Cited by 2,066Adipokines, Inflammation, and Metabolic DiseasesDiabetes Treatment and ManagementSkin Diseases and Diabetes

The DOI matches its Crossref record; 415 of the 422 references it cites were found in a registry or an index.

Inflammation in obesity, diabetes, and related disorders

Open access

Rohm, Theresa V., Meier, Daniel T., Olefsky, Jerrold M., Donath, Marc Y.·2022·Immunity

DOI 10.1016/j.immuni.2021.12.013PMC PMC8773457

Open this paper in CoChat — free account

Abstract

Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state contributes to long-term complications of diabetes, including non-alcoholic fatty liver disease (NAFLD), retinopathy, cardiovascular disease, and nephropathy, and may underlie the association of type 2 diabetes with other conditions such as Alzheimer's disease, polycystic ovarian syndrome, gout, and rheumatoid arthritis. Here, we review the current understanding of the mechanisms underlying inflammation in obesity, T2D, and related disorders. We discuss how chronic tissue inflammation results in IR, impaired insulin secretion, glucose intolerance, and T2D and review the effect of inflammation on diabetic complications and on the relationship between T2D and other pathologies. In this context, we discuss current therapeutic options for the treatment of metabolic disease, advances in the clinic and the potential of immune-modulatory approaches.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2021.12.013

Cites

415 of 415 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Zinman, B., Wanner, C., Lachin, J. M., Fitchett, D., Bluhmki, E., Hantel, S., Mattheus, M., Devins, T., Johansen, O. E., Woerle, H. J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504720 · Cited by 12,315
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638

Show all 422 references

Research works printed but not linked: 4

Ebstein, 1876, Zur Therapie des Diabetes Mellitus, insbesondere über die Anwendung des Salicylsauren Natron bei demselben, Berliner Klinische Wochenschrift., 24, 337
Jonsson, 2013, TREM2 and neurodegenerative disease, N. Engl. J. Med., 369, 1568
Klover, 2003, Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice, Diabetes, 52, 2784, 10.2337/diabetes.52.11.2784 · DOI · Paper page
Rohm, 2017, Increased Inflammatory Intestinal Macrophage Subpopulations after High-Fat Diet, Diabetes, 66, 51

Sorted by citations

Items 601–700 of 1,003

C-reactive protein during pregnancy and in the early postpartum predicts adverse metabolic health outcomes at 1 year postpartum in women with gestational diabetes
Quansah, D. Y., Horsch, A., Gilbert, L., Donath, M. Y., Puder, J. J., Arhab, A., Bovet, P., Chiolero, A., Bernardo, S. D., Epure, A. M., et al. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02034-9 · Cited by 13
Self-citation
Exploring the impacts of ketogenic diet on reversible hepatic steatosis: initial analysis in male mice
Ravaut, G., Carneiro, A., & Mounier, C. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1290540 · Cited by 12
Glycolaldehyde-derived advanced glycation end products suppress STING/TBK1/IRF3 signaling via CD36
Nishinaka, T., Hatipoğlu, Ö. F., Wake, H., Watanabe, M., Toyomura, T., Mori, S., Nishibori, M., & Takahashi, H. K. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121116 · Cited by 11
Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis
Xu, R., & Jiang, L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1572089 · Cited by 10
Incretin signaling at the crossroads of metabolism, inflammation, and tumorigenesis: implications for obesity patients
Wawrzak-Pienkowska, K., Pienkowski, T., Golonko, A., Krupa, A., Warpechowski, M., Płoński, A. F., Mojsak, P., Daniluk, J., Dâbrowski, A., & Kurek, K. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178290 · Cited by 10
A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling
Lv, N., Sun, H., Tang, W., Li, Y., Qian, Z., Hong, L., Chen, C., Li, H., Bai, J., Qiao, Y., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202515820 · Cited by 10
Immune activation induced by dysregulated lipid metabolism in the pathogenesis of type 2 diabetes
Yang, H., Yu, W., Mao, Q., & Zhao, L. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i12.114395 · Cited by 11
Stress hyperglycemia predicts early neurological deterioration and poor outcomes in patients with single subcortical infarct
Liu, H., Yao, Y., Zhang, K., Zong, C., Yang, H., Li, S., Wang, X., Liu, K., Song, B., Xu, Y., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110689 · Cited by 10
Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity
Tercan, H., Cossins, B. C., van Deuren, R. C., Rutten, J. H. W., Joosten, L. A. B., Netea, M. G., Hoischen, A., Bekkering, S., & Riksen, N. P. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031665 · Cited by 11
Leveraging Artificial Intelligence and Participatory Modeling to Support Paradigm Shifts in Public Health: An Application to Obesity and Evidence-Based Policymaking
Giabbanelli, P. J., & MacEwan, G. W. (2024) · Information · doi:10.3390/info15020115 · Cited by 10
The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity
Cai, M., Wan, J., Cai, K., Li, S., Du, X., Song, H., Sun, W., & Hu, J. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01490-x · Cited by 11
Near-infrared laser-assisted Ag@Chi-PB nanocompounds for synergistically eradicating multidrug-resistant bacteria and promoting diabetic abscess healing
Shen, J., Tong, A., Zhong, X., Yin, C., Ahmad, B. M., Zhou, W., Yang, Y., & Tong, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116311 · Cited by 10
Effect of laparoscopic sleeve gastrectomy on male reproductive function in Chinese men with obesity: a prospective cohort study
Gao, X., Li, P., Wang, G., Li, W., Song, Z. J., Zhu, S., & Zhu, L. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001328 · Cited by 10
Role and molecular mechanism of Salvia miltiorrhiza associated with chemical compounds in the treatment of diabetes mellitus and its complications: A review
Li, J., Liu, J., Shi, W., & Guo, J. (2024) · Medicine · doi:10.1097/md.0000000000037844 · Cited by 10
Inflammatory cytokines may mediate the causal relationship between gut microbiota and male infertility: a bidirectional, mediating, multivariate Mendelian randomization study
Zou, H., Xu, N., Xu, H. Y., Xing, X., Chen, Y., & Wu, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1368334 · Cited by 11
Effects of Combustible Cigarettes and Heated Tobacco Products on Systemic Inflammatory Response in Patients with Chronic Inflammatory Diseases
Kastratović, N., Zdravković, N., Čekerevac, I., Sekeruš, V., Harrell, C. R., Mladenović, V., Djukić, A., Volarevic, A., Branković, M., Gmizić, T., et al. (2024) · Diseases · doi:10.3390/diseases12070144 · Cited by 10
REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes
Sunilkumar, S., & Dennis, M. D. (2024) · Diabetes · doi:10.2337/dbi24-0013 · Cited by 10
Multi-Omics Analysis Revealed the rSNPs Potentially Involved in T2DM Pathogenic Mechanism and Metformin Response
Damarov, I. S., Korbolina, E. E., RYKOVA, E. Y., & Merkulova, T. I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179297 · Cited by 11
Age and duration of obesity modulate the inflammatory response and expression of neuroprotective factors in mammalian female brain
Eroglu, B., Isales, C. M., & Eroğlu, A. (2024) · Aging Cell · doi:10.1111/acel.14313 · Cited by 10
Healthy lifestyle associated with dynamic progression of type 2 diabetes: A multi-state analysis of a prospective cohort
Ma, Y., Chen, Y., Ge, A., Long, G., Yao, M., Shi, Y., & He, X. (2024) · Journal of Global Health · doi:10.7189/jogh.14.04195 · Cited by 11
RETRACTED: Association between reduced hemoglobin-to-red cell distribution width ratio and elevated cardiovascular mortality in patients with diabetes: Insights from the National Health and Nutrition Examination Study, 1999–2018
Deng, J., Wu, W., Zhang, Z., Ma, X., Chen, C., Huang, Y., Lai, Y., Chen, L., & Chen, L. (2024) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-242209 · Cited by 10
Retracted
Rheumatic diseases and metabolism: where centre and periphery meet
López, M., & Gualillo, O. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01178-6 · Cited by 11
An update and overview of the various health‐related benefits of probiotics: A focus on clinical trials demonstrating efficacy, tolerability and use in patients with impaired glucose tolerance and type 2 diabetes
Toshimitsu, T., & Irie, J. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16273 · Cited by 10
Plasma proteomic signatures for type 2 diabetes and related traits in the UK Biobank cohort
Gupte, T. P., Azizi, Z., Kho, P. F., Zhou, J., Nzenkue, K., Chen, M., Panyard, D. J., Guarischi‐Sousa, R., Hilliard, A. T., Sharma, D., et al. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112194 · Cited by 11
p-Synephrine ameliorates non-alcoholic fatty liver disease by regulating liver-adipose axis via AMPK/NF-kappa B pathway
Cai, W., Chen, Q.-C., Ni, Q., Liu, L., Yang, C., Yi, Y., Liu, L., Liu, Q., Liu, W., Jiang, C., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119890 · Cited by 10
Hearts apart: exploring sex disparity in the global and regional burden of ischemic heart disease; a systematic analysis from the global burden of disease study 1990–2021
Mahalleh, M., Javid, R. N., Izadpanahi, K., Eshraghi, R., Behboodi, K., Afzalian, A., Hashempoor, A., Thachil, R., May, H. T., Waheed, A., et al. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04770-0 · Cited by 10
Discovery of Highly Potent, Selective, and Liver-Targeting HSD17B13 Inhibitor with Robust In Vivo Anti-MASH Activity
Chen, L., Liang, Z., Mao, J., Liao, Z., Liu, Y., Ou, D., Liu, C., & Li, Z. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00119 · Cited by 10
Maladaptive trained immunity of adipose tissue macrophages unraveling the link to obesity, T2DM, and beyond
Chen, S., Fu, J., Yan, J., Zhao, R., Qian, C., Yisimayili, Z., & Wu, J. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00071.2025 · Cited by 10
TNF as a mediator of metabolic inflammation and body-brain interaction in obesity-driven neuroinflammation and neurodegeneration
Lo, C. H., & Zeng, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102891 · Cited by 14
Diurnal Cortisol Features and Type 2 Diabetes Risk in Patients With Hypertension and Obstructive Sleep Apnea: A Cohort Study
Gan, L., Li, N., Heizhati, M., Li, M., Yao, L., Hong, J., Wu, T., Wang, H., Liu, M., & Maitituersun, A. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad184 · Cited by 10
SAA1 exacerbates pancreatic β-cell dysfunction through activation of NF-κB signaling in high-fat diet-induced type 2 diabetes mice
Wang, Q., Li, H., Lu, H., Wang, S., Li, Y., Zhang, Z., Han, J., Yang, Z., Yang, Y., & Hong, Y. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112043 · Cited by 10
Inhibition of CK2α accelerates skin wound healing by promoting endothelial cell proliferation through the Hedgehog signaling pathway
Zhu, J., Chen, P., Liang, J., Wu, Z., Jin, H. Y., Xu, T., Zheng, Y., Ma, H., Cong, W., Wang, X., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202300478rr · Cited by 10
C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity
Sekiya, M., Kainoh, K., Saito, K., Yamazaki, D., Tsuyuzaki, T., Chen, W., Kobari, Y., Nakata, A., Babe, H., & Shimano, H. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv22014 · Cited by 10
Pleurotus abieticola Polysaccharide Alleviates Hyperlipidemia Symptoms via Inhibition of Nuclear Factor-κB/Signal Transducer and Activator of Transcription 3-Mediated Inflammatory Responses
Zhang, Y., Lin, Y., Wu, K., Jiang, M., Li, L., & Liu, Y. (2023) · Nutrients · doi:10.3390/nu15234904 · Cited by 13
Silymarin Reduced Insulin Resistance in Non-Diabetic Women with Obesity
MacDonald-Ramos, K., Monroy, A., Bobadilla‐Bravo, M., & Cerbón, M. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042050 · Cited by 10
Sodium butyrate attenuate hyperglycemia-induced inflammatory response and renal injury in diabetic mice
Yan, M., Zhang, Y.-Y., Xi, Y., Ding, L., Sun, C. L., Qu, L.-J., Qian, X., Xu, J., Sun, W. S., & Wu, L. (2023) · Acta Pharmaceutica · doi:10.2478/acph-2023-0008 · Cited by 10
Association between dietary antioxidant quality score and periodontitis: A cross-sectional study
Zhang, T., Hao, Y., Zhang, R., & Lin, S. (2023) · Journal of Dental Sciences · doi:10.1016/j.jds.2023.05.021 · Cited by 9
Dietary Betaine Improves Glucose Metabolism in Obese Mice
Xu, G., Pan, H., Fan, L., Zhang, L., Li, J., Cheng, S., Meng, L., Shen, N., Liu, Y., Li, Y., et al. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.02.025 · Cited by 9
White blood cells and type 2 diabetes: A Mendelian randomization study
Bi, Y., Gao, Y., Xie, Y., Zhou, M., Liu, Z., Tian, S., & Sun, C. (2024) · PLoS ONE · doi:10.1371/journal.pone.0296701 · Cited by 9
Thromboelastography with Platelet Mapping Identifies High Platelet Reactivity is Associated with Obesity, Diabetes, and Thrombotic Events
Hall, R. P., Suarez, S. P., Majumdar, M., Lee, I., Zacharias, N., Gee, D. W., & Dua, A. (2024) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.12.079 · Cited by 9
Circulating immune cell phenotyping is potentially relevant for diabetic retinopathy risk assessment
Li, B., Zhao, X., Hong, Z., Ding, Y., & Zhang, Y. X. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111667 · Cited by 10
Novel role of Quercetin in ameliorating metabolic syndrome via VDR mediated activation of adiponectin/AdipoR2 signaling
Gowda, N. G. S., Shiragannavar, V. D., Karunakara, S. H., Veeranna, R. P., Suvarna, D., Kumar, D. P., & Santhekadur, P. K. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101754 · Cited by 9
When IGF-1 Meets Metabolic Inflammation and Polycystic Ovary Syndrome
Li, X., Lin, S., Yang, X., Chen, C., Cao, S., Zhang, Q., Ma, J., Zhu, G., Zhang, Q., Fang, Q., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112529 · Cited by 9
Exploring the causal relationship between body mass index and keratoconus: a Mendelian randomization study
Wang, J. T., Liu, F.-Y., Mo, J., Gong, D., Zheng, F., Su, J., Ding, S., Yang, W., & Guo, P. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1402108 · Cited by 9
Insights into the phytochemical profiling, antidiabetic and antioxidant potentials of Lepionurus sylvestris Blume extract in fructose/streptozotocin-induced diabetic rats
Pan, X., Olatunji, O. J., Basit, A., Sripetthong, S., Nalinbenjapun, S., & Ovatlarnporn, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1424346 · Cited by 9
Comparison of dietary inflammatory index and inflammatory biomarkers between vegetarians and omnivores in Chinese population
Wang, C., Wu, R., Yao, D., Yu, Z., & Shen, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-69168-y · Cited by 9
Type 2 diabetes: a sacrifice program handling energy surplus
Ye, J., & Yin, J. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae033 · Cited by 9
N ADPH oxidases in healthy white adipose tissue and in obesity: function, regulation, and clinical implications
Jornayvaz, F. R., Gariani, K., Somm, E., Jaquet, V., Bouzakri, K., & Szántó, I. (2024) · Obesity · doi:10.1002/oby.24113 · Cited by 12
Biocompatible Poly(ε-Caprolactone) Nanocapsules Enhance the Bioavailability, Antibacterial, and Immunomodulatory Activities of Curcumin
D’Angeli, F., Granata, G., Romano, I. R., Distefano, A., Furno, D. L., Spila, A., Leo, M., Miele, C., Ramadan, D., Ferroni, P., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910692 · Cited by 9
Accuracy of novel anthropometric indices for assessing the risk for progression of prediabetes to diabetes; 13 years of results from Isfahan Cohort Study
Fakhrolmobasheri, M., Shafie, D., Manshaee, B., Karbasi, S., Mazroui, A., Najafabadi, M. M., Mazaheri‐Tehrani, S., Sadeghi, M., Roohafza, H., Emamimeybodi, M., et al. (2024) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2023-0269 · Cited by 10
Co‐Micronized Palmitoylethanolamide and Rutin Associated With Hydroxytyrosol Recover Diabesity‐Induced Hepatic Dysfunction in Mice: In Vitro Insights Into the Synergistic Effect
Melini, S., Pirozzi, C., Lama, A., Comella, F., Opallo, N., Piano, F. D., Napoli, E. D., Mollica, M. P., Paciello, O., Ferrante, M. C., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8361 · Cited by 9
Gut Microbiota–microRNA Interactions and Obesity Pathophysiology: A Systematic Review of Integrated Studies
Azari, H., George, M., & Albracht‐Schulte, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312836 · Cited by 10
Patient-related factors that link chronic kidney disease and periodontitis: a scoping review
Kaymaz, K., Brunet‐Llobet, L., Rocha-Eiroa, M. D., Ramírez‐Rámiz, A., Mahmoud, M. A., Mashala, E. I., & Miranda‐Rius, J. (2024) · Odontology · doi:10.1007/s10266-024-01031-y · Cited by 9
The role of obesity in altering the effects of short chain fatty acids (SCFA) on metabolic hormone regulation: A systematic review and meta-analysis
Faradilah, A., Bukhari, A., Aminuddin, A., & Syauki, A. Y. (2025) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2025.01.011 · Cited by 12
Evaluating the effects of seed oils on lipid profile, inflammatory and oxidative markers, and glycemic control of diabetic and dyslipidemic patients: a systematic review of clinical studies
Laurindo, L. F., Laurindo, L. F., Rodrigues, V. D., Oliveira, J. D. S. C., Boaro, B. L., Araújo, A. C., Guiguer, É. L., Detregiachi, C. R. P., Catharin, V. M. C. S., Chagas, E. F. B., et al. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1502815 · Cited by 10
CircRNA-mediated ceRNA regulatory networks: transcriptomic insights into obesity type 2 diabetes progression and treatment strategies
Zhen, X., Hu, R.-T., Liu, N., Dou, J.-F., Wu, T., Zhang, Y., Zhang, C.-Y., Ma, L., & Jiang, G. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01578-y · Cited by 10
Developmental stage of childhood trauma exposure and markers of inflammation at age 24
Murphy, J., Healy, C., Mongan, D., Susai, S. R., Cannon, M. D., & Cotter, D. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.02.020 · Cited by 10
Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy
Mi, C., Zhou, S., & Xue, J. (2025) · Aging and Disease · doi:10.14336/ad.2025.0061 · Cited by 10
IgG N-glycosylation contributes to different severities of insulin resistance: implications for 3P medical approaches
Chen, X., Balmer, L. A., Lin, K., Cao, W., Huang, Z., Chen, X., Song, M., & Chen, Y. (2025) · The EPMA Journal · doi:10.1007/s13167-025-00410-x · Cited by 9
Microbial Production of Nicotinamide Mononucleotide: Key Enzymes Discovery, Host Cells Selection, and Pathways Design and Optimization
Xing, S., Kang, X., Wang, R., Wang, C., Wang, Y., Bao, X., & Zhao, J. (2025) · ACS Synthetic Biology · doi:10.1021/acssynbio.5c00038 · Cited by 9
The immune tolerance role of Bregs in inhibiting human inflammatory diseases, with a focus on diabetes mellitus
Zhang, Q., Liao, J., Liu, Z., Song, S., Tian, L., & Wáng, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1565158 · Cited by 11
Targeting Muscle Regeneration with Small Extracellular Vesicles from Adipose Tissue-Derived Stem Cells—A Review
Laurindo, L. F., de Lima, E. P., Araújo, A. C., Rodrigues, V. D., Dias, J. A., Filho, M. B. T., Zuccari, D. A. P. D. C., Laurindo, L. F., Miglino, M. A., Chagas, E. F. B., et al. (2025) · Cells · doi:10.3390/cells14100683 · Cited by 9
Systemic inflammatory markers and neurovascular changes in the retina and choroid of diabetic patients without retinopathy: insights from wide-field SS-OCTA
Wu, Q., Zhao, B., Dongye, S., Sun, L., An, B., & Xu, Q. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1566047 · Cited by 9
Metabolic surgery reduces CRC disease progression through circulating bile acid diversion
Laessle, C., Mauerer, B., Marx, L., Feuerstein, R., Braumüller, H., Broghammer, V., Schäfer, L., Enderle, C., Lünstedt, J., Seifert, G. J., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.ads9705 · Cited by 9
Investigation of multimorbidity patterns and association rules in patients with type 2 diabetes mellitus using association rules mining algorithm
Liu, L., Wang, X., Gui, M., Ju, F., Cao, L. J., & Bi, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-09926-8 · Cited by 9
Naringenin Accelerates Diabetic Wound Healing via Regulating Macrophage M2 Polarization and Efferocytosis
Wang, B., Huang, Y., Ding, Y., Chen, J., Chen, Y., Zhang, H., & Tan, Q. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70688 · Cited by 9
Comparative ocular outcomes of tirzepatide versus other anti-obesity medications in people with obesity
Huang, Y., Chen, J.-C., Li, P., Hsu, M., Cheng, C., Meyerowitz‐Katz, G., & Su, P. (2025) · Communications Medicine · doi:10.1038/s43856-025-01066-4 · Cited by 10
Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis
Cui, L., Lu, D., Tan, S., & Cao, L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1462104 · Cited by 11
Repurposing metabolic drugs as anti-inflammatory agents
Hogan, A. E., Davis, C., Jenkins, B., Jones, N., & O'Shea, D. B. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.07.003 · Cited by 14
Progress in the study of the role of C5a-induced tubular cell senescence in the progression of diabetic kidney disease
Guo, C., Li, X., Fan, Z., Zhang, J., & Chen, M. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2561232 · Cited by 10
Type 1 Diabetes Mellitus and Alexithymia: A Systematic Review
Merlo, E. M., Myles, L. A. M., Silvestro, O., Ruggeri, D., Russo, G. T., Squadrito, G., & Martino, G. (2025) · Healthcare · doi:10.3390/healthcare13192402 · Cited by 9
Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease
Cheng, Z., & Montgomery, M. K. (2025) · Clinical Science · doi:10.1042/cs20257631 · Cited by 9
The emerging role of extracellular vesicles in diabetes and complications: mechanistic insights and translational prospects
Liu, S., Pan, Z., Chen, X., Wang, Z., Zhong, W., Ling, J., Chen, Y., Xia, P., Zhang, D., Liu, X., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1674028 · Cited by 10
The role of pancreatic islet macrophages in type 2 diabetes mellitus: from underlying pathological mechanisms to therapeutic target discovery
Qiu, Z., & Shang, D. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100418 · Cited by 9
Combined association of triglyceride-glucose index and the atherogenic index of plasma with the incidence of cardiovascular diseases among middle-aged and older population
Chen, X., Zhao, X., Fei, H., Zhang, Y., Pang, J., Liu, Z., Wang, W., Qiao, J., & Cuiping, X. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-03038-3 · Cited by 9
Bone inflammation in postmenopausal women with type 2 diabetes or obesity in relation to Wnt signaling and bone strength
Leanza, G., Faraj, M., Cannata, F., Viola, V., Pellegrini, N., Tramontana, F., Pedone, C., Vadalà, G., Piccoli, A., Strollo, R., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156492 · Cited by 10
Associated lifestyle factors and comorbidities of difficult-to-treat rheumatoid arthritis: a systematic review and meta-analysis
Xie, W., Chen, T., Chen, Y., Zhang, Z., & Xiao, S. (2026) · The Lancet Rheumatology · doi:10.1016/s2665-9913(26)00041-x · Cited by 9
Identification of Active Compounds from Averrhoa bilimbi L. (Belimbing Wuluh) Flower using LC-MS and Antidiabetic Activity Test using in vitro and in silico Approaches
Widiastuti, D., Sinaga, S. E., Warnasih, S., Pujiyawati, E., Salam, S., & Putra, W. E. (2023) · Trends in Sciences · doi:10.48048/tis.2023.6761 · Cited by 9
Glucose-dependent inflammatory responses in obese compared to lean individuals
Lundqvist, M., Pereira, M. J., & Eriksson, J. W. (2023) · Endocrine · doi:10.1007/s12020-023-03433-4 · Cited by 10
Anti-obesity and antihyperlipidemic effects of Phaleria macrocarpa fruit liquid CO2 extract: In vitro, in silico and in vivo approaches
Mia, M. A. R., Ahmed, Q. U., Ferdosh, S., Helaluddin, A. B. M., Azmi, S. N. H., Alotaibi, F. A., Parveen, H., Mukhtar, S., Ahmed, M. Z., & Sarker, M. Z. I. (2023) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2023.102865 · Cited by 9
A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome
Sionov, R. V., & Ahdut-HaCohen, R. (2023) · Biomedicines · doi:10.3390/biomedicines11092558 · Cited by 13
Identification of biomarkers associated with immune scores in diabetic retinopathy
Zhang, Y., Zhu, W., Wang, J., & Zuo, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1228843 · Cited by 9
O‐GlcNAcylation of TLR4 inhibits osteogenic differentiation of periodontal ligament stem cells
Yu, B., Li, Q., Sun, X., & Yin, Y. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13193 · Cited by 9
Djulis Hull Enhances the Efficacy of Ferric Citrate Supplementation via Restoring Normal Iron Efflux through the IL-6–Hepcidin–Ferroportin Pathway in High-Fat-Diet-Induced Obese Rats
Faradina, A., Tung, Y., Chen, S.-H., Liao, Y.-C., Chou, M.-J., Teng, I., Lin, W.-L., Wang, C., Sheu, M., Chou, P.-Y., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02826 · Cited by 9
Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells
Hua, K., Li, L.-H., Yu, H.-C., Wong, W.-T., & Hsu, H.-T. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s431026 · Cited by 11
Effects of Metabolic Syndrome and its components on the postoperative recurrence in Chronic Rhinosinusitis with Nasal Polyps’ patients
Chen, Y., Wang, T., Gao, R., & Wang, F. (2023) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2023.101371 · Cited by 10
Associations of dichlorophenol with metabolic syndrome based on multivariate-adjusted logistic regression: a U.S. nationwide population-based study 2003-2016
Cai, J., Yang, Z., Zhao, S., & Xing, K. (2023) · Environmental Health · doi:10.1186/s12940-023-01037-z · Cited by 9
The Effect of Obesity on Vaginoplasty Outcomes
Berger, L. E., Lava, C. X., Spoer, D. L., Huffman, S. S., Martin, T., Bekeny, J. C., Fan, K. L., Lisle, D. M., & Corral, G. A. D. (2024) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000003808 · Cited by 9
IL-4 activates the futile triacylglyceride cycle for glucose utilization in white adipocytes
Michurina, S. S., Agareva, M. Y., Zubkova, E., Menshikov, M. Y., Stafeev, I., & Parfyonova, Y. V. (2024) · Biochemical Journal · doi:10.1042/bcj20230486 · Cited by 9
Immunotherapy targeting the obese white adipose tissue microenvironment: Focus on non-communicable diseases
Priscilla, L., Yoo, C., Jang, S., Park, S., Lim, G., Kim, T., & Lee, D. Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.01.027 · Cited by 10
Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease
Rodrigues, M. E. D. S., Bolen, M. L., Blackmer‐Raynolds, L., Schwartz, N., Chang, J., Tansey, M. G., & Sampson, T. R. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106511 · Cited by 9
Molecular mechanisms of enteric neuropathies in high‐fat diet feeding and diabetes
Cingolani, F., Balasubramaniam, A., & Srinivasan, S. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14897 · Cited by 10
Selenium polysaccharide form sweet corn cob mediated hypoglycemic effects in vitro and untargeted metabolomics study on type 2 diabetes
Wang, J., Wang, X., Xiu, W., Li, C., Yu, S., Zhu, H., Shi, X., Zhou, K., & Yong-qiang, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136388 · Cited by 9
Bioinformatics based exploration of the anti-NAFLD mechanism of Wang’s empirical formula via TLR4/NF-κB/COX2 pathway
Chen, S., Zhou, C., Huang, J.-H., Qiao, Y., Wang, N., Huang, Y., Li, B., Xu, W., He, X., Wang, K., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-01022-3 · Cited by 11
Genetic Commonalities Between Metabolic Syndrome and Rheumatic Diseases Through Disease Interactome Modules
Shi, Y., Guan, S., Liu, X., Zhai, H., Zhang, Y., Liu, J., Yang, W., & Wang, Z. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70329 · Cited by 9
Recent advances, strategies, and future perspectives of peptide-based drugs in clinical applications
Yang, Q., Hu, Z., Jiang, H., Wang, J., Han, H., Shi, W., & Qian, H. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60800-4 · Cited by 11
Imo-induced changes in gut hormones and glucose metabolism: A key to improving insulin sensitivity in type 2 diabetes
Naseem, S., & Rizwan, M. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112285 · Cited by 10
Effect and correlation of Cordyceps guangdongensis ethanolic extract on obesity, dyslipidemia and gut microbiota dysbiosis in high-fat diet mice
Gangzheng, W., Sun, C., Qiuju, H., Chenghua, Z., Min, L., Li, T., Jian-ping, X., & Wangqiu, D. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105663 · Cited by 9
Polyscias scutellaria: An emerging source of natural antioxidants and anti-inflammatory compounds for health
Muhar, A. M., Velaro, A. J., Prananda, A. T., Nugraha, S. E., Çamlık, G., Wasnik, S., abidin, S. Z., Sjofjan, O., Harahap, M. A. Y., Syahrian, M. F., et al. (2023) · Pharmacia · doi:10.3897/pharmacia.70.e112502 · Cited by 8
Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice
Yao, S., Lu, H., Zhou, T., Jiang, Q., Jiang, C., Hu, W., Li, M., Tan, C. P., Feng, Y., Du, Q., et al. (2024) · Food & Function · doi:10.1039/d3fo04527g · Cited by 8

Authors: Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y.
Affiliations: University of California San Diego (US)
University of Basel (CH)
Corresponding author: Donath, Marc Y.
ORCID: Rohm, Theresa V.
Meier, Daniel T.
Olefsky, Jerrold M.
Donath, Marc Y.
Venue: Immunity
Publisher: Elsevier BV
Published: 2022-01
Volume: 55
Issue: 1
Pages: 31-55
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2021.12.013
PMC: PMC8773457
OpenAlex: W4206799195
Cited by: 2,066
References: 422
Citations by year: 2026: 450 · 2025: 649 · 2024: 512 · 2023: 345 · 2022: 108
FWCI: 64.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK063491, DK101395)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (P2BSP3_200177)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Keywords: obesity, type 2 diabetes, chronic inflammation, insulin resistance, beta-cell dysfunction, insulin secretion, impaired glucose tolerance, non-alcoholic fatty liver disease, diabetes complications, Alzheimer's disease, polycystic ovary syndrome, gout, rheumatoid arthritis, cardiovascular disease, kidney disease, retinopathy, immunomodulatory therapy, metabolic disease treatment
MeSH terms: Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Obesity, Diabetes Complications, Immunomodulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation in obesity, diabetes, and related disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks