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Cited by 16Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model

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Kudo, Takehiro, Takuwa, Hiroyuki, Takahashi, Manami, Urushihata, Takuya, Shimojo, Masafumi, Sampei, Kazuaki, Yamanaka, Mitsugu, Tomita, Yutaka +3 more·2023·iScience
DOI 10.1016/j.isci.2023.106342PMC PMC10031157
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Abstract

In Alzheimer's disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of hyperexcitability. However, it is still unknown how INs are functionally affected in tau pathology, which is a major pathology in AD. To clarify this, we evaluated the neuronal activity of cortical INs in 6-month-old rTg4510 mice, a model of tauopathy. Calcium imaging with mDlx enhancer-driven labeling revealed that neuronal activity in INs was decreased in rTg4510 mice. In the patch clamp recording, the firing properties of fast-spiking INs were altered so as to reduce their activity in rTg4510 mice. In parallel with microglial activation, perineuronal nets around parvalbumin-positive INs were partially disrupted in rTg4510 mice. Taken together, our data indicate that the excitability of cortical fast-spiking INs is decreased, possibly because of the disruption of perineuronal nets.

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  • A recent study performed in 3-month-old and 6-month-old rTg4510 (P301L) mice showed an age-associated decrease in cortical WFA+ PNNs only after the accumulation of pTau and gliosis.

    “A recent study performed in 3-month-old and 6-month-old rTg4510 (P301L) mice, a mouse model of tauopathy associated with familial frontotemporal dementia, showed an age-associated decrease in cortical WFA+ PNNs only after the accumulation of pTau and gliosis (Kudo et al. 2023).”

    From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Kudo et al. 2023

    The Results section on perineuronal nets (page unavailable) reports significantly reduced WFA-labeling intensity in the somatosensory cortex of 6-month-old rTg4510 mice, but only a slight reduction at 3 months. The Results also report increased microglia and accumulated hyperphosphorylated tau at 6 months. They do not establish that the PNN change occurred only *after* those changes; the paper describes it as occurring in parallel with microglial activation. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • The rTg4510 study implicates pTau and/or gliosis as a driver for PNN CS-GAG loss.

    “Although this study implicates pTau and/or gliosis as a driver for PNN CS-GAG loss, core protein abundance was not examined.”

    From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Kudo et al. 2023

    The Results section reports reduced WFA labeling of PNNs in six-month-old rTg4510 mice, alongside microglial activation. The Discussion suggests that glial proteases might mediate PNN degradation as tau pathology progresses, but it does not establish pTau or gliosis as a causal driver or specifically measure CS-GAG loss. No page numbers are available in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • In the rTg4510 study, core protein abundance was not examined.

    “core protein abundance was not examined.”

    From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Kudo et al. 2023

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Cited by

Sorted by citations

Authors
Kudo, T., Takuwa, H., Takahashi, M., Urushihata, T., Shimojo, M., Sampei, K., Yamanaka, M., Tomita, Y., Sahara, N., Suhara, T., & Higuchi, M.
Affiliations
  • Tohoku University (JP)
  • National Institutes for Quantum Science and Technology (JP)
  • Sumitomo Dainippon Pharma (Japan) (JP)
Corresponding author
  • Takuwa, Hiroyuki
  • Higuchi, Makoto
ORCID
Venue
iScience
Publisher
Elsevier BV
Published
2023-04
Volume
26
Issue
4
Pages
106342
ISSN
2589-0042 (ISSN-L)
DOI
10.1016/j.isci.2023.106342
PMC
PMC10031157
OpenAlex
W4323257053
Cited by
16
References
6
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 2
FWCI
2.84
Type
journal article
Language
en
Open access
Licence
Locations
  • iScience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion, cc-by-nc-nd)
  • QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion)
Funders
  • Japan Agency for Medical Research and Development (19dk0207049)
  • JSPS
  • Japan Society for the Promotion of Science (21H05705)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
perineuronal nets, tauopathy, Alzheimer's disease, rTg4510 mice, network hyperexcitability, parvalbumin interneurons, microglial activation, neuronal excitability, calcium imaging

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