exacerbated autoimmune arthritis in the K/BxN mouse model. Several off-the-shelf probiotic preparations that include Bifidobacterium strains also drove intestinal Th17 cell accumulation.
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The ability of other TH17-inducing gut bacteria to produce ATP has not been determined, but a common property appears to be their ability to adhere to the intestinal epithelium.
“The capability of other TH17-inducing gut bacteria to produce ATP has not been determined yet, but a common property appears to be their ability to adhere to the intestinal epithelium (Atarashi et al., 2015; Tan et al., 2016).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Tan et al., 2016
Th17 cells are absent in GF mice and are inducible upon microbial colonization, most notably with segmented filamentous bacteria, but also other commensal bacteria.
“Th17 cells are absent in GF mice and are inducible upon microbial colonization, most notably with segmented filamentous bacteria (SFB),33,34 but also other commensal bacteria.35”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [35]
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“The capability of other TH17-inducing gut bacteria to produce ATP has not been determined yet, but a common property appears to be their ability to adhere to the intestinal epithelium (Atarashi et al., 2015; Tan et al., 2016).”
BackgroundMining the Human Gut Microbiota for Immunomodulatory Organisms
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Mining the microbiota for microbial and metabolite-based immunotherapies
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TH17 cell heterogeneity and its role in tissue inflammation
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Intestinal epithelial cells: At the interface of the microbiota and mucosal immunity
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Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
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The role of the gut microbiota in multiple sclerosis
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GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk
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- Authors
- Tan, T. G., Sefik, E., Geva-Zatorsky, N., Kua, L., Naskar, D., Teng, F., Pasman, L., Ortiz-Lopez, A., Jupp, R., Wu, H.-J. J., Kasper, D. L., Benoist, C., & Mathis, D.
- Affiliations
- Harvard University (US)
- Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;
- University of Arizona (US)
- UCB Pharma (United Kingdom) (GB)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-11-23
- Volume
- 113
- Issue
- 50
- Pages
- E8141-E8150
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5167147
- OpenAlex
- W2552260644
- Cited by
- 427
- References
- 69
- Citations by year
- 2026: 23 · 2025: 28 · 2024: 45 · 2023: 53 · 2022: 49 · 2021: 60 · 2020: 46 · 2019: 52 · 2018: 33 · 2017: 37 · 2016: 1
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI107117)
- Human Frontier Science Program (LT00079/2012)
- European Molecular Biology Organization (ALTF 251-2011)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- Th17 cells, Bifidobacterium adolescentis, segmented filamentous bacteria, gut microbiota, probiotics, autoimmune arthritis, K/BxN mice, intestinal epithelium
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium adolescentis, Animals, Arthritis, Experimental, Female, Germ-Free Life, Humans, Intestinal Mucosa, Male, Mice, Inbred C57BL, Symbiosis, Inflammatory Bowel Diseases, Immunity, Mucosal, Probiotics, Gene Expression Profiling, Mice, Th17 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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