Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells
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T cell development is orchestrated by transcription factors that regulate the expression of genes initially buried within inaccessible chromatin, but the transcription factors that establish the regulatory landscape of the T cell lineage remain unknown. Profiling chromatin accessibility at eight stages of T cell development revealed the selective enrichment of TCF-1 at genomic regions that became accessible at the earliest stages of development. TCF-1 was further required for the accessibility of these regulatory elements and at the single-cell level, it dictated a coordinate opening of chromatin in T cells. TCF-1 expression in fibroblasts generated de novo chromatin accessibility even at chromatin regions with repressive marks, inducing the expression of T cell-restricted genes. These results indicate that a mechanism by which TCF-1 controls T cell fate is through its widespread ability to target silent chromatin and establish the epigenetic identity of T cells.
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PU.1 recognition motifs are the most highly enriched of all defined motifs at sites that start out highly accessible in early pro-T cell stages and lose accessibility during commitment.
“PU.1 recognition motifs are the most highly enriched of all defined motifs at sites that start out highly accessible in early pro-T cell stages, when PU.1 is present, and lose accessibility during commitment, i.e., as PU.1 levels decline (44, 85, 95).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [95]
The Results sections on chromatin remodeling and TCF-1 enrichment report that many sites open at the early ETP stage later lose accessibility, and that early regulatory elements deactivated before maturation are enriched for PU.1 binding. Our copy does not establish that PU.1 recognition motifs are the most highly enriched of all defined motifs at those sites, or that their accessibility is lost specifically during commitment. (LLM, conf=0.86)
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Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422 · see citing works
FIMO: scanning for occurrences of a given motif
Grant, C. E., Bailey, T. L., & Noble, W. S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr064 · Cited by 4,247 · see citing works
Single-cell chromatin accessibility reveals principles of regulatory variation
Buenrostro, J. D., Wu, B., Litzenburger, U. M., Ruff, D., Gonzales, M. L., Snyder, M. P., Chang, H. Y., & Greenleaf, W. J. (2015) · Nature · doi:10.1038/nature14590 · Cited by 2,308 · see citing works
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070 · see citing works
The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project Consortium, Heng, T. S. P., Painter, M. W., Elpek, K., Lukacs-Kornek, V., Mauermann, N., Turley, S. J., Koller, D., Kim, F. S., Wagers, A. J., et al. (2008) · Nature Immunology · doi:10.1038/ni1008-1091 · Cited by 1,864 · see citing works
chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
Schep, A. N., Wu, B., Buenrostro, J. D., & Greenleaf, W. J. (2017) · Nature Methods · doi:10.1038/nmeth.4401 · Cited by 1,680 · see citing works
Pioneer transcription factors: establishing competence for gene expression
Zaret, K. S., & Carroll, J. S. (2011) · Genes & Development · doi:10.1101/gad.176826.111 · Cited by 1,589 · see citing works
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Pauken, K. E., Sammons, M. A., Odorizzi, P. M., Manne, S., Godec, J., Khan, O., Drake, A. M., Chen, Z., Sen, D. R., Kurachi, M., et al. (2016) · Science · doi:10.1126/science.aaf2807 · Cited by 1,348 · cited 2× · see citing works
“, 2012) and CD8 T effector responses (Gray et al., 2017; Pauken et al., 2016; Yu et al., 2017), and reports on the dynamics of histone modifications during T cell development (Dose et al.”
BackgroundSelf-citationA Validated Regulatory Network for Th17 Cell Specification
Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C. N., Muratet, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.016 · Cited by 1,160 · see citing works
The UCSC Genome Browser database: 2015 update
Rosenbloom, K., Armstrong, J., Barber, G. P., Casper, J., Clawson, H., Diekhans, M., Dreszer, T. R., Fujita, P. A., Guruvadoo, L., Haeussler, M., et al. (2014) · Nucleic Acids Res. · doi:10.1093/nar/gku1177 · Cited by 1,011 · see citing works
Measuring reproducibility of high-throughput experiments
Li, Q., Brown, J. B., Huang, H., & Bickel, P. J. (2011) · The Annals of Applied Statistics · doi:10.1214/11-aoas466 · Cited by 1,008 · see citing works
Measuring reproducibility of high-throughput experiments
Li, Q., Brown, J. B., Huang, H., & Bickel, P. J. (2010) · UC Berkeley · Cited by 915 · see citing works
Soufi, A., Donahue, G., & Zaret, K. (2012) · Cell · doi:10.1016/j.cell.2012.09.045 · Cited by 888 · see citing works
Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming
Soufi, A., Garcia, M. F., Jaroszewicz, A., Osman, N., Pellegrini, M., & Zaret, K. S. (2015) · Cell · doi:10.1016/j.cell.2015.03.017 · Cited by 780 · cited 4× · see citing works
“The extent to which TCF-1 bound to nucleosome-occupied regions in fibroblasts was comparable to reprogramming transcription factors such as OCT4 (85%), SOX2 (80%), and KLF4 (65%) (Soufi et al., 2015).”
BackgroundInfluentialThe pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses
Naviaux, R. K., Costanzi, E., Haas, M., & Verma, I. M. (1996) · Journal of Virology · doi:10.1128/jvi.70.8.5701-5705.1996 · Cited by 735 · see citing works
Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1
Zhou, X.-Y., Yu, S.-Y., Zhao, D.-M., Harty, J., Badovinac, V., & Xue, H.-H. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.002 · Cited by 689 · see citing works
Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666 · see citing works
An HMG-box-containing T-cell factor required for thymocyte differentiation
Verbeek, S., Izon, D., Hofhuis, F., Robanus-Maandag, E., Riele, H. T., van de Watering, M., Oosterwegel, M., Wilson, A., Macdonald, H., & Clevers, H. (1995) · Nature · doi:10.1038/374070a0 · Cited by 585 · see citing works
Structural basis for DNA bending by the architectural transcription factor LEF-1
Love, J. J., Li, X., Case, D. A., Giese, K., Grosschedl, R., & Wright, P. E. (1995) · Nature · doi:10.1038/376791a0 · Cited by 573 · see citing works
Fundamentally Different Logic of Gene Regulation in Eukaryotes and Prokaryotes
Struhl, K. (1999) · Cell · doi:10.1016/s0092-8674(00)80599-1 · Cited by 486 · see citing works
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
Chen, J., He, L., Liu, J., Qi, J. Y., Wei, B., Yang, J., Liang, H., Chen, Y., Chen, J., Wu, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.2491 · Cited by 483 · see citing works
Launching the T-cell-lineage developmental programme
Rothenberg, E. V., Moore, J. E., & Yui, M. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2232 · Cited by 475 · see citing works
DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina
Zullo, J., Demarco, I. A., Piqué-Regi, R., Gaffney, D. J., Epstein, C. B., Spooner, C. J., Luperchio, T. R., Bernstein, B., Pritchard, J. K., Reddy, K. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.035 · Cited by 448 · see citing works
Chromatin Higher Order Folding--Wrapping up Transcription
Horn, P. J., & Peterson, C. L. (2002) · Science · doi:10.1126/science.1074200 · Cited by 430 · see citing works
A critical role for TCF-1 in T-lineage specification and differentiation
Weber, B., Chi, A. W. S., Chavez, A., Yashiro–Ohtani, Y., Yang, Q., Shestova, O. E., & Bhandoola, A. (2011) · Nature · doi:10.1038/nature10279 · Cited by 420 · see citing works
Self-citationDANPOS: Dynamic analysis of nucleosome position and occupancy by sequencingPreprint
Chen, K.-F., Xi, Y., Pan, X.-W., Li, Z.-Y., Kaestner, K., Tyler, J. K., Dent, S., He, X.-W., & Li, W. (2013) · Genome Research · doi:10.1101/gr.142067.112 · Cited by 415 · see citing works
Schep, A. N., Buenrostro, J. D., Denny, S. K., Schwartz, K., Sherlock, G., & Greenleaf, W. J. (2015) · Genome Research · doi:10.1101/gr.192294.115 · Cited by 375 · see citing works
Super-enhancers delineate disease-associated regulatory nodes in T cells
Vahedi, G., Kanno, Y., Furumoto, Y., Jiang, K., Parker, S. C. J., Erdos, M. R., Davis, S. R., Roychoudhuri, R., Restifo, N. P., Gadina, M., et al. (2015) · Nature · doi:10.1038/nature14154 · Cited by 369 · see citing works
Self-citationSTATs Shape the Active Enhancer Landscape of T Cell Populations
Vahedi, G., Takahashi, H., Nakayamada, S., Sun, H., Sartorelli, V., Kanno, Y., & O’Shea, J. J. (2012) · Cell · doi:10.1016/j.cell.2012.09.044 · Cited by 365 · see citing works
Self-citationZhang, J. A., Mortazavi, A., Williams, B. A., Wold, B. J., & Rothenberg, E. V. (2012) · Cell · doi:10.1016/j.cell.2012.01.056 · Cited by 337 · see citing works
Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
Wei, G., Abraham, B. J., Yagi, R., Jothi, R., Cui, K., Sharma, S., Narlikar, L., Northrup, D. L., Tang, Q., Paul, W. E., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.007 · Cited by 337 · see citing works
Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality
Shih, H.-Y., Sciumè, G., Mikami, Y., Guo, L., Sun, H.-W., Brooks, S. R., Urban, J. F., Davis, F. P., Kanno, Y., & O’Shea, J. J. (2016) · Cell · doi:10.1016/j.cell.2016.04.029 · Cited by 334 · see citing works
Exhaustion-associated regulatory regions in CD8 + tumor-infiltrating T cells
Mognol, G. P., Spreafico, R., Wong, V., Scott-Browne, J. P., Togher, S., Hoffmann, A., Hogan, P. G., Rao, A., & Trifari, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620498114 · Cited by 312 · see citing works
Genome-wide nucleosome positioning during embryonic stem cell development
Teif, V. B., Vainshtein, Y., Caudron-Herger, M., Mallm, J.-P., Marth, C., Höfer, T., & Rippe, K. (2012) · Nature Structural &Molecular Biology · doi:10.1038/nsmb.2419 · Cited by 260 · see citing works
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation
Yu, B., Zhang, K., Milner, J. J., Toma, C., Chen, R., Scott-Browne, J. P., Pereira, R. M., Crotty, S., Chang, J. T., Pipkin, M. E., et al. (2017) · Nature Immunology · doi:10.1038/ni.3706 · Cited by 248 · see citing works
Gray, S. M., Amezquita, R. A., Guan, T., Kleinstein, S. H., & Kaech, S. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.012 · Cited by 245 · see citing works
Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity
Xing, S., Li, F., Zeng, Z., Zhao, Y., Yu, S., Shan, Q., Li, Y., Phillips, F. C., Maina, P. K., Qi, H. H., et al. (2016) · Nature Immunology · doi:10.1038/ni.3456 · Cited by 226 · see citing works
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Germar, K., Dose, M., Konstantinou, T., Zhang, J., Wang, H., Lobry, C., Arnett, K. L., Blacklow, S. C., Aifantis, I., Aster, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110230108 · Cited by 219 · see citing works
Barozzi, I., Simonatto, M., Bonifacio, S., Yang, L., Rohs, R., Ghisletti, S., & Natoli, G. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.006 · Cited by 209 · see citing works
C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells
Stefano, B. D., Sardina, J. L., van Oevelen, C. J. C., Collombet, S., Kallin, E. M., Vicent, G. P., Lü, J., Thieffry, D., Beato, M., & Graf, T. (2013) · Nature · doi:10.1038/nature12885 · Cited by 201 · see citing works
Creating reference gene annotation for the mouse C57BL6/J genome assembly
Mudge, J. M., & Harrow, J. (2015) · Mammalian Genome · doi:10.1007/s00335-015-9583-x · Cited by 169 · see citing works
Boller, S., Ramamoorthy, S., Akbas, D., Nechanitzky, R., Burger, L., Murr, R., Schübeler, D., & Grosschedl, R. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.021 · Cited by 133 · see citing works
A far downstream enhancer for murine Bcl11b controls its T-cell specific expression
Li, L., Zhang, J. A., Dose, M., Kueh, H. Y., Mosadeghi, R., Gounari, F., & Rothenberg, E. V. (2013) · Blood · doi:10.1182/blood-2012-08-447839 · Cited by 115 · see citing works
Divergent transcription is associated with promoters of transcriptional regulators
Lepoivre, C., Belhocine, M., Bergon, A., Griffon, A., Yammine, M., Vanhille, L., Cabeza, J. Z., Garibal, M., Koch, F., Maqbool, M. A., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-914 · Cited by 111 · see citing works
β-Catenin induces T-cell transformation by promoting genomic instability
Dose, M., Emmanuel, A. O., Chaumeil, J., Zhang, J., Sun, T., Germar, K., Aghajani, K., Davis, E. M., Keerthivasan, S., Bredemeyer, A. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315752111 · Cited by 63 · see citing works
Wöhrle, S., Wallmen, B., & Hecht, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00555-07 · Cited by 56 · see citing works
Regulation of antigen receptor gene assembly by genetic–epigenetic crosstalk
Osipovich, O. A., & Oltz, E. M. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2010.07.001 · Cited by 23 · see citing works
Oestreich, K. J., & Weinmann, A. S. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_141 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Khan, O., Giles, J. R., McDonald, S., Manne, S., Ngiow, S. F., Patel, K. P., Werner, M. T., Huang, A. C., Alexander, K. A., Wu, J. E., et al. (2019) · Nature · doi:10.1038/s41586-019-1325-x · Cited by 1,646 · see citing works
Self-citationSatpathy, A. T., Granja, J. M., Yost, K. E., Qi, Y., Meschi, F., McDermott, G. P., Olsen, B. N., Mumbach, M. R., Pierce, S. E., Corces, M. R., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0206-z · Cited by 980 · see citing works
Sexual-dimorphism in human immune system aging
Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Nehar-Belaid, D., Eroglu, A., Mellert, D. J., Kuchel, G. A., Banchereau, J., & Ucar, D. (2020) · Nature Communications · doi:10.1038/s41467-020-14396-9 · Cited by 584 · see citing works
The emerging role of epigenetic therapeutics in immuno-oncology
Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R., & Baylin, S. B. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0266-5 · Cited by 433 · see citing works
Pioneer Transcription Factors Initiating Gene Network Changes
Zaret, K. S. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-030220-015007 · Cited by 398 · see citing works
Towards targeting the breast cancer immune microenvironment
Harris, M., Savas, P., Virassamy, B., O’Malley, M. M. R., Kay, J., Mueller, S. N., Mackay, L., Salgado, R., & Loi, S. (2024) · Nature Reviews. Cancer · doi:10.1038/s41568-024-00714-6 · Cited by 376 · see citing works
Philipp, N., Pasikhani, M. K., Nicholls, A., Vick, B., Wulf, J., Straub, T., Scheurer, M., Muth, A., Hänel, G., Nixdorf, D., et al. (2022) · Blood · doi:10.1182/blood.2022015956 · Cited by 285 · see citing works
Epigenetic control of innate and adaptive immune memory
Lau, C. M., Adams, N. M., Geary, C. D., Weizman, O.-E., Rapp, M., Pritykin, Y., Leslie, C. S., & Sun, J. C.-Y. (2018) · Nature Immunology · doi:10.1038/s41590-018-0176-1 · Cited by 279 · see citing works
Pioneer factors as master regulators of the epigenome and cell fate
Balsalobre, A., & Drouin, J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00464-z · Cited by 251 · see citing works
TCF1 in T cell immunity: a broadened frontier
Zhao, X., Shan, Q., & Xue, H. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00563-6 · Cited by 252 · see citing works
How transcription factors drive choice of the T cell fate
Hosokawa, H., & Rothenberg, E. V. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00426-6 · Cited by 239 · see citing works
WNT Signaling in Cancer Immunosurveillance
Galluzzi, L., Spranger, S., Fuchs, E. V., & López‐Soto, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.08.005 · Cited by 240 · see citing works
TOX is expressed by exhausted and polyfunctional human effector memory CD8 + T cells
Sekine, T., Perez‐Potti, A., Nguyen, S., Gorin, J., Wu, V. H., Emma Gostick, D., Llewellyn‐Lacey, S., Hammer, Q., Falck‐Jones, S., Vangeti, S., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba7918 · Cited by 238 · see citing works
Wang, Y., Tong, C., Dai, H., Wu, Z., Han, X., Guo, Y., Chen, D., Wei, J., Ti, D., Liu, Z. Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20696-x · Cited by 237 · see citing works
FOXO1 is a master regulator of memory programming in CAR T cells
Doan, A. E., Mueller, K. P., Chen, A. Y., Rouin, G. T., Chen, Y.-S., Daniel, B., Lattin, J., Markovska, M., Mozarsky, B., Arias-Umana, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07300-8 · Cited by 210 · see citing works
T cell factor 1: A master regulator of the T cell response in disease
Escobar, G., Mangani, D., & Anderson, A. C. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb9726 · Cited by 211 · see citing works
Chen, G. M., Chen, C., Das, R. K., Gao, P., Chen, C., Bandyopadhyay, S., Ding, Y., Uzun, Y., Yu, W., Zhu, Q., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1677 · Cited by 211 · see citing works
Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
Chen, Y., Zander, R., Khatun, A., Schauder, D., & Cui, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02826 · Cited by 146 · see citing works
Single‐cell analyses reveal suppressive tumor microenvironment of human colorectal cancer
Mei, Y., Xiao, W., Hu, H., Lu, G., Chen, L., Sun, Z., Lü, M., Ma, W., Jiang, T., Gao, Y., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.422 · Cited by 147 · see citing works
Epigenetic mechanisms regulating T-cell responses
Schmidl, C., Delacher, M., Huehn, J., & Feuerer, M. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.07.014 · Cited by 144 · see citing works
Pioneer factors: roles and their regulation in development
Barral, A., & Zaret, K. S. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.10.007 · Cited by 126 · see citing works
Cheng, Z.-Y., He, T., Gao, X., Zhao, Y., & Wang, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713294 · Cited by 117 · see citing works
van der Veeken, J., Glasner, A., Zhong, Y., Hu, W., Wang, Z.-M., Bou-Puerto, R., Charbonnier, L., Chatila, T. A., Leslie, C. S., & Rudensky, A. Y. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.010 · Cited by 107 · see citing works
Regulation of signaling pathways in hair follicle stem cells
Wang, X., Liu, Y., He, J., Wang, J., Chen, X., & Yang, R. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac022 · Cited by 113 · see citing works
T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
Gao, Z., Feng, Y., Xu, J., & Liang, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977394 · Cited by 111 · see citing works
Ford, B. R., Vignali, P., Rittenhouse, N., Scharping, N. E., Peralta, R. M., Lontos, K., Frisch, A. T., Delgoffe, G. M., & Poholek, A. C. (2022) · Science Immunology · doi:10.1126/sciimmunol.abj9123 · Cited by 110 · see citing works
Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1.
Raghu, D., Xue, H.-H., & Mielke, L. (2019) · Trends in immunology · doi:10.1016/j.it.2019.10.006 · Cited by 95 · see citing works
Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99 · see citing works
Le, J., Park, J. E., Ha, V. L., Luong, A., Branciamore, S., Rodin, A. S., Gogoshin, G., Li, F., Loh, Y. E., Camacho, V., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.010 · Cited by 97 · see citing works
TCF-1: A maverick in T cell development and function
Gounari, F., & Khazaie, K. (2022) · Nature Immunology · doi:10.1038/s41590-022-01194-2 · Cited by 73 · see citing works
Yu, H., Chen, M., Hu, Y., Ou, S., Xiu, Y., Liang, S., Li, N., Yang, M., Kong, X., Sun, C., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.06.006 · Cited by 97 · see citing works
Role of TCF‐1 in differentiation, exhaustion, and memory of CD8 + T cells: A review
Zhang, J., Lyu, T., Cao, Y., & Feng, H. (2021) · The FASEB Journal · doi:10.1096/fj.202002566r · Cited by 95 · see citing works
Shan, Q., Li, X., Chen, X., Zeng, Z., Zhu, S., Gai, K., Peng, W., & Xue, H. (2021) · Nature Communications · doi:10.1038/s41467-021-26159-1 · Cited by 95 · see citing works
Shan, Q., Hu, S. S., Chen, X., Danahy, D. B., Badovinac, V. P., Zang, C., & Xue, H. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0436-5 · Cited by 90 · see citing works
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
Rutishauser, R. L., Deguit, C. D. T., Hiatt, J. B., Blaeschke, F., Roth, T. L., Wang, L., Raymond, K. A., Starke, C. E., Mudd, J. C., Chen, W., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.136648 · Cited by 93 · see citing works
Peng, Y., Xiao, L., Rong, H., Ou, Z., Cai, T., Liu, N., Li, B., Zhang, L., Wu, F., Lan, T., et al. (2021) · Oral Oncology · doi:10.1016/j.oraloncology.2021.105348 · Cited by 88 · see citing works
Epigenetic reprogramming of immune cells in injury, repair, and resolution
Placek, K., Schultze, J. L., & Aschenbrenner, A. C. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124619 · Cited by 83 · see citing works
Iwafuchi, M., Cuesta, I., Donahue, G., Takenaka, N., Osipovich, A. B., Magnuson, M. A., Röder, H., Seeholzer, S. H., Santisteban, P., & Zaret, K. S. (2020) · Nature Genetics · doi:10.1038/s41588-020-0591-8 · Cited by 82 · see citing works
The Transcription Factor TCF1 in T Cell Differentiation and Aging
Kim, C., Jin, J., Weyand, C. M., & Goronzy, J. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186497 · Cited by 81 · see citing works
Programming for T-lymphocyte fates: modularity and mechanismsPreprint
Rothenberg, E. V. (2019) · Genes & Development · doi:10.1101/gad.327163.119 · Cited by 74 · see citing works
TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors
Wang, W., Chandra, A., Goldman, N., Yoon, S., Ferrari, E. K., Nguyen, S. C., Joyce, E., & Vahedi, G. (2022) · Nature Immunology · doi:10.1038/s41590-022-01232-z · Cited by 53 · see citing works
Self-citationZhong, Y., Walker, S. K., Pritykin, Y., Leslie, C. S., Rudensky, A. Y., & van der Veeken, J. (2021) · Nature Immunology · doi:10.1038/s41590-021-01086-x · Cited by 67 · see citing works
The chromatin signatures of enhancers and their dynamic regulation
Barral, A., & Déjardin, J. (2023) · Nucleus · doi:10.1080/19491034.2022.2160551 · Cited by 71 · see citing works
Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum
Ruiz, J. L., Tena, J. J., Bancells, C., Cortés, A., Gómez-Skármeta, J. L., & Gómez‐Díaz, E. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky643 · Cited by 68 · see citing works
TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis
Mielke, L. A., Liao, Y., Clemens, E. B., Firth, M. A., Duckworth, B. C., Huang, Q., Almeida, F. F., Chopin, M., Koay, H., Bell, C. A., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181778 · Cited by 68 · see citing works
Emmanuel, A. O., Arnovitz, S., Haghi, L., Mathur, P., Mondal, S., Quandt, J., Okoreeh, M. K., Maienschein‐Cline, M., Khazaie, K., Dose, M., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0254-4 · Cited by 66 · see citing works
Cildir, G., Toubia, J., Yip, K. H., Zhou, M., Pant, H., Hissaria, P., Zhang, J., Hong, W., Robinson, N., Grimbaldeston, M. A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.021 · Cited by 65 · see citing works
Stripenn detects architectural stripes from chromatin conformation data using computer vision
Yoon, S., Chandra, A., & Vahedi, G. (2021) · Nature Communications · doi:10.1038/s41467-022-29258-9 · Cited by 47 · see citing works
Self-citationTcf1–CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis
Shan, Q., Zhu, S., Chen, X., Liu, J., Yuan, S., Li, X., Peng, W., & Xue, H. (2022) · Nature Immunology · doi:10.1038/s41590-022-01263-6 · Cited by 63 · see citing works
Miyazaki, K., Watanabe, H., Yoshikawa, G., Chen, K., Hidaka, R., Aitani, Y., Osawa, K., Takeda, R., Ochi, Y., Tani‐ichi, S., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb1455 · Cited by 61 · see citing works
Zhou, W., Gao, F., Romero-Wolf, M., Jo, S., & Rothenberg, E. V. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm1920 · Cited by 56 · see citing works
Fasolino, M., Goldman, N., Wang, W.-L., Cattau, B., Zhou, Y., Petrovic, J., Link, V. M., Coté, A., Chandra, A., Silverman, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.003 · Cited by 48 · see citing works
Self-citationShin, B., Hosokawa, H., Romero-Wolf, M., Zhou, W., Masuhara, K., Tobin, V. R., Levanon, D., Groner, Y., & Rothenberg, E. V. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019655118 · Cited by 53 · see citing works
Metabolic regulation of epigenetic remodeling in immune cells
Britt, E. C., John, S. V., Locasale, J. W., & Fan, J. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.12.008 · Cited by 53 · see citing works
The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home
van Loosdregt, J., & Coffer, P. J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800633 · Cited by 50 · see citing works
The 3D enhancer network of the developing T cell genome is shaped by SATB1
Zelenka, T., Klonizakis, A., Tsoukatou, D., Papamatheakis, D.-A., Franzenburg, S., Tzerpos, P., Tzonevrakis, I.-R., Papadogkonas, G., Kapsetaki, M., Nikolaou, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34345-y · Cited by 42 · see citing works
Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells
Li, P., & Leonard, W. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02738 · Cited by 47 · see citing works
Wang, W., Fasolino, M., Cattau, B., Goldman, N., Kong, W., Frederick, M. A., McCright, S. J., Kiani, K., Fraietta, J. A., & Vahedi, G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919259117 · Cited by 46 · see citing works
Self-citationFunctional definition of a transcription factor hierarchy regulating T cell lineage commitment
García-Pérez, L., Famili, F., Cordes, M., Brugman, M. H., van Eggermond, M. C. J. A., Wu, H., Chouaref, J., León, D. S., Tiemessen, M. M., Pike‐Overzet, K., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaw7313 · Cited by 40 · see citing works
γδ T, NKT, and MAIT Cells During Evolution: Redundancy or Specialized Functions?
Harly, C., Robert, J., Legoux, F. P., & Lantz, O. J. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200105 · Cited by 39 · see citing works
Self-citationHarly, C., Kenney, D., Wang, Y., Ding, Y., Zhao, Y., Awasthi, P., & Bhandoola, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00470 · Cited by 37 · see citing works
Self-citationCell lineage-specific transcriptome analysis for interpreting cell fate specification of proembryos
Zhou, X., Liu, Z., Shen, K., Zhao, P., & Sun, M. (2020) · Nature Communications · doi:10.1038/s41467-020-15189-w · Cited by 37 · see citing works
Chandra, A., Yoon, S., Michieletto, M. F., Goldman, N., Ferrari, E. K., Abedi, M., Johnson, I., Fasolino, M., Pham, K., Joannas, L., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.05.004 · Cited by 34 · see citing works
Self-citationSingle-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human
Rothenberg, E. V. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2020.12.005 · Cited by 35 · see citing works
The E protein-TCF1 axis controls γδ T cell development and effector fate
Fahl, S. P., Contreras, A. V., Verma, A., Qiu, X., Harly, C., Radtke, F., Zúñiga‐Pflücker, J. C., Murre, C., Xue, H., Sen, J. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108716 · Cited by 36 · see citing works
Self-citationLerner, J., Katznelson, A., Zhang, J., & Zaret, K. S. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112748 · Cited by 35 · see citing works
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development
Dolens, A., Durinck, K., Lavaert, M., der Meulen, J. V., Velghe, I., Medts, J. D., Weening, K., Roels, J., Katrien De Mulder, A., Volders, P., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949006 · Cited by 33 · see citing works
Mangani, D., Subramanian, A., Huang, L., Cheng, H., Krovi, S. H., Wu, Y., Yang, D., Moreira, T. G., Escobar, G., Schnell, A., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.017 · Cited by 35 · see citing works
Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
Pagé, N., Lemeille, S., Vincenti, I., Klimek, B., Mariotte, A., Wagner, I., Liberto, G. D., Kaye, J. G., & Merkler, D. (2021) · Nature Communications · doi:10.1038/s41467-021-21109-3 · Cited by 34 · see citing works
T FH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function
Li, F., Zhao, X., Zhang, Y., Shao, P., Ma, X., Paradee, W. J., Liu, C., Wang, J., & Xue, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014562118 · Cited by 32 · see citing works
Chen, Z., Zhu, Z., Hu, T., Yao, C., & Wu, T. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01378-4 · Cited by 36 · see citing works
The epigenetic landscape of fate decisions in T cells
Jay, A., Pondevida, C. M., & Vahedi, G. (2025) · Nature Immunology · doi:10.1038/s41590-025-02113-x · Cited by 31 · see citing works
Self-citationPioneer Factors in Animals and Plants—Colonizing Chromatin for Gene Regulation
Lai, X., Verhage, L., Hugouvieux, V., & Zubieta, C. (2018) · Molecules · doi:10.3390/molecules23081914 · Cited by 28 · see citing works
Georgakilas, G. K., Perdikopanis, N., & Hatzigeorgiou, A. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-57811-3 · Cited by 29 · see citing works
Self-citationEpigenetics of T cell fate decision
Pace, L., & Amigorena, S. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.01.002 · Cited by 29 · see citing works
Wang, F., Qi, Z., Yao, Y., Yu, G., Feng, T., Zhao, T., Xue, H., Zhao, Y., Jiang, P., Bao, L., et al. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00527-1 · Cited by 29 · see citing works
Miyazaki, K., & Miyazaki, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659761 · Cited by 29 · see citing works
Zhou, Y., Petrovic, J., Zhao, J.-R., Zhang, W., Bigdeli, A., Zhang, Z., Berger, S., Pear, W., & Faryabi, R. (2022) · Molecules and Cells · doi:10.1016/j.molcel.2022.01.015 · Cited by 29 · see citing works
Self-citationRen, G., Lai, B., Harly, C., Baek, S., Ding, Y., Zheng, M., Cao, Y., Cui, K., Yu, Y., Zhu, J., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.019 · Cited by 30 · see citing works
Self-citationTunable, division-independent control of gene activation timing by a polycomb switch
Pease, N. A., Nguyen, P. H., Woodworth, M. A., Ng, K. K. H., Irwin, B., Vaughan, J. C., & Kueh, H. Y. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108888 · Cited by 28 · see citing works
Chaudhary, O., Trotta, D., Wang, K., Wang, X., Chu, X., Bradley, C., Okulicz, J. F., Maves, R. C., Kronmann, K., Schofield, C. M., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004564 · Cited by 28 · see citing works
Transcriptional network dynamics in early T cell development
Shin, B., Chang, S. J., MacNabb, B. W., & Rothenberg, E. V. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20230893 · Cited by 28 · see citing works
SATB1-mediated chromatin landscape in T cells
Ζελένκα, Τ., & Spilianakis, C. G. (2020) · Nucleus · doi:10.1080/19491034.2020.1775037 · Cited by 27 · see citing works
Transcriptional Regulation of Early T-Lymphocyte Development in Thymus
Bao, X., Qin, Y., Lu, L., & Zheng, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884569 · Cited by 26 · see citing works
HIV UTR, LTR, and Epigenetic Immunity
Zhang, J., & Crumpacker, C. S. (2022) · Viruses · doi:10.3390/v14051084 · Cited by 26 · see citing works
Alam, M. R., Akinyemi, A. O., Wang, J., Howlader, M., Farahani, M. E., Nur, M., Zhang, M., Gu, L., & Li, Z. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103757 · Cited by 24 · see citing works
Wen, J., Li, X., Zhao, Q., Yang, X., Wu, M., Yan, Q., Chang, J., Wang, H., Jin, X., Su, X., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2026198 · Cited by 24 · see citing works
Gene Regulatory Circuits in Innate and Adaptive Immune Cells
Saini, A., Ghoneim, H. E., Lio, C. J., Collins, P. L., & Oltz, E. M. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-025949 · Cited by 24 · see citing works
3D Genome Organization as an Epigenetic Determinant of Transcription Regulation in T Cells
Papadogkonas, G., Papamatheakis, D.-A., & Spilianakis, C. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.921375 · Cited by 22 · see citing works
Lee, S., Kim, J., Min, H., & Seong, R. H. (2020) · iScience · doi:10.1016/j.isci.2020.101106 · Cited by 24 · see citing works
Yang, J., Li, Y., He, M., Qiao, J., Sang, Y., Cheang, L. H., Gomes, F. C., Hu, Y., Li, Z., Liu, N., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29283 · Cited by 23 · see citing works
Goldman, N., Chandra, A., Johnson, I., Sullivan, M. A., Patil, A. R., Vanderbeck, A., Jay, A., Zhou, Y., Ferrari, E. K., Mayne, L. C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01599-7 · Cited by 22 · see citing works
Self-citationYe, Z., Gould, T. M., Zhang, H., Jin, J., Weyand, C. M., & Goronzy, J. J. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00056-9 · Cited by 20 · see citing works
Thillo, Q. V., Bie, J. D., Seneviratne, J. A., Demeyer, S., Omari, S. A., Balachandran, A., Zhai, V., Tam, W. L., Sweron, B., Geerdens, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24442-9 · Cited by 20 · see citing works
Piątek, P., Tarkowski, M., Namiecińska, M., Riva, A., Wieczorek, M., Michlewska, S., Dulska, J., Domowicz, M., Michalska, M. K. , Lewkowicz, N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.682094 · Cited by 20 · see citing works
Hirano, K.-I., Hosokawa, H., Koizumi, M., Endo, Y., Yahata, T., Ando, K., & Hozumi, K. (2021) · eLife · doi:10.7554/elife.68227 · Cited by 20 · see citing works
Arnovitz, S., Mathur, P. S., Tracy, M., Mohsin, A., Mondal, S., Quandt, J., Hernandez, K., Khazaie, K., Dose, M., Emmanuel, A., et al. (2022) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2201493119 · Cited by 13 · see citing works
Signaling‐to‐chromatin pathways in the immune system
de Paz, A. M., & Josefowicz, S. Z. (2021) · Immunological Reviews · doi:10.1111/imr.12955 · Cited by 18 · see citing works
Liu, J., Wang, Z., Hao, S., Wang, F., Yao, Y., Zhang, Y., Zhao, Y., Guo, W., Yu, G., Ma, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.791220 · Cited by 18 · see citing works
Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment
Rothenberg, E. V. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.04.002 · Cited by 16 · see citing works
- Authors
- Johnson, J. L., Georgakilas, G., Petrovic, J., Kurachi, M., Cai, S., Harly, C., Pear, W. S., Bhandoola, A., Wherry, E. J., & Vahedi, G.
- Affiliations
- University of Pennsylvania (US)
- National Institutes of Health (US)
- Corresponding author
- Vahedi, Golnaz
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 48
- Issue
- 2
- Pages
- 243-257.e10
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC5824646
- OpenAlex
- W2788726131
- Cited by
- 226
- References
- 57
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 23 · 2023: 37 · 2022: 37 · 2021: 37 · 2020: 36 · 2019: 12 · 2018: 15
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Cancer Institute (P01CA119070, R01CA215518)
- National Institute of Allergy and Infectious Diseases (R01AI115712, R01AI047833, R01AI105343, K22AI112570, U19AI117950, P01AI112521, R21AI117718, U19AI082630, P01AI108545)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- TCF1, T cell development, chromatin accessibility, transcription factors, lineage determination, chromatin opening, T cell fate
- MeSH terms
- Animals, Chromatin, Fibroblasts, T-Lymphocytes, Transcription, Genetic, Cell Lineage, NIH 3T3 Cells, Chromatin Assembly and Disassembly, Mice, Hepatocyte Nuclear Factor 1-alpha, T Cell Transcription Factor 1, Epigenomics
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