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Cited by 1,010Cytokine Signaling Pathways and InteractionsNF-κB Signaling PathwaysProtein Tyrosine Phosphatases

The DOI matches its Crossref record; 182 of the 184 references it cites were found in a registry or an index.

The role of JAK/STAT signaling pathway and its inhibitors in diseases.

Xin, Ping, Xu, Xiaoyun, Deng, Chengjie, Liu, Shuang, Wang, Youzhi, Zhou, Xuegang, Ma, Hongxing, Wei, Donghua, Sun, Shiqin·2020·International Immunopharmacology
DOI 10.1016/j.intimp.2020.106210
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Abstract

The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug. The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases. In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy.

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Research works printed but not linked: 3

  1. Seif, 2017, The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells, Cell Commun. Sign., 15, 1
  2. Oshea, 2015, The JAK-STAT pathway: impact on human disease and therapeutic intervention*, Annu. Rev. Med., 66, 311, 10.1146/annurev-med-051113-024537 · DOI
  3. Yan, 2018, Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases, Clin. Immunol., 189, 4, 10.1016/j.clim.2016.09.014 · DOI · Paper page

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Metadata

Authors
Xin, P., Xu, X., Deng, C., Liu, S., Wang, Y., Zhou, X., Ma, H., Wei, D., & Sun, S.
Affiliations
  • Harbin Medical University (CN)
  • China Pharmaceutical University (CN)
  • Southeast University (CN)
Corresponding author
Sun, Shiqin
ORCID
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2020-03
Volume
80
Pages
106210
ISSN
1567-5769 (ISSN-L)
DOI
10.1016/j.intimp.2020.106210
OpenAlex
W3001733563
Cited by
1,010
References
184
Citations by year
2026: 125 · 2025: 229 · 2024: 224 · 2023: 195 · 2022: 160 · 2021: 56 · 2020: 20
FWCI
11.60
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundamental Research Funds for the Central Universities (2018XN-25, JFWLD201904)
  • National Natural Science Foundation of China (81903763)
  • China Postdoctoral Science Foundation (2019M661312)
  • Natural Science Foundation of Heilongjiang Province (YQ2019H005)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords
JAK/STAT signaling, JAK inhibitors, STAT proteins, JAK kinases, inflammatory diseases, cancer, immune regulation, signaling crosstalk, cell proliferation and differentiation, apoptosis
MeSH terms
Animals, Disease Models, Animal, Humans, Immune System Diseases, Inflammation, Signal Transduction, Cytokines, Protein Kinase Inhibitors, STAT Transcription Factors, Janus Kinases

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