The role of JAK/STAT signaling pathway and its inhibitors in diseases.

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110

STATs and Gene Regulation

Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979

Rheumatoid arthritis

Scott, D. L., Wolfe, F., & Huizinga, T. W. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60826-4 · Cited by 3,263

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

Hotchkiss, R. S., Monneret, G., & Payen, D. (2013) · Nature Reviews Immunology · doi:10.1038/nri3552 · Cited by 2,772

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490

A quantitative analysis of kinase inhibitor selectivity

Karaman, M. W., Herrgard, S., Treiber, D. K., Gallant, P., Atteridge, C. E., Campbell, B. T., Chan, K. W., Ciceri, P., Davis, M. I., Edeen, P. T., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1358 · Cited by 2,466

Epidemiology of Parkinson’s disease

Tysnes, O., & Storstein, A. M. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1686-y · Cited by 2,437

The STATs of cancer — new molecular targets come of age

Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278

Jinmaitong alleviates diabetic neuropathic pain by inhibiting JAK2/STAT3 signaling in microglia of diabetic rats

Wang, S., Taledaohan, A., Tuohan, M. M., Zhang, J., Li, Y., Song, W., Wang, Y., Liang, X., & Wu, Q. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118442 · Cited by 19

Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model

Mughal, K. S., Ikram, M., Uddin, Z., Rashid, A., Rashid, U., Khan, M., Zehra, N., Mughal, U. S., Shah, N., & Amirzada, M. I. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150777 · Cited by 16

Levetiracetam Reduces Early Inflammatory Response After Experimental Intracerebral Hemorrhage by Regulating the Janus Kinase 2 (JAK2)–Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway

Xiong, J., Zhou, H., Lu, D., Wang, Z., Liu, H.-J., Sun, Y., Xu, J., Feng, Y., & Xing, A. (2020) · Medical Science Monitor · doi:10.12659/msm.922741 · Cited by 16

MicroRNA-363-3p promote the development of acute myeloid leukemia with RUNX1 mutation by targeting SPRYD4 and FNDC3B

Chen, Y., Chen, S., Lu, J., Yuan, D., He, L. C., Qin, P., Tan, H., & Xu, L. (2021) · Medicine · doi:10.1097/md.0000000000025807 · Cited by 16

Identification of SNHG11 as a Therapeutic Target in Pulmonary Hypertension

Li, H., Liu, Q., Liu, C.-Y., Wang, S., Zhang, Y., Pan, J., Liu, K., Huang, S., Chu, T., Shang, L., et al. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0428oc · Cited by 15

Psoriasis-Associated Inflammatory Conditions Induce IL-23 mRNA Expression in Normal Human Epidermal Keratinocytes

Kelemen, E., Ádám, É., Sági, S. M., Göblös, A., Kemény, L. V., Bata‐Csörgõ, Z., Széll, M., & Danis, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010540 · Cited by 15

Hyperin promotes proliferation, migration, and invasion of HTR-8/SVneo trophoblast cells via activation of JAK1/STAT3 pathway in recurrent spontaneous abortions

Mu, Z., Shen, S., Tang, L., Liu, Y., Zhou, Z., & Lei, L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e12958 · Cited by 15

Analysis of copy number variations and possible candidate genes in spontaneous abortion by copy number variation sequencing

Bai, W., Zhang, Q., Lin, Z., Ye, J., Shen, X., Zhou, L., & Cai, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1218793 · Cited by 16

Successful Treatment of Granulomatous Rosacea by JAK Inhibitor Abrocitinib: A Case Report

Ren, M., Yang, X., Teng, Y., Lü, W., Ding, Y., & Tao, X. (2023) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s440138 · Cited by 15

Therapeutic potential of natural coumarins in autoimmune diseases with underlying mechanisms

Li, Y., Wang, G., & Li, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1432846 · Cited by 16

Relevance of BET Family Proteins in SARS-CoV-2 Infection

Lara-Ureña, N., & García‐Domínguez, M. (2021) · Biomolecules · doi:10.3390/biom11081126 · Cited by 15

Novel enzyme-sensitive poly-tioxolone membranes for peritendinous anti-adhesion

Li, Y., Yu, Q., Ling, Z., Chen, H., Liu, X., Wu, T., Hu, B., Fan, C., Jiang, X., & Liu, S. (2022) · Composites Part B Engineering · doi:10.1016/j.compositesb.2022.109904 · Cited by 15

Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking andin vivoexperimental verification

Xin, P., Xu, X., Zhang, H., Hu, Y., Deng, C., Sun, S., Liu, S., Zhou, X., Ma, H., & Li, X. (2023) · Pharmaceutical Biology · doi:10.1080/13880209.2023.2252854 · Cited by 14

Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury

Shi, L., Liu, S., Chen, J., Wang, H., & Wang, Z. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00810 · Cited by 15

Small Molecules in the Treatment of Acute Severe Ulcerative Colitis: A Review of Current Evidence

Pellegrino, R., Imperio, G., Costanzo, I. D., Izzo, M., Landa, F., Tambaro, A., Gravina, A. G., & Federico, A. (2025) · Pharmaceuticals · doi:10.3390/ph18030308 · Cited by 16

Novel inhibitors of STAT3: an updated patent review (2022–present)

Bao, K., Li, P., & Gao, D. (2025) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2025.2494857 · Cited by 14

Advances in the mechanism for steroid-induced osteonecrosis of the femoral head

Zhou, R., Bian, Y., Cai, X., Sun, H., Lv, Z., Xu, Y., Wang, Y., Wang, H., Zhu, W., Feng, B., et al. (2026) · Bone Research · doi:10.1038/s41413-025-00477-2 · Cited by 17

Synthesis and biological evaluation of novel 2,4-dianilinopyrimidine derivatives as potent dual janus kinase 2 and histone deacetylases inhibitors

Zhou, H., Jiang, J., Lu, J., Ran, D., & Gan, Z. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.132200 · Cited by 14

Cuproptosis Combined with lncRNAs Predicts the Prognosis and Immune Microenvironment of Breast Cancer

Zhang, L., Zhang, Y., Bao, J., Gao, W., Wang, D., & Pan, H. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/5422698 · Cited by 16

Anti-inflammatory effects of vagus nerve stimulation in pediatric patients with epilepsy

Kaur, S., Selden, N. R. W., & Aballay, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1093574 · Cited by 14

Molecular Profiling of Inflammatory Processes in a Mouse Model of IC/BPS: From the Complete Transcriptome to Major Sex-Related Histological Features of the Urinary Bladder

Peskar, D., Kuret, T., Lakota, K., & Erman, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065758 · Cited by 16

The enteroprotective effect of nifuroxazide against methotrexate-induced intestinal injury involves co-activation of PPAR-γ, SIRT1, Nrf2, and suppression of NF-κB and JAK1/STAT3 signals

Abd‐alhameed, E. K., Azouz, A. A., Abo‐Youssef, A. M., & Ali, F. E. M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111298 · Cited by 14

Molecular mechanisms of macrophage immunomodulation mediated by Areca inflorescence polysaccharides based on RNA-seq analysis

Chen, D., Kang, Z., Chen, H., & Fu, P. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130076 · Cited by 14

IL-1β, the first piece to the puzzle of sepsis-related cognitive impairment?

Zhu, Q. C., Wan, L., Huang, H., & Liao, Z. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1370406 · Cited by 15

The Role of the JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia

Ziętara, K. J., Wróblewska, K., Zajączkowska, M., Taczała, J., & Lejman, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136844 · Cited by 14

Tetrastigma hemsleyanum polysaccharide ameliorates cytokine storm syndrome via the IFN-γ-JAK2/STAT pathway

Fu, S., Bao, X., Mao, Z., Lv, Y., Zhu, B., Chen, Y., Zhou, M., Tian, S., Zhou, F., & Ding, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133427 · Cited by 14

Comparing available JAK inhibitors for treating patients with psoriasis

Funk, P. J., Perche, P. O., Singh, R., Kelly, K. A., & Feldman, S. R. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2039121 · Cited by 16

The immune-related circRNA-miRNA-mRNA ceRNA regulatory network in the liver of turbot (Scophthalmus maximus L.) induced by Vibrio anguillarum

Cai, X. M., Gao, C., Lymbery, A. J., Armstrong, N. J., Ma, L., & Li, C. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.108506 · Cited by 14

Single-cell sequencing combined with machine learning reveals the mechanism of interaction between epilepsy and stress cardiomyopathy

Ji, X., Pei, Q., Zhang, J., Lin, P., Li, B., Yin, H., Sun, J., Su, D., Qu, X., & Yin, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1078731 · Cited by 15

Targeting intracellular pathways in idiopathic inflammatory myopathies: A narrative review

Rocca, G. L., Ferro, F., Baldini, C., Libra, A., Sambataro, D., Colaci, M., Malatino, L., Palmucci, S., Vancheri, C., & Sambataro, G. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1158768 · Cited by 14

Development of JAK inhibitors for the treatment of immune-mediated diseases: kinase-targeted inhibitors and pseudokinase-targeted inhibitors

Kim, H.-O. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01282-7 · Cited by 14

Natural Products in Liver Fibrosis Management: A Five-year Review

Wang, T., Lü, Z., Sun, G., He, K.-Y., Chen, Z., Qu, X.-H., & Han, X. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673288458240203064112 · Cited by 14

Puerarin alleviates osteoporosis in rats by targeting the JAK2/STAT3 signaling pathway

Zhao, X., Zhou, J., Liu, Y., Wang, J., Liu, Y., Wang, B., Han, C., Zhao, S., & Zhang, Y. (2024) · Biomolecules and Biomedicine · doi:10.17305/bb.2024.10500 · Cited by 13

Fucoxanthin ameliorates ulcerative colitis by maintaining the epithelial barrier via blocking JAK2/STAT3 signaling pathway

Ma, J., Yue, S., Liu, Y., Gong, L., He, P., Yang, Y., Fu, Z., Han, D., Hu, Q., Liao, F., et al. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117213 · Cited by 13

Network Pharmacology‐Based and Experimental Validation Elucidate the Target Mechanism of Vinorine in Ameliorating Secondary Brain Injury After Intracerebral Hemorrhage

Wu, J., Zhou, Y., Wang, B., Wang, P., Zhang, X., Du, S., Lu, X., Miao, Z., & Zhao, X. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70609 · Cited by 13

Interferons in Autoimmunity: From Loss of Tolerance to Chronic Inflammation

Mihăescu, G., Pîrcălăbioru, G. G., Roznovan, C. N., Diţu, L.-M., Comanici, M. M., & Savu, O. (2025) · Biomedicines · doi:10.3390/biomedicines13102472 · Cited by 13

γ-Glutamylcysteine rescues mice from TNBS-driven inflammatory bowel disease through regulating macrophages polarization

Zhou, J., Yan, X., Bi, X., Lü, S., Liu, X., Yang, C., Shi, Y., Luo, L., & Yin, Z. (2023) · Inflammation Research · doi:10.1007/s00011-023-01691-6 · Cited by 14

High‐mobility group box 1 emerges as a therapeutic target for asthma

Yang, Q., Li, M., Hou, Y., He, H., & Sun, S. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.1124 · Cited by 12

What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson’s Disease?

Xue, J., Tao, K., Wang, W., & Wang, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031641 · Cited by 19

Optimized DLP 3D-printed high-resolution nano zirconia-hydroxyapatite scaffold with craniomaxillofacial soft tissue invasion resistance and pro-osteogenic properties via dectin-1/syk inflammatory axis

Gao, X., Yang, J., Gan, X., Lin, Y., Xu, J., Shan, Z., Han, Z., Chen, S., Huang, B., Fan, B., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152044 · Cited by 13

Evaluation of antioxidant and anti-inflammatory activity and identification of bioactive compound from the marine diatom, Odontella aurita extract

Cuong, D. M., Yang, S. H., Kim, J. S., Moon, J. Y., Choi, J., Go, G. M., & Cho, S. K. (2024) · Applied Biological Chemistry · doi:10.1186/s13765-024-00898-3 · Cited by 13

Research progress of propofol in alleviating cerebral ischemia/reperfusion injury

Zheng, H., Xiao, X., Han, Y., Wang, P., Zang, L., Wang, L., Zhao, Y., Shi, P., Yang, P., Guo, C., et al. (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00620-6 · Cited by 15

Plaque-type psoriasis inhibitors

Shobeiri, S. S., Khorrami, M., & Sankian, M. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108326 · Cited by 13

Recent progress on tyrosine kinase 2 JH2 inhibitors

Deng, L., Wan, L., Liao, T., Wang, L., Wang, J., Wu, X., & Shi, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110434 · Cited by 13

Probiotic Lactobacilli Improved Growth Performance and Attenuated Salmonella Typhimurium Infection Via Jak/Stat Signaling in Broilers

Shi, H., Deng, X., Deng, Q., Liu, Z., & Liu, N. (2021) · Brazilian Journal of Poultry Science · doi:10.1590/1806-9061-2020-1328 · Cited by 13

Natural products in rheumatoid arthritis: Cell type-specific mechanisms and therapeutic implications

Liao, Y., Xiao, X., Cheng, W., Wang, Y., Lu, J., Zhang, J., Zhang, J., Liu, P., Liu, L., & Pan, H. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156980 · Cited by 13

Multifaceted roles of extracellular vesicles in the interplay of neuroinflammation and neurodegenerative diseases

Deng, Z., Chen, H., Chen, J., Du, Z., Zhou, W., & Yuan, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167960 · Cited by 14

Novel regulators of hepatic macrophages in liver fibrosis

Tang, X., Bai, M., Du, X., Wang, H., Liu, M., Fu, X., Zhang, H., Liang, S., & Wang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1705503 · Cited by 12

Betulonic acid regulates oviduct epithelial cell inflammation through the TLR4, MAPK, and JAK/STAT signalling pathways

Shao, L., Yan, Y., Wang, N., Tan, Q., Huang, Y., Lei, L., Yang, D., & Liu, L. (2023) · Reproduction Fertility and Development · doi:10.1071/rd21380 · Cited by 12

Liuwei Anxiao San protects gastric mucosa from gastric ulcer in rats by regulating the JAK2/STAT3 pathway

Qu, Z., Jiang, D., Liu, Y., & Hou, M. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102145 · Cited by 12

Artificial Intelligence (AI) and Ethics in Medicine at a Global Level: Benefits and Risks

Elasan, S., & Ateş, Y. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub128.c508 · Cited by 12

Effectiveness and safety of baricitinib in patients with moderate‐to‐severe refractory alopecia areata in real world: An open‐label, single‐center study

Bi, L., Wang, C., Du, Y., Su, T., Zhao, M., Lin, X., Fan, W., & Sun, W. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16123 · Cited by 12

The therapeutic effect of gold clusters in an EAE model of multiple sclerosis by regulating T cell differentiation

He, Z., Lai, J., Wang, H., He, Y., Zhang, C., Gao, L., Huang, H., Zheng, L., Hao, J., Gao, X., et al. (2024) · Nano Today · doi:10.1016/j.nantod.2023.102128 · Cited by 12

Effects of scutellarin on the mechanism of cardiovascular diseases: a review

Zhang, X., Yin, T., Wang, Y., Du, J., Dou, J., & Zhang, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1329969 · Cited by 12

Topical application of berberine ameliorates imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing JAK1/STAT1 signaling pathway

Chen, Y., Song, S., Wang, Y., Zhang, X., Zhang, J., Wu, L., Wu, J., & Li, X. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.105612 · Cited by 13

Function and Mechanism of Abscisic Acid on Microglia-Induced Neuroinflammation in Parkinson’s Disease

Han, T., Xu, Y., Liu, H., Sun, L., Cheng, X., Shen, Y., & Wei, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094920 · Cited by 14

Monotropein mitigates atopic dermatitis-like skin inflammation through JAK/STAT signaling pathway inhibition

Yang, I., Jeong, N., Choi, Y., Kwon, T. K., Lee, S., Khang, D., & Kim, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116911 · Cited by 12

Traditional Chinese medicine in the treatment of Helicobacter pylori -related gastritis: The mechanisms of signalling pathway regulations

Zhang, P., Liang, L., Qu, H.-Y., Chen, G.-Y., Xie, M., & Chen, Y.-K. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i3.96582 · Cited by 16

Clinical application of biological agents in rheumatoid arthritis

Cheng, L., & Rong, X. (2025) · Transplant Immunology · doi:10.1016/j.trim.2025.102187 · Cited by 12

A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities

Cai, H., Wu, Y., & Zhang, X. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60821-1 · Cited by 12

Topical delgocitinib for the treatment of chronic hand eczema

Abdelhalim, A., Yilmaz, O., Berair, M. E., & Torres, T. R. (2025) · Journal of Dermatological Treatment · doi:10.1080/09546634.2025.2479126 · Cited by 12

Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges

Wu, J., Wang, B., Shen, L.-P., Chen, Y.-L., Du, Z., Du, S., Lu, X.-J., & Zhao, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04834-4 · Cited by 11

New insight into the role of SOCS family in immune regulation and autoimmune pathogenesis

Liu, S., Wang, M., Xu, L., Deng, D., Lu, L., Tian, J., Zhou, D., & Rui, K. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.05.020 · Cited by 13

Tofacitinib Suppresses IL-10/IL-10R Signaling and Modulates Host Defense Responses in Human Macrophages

Knoke, K., Rongisch, R., Grzes, K. M., Schwarz, R., Lorenz, B., Yogev, N., Pearce, E. L., Pearce, E. J., Kofler, D. M., & Fabri, M. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.07.180 · Cited by 12

Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and vaccine

Shirzad, M., Nourigorji, M., Sajedi, A., Ranjbar, M., Rasti, F., Sourani, Z., Moradi, M., Mir, S. M., & Memar, M. Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109161 · Cited by 13

Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment (Review)

Jin, N. Y., Xia, Y., & Gao, Q. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5476 · Cited by 12

Topical and systemic JAK inhibitors in hand eczema – a narrative review

Zalewski, A., & Szepietowski, J. C. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2174526 · Cited by 12

Quantitative Proteomic Analysis Reveals the Mechanisms of Sinapine Alleviate Macrophage Foaming

Liu, A., Liao, B., Yin, S., Ye, Z., He, M., Li, X., Liu, Y., & Xu, Y. (2023) · Molecules · doi:10.3390/molecules28052012 · Cited by 12

Interferon-Alpha Decreases Cancer Stem Cell Properties and Modulates Exosomes in Malignant Melanoma

García‐Ortega, M. B., Aparicio‐Puerta, E., Griñán‐Lisón, C., Jiménez, G., López‐Ruiz, E., Palacios, J. L., Ruiz-Alcalá, G., Alba, C., Martínez‐Amat, A., Boulaiz, H., et al. (2023) · Cancers · doi:10.3390/cancers15143666 · Cited by 12

Computer-Aided Drug Design of Novel Derivatives of 2-Amino-7,9-dihydro-8H-purin-8-one as Potent Pan-Janus JAK3 Inhibitors

Faris, A., Ibrahim, I. M., Kamaly, O. M. A., Saleh, A., & Elhallaoui, M. (2023) · Molecules · doi:10.3390/molecules28155914 · Cited by 13

Integrated network pharmacology and metabolomics reveal the mechanisms of Jasminum elongatum in anti-ulcerative colitis

Qiu, J., Xiao, G., Yang, M., Huang, X., Cai, D., Xie, C., Chen, Z., Bi, X., & Aili, X. (2023) · Scientific Reports · doi:10.1038/s41598-023-49792-w · Cited by 12

miR-518a-3p Suppresses Triple-Negative Breast Cancer Invasion and Migration Through Regulation of TMEM2

Gan, L., Yang, H., Xiong, Z., Yang, Z., Wang, T., & Lyu, G. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820977523 · Cited by 12

Transcriptional Analysis of Total CD8+ T Cells and CD8+CD45RA- Memory T Cells From Young and Old Healthy Blood Donors

Toma, G. A., Lemnian, I., Karapetian, E., Große, I., & Seliger, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.806906 · Cited by 12

N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves’ ophthalmopathy progression through glycolysis to affect Th17/Treg balance

Li, L.-N., Wu, J.-M., Zheng, Z., Li, S., Cai, M.-Y., & Zou, M. (2024) · Autoimmunity · doi:10.1080/08916934.2024.2433628 · Cited by 11

A review of the mechanism, diagnosis, and treatment of Naegleria fowleri infection

Dai, L., Guo, X.-R., Chen, X.-R., Ma, M.-H., Liu, Z., Lai, J., Lü, J., Ming, F., Liu, X.-X., & Yang, S. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1686695 · Cited by 11

Baicalein self‐microemulsion based on drug–phospholipid complex for the alleviation of cytokine storm

Liao, H., Ye, J., Gao, Y., Lian, C., Liu, L., Xu, X., Feng, Y., Yang, Y., Yang, Y., Shen, Q., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10357 · Cited by 11

Machine Learning‐Enabled Virtual Screening with Multiple Protein Structures toward the Discovery of Novel JAK3 Inhibitors: Integration of Molecular Docking, Pharmacophore, and Naïve Bayesian Classification

Zhu, J., Sun, J., Jia, L., Xu, L., Cai, Y., Chen, Y., & Jin, J. (2023) · Advanced Theory and Simulations · doi:10.1002/adts.202200835 · Cited by 11

Radical S-adenosyl methionine domain-containing 2, a potential target of D-tryptophan in asthma treatment, regulates T helper cell type 1/2 balance

Wang, F., & Shang, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111581 · Cited by 11

Dysregulated expression of the suppressors of cytokine signaling (SOCS) contributes to the development of prostate cancer

Jafarzadeh, A., Zandvakili, R., Jafarzadeh, Z., & Nemati, M. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155558 · Cited by 11

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

Zhang, Z., Wang, P., Lei, T., Guo, J., Jiang, Y., Li, Y., Zheng, J., Wang, S., Xu, H., Jian, G., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1480844 · Cited by 12

Bacillus velezensis MZ09 alleviates DSS-induced colitis in piglets by remodeling the intestinal microbiota activating the SCFAs–GPR43–STAT3 pathway and suppressing NLRP3 inflammasome-mediated pyroptosis

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