Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice
Abstract
Mangifera indica Linn, a plant widely used in the traditional medicinal systems of India, has been reported to possess antiviral, antibacterial and anti-inflammatory activities. In the present study, the alcoholic extract of stem bark of Mangifera indica Linn (Extract I containing mangiferin 2.6%), has been investigated for its effect on cell mediated and humoral components of the immune system in mice. Administration of test extract I produced increase in humoral antibody (HA) titre and delayed type hypersensitivity (DTH) in mice. It is concluded that test extract I is a promising drug with immunostimulant properties.
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Mangifera indica extract containing 2.6% mangiferin has immunoprotective effects in mice, via increasing the frequency of delayed type hypersensitivity reactions and humoral antibody titer.
“Mangiferaindica (extract containing 2.6% mangiferin) has been investigated for its immunoprotective effects, via increasing the frequency of delayed type hypersensitivity (DTH) reactions and the humoral antibody (HA) titer in mice (105).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [105]
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- Authors
- Makare, N., Bodhankar, S., & Rangari, V.
- Affiliations
- Bharati Vidyapeeth (Deemed to be University) (IN)
- Corresponding author
- Bodhankar, Subhash
- ORCID
- Bodhankar, Subhash
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 78
- Issue
- 2-3
- Pages
- 133-137
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2029555805
- Semantic Scholar
- 543bebb4728f5187a87ea4985487c904a1890980
- Cited by
- 258
- References
- 19
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 7 · 2021: 19 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 16 · 2016: 10 · 2015: 12 · 2014: 25 · 2013: 24 · 2012: 16
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- mango, alcoholic extract, immunomodulation, immunostimulant activity, humoral immunity, antibody titers, delayed-type hypersensitivity, cell-mediated immunity, mangiferin, traditional medicine
- MeSH terms
- Adjuvants, Immunologic, Animals, Antibody Formation, Cyclophosphamide, Female, Hypersensitivity, Delayed, Immunosuppressive Agents, India, Male, Medicine, Traditional, Plant Extracts, Xanthenes, Xanthones, Mice
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