Cited by 152Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis

Hasani, Alka, Ebrahimzadeh, Saba, Hemmati, Fatemeh, Khabbaz, Aytak, Hasani, Akbar, Gholizadeh, Pourya·2021·Journal of Medical Microbiology

Abstract

Alteration in the composition of the gut microbiota can lead to a number of chronic clinical diseases. Akkermansia muciniphila is an anaerobic bacteria constituting 3–5% of the gut microbial community in healthy adults. This bacterium is responsible for degenerating mucin in the gut; its scarcity leads to diverse clinical disorders. In this review, we focus on the role of A. muciniphila in diabetes, obesity and atherosclerosis, as well as the use of this bacterium as a next-generation probiotic. In regard to obesity and diabetes, human and animal trials have shown that A. muciniphila controls the essential regulatory system of glucose and energy metabolism. However, the underlying mechanisms by which A. muciniphila alleviates the complications of obesity, diabetes and atherosclerosis are unclear. At the same time, its abundance suggests improved metabolic disorders, such as metabolic endotoxemia, adiposity insulin resistance and glucose tolerance. The role of A. muciniphila is implicated in declining aortic lesions and atherosclerosis. Well-characterized virulence factors, antigens and cell wall extracts of A. muciniphila may act as effector molecules in these diseases. These molecules may provide novel mechanisms and strategies by which this bacterium could be used as a probiotic for the treatment of obesity, diabetes and atherosclerosis.

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Crossref · 10.1099/jmm.0.001435

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  • The gut microbiota plays a significant role in modulating the body's metabolism, thereby influencing the development and advancement of chronic conditions like obesity, diabetes, and atherosclerosis.

    “Recent research indicates that the gut microbiota plays a significant role in modulating the body’s metabolism, thereby influencing the development and advancement of chronic conditions like obesity, diabetes, and atherosclerosis (Hasani et al., 2021).”

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Authors
Hasani, A., Ebrahimzadeh, S., Hemmati, F., Khabbaz, A., Hasani, A., & Gholizadeh, P.
Affiliations
  • Tabriz University of Medical Sciences (IR)
  • Urmia University (IR)
Venue
Journal of Medical Microbiology
Published
2021-10-08
Volume
70
Issue
10
ISSN
  • 0022-2615 (ISSN-L)
  • 1473-5644
OpenAlex
W3201745732
Cited by
152
References
102
Citations by year
2026: 15 · 2025: 45 · 2024: 37 · 2023: 34 · 2022: 20 · 2021: 1
FWCI
2.88
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Medical Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
Akkermansia muciniphila, gut microbiota, obesity, diabetes mellitus, atherosclerosis, mucin degradation, probiotics, insulin resistance, glucose tolerance, metabolic endotoxemia, virulence factors, cell wall extract, aortic lesions
MeSH terms
Gastrointestinal Microbiome, Akkermansia, Animals, Diabetes Mellitus, Energy Metabolism, Humans, Obesity, Probiotics, Atherosclerosis

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