Cited by 1,010Cytokine Signaling Pathways and InteractionsNF-κB Signaling PathwaysProtein Tyrosine Phosphatases

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The role of JAK/STAT signaling pathway and its inhibitors in diseases.

Xin, Ping, Xu, Xiaoyun, Deng, Chengjie, Liu, Shuang, Wang, Youzhi, Zhou, Xuegang, Ma, Hongxing, Wei, Donghua, Sun, Shiqin·2020·International Immunopharmacology

DOI 10.1016/j.intimp.2020.106210

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Abstract

The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug. The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases. In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy.

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Authors: Xin, P., Xu, X., Deng, C., Liu, S., Wang, Y., Zhou, X., Ma, H., Wei, D., & Sun, S.
Affiliations: Harbin Medical University (CN)
China Pharmaceutical University (CN)
Southeast University (CN)
Corresponding author: Sun, Shiqin
ORCID: Xin, Ping
Wang, Youzhi
Venue: International Immunopharmacology
Publisher: Elsevier BV
Published: 2020-03
Volume: 80
Pages: 106210
ISSN: 1567-5769 (ISSN-L)
DOI: 10.1016/j.intimp.2020.106210
OpenAlex: W3001733563
Cited by: 1,010
References: 184
Citations by year: 2026: 125 · 2025: 229 · 2024: 224 · 2023: 195 · 2022: 160 · 2021: 56 · 2020: 20
FWCI: 11.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: International Immunopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Fundamental Research Funds for the Central Universities (2018XN-25, JFWLD201904)
National Natural Science Foundation of China (81903763)
China Postdoctoral Science Foundation (2019M661312)
Natural Science Foundation of Heilongjiang Province (YQ2019H005)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: JAK/STAT signaling, JAK inhibitors, STAT proteins, JAK kinases, inflammatory diseases, cancer, immune regulation, signaling crosstalk, cell proliferation and differentiation, apoptosis
MeSH terms: Animals, Disease Models, Animal, Humans, Immune System Diseases, Inflammation, Signal Transduction, Cytokines, Protein Kinase Inhibitors, STAT Transcription Factors, Janus Kinases

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The role of JAK/STAT signaling pathway and its inhibitors in diseases.

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