Toll-like receptor (TLR) and inflammasome actions in the central nervous system

Hanamsagar, Richa; Hanke, Mark L.; Kielian, Tammy

doi:10.1016/j.it.2012.03.001

Cited by 203Inflammasome and immune disordersImmune Response and InflammationNeuroinflammation and Neurodegeneration Mechanisms

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

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Hanamsagar, Richa, Hanke, Mark L., Kielian, Tammy·2012·Trends in Immunology

DOI 10.1016/j.it.2012.03.001PMC PMC3383346

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Abstract

During the past 10 years, much attention has been focused towards elucidating the impact of Toll-like receptors (TLRs) in central nervous system (CNS) innate immunity. TLR signaling triggers the transcriptional activation of pro-interleukin-1β (pro-IL-1β) and pro-IL-18 that are processed into their active forms by the inflammasome. Recent studies have demonstrated inflammasome involvement during CNS infection, autoimmune disease, and injury. This review will address inflammasome actions within the CNS and how cooperation between TLR and inflammasome signaling may influence disease outcome. In addition, the concept of alternative inflammasome functions independent of IL-1 and IL-18 processing are considered in the context of CNS disease.

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Signaling at TLR2 and TLR4 initiates an NF-κB-dependent signaling cascade that transcribes pro-IL-1β and NLRP3.
“Importantly, signaling at TLR2 and TLR4 initiates an NF-κB-dependent signaling cascade that transcribes pro-IL-1β and NLRP3 (Hanamsagar et al, 2012).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Hanamsagar et al, 2012

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[83]Lim JE MyD88 Deficiency Ameliorates beta-Amyloidosis in an Animal Model of Alzheimer's Disease Am J Pathol 2011 PMC3157279 21763676

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Authors: Hanamsagar, R., Hanke, M. L., & Kielian, T.
Affiliations: University of Nebraska Medical Center (US)
Corresponding author: Kielian, Tammy
ORCID: Hanamsagar, Richa
Kielian, Tammy
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2012-07
Volume: 33
Issue: 7
Pages: 333-342
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2012.03.001
PMC: PMC3383346
OpenAlex: W2035824519
Cited by: 203
References: 106
Citations by year: 2026: 3 · 2025: 14 · 2024: 11 · 2023: 7 · 2022: 15 · 2021: 17 · 2020: 10 · 2019: 14 · 2018: 12 · 2017: 15 · 2016: 18 · 2015: 17 · 2014: 24 · 2013: 24 · 2012: 2
FWCI: 1.95
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Nebraska Medical Center
National Institute of Neurological Disorders and Stroke (R01NS055385, R01NS040730, R01NS053487, NS053487)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Toll-like receptors, inflammasome, central nervous system, innate immunity, IL-1β, IL-18, neuroinflammation, central nervous system infection, autoimmune disease, central nervous system injury
MeSH terms: Animals, Central Nervous System, Humans, Signal Transduction, Autoimmunity, Toll-Like Receptors, Inflammasomes

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Toll-like receptor (TLR) and inflammasome actions in the central nervous system

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