Cited by 1,010Cytokine Signaling Pathways and InteractionsNF-κB Signaling PathwaysProtein Tyrosine Phosphatases

The DOI matches its Crossref record; 182 of the 184 references it cites were found in a registry or an index.

The role of JAK/STAT signaling pathway and its inhibitors in diseases.

Xin, Ping, Xu, Xiaoyun, Deng, Chengjie, Liu, Shuang, Wang, Youzhi, Zhou, Xuegang, Ma, Hongxing, Wei, Donghua, Sun, Shiqin·2020·International Immunopharmacology

DOI 10.1016/j.intimp.2020.106210

Open this paper in CoChat — free account

Abstract

The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug. The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases. In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy.

Integrity signals

Registry

Crossref · 10.1016/j.intimp.2020.106210

Cites

182 of 182 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: MicroRNA-30e promotes hepatocyte proliferation and inhibits apoptosis in cecal ligation and puncture-induced sepsis through the JAK/STAT signaling pathway by binding to FOSL2
Ling, L., Zhang, S., Zhi, L.-D., Li, H., Wen, Q.-K., Li, G., & Zhang, W. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.042 · Cited by 31
Retracted
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
Rheumatoid arthritis
Scott, D. L., Wolfe, F., & Huizinga, T. W. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60826-4 · Cited by 3,263
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
Hotchkiss, R. S., Monneret, G., & Payen, D. (2013) · Nature Reviews Immunology · doi:10.1038/nri3552 · Cited by 2,772
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490
A quantitative analysis of kinase inhibitor selectivity
Karaman, M. W., Herrgard, S., Treiber, D. K., Gallant, P., Atteridge, C. E., Campbell, B. T., Chan, K. W., Ciceri, P., Davis, M. I., Edeen, P. T., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1358 · Cited by 2,466
Epidemiology of Parkinson’s disease
Tysnes, O., & Storstein, A. M. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1686-y · Cited by 2,437
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278

Flagged first, then by citations

Show all 184 references

2 of the 184 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Seif, 2017, The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells, Cell Commun. Sign., 15, 1
Oshea, 2015, The JAK-STAT pathway: impact on human disease and therapeutic intervention*, Annu. Rev. Med., 66, 311, 10.1146/annurev-med-051113-024537 · DOI
Yan, 2018, Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases, Clin. Immunol., 189, 4, 10.1016/j.clim.2016.09.014 · DOI · Paper page

Sorted by citations

Items 501–600 of 1,000

Antimicrobial peptides in bone regeneration: mechanism and potential
Wang, Z., Chen, X., Yan, L., Wang, W., Zheng, P., Atashbahar, M., & Liu, Q. (2024) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2024.2337239 · Cited by 8
The Protective Effects of an Aged Black Garlic Water Extract on the Prostate
Libero, M. L., Montero‐Hidalgo, A. J., Recinella, L., Luque, R. M., Generali, D., Acquaviva, A., Orlando, G., Ferrante, C., Menghini, L., Simone, S. C. D., et al. (2024) · Nutrients · doi:10.3390/nu16173025 · Cited by 10
Astaxanthin-loaded PLGA nanoparticles inhibit survival of MKN-45 gastric cancer cell line by modulating JAK2/STAT3/mTOR/PI3K pathway
YektaKooshali, M. H., SobhZahedi, M., Tousi, S. M. T. R., Hamidi, M., & Modiri, L. (2025) · BMC Cancer · doi:10.1186/s12885-024-13401-4 · Cited by 7
Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protocol
Geertsema-Hoeve, B. C., van Laar, J. A. M., Raaphorst, J., Tas, S. W., Welsing, P. M. J., Goekoop, R. J., Checa, C. M., Thurlings, R. M., Rekers, N. H., Present, E., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-089827 · Cited by 7
Unveiling prognostic value of JAK/STAT signaling pathway related genes in colorectal cancer: a study of Mendelian randomization analysis
Zhang, N., Yue, W., Jiao, B., Cheng, D., Wang, J., Liang, F., Wang, Y., Liang, X., Li, K., Liu, J., et al. (2025) · Infectious Agents and Cancer · doi:10.1186/s13027-025-00640-8 · Cited by 6
Self-citation
Advancements in pharmacological interventions for atopic dermatitis current strategies and future directions
Zhang, Y., Yuan, S., Wu, Y., Nie, W., You, T., Yang, H., & Liu, B. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01659-4 · Cited by 8
YTHDF2 promotes the metastasis of oral squamous cell carcinoma through the JAK-STAT pathway
Chen, Z., Zhao, D., Yuan, Y., Zeng, L., Luo, Z., Chen, J., Lan, X., He, Y., & Liu, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-92428-4 · Cited by 7
Reg3β: A Potential Therapeutic Target for Tissue Injury and Inflammation-Associated Disorders
Cao, Y., Tian, Y., Liu, Y., & Su, Z. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2020.1869731 · Cited by 7
The Acetyltransferase KAT5 Inhibitor NU 9056 Promotes Apoptosis and Inhibits JAK2/STAT3 Pathway in Extranodal NK/T Cell Lymphoma
Sang, W., Xu, K., Xu, L., Qin, Y., Liu, M., Jiao, J., Tu, D., Zhang, M., Yan, D., Song, X., et al. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210908103306 · Cited by 7
Comparative transcriptomic analysis of the liver and spleen in marbled rockfish (Sebastiscus marmoratus) challenged with polyriboinosinic polyribocytidylic acid (poly(I:C))
Zhang, Y., Wang, X., Shi, H., Song, N., Han, F., Chai, X., Liu, Q., Wang, Y., & Gao, T. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738144 · Cited by 7
Self-citation
Effect of baricitinib in regulating programmed death 1 and ligand programmed cell death ligand 1 through JAK/STAT pathway in psoriasis
Deepak, H. B., Prince, S. E., & Deshpande, P. (2022) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_1089_20 · Cited by 7
Molecular cloning, expression and functional analysis of STAT2 in orange-spotted grouper, Epinephelus coioides
Qin, Y., Liu, H., Zhang, P., Deng, S., Qiu, R., & Yao, L. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.09.075 · Cited by 7
JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway
Lin, Q., Chen, Z., Shi, W. M., Lv, Z., Wan, X., & Gao, K. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00990-5 · Cited by 7
Genetic Variation in Hypothalamic-Pituitary Axis Candidate Genes and Their Effects on Milk Production Traits in Iranian Holstein Cattle
Sadeghi, M., Mokhber, M., & Shahrbabak, M. M. (2022) · Russian Journal of Genetics · doi:10.1134/s1022795422110096 · Cited by 7
Case report: Recurrent lung infections following treatment with pralsetinib for an elderly patient with RET-fusion positive NSCLC
An, L., Chen, P., Wang, J., Qin, X., Liu, T., Gao, Y., Wang, P., Zhang, D., Fang, X., & Zhang, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1024365 · Cited by 7
Material Basis and Mechanism of Chansu Injection for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking Technology
Xu, Y., Peng, W., Han, D., Wang, Z., Feng, F., Zhou, X., & Wu, Q. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/7697785 · Cited by 7
Self-citation
Prevention of neointimal hyperplasia after coronary artery bypass graft via local delivery of sirolimus and rosuvastatin: network pharmacology and in vivo validation
Ryu, J.-Y., Jang, E. H., Lee, J., Kim, J.-H., & Youn, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04875-8 · Cited by 7
Synthesis, biological activities and mechanistic studies of C20-ketone pachysandra alkaloids as anti-hepatocellular carcinoma agents
Zhao, J., Bai, J., Yu, X., Zhang, W., Zhao, C., Ye, J.-H., Wei, P., He, K., & Zou, J. (2024) · Molecular Diversity · doi:10.1007/s11030-024-10961-2 · Cited by 6
Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice
Rinne, V., Gröndahl‐Yli‐Hannuksela, K., Fair-Mäkelä, R., Salmi, M., Rantakari, P., Lönnberg, T., Alinikula, J., Pietikäinen, A., & Hytönen, J. (2024) · Microbes and Infection · doi:10.1016/j.micinf.2024.105424 · Cited by 6
JAK/STAT signaling pathway is involved in antibacterial immunity in the green peach aphid Myzus persicae (Sulzer)
Ding, B., Zhang, C., He, L., Zeng, Q., 张森文, Yang, H.-Z., & Yang, H. (2024) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2024.106168 · Cited by 6
Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy
Nair, B., Menon, A., Kalidas, M. R., Nath, L. R., Călina, D. C., & Sharifi‐Rad, J. (2025) · Discover Oncology · doi:10.1007/s12672-025-02369-7 · Cited by 9
Baricitinib and Lonafarnib Synergistically Target Progerin and Inflammation, Improving Lifespan and Health in Progeria Mice
Krüger, P., Schroll, M., Fenzl, F. Q., Hartinger, R., Lederer, E.-M., Görlach, A., Gordon, L. B., Cavalcante, P., Iacomino, N., Rathkolb, B., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104849 · Cited by 6
Potential impacts of acupuncture on motor function recovery after ischemic stroke: insights from basic and clinical studies
He, J., Ma, L., Wen, J.-S., Zhuang, Y.-X., Qian, X., Ma, L.-H., Xiu, J., Wang, X., & Chen, M. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1623535 · Cited by 6
Unlocking the molecular pathway of atopic dermatitis: journey so far and roads ahead
Kumar, S., Sharma, R. R., Komal, K., Kumar, D., Ghosh, R., & Kumar, M. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01900-0 · Cited by 6
Potential of herbal formulas and bioactive metabolites in treating atherosclerosis: targeted modulation of macrophage polarization
Liu, S., Jing, J., Zhang, Y., Sun, J., & Zhu, C. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1631274 · Cited by 8
Self-citation
Major Adverse Cardiovascular Events and VTE in Patients with IBD Taking Anti-TNF versus JAK Inhibitors: A Multicenter Cohort Analysis
Alsakarneh, S., Aburumman, R., Khraisat, F. A., Odeh, T., Jana, H., Pardi, D. S., & Farraye, F. A. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-09729-5 · Cited by 6
Treating sarcoidosis and potential new drugs
Caliskan, C., & Prasse, A. (2022) · European Respiratory Society eBooks · doi:10.1183/2312508x.10033620 · Cited by 6
The proteolysis targeting chimera GMB-475 combined with dasatinib for the treatment of chronic myeloid leukemia with BCR::ABL1 mutants
Wu, Y., Wu, X., Wang, X., Wei, X., Tang, Y., Ouyang, X., & Gong, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.931772 · Cited by 6
First Characterization and Regulatory Function of piRNAs in the Apis mellifera Larval Response to Ascosphaera apis Invasion
Sun, M., Fan, X., Long, Q., Zang, H., Zhang, Y., Liu, X., Feng, P., Song, Y., Li, K., Wu, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216358 · Cited by 6
Iron chelation and supplementation: A comparison in the management of inflammatory bowel disease using drosophila
Usman, D., Abubakar, M. B., Ibrahim, K. G., & Imam, M. U. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122328 · Cited by 7
Rutin promotes M2 phenotype microglia polarization by suppressing the JAK/STAT3 signaling to protect against retinal ischemia-reperfusion injury
Su, A.-L., Zhao, S., Hong-Na, Z. H. U., Ying, Q. I. A. O., & Zhang, T. (2024) · Biomedical Research · doi:10.2220/biomedres.45.13 · Cited by 6
Solamargine improves the therapeutic efficacy of anti-PD-L1 in lung adenocarcinoma by inhibiting STAT1 activation
Liu, Q., Xu, M., Qiu, M., Yu, J., Wang, Q., Zhou, Y., Lin, Q., Cai, X., Yang, L., Zhao, H., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155538 · Cited by 6
Hsp60 deletion in cholinergic neurons: Impact on neuroinflammation and memory
Li, W., Luo, Y., Ali, T., Huang, Y., Yu, Z., Hao, L., & Li, S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113022 · Cited by 6
LSD1 is a promising target to treat cancers by modulating cell stemness
Tong, Y., Wang, X., Li, R., Xu, X., Dai, M., Wang, N., Fan, B., Feng, S., & Ma, T. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116549 · Cited by 6
Self-citation
Type 2 cytokine-JAK1 signaling is involved in the development of dry skin-induced mechanical alloknesis
Toyosawa, Y., Komiya, E., Kaneko, T., Suga, Y., Tominaga, M., & Takamori, K. (2024) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2024.10.002 · Cited by 6
Functional Involvement of Signal Transducers and Activators of Transcription in the Pathogenesis of Influenza A Virus
Liu, S., Qiu, F., Gu, R., & Xu, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413589 · Cited by 6
Self-citation
Construction and investigation of β3GNT2-associated regulatory network in esophageal carcinoma
Luo, Z., Hu, Q., Tang, Y., Leng, Y., Tian, T., Tian, S., Huang, C., Liu, A., Deng, X., & Shen, L. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00306-y · Cited by 6
Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Analyses
Wei, X., Zhang, Q., Liu, C., Wu, S., Nong, W., Ge, Y., Lin, L., Li, F., Xie, X., & Luo, B. (2022) · Current Medical Science · doi:10.1007/s11596-022-2593-5 · Cited by 6
Comprehensive analysis of immune-related biomarkers and pathways in intracerebral hemorrhage using weighted gene co-expression network analysis and competing endogenous ribonucleic acid
Hao, Y., Xu, X., Wang, Y., Jin, F., Tang, L. Y., Zheng, W., Zhang, H., & He, Z. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.955818 · Cited by 6
Self-citation
Exploration of comorbidity mechanisms and potential therapeutic targets of rheumatoid arthritis and pigmented villonodular synovitis using machine learning and bioinformatics analysis
Heng, H., Li, D., Su, W., Liu, X., Yu, D., Bian, Z., & Li, J. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1095058 · Cited by 6
Machine learning-based immune prognostic model and ceRNA network construction for lung adenocarcinoma
He, X., Su, Y., Liu, P., Chen, C., Chen, C., Guan, H., Lv, X., & Guo, W. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04609-1 · Cited by 6
Cyanidin-3-O-glucoside plays a protective role against renal ischemia/ reperfusion injury via the JAK/STAT pathway
Xiong, Y., Jian, J., Yu, H., Wu, J., Mao, H., Feng, R., Wang, L., Jian, Y., & Liu, X. (2023) · Acta Cirúrgica Brasileira · doi:10.1590/acb381023 · Cited by 6
ePhyscion prevents induction of optic nerve injury in rats via inhibition of the JAK2/STAT3 pathway
Li, J., Zhu, Y., Xu, M., Li, P., Zhou, Y., Song, Y., & Cai, Q. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12080 · Cited by 6
Lung cancer treatment potential and limits associated with the STAT family of transcription factors
Faida, P., Attiogbe, M. K. I., Majeed, U., Zhao, J., Qu, L., & Fan, D. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110797 · Cited by 6
High-throughput virtual screening of phenylpyrimidine derivatives as selective JAK3 antagonists using computational methods
Faris, A., Ibrahim, I. M., Hadni, H., & Elhallaoui, M. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2240413 · Cited by 6
Silencing SIRT1 promotes the anti-HBV action of IFN-α by regulating Pol expression and activating the JAK-STAT signaling pathway
Tang, Q., Meng, C., Liu, Y., Cheng, Y., Liu, Y., Long, Y., Sun, S., & Feng, F. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110939 · Cited by 6
Self-citation
Recurrent herpes zoster in a rheumatoid arthritis patient treated with tofacitinib: A case report and review of the literature
Lin, Q.-X., Meng, H.-J., Pang, Y.-Y., & Qu, Y. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i24.8703 · Cited by 6
Treatment with tofacitinib attenuates muscle loss through myogenin activation in the collagen-induced arthritis
da Rosa, T. H., Bartikoski, B. J., Santo, R. C. D. E., Farinon, M., Silva, J. M. D. S., Pedó, R. T., Gasparini, M. L., Karnopp, T. E., dos Santos, L. P., Chapacais, G. F., et al. (2024) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-024-00416-5 · Cited by 5
Ferrocenyl-Substituted Curcumin Derivatives as Potential SHP-2 Inhibitors for Anticolorectal Cancer: Design, Synthesis and In Vitro Evaluation
Zhang, X.-Z., Li, G., Hu, G., Wang, C.-L., Fang, Y.-Q., Li, Y., Qi, X., & Duan, L. (2024) · ACS Omega · doi:10.1021/acsomega.4c10629 · Cited by 5
Umbilical cord-derived mesenchymal stem cells combined with kaempferol synergistically promote repair of damaged endometrium by modulating JAK2/STAT3 signaling pathway
Shang, D., Chen, Y., & Sun, D. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04056-4 · Cited by 5
Identification of Resistance Loci to Avian Leukosis via Genome-Wide Association Analysis in Chengkou Mountain Chickens
Li, Y., Tan, M., Yang, G., Xu, Q., Wang, Q.-G., Wang, H.-W., & Lan, X. (2025) · Animals · doi:10.3390/ani15101365 · Cited by 5
JAK inhibitors alleviate metabolic dysregulation, inflammation and fibrosis in osteoarthritis: insights from human joint cells and synovium
Paulissen, G., Malaise, O., Deroyer, C., Charlier, E., Neuville, S., Plener, Z., Thirion, T., Daniel, C., Ribbens, C., & de Seny, D. (2025) · Lara D. Veeken · doi:10.1093/rheumatology/keaf298 · Cited by 5
Favorable responses to upadacitinib, a JAK1 inhibitor, in long COVID patients with predominant neuropsychiatric symptoms: case reports in 2 autistic patients and one typically developing patient
Jyonouchi, H., Kornitzer, J., & Geng, L. (2025) · BMC Neurology · doi:10.1186/s12883-025-04341-y · Cited by 5
Hepatotoxicity of 8:2 Polyfluoroalkyl Phosphate Diesters Exposure via JAK2/STAT3 Pathway Activation and M1 Macrophage Polarization in Mice
Liu, Y., Jiao, X., Meng, X., Guo, Y., Pan, Y., Dong, C., Yu, Y., & Zhang, J. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c06681 · Cited by 5
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis
Amona, F. M., Pang, Y.-P., Chen, X.-H., Liu, Z.-L., Su, C., Yang, J., Liu, K., Wu, Q.-Y., Liu, B.-B., Chen, X., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102491 · Cited by 5
Pan-JAK Inhibition Across Chronic Hand Eczema and Other Cutaneous Diseases: An Updated Review on Topical Delgocitinib
Termini, D., Avallone, G., Tavoletti, G., Beaziz, J., Moltrasio, C., Boero, V., Marzano, A. V., & Ferrucci, S. M. (2025) · Drugs · doi:10.1007/s40265-025-02262-1 · Cited by 5
Clinical updates of JAK inhibitors in cutaneous granulomatous diseases
Gu, J., He, X., Lu, B., Wang, J., Chen, K., Wang, Q., Jian, X., Huang, C., & Yu, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1698816 · Cited by 5
Expanding landscape of kinase inhibitor research in 25 years (2001-2025) and advancements of next-generation kinase inhibitors
Das, D., Xie, L., & Hong, J. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109617 · Cited by 5
Filgotinib Modulates Inflammation-Associated Peripheral Blood Protein Biomarkers in Adults with Active Rheumatoid Arthritis and Prior Inadequate Response to Methotrexate
Tanaka, Y., Taylor, P. C., Elboudwarej, E., Hertz, A. L., Shao, X., Malkov, V. A., Matsushima, H., Emoto, K., Downie, B., & Takeuchi, T. (2023) · Rheumatology and Therapy · doi:10.1007/s40744-023-00583-9 · Cited by 5
Correlative analysis of transcriptome and proteome in Penaeus vannamei reveals key signaling pathways are involved in IFN-like antiviral regulation mediated by interferon regulatory factor (PvIRF)
Liu, Y., He, Y., Cao, J., Lu, H., Zou, R., Zuo, Z., Li, R., Zhang, Y., & Sun, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127138 · Cited by 5
Pathogenicity and transcriptomic profiling reveals immunology molecular hallmarks after CA10 virus infection
Peng, W., Wu, J., Zhao, B., Zhang, L., Chen, X., Wei, X., Rong, N., Han, Y., & Liu, J. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12415 · Cited by 5
Transcriptome-based network analysis reveals hub immune genes and pathways of hepatopancreas against LPS in Amphioctopus fangsiao
Li, Z., Gu, J., Huang, X., Lu, Z., Feng, Y., Xu, X., & Yang, J. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109696 · Cited by 5
Self-citation
Bone morphogenetic protein 4 alleviates pulmonary fibrosis by regulating macrophages
Jiang, Y., Chen, Y., Fu, J., Zhao, R., Xu, J., & Liu, Y. F. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112530 · Cited by 6
LncRNA XIST/miR-381-3P/STAT1 axis as a potential biomarker for lupus nephritis
Chen, J., Li, M., Shang, S., Cheng, L., Tang, Z., & Huang, C. (2024) · Lupus · doi:10.1177/09612033241273072 · Cited by 5
CASQ2 alleviates lung cancer by inhibiting M2 tumor‐associated macrophage polarization and JAK/STAT pathway
Ding, Y. P., Yuan, X., Wang, Y., & Yan, J. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23801 · Cited by 5
Self-citation
Unraveling the role of ubiquitin-conjugating enzyme 5 (UBC5) in disease pathogenesis: A comprehensive review
Shi, J., Chen, R.-Y., Liu, Y., Li, C.-Y., Yu, J. X., Tu, F.-Y., Sheng, J.-X., Lu, J., Zhang, L., Yang, G., et al. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111376 · Cited by 5
Navigating therapeutic challenges in VEXAS syndrome: exploring IL-6 and JAK inhibitors at the forefront
Li, X., Huang, W. H., Yang, X., Yang, Q. L., Zheng, Y., Huo, Y. B., Xie, T., Huang, C. H., & Yu, S. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00922-8 · Cited by 5
A novel in silico approach for identifying multi-target JAK/STAT inhibitors as anticancer agents
Bono, A., Monica, G. L., Alamia, F., Lauria, A., & Martorana, A. (2024) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2024.108913 · Cited by 5
Tofacitinib in focus: Fascinating voyage from conventional formulations to novel delivery systems
Yadav, P., & Wairkar, S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125253 · Cited by 5
Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway
Zhu, G., Liu, Y., Luo, S., Tang, C., Zhao, C., & Lu, X. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.101926 · Cited by 5
Investigating the functional role of BUB1B in aflatoxin B1-associated hepatocarcinogenesis
Hamdy, H., Aly, W. A., & Elkord, E. (2025) · Toxicology · doi:10.1016/j.tox.2025.154127 · Cited by 5
Lentinan attenuates histone deacetylation of SOCS1 promoter to remodel autophagy via JAK2/STAT3 pathway for the prevention of intervertebral disc degeneration
Song, K., Gu, H., Li, Q., Kong, X., Li, Y., Meng, Q., Liu, K., Liu, Z., Wang, Z., Zhang, Y., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146457 · Cited by 5
Discovery of grey matter lesion-related immune genes for diagnostic prediction in multiple sclerosis
Zhao, P., Liu, X., Wang, Y., Zhang, X., Wang, H., Du, X., Du, Z., Yang, L., & Hou, J. (2023) · PeerJ · doi:10.7717/peerj.15299 · Cited by 5
Self-citation
The role of IL‐6/JAK/STAT signal in female infertility caused by hydrosalpinx
Deng, J. H., Huang, Y., Wang, L., & Sun, X. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.871 · Cited by 5
Establishment of comorbidity target pools and prediction of drugs candidate for multiple sclerosis and autoimmune thyroid diseases based on GWAS and transcriptome data
Wang, X., Wang, Y., Zhang, X., Hong, X., Rang, X., Yang, D., HUANG, S. H., Xu, C., & Fu, J. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104903 · Cited by 5
Self-citation
Synergistic anticancer effects of SMYD2 inhibitor BAY-598 and doxorubicin in non-small cell lung cancer
Meng, J., Yang, W., Li, C., & Li, F. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32015 · Cited by 5
Emerging Therapeutic Frontiers in Prostate Health: Novel Molecular Targets and Classical Pathways in comparison with BPH and Prostate Cancer.
Hassan, M. S., Irfan, H., Alamgeer, Sarwar, M., Jabbar, Z., & Nawaz, S. (2024) · Critical reviews in oncology/hematology · doi:10.1016/j.critrevonc.2024.104590 · Cited by 5
Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model
Xiong, S., Yang, J., Yang, M., Xiao, M., Ha, S., Tao, W., Ma, L., Ji, C., Xiang, H., & Luo, G. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00027 · Cited by 5
Da Cheng Qi Decoction Alleviates Cerulein-Stimulated AR42J Pancreatic Acinar Cell Injury via the JAK2/STAT3 Signaling Pathway
Zhou, Z., Chen, Y., Dong, W., An, R., Liang, K., & Wang, X. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6657036 · Cited by 5
Yinma Jiedu Granule attenuates LPS-induced acute lung injury in rats via suppressing inflammation level
Li, G. L., Ma, J., Yang, Y., Zang, C., Ju, C., Yuan, F., Ning, J., Shang, M., Chen, Q., Jiang, Y., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116292 · Cited by 5
Increased serum α‐tocopherol acetate mediated by gut microbiota ameliorates alveolar bone loss through the STAT3 signalling pathway in diabetic periodontitis
Lu, M., Zhang, Y., Yuan, X., Zhang, Y., Zhou, M., Zhang, T., & Song, J. (2023) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13862 · Cited by 5
STAT2 negatively regulates RIG-I in the antiviral innate immunity of black carp
Liu, J., Dai, C., Lijun, Y., Yang, X., Yan, J., Liu, M., Wu, H., Xiao, J., Kong, W., Xu, Z., et al. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109510 · Cited by 5
TMEM200A is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer
Fang, F., Zhang, T., Lei, H., & Shen, X. (2023) · PeerJ · doi:10.7717/peerj.15613 · Cited by 4
The mechanism of Shoutai Wan in the treatment of recurrent spontaneous abortion - A review
Dang, X., Feng, Y., Zheng, P., Liu, D., Nuerbiye, Y., Liao, Z., Liu, F., & Che, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33213 · Cited by 4
CDCA4 promotes bladder cancer progression by JAK/STAT signaling pathway
Wan, P., Ren, Y., Deng, H., & Li, H. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06109-w · Cited by 4
Regulation of pathologic fibroblast functions in digestive diseases: a role for hypoxia?
Ohlendieck, C. M., Matellan, C., & Manresa, M. C. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00277.2024 · Cited by 5
Baricitinib for Takayasu arteritis refractory to TNF-α inhibitors: a multicentre, single-arm trial
Li, J., Xia, W., Ji, H., Gong, X., Dong, Q., Wu, Y., Wang, L., Peng, M., Liu, J., Ma, K., et al. (2025) · Lara D. Veeken · doi:10.1093/rheumatology/keaf286 · Cited by 4
Molecular mechanisms related to bone damage in spinal tuberculosis revealed by 4D-label-free proteomics analysis
Xiao, W., Yang, G., Xu, S., Song, S. L., Tang, Y., Zhou, T., Huang, W., Zhang, P., & Gu, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1629805 · Cited by 4
Cardioprotective potential of azaleatin against sodium arsenite instigated sub-chronic cardiotoxicity via targeting TLR4/MyD88, JAK1/STAT3, and NF-κB in Sprague Dawley rats
Hassan, H. M., Bibi, A., Hayat, M. F., Alzahrani, K. J., Alzahrani, F. M., Alsuwat, M. A., & Al-Aream, M. A. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127763 · Cited by 4
JAK Inhibition Prevents Bone Loss and Reduces Inflammation in Experimental Periodontitis
de Godoi, M. A., Leite, F. R. M., Camilli, Â. C., Gonzales, K. G. A., Costa, V. B., de Matos, I. A. F., Papathanasiou, E., & Guimarães, M. R. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70042 · Cited by 4
Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA
Chen, W., Xu, J., Zeng, G., Ou, R., Yang, C., Xu, C., Wang, Y., Wang, X., Li, Q., Zhao, C., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-01220-y · Cited by 4
Self-citation
Synthesis and characterization of piperic acid conjugates with homochiral and heterochiral dipeptides containing phenylalanine and their application in skin cancer
Rahim, J. U., Faheem, M. M., Nawaz, S., Goswami, A., & Rai, R. (2023) · Peptides · doi:10.1016/j.peptides.2023.171113 · Cited by 4
Sinapine thiocyanate alleviates intervertebral disc degeneration by not regulating JAK1/STAT3/NLRP3 signal pathway
Yu, P., Ma, Z., Jiang, H., Liu, J., & Li, H. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/174508 · Cited by 4
Design and synthesis of novel pyrrolo[2,3-d]pyrimidine derivatives as potent JAK3 and SYK dual inhibitors
Wang, L., Zhang, X., Huang, Y., Xu, Z., Li, X., Li, X., Ke, Y., Xiao, W., & Zhang, R. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.139213 · Cited by 4
Rlip76 in ageing and Alzheimer’s disease: Focus on oxidative stress and mitochondrial mechanisms
Bandaru, M., Sultana, O. F., Islam, M. A., Alvir, R. V., & Reddy, P. H. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102600 · Cited by 4
Cianidanol from Sea Buckthorn Exert Anti-Inflammatory Effects by the Inhibiting JAK2/STAT3 Signaling Pathway via an Integrative Pharmacology Strategy
Liu, C., Yi, X., Li, Y., Xu, H., Wang, P., Yang, W., Li, L., & Tu, Y. (2025) · Plant Foods for Human Nutrition · doi:10.1007/s11130-024-01290-8 · Cited by 4
Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a systematic review
Jiang, J., Wang, Q., Wu, Q., Deng, B., Guo, C. X., Chen, J., Zeng, J., Guo, Y., & Ma, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1523713 · Cited by 4
The Effects of Iridin and Irigenin on Cancer: Comparison with Well-Known Isoflavones in Breast, Prostate, and Gastric Cancers
Won, Y., Kim, H. H., Jeong, S.-H., Bhosale, P. B., Abusaliya, A., Heo, J.-D., Seong, J. K., Ahn, M., Kim, H. J., & Kim, G. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062390 · Cited by 4
MTHFD2: A metabolic checkpoint altering trophoblast invasion and migration by remodeling folate-nucleotide metabolism in recurrent spontaneous abortion
Xu, Q., Zhou, Y., Wu, M., Wu, S., Yu, J., Xu, Y., Wei, Z., & Jin, L. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111808 · Cited by 4
Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages
Long, K., Xiang, K., Zeng, Q., & Dong, W. (2025) · European Journal of Histochemistry · doi:10.4081/ejh.2025.4176 · Cited by 4

Authors: Xin, P., Xu, X., Deng, C., Liu, S., Wang, Y., Zhou, X., Ma, H., Wei, D., & Sun, S.
Affiliations: Harbin Medical University (CN)
China Pharmaceutical University (CN)
Southeast University (CN)
Corresponding author: Sun, Shiqin
ORCID: Xin, Ping
Wang, Youzhi
Venue: International Immunopharmacology
Publisher: Elsevier BV
Published: 2020-03
Volume: 80
Pages: 106210
ISSN: 1567-5769 (ISSN-L)
DOI: 10.1016/j.intimp.2020.106210
OpenAlex: W3001733563
Cited by: 1,010
References: 184
Citations by year: 2026: 125 · 2025: 229 · 2024: 224 · 2023: 195 · 2022: 160 · 2021: 56 · 2020: 20
FWCI: 11.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: International Immunopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Fundamental Research Funds for the Central Universities (2018XN-25, JFWLD201904)
National Natural Science Foundation of China (81903763)
China Postdoctoral Science Foundation (2019M661312)
Natural Science Foundation of Heilongjiang Province (YQ2019H005)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: JAK/STAT signaling, JAK inhibitors, STAT proteins, JAK kinases, inflammatory diseases, cancer, immune regulation, signaling crosstalk, cell proliferation and differentiation, apoptosis
MeSH terms: Animals, Disease Models, Animal, Humans, Immune System Diseases, Inflammation, Signal Transduction, Cytokines, Protein Kinase Inhibitors, STAT Transcription Factors, Janus Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of JAK/STAT signaling pathway and its inhibitors in diseases.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks