The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway
Abstract
Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored the regulatory mechanism of the gut flora in the host defense against lipopolysaccharide (LPS)-induced ALI through the TLR4/NF-kB pathway by constructing a gut microflora dysbiosis-model with antibiotic administration and reconstruction of the intestinal microecology. Then, high-throughput sequencing was performed, and the levels of secreted IgA (sIgA), β-defensins, and Muc2 were measured to assess the gut flora and mucosal barrier. The expression of TLR4, NF-kB, TNF-α, IL-1β, oxidative stress and the lung wet/dry (W/D) ratio were evaluated to assess lung damage. Hematoxylin and eosin (HE) staining was performed to evaluate the damage to the gut and lung tissues. Accordingly, gut microbiota imbalance may regulate the TLR4/NF-kB signaling pathway in the lung immune system, activating oxidative stress in the lung and mediating lung injury through the regulation of the gut barrier. However, fecal microbiota transplantation (FMT) impairs the activity of the TLR4/NF-kB signaling pathway in the lung and decreases oxidative stress in animals with ALI by restoring the gut microecology. CONCLUSIONS: Our results indicated the protective effect of gut flora in regulating immunity of LPS-induced ALI by modulating the TLR4/NF-kB signaling pathway which may induce inflammation and oxidative stress.
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Cites
1 retracted
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Cited by
Lung microbiome: new insights into the pathogenesis of respiratory diseases
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“This inhibits the activation of the TLR4/NF-κB signaling pathway in the lung, inflammation, and the release of oxidative stress factors in ALI animals (Tang et al., 2021).”
BackgroundThe Role of Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy
(2021) · doi:10.3389/fonc.2021.720842 · Cited by 136
New insights into lipopolysaccharide inactivation mechanisms in sepsis
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Metadata
- Authors
- Tang, J., Xu, L., Zeng, Y., & Gong, F.
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 91
- Pages
- 107272
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W3116855691
- Cited by
- 498
- References
- 35
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Funders
- Chongqing Medical University
- Chongqing Municipal Education Commission (KJQN201900420)
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- Tang, J., Xu, L., Zeng, Y., & Gong, F. (2021). Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway. International Immunopharmacology. https://doi.org/10.1016/j.intimp.2020.107272
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