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Cited by 33Mangiferin and Mango ExtractsAcute Kidney Injury ResearchCardiac Ischemia and Reperfusion

Mangiferin attenuates renal ischemia-reperfusion injury by inhibiting inflammation and inducing adenosine production

Wang, Bin, Wan, Jingyuan, Gong, Xia, Kuang, Ge, Cheng, Xiahong, Min, Su·2015·International Immunopharmacology
DOI 10.1016/j.intimp.2014.11.011
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Abstract

Aim Ischemia reperfusion injury (IRI) is a leading cause of acute kidney injury, which is associated with high morbidity. The aims of the present study were to examine whether mangiferin attenuates renal IRI in an animal model and to identify the underlying mechanism(s). Methods Male mice were subjected to right renal ischemia for 30min followed by reperfusion for 24h or to a sham operation during which the left kidney was removed. After the 24h reperfusion, all mice were humanely euthanized and kidney tissues collected. Renal damage and apoptosis were investigated by examining hematoxylin and eosin-stained tissues, and by TUNEL assay and immunohistochemistry. Renal function was examined by measuring the concentrations of creatinine, blood urea nitrogen, and potassium (K(+)) in the serum. MPO activity, the levels of NO, TNF-α, IL-1β, and adenosine, and CD73 expression in renal tissue were also examined. Results Mangiferin reduced ischemia reperfusion-induced injury, improved kidney function, and inhibited both proinflammatory responses and tubular apoptosis. In addition, treatment with mangiferin increased adenosine production and CD73 expression in kidney's suffering IRI. Conclusion Mangiferin appears to attenuate renal IRI by inhibiting proinflammatory responses and tubular apoptosis and by increasing adenosine production. These effects are associated with the adenosine-CD73 signaling pathway.

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  • In mouse ischemia-reperfusion injury, MGF (10, 30, or 100 mg/kg) protects renal tubular cells by reducing inflammation and apoptosis via activation of the adenosine-CD73 pathway.

    “In a mouse model of ischemia-reperfusion injury, MGF (10, 30 or 100 mg/kg) protects renal tubular cells by reducing inflammation and apoptosis through activation of the adenosine-CD73 pathway (141).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [141]

  • In vitro, MGF suppresses IL-6 and IL-8 production by inhibiting MAPK and NF-κB pathways in renal epithelial cells.

    “In vitro studies have shown that MGF suppresses IL-6 and IL-8 production by inhibiting the MAPK and NF-κB pathways, thereby attenuating inflammatory responses in renal epithelial cells (141).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [141]

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Authors
Wang, B., Wan, J., Gong, X., Kuang, G., Cheng, X., & Min, S.
Affiliations
Chongqing Medical University (CN)
Corresponding author
Min, Su
ORCID
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2015-03
Volume
25
Issue
1
Pages
148-154
ISSN
1567-5769 (ISSN-L)
DOI
10.1016/j.intimp.2014.11.011
OpenAlex
W1991328746
Cited by
32
References
53
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 3
FWCI
7.17
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
mangiferin, renal ischemia-reperfusion injury, acute kidney injury, inflammation, adenosine, CD73, tubular apoptosis, nitric oxide, TNF-α, IL-1β, myeloperoxidase, renal function
MeSH terms
Adenosine, Animals, Blood Urea Nitrogen, Creatinine, Disease Models, Animal, Gene Expression Regulation, Humans, Kidney, Male, Mice, Inbred C57BL, Peroxidase, Nitric Oxide, Potassium, Tumor Necrosis Factor-alpha, Signal Transduction, Reperfusion Injury, 5'-Nucleotidase, Apoptosis, Mice, Interleukin-1beta

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