The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis
Abstract
Alteration in the composition of the gut microbiota can lead to a number of chronic clinical diseases. Akkermansia muciniphila is an anaerobic bacteria constituting 3–5% of the gut microbial community in healthy adults. This bacterium is responsible for degenerating mucin in the gut; its scarcity leads to diverse clinical disorders. In this review, we focus on the role of A. muciniphila in diabetes, obesity and atherosclerosis, as well as the use of this bacterium as a next-generation probiotic. In regard to obesity and diabetes, human and animal trials have shown that A. muciniphila controls the essential regulatory system of glucose and energy metabolism. However, the underlying mechanisms by which A. muciniphila alleviates the complications of obesity, diabetes and atherosclerosis are unclear. At the same time, its abundance suggests improved metabolic disorders, such as metabolic endotoxemia, adiposity insulin resistance and glucose tolerance. The role of A. muciniphila is implicated in declining aortic lesions and atherosclerosis. Well-characterized virulence factors, antigens and cell wall extracts of A. muciniphila may act as effector molecules in these diseases. These molecules may provide novel mechanisms and strategies by which this bacterium could be used as a probiotic for the treatment of obesity, diabetes and atherosclerosis.
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The gut microbiota plays a significant role in modulating the body's metabolism, thereby influencing the development and advancement of chronic conditions like obesity, diabetes, and atherosclerosis.
“Recent research indicates that the gut microbiota plays a significant role in modulating the body’s metabolism, thereby influencing the development and advancement of chronic conditions like obesity, diabetes, and atherosclerosis (Hasani et al., 2021).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Hasani et al., 2021
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Ameliorating effects of Orostachys japonica against high-fat diet-induced obesity and gut dysbiosis
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Akkermansia muciniphila: promises and pitfallsfor next-generation beneficial microorganisms
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Physiology Reconfigured: How Does Bariatric Surgery Lead to Diabetes Remission?
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Modulation of mercaptopurine intestinal toxicity and pharmacokinetics by gut microbiota
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Editorial: Nutrients, Gut Microbiome, and Intestinal Inflammation
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The Microbial Revolution in the World of Joint Replacement Surgery
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- Authors
- Hasani, A., Ebrahimzadeh, S., Hemmati, F., Khabbaz, A., Hasani, A., & Gholizadeh, P.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Urmia University (IR)
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 2021-10-08
- Volume
- 70
- Issue
- 10
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W3201745732
- Cited by
- 152
- References
- 102
- Citations by year
- 2026: 15 · 2025: 45 · 2024: 37 · 2023: 34 · 2022: 20 · 2021: 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Akkermansia muciniphila, gut microbiota, obesity, diabetes mellitus, atherosclerosis, mucin degradation, probiotics, insulin resistance, glucose tolerance, metabolic endotoxemia, virulence factors, cell wall extract, aortic lesions
- MeSH terms
- Gastrointestinal Microbiome, Akkermansia, Animals, Diabetes Mellitus, Energy Metabolism, Humans, Obesity, Probiotics, Atherosclerosis
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