Cited by 2,066Adipokines, Inflammation, and Metabolic DiseasesDiabetes Treatment and ManagementSkin Diseases and Diabetes

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Inflammation in obesity, diabetes, and related disorders

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Rohm, Theresa V., Meier, Daniel T., Olefsky, Jerrold M., Donath, Marc Y.·2022·Immunity

DOI 10.1016/j.immuni.2021.12.013PMC PMC8773457

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Abstract

Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state contributes to long-term complications of diabetes, including non-alcoholic fatty liver disease (NAFLD), retinopathy, cardiovascular disease, and nephropathy, and may underlie the association of type 2 diabetes with other conditions such as Alzheimer's disease, polycystic ovarian syndrome, gout, and rheumatoid arthritis. Here, we review the current understanding of the mechanisms underlying inflammation in obesity, T2D, and related disorders. We discuss how chronic tissue inflammation results in IR, impaired insulin secretion, glucose intolerance, and T2D and review the effect of inflammation on diabetic complications and on the relationship between T2D and other pathologies. In this context, we discuss current therapeutic options for the treatment of metabolic disease, advances in the clinic and the potential of immune-modulatory approaches.

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Authors: Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y.
Affiliations: University of California San Diego (US)
University of Basel (CH)
Corresponding author: Donath, Marc Y.
ORCID: Rohm, Theresa V.
Meier, Daniel T.
Olefsky, Jerrold M.
Donath, Marc Y.
Venue: Immunity
Publisher: Elsevier BV
Published: 2022-01
Volume: 55
Issue: 1
Pages: 31-55
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2021.12.013
PMC: PMC8773457
OpenAlex: W4206799195
Cited by: 2,066
References: 422
Citations by year: 2026: 450 · 2025: 649 · 2024: 512 · 2023: 345 · 2022: 108
FWCI: 64.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK063491, DK101395)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (P2BSP3_200177)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Keywords: obesity, type 2 diabetes, chronic inflammation, insulin resistance, beta-cell dysfunction, insulin secretion, impaired glucose tolerance, non-alcoholic fatty liver disease, diabetes complications, Alzheimer's disease, polycystic ovary syndrome, gout, rheumatoid arthritis, cardiovascular disease, kidney disease, retinopathy, immunomodulatory therapy, metabolic disease treatment
MeSH terms: Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Obesity, Diabetes Complications, Immunomodulation

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