Understanding the Role of T Cells in CNS Homeostasis

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works

More hippocampal neurons in adult mice living in an enriched environment

Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,513 · see citing works

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M.-H., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/649858 · Cited by 2,660 · see citing works

FOXP3+ regulatory T cells in the human immune system

Sakaguchi, S., Miyara, M., Costantino, C. M., & Hafler, D. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2785 · Cited by 2,443 · see citing works

Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus

Aşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315 · see citing works

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198 · see citing works

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858 · see citing works

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,669 · see citing works

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

Yu, X., Harden, K., Gonzalez, L. C., Francesco, M. R., Chiang, E. Y., Irving, B. A., Tom, I., Ivelja, S., Refino, C. J., Clark, H. F., et al. (2008) · Nature Immunology · doi:10.1038/ni.1674 · Cited by 1,486 · see citing works

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

Borsellino, G., Kleinewietfeld, M., Mitri, D. D., Sternjak, A., Diamantini, A., Giometto, R., Höpner, S., Centonze, D., Bernardi, G., Dell’Acqua, M. L., et al. (2007) · Blood · doi:10.1182/blood-2006-12-064527 · Cited by 1,287 · see citing works

Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

Bloomgren, G., Richman, S., Hotermans, C., Subramanyam, M., Goelz, S. E., Natarajan, A., Lee, S., Plavina, T., Scanlon, J. V., Sandrock, A. W., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107829 · Cited by 1,239 · see citing works

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209 · see citing works

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

Tzartos, J. S., Friese, M. A., Craner, M. J., Palace, J. A., Newcombe, J., Esiri, M. M., & Fugger, L. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070690 · Cited by 1,180 · see citing works

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Brochard, V., Combadière, B., Prigent, A., Laouar, Y., Perrin, A., Beray-Berthat, V., Bonduelle, O., Alvarez-Fischer, D., Callebert, J., Launay, J.-M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36470 · Cited by 1,172 · see citing works

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · cited 1× · see citing works

Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.

Medawar, P. B. (1948) · PubMed · Cited by 1,084 · see citing works

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T., & Veltkamp, R. (2009) · Nature Medicine · doi:10.1038/nm.1927 · Cited by 1,059 · see citing works

Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

Kerschensteiner, M., Gallmeier, E., Behrens, L., Vargas-Leal, V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R. L., Bartke, I., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.865 · Cited by 1,019 · see citing works

Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis

The CAMMS Trial Investigators (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802670 · Cited by 1,012 · see citing works

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.393 · Cited by 951 · see citing works

Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses

Joller, N., Lozano, E., Burkett, P. R., Patel, B., Xiao, S., Zhu, C., Xia, J., Tan, T.-G., Sefik, E., Yajnik, V., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.012 · Cited by 904 · see citing works

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882 · see citing works

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1999 · Cited by 842 · see citing works

Prevalence of Polyomavirus BK and JC Infection and Replication in 400 Healthy Blood Donors

Egli, A., Infanti, L., Dumoulin, A., Buser, A. S., Samaridis, J., Stebler, C., Gosert, R., & Hirsch, H. H. (2009) · The Journal of Infectious Diseases · doi:10.1086/597126 · Cited by 781 · see citing works

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

Stumhofer, J. S., Silver, J. S., Laurence, A. D. J., Porrett, P. M., Harris, T. H., Turka, L. A., Ernst, M., Saris, C. J. M., O’Shea, J. J., & Hunter, C. A. (2007) · Nature Immunology · doi:10.1038/ni1537 · Cited by 777 · see citing works

The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms

Engelhardt, B., & Ransohoff, R. M. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.07.004 · Cited by 676 · see citing works

Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement

Turrigiano, G. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153238 · Cited by 671 · see citing works

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

Perreau, M., Savoye, A.-L., Crignis, E. D., Corpataux, J.-M., Cubas, R. A., Haddad, E. K., de Leval, L., Graziosi, C., & Pantaleo, G. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121932 · Cited by 632 · see citing works

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

Wakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 577 · see citing works

Human cerebrospinal fluid central memory CD4 + T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin

Kivisäkk, P., Mahad, D., Callahan, M. K., Trebst, C., Tucky, B. H., Wei, T., Wu, L., Bækkevold, E. S., Lassmann, H., Staugaitis, S. M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1433000100 · Cited by 546 · see citing works

Herpes simplex encephalitis: adolescents and adults.

Whitley, R. (2006) · Antiviral Research · doi:10.1016/j.antiviral.2006.04.002 · Cited by 532 · see citing works

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells

Fitzgerald, D. C., Zhang, G.-X., El-Behi, M., Fonseca-Kelly, Z., Li, H., Yu, S., Saris, C. J. M., Gran, B., Ciric, B., & Rostami, A. (2007) · Nature Immunology · doi:10.1038/ni1540 · Cited by 529 · see citing works

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

Dominguez-Villar, M., Baecher-Allan, C. M., & Hafler, D. A. (2011) · Nature Medicine · doi:10.1038/nm.2389 · Cited by 526 · see citing works

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

Kipnis, J., Cohen, H., Cardon, M., Ziv, Y., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402268101 · Cited by 510 · see citing works

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

Baruch, K., Rosenzweig, N., Kertser, A., Deczkowska, A., Sharif, A. M., Spinrad, A., Tsitsou-Kampeli, A., Sarel, A., Cahalon, L., & Schwartz, M. (2015) · Nature Communications · doi:10.1038/ncomms8967 · Cited by 491 · see citing works

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

Fletcher, J. M., Lonergan, R. M., Costelloe, L., Kinsella, K., Moran, B., O’Farrelly, C., Tubridy, N. J., & Mills, K. H. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901881 · Cited by 476 · see citing works

The TIGIT/CD226 Axis Regulates Human T Cell Function

Lozano, E., Dominguez‐Villar, M., Kuchroo, V. K., & Hafler, D. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103627 · Cited by 475 · see citing works

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

Beers, D. R., Henkel-Tigges, J., Zhao, W., Wang, J., & Appel, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807419105 · Cited by 468 · see citing works

Cytokines as mediators of depression: what can we learn from animal studies?

Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

Gelderblom, M., Weymar, A., Bernreuther, C., Velden, J., Arunachalam, P., Steinbach, K., Orthey, E., Arumugam, T. V., Leypoldt, F., Simova, O., et al. (2012) · Blood · doi:10.1182/blood-2012-02-412726 · Cited by 457 · see citing works

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

Beers, D. R., Henkel-Tigges, J., Zhao, W., Wang, J., Huang, A., Wen, S., Liao, B., & Appel, S. H. (2011) · Brain · doi:10.1093/brain/awr074 · Cited by 427 · see citing works

Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring

Kappos, L., Bates, D., Hartung, H., Havrdová, E., Miller, D. H., Polman, C. H., Ravnborg, M. H., Hauser, S. L., Rudick, R. A., Weiner, H. L., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70078-9 · Cited by 420 · see citing works

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

Liesz, A., Zhou, W., Mracsko, E. Z., Karcher, S., Bauer, H., Schwarting, S., Sun, L., Bruder, D., Stegemann‐Koniszewski, S., Cerwenka, A., et al. (2011) · Brain · doi:10.1093/brain/awr008 · Cited by 410 · see citing works

Herpes Simplex Virus-Specific Memory CD8+ T Cells Are Selectively Activated and Retained in Latently Infected Sensory Ganglia

Khanna, K. M., Bonneau, R. H., Kinchington, P. R., & Hendricks, R. L. (2003) · Immunity · doi:10.1016/s1074-7613(03)00112-2 · Cited by 403 · see citing works

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

Chiu, I., Chen, A., Zheng, Y., Kosaras, B., Tsiftsoglou, S., Vartanian, T., Brown, R. H., & Carroll, M. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0804610105 · Cited by 374 · see citing works

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases.

Zipp, F., & Aktas, O. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.006 · Cited by 373 · see citing works

Decreased FOXP3 levels in multiple sclerosis patients

Huan, J., Culbertson, N. E., Spencer, L., Bartholomew, R. M., Burrows, G. G., Chou, Y. K., BOURDETTE, D. N., Ziegler, S. F., Offner, H., & Vandenbark, A. A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20522 · Cited by 369 · see citing works

Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease

Monsonego, A., Zota, V., Karni, A., Krieger, J. I., Bar-Or, A., Bitan, G., Budson, A. E., Sperling, R., Selkoe, D. J., & Weiner, H. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318104 · Cited by 367 · see citing works

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

Wakim, L. M., Davis, A. S. W., Liu, R., Hu, Y., Villadangos, J. A., Smyth, G. K., & Bevan, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201305 · Cited by 365 · see citing works

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.

Kleinschnitz, C., Schwab, N., Kraft, P., Hagedorn, I., Dreykluft, A., Schwarz, T. J., Austinat, M., Nieswandt, B., Wiendl, H., & Stoll, G. (2010) · Blood · doi:10.1182/blood-2009-10-249078 · Cited by 361 · see citing works

Compromised CD4+ CD25high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3‐positive cells and reduced FOXP3 expression at the single‐cell level

Venken, K., Hellings, N., Thewissen, M. M., Somers, V. A., Hensen, K., Rummens, J., Medaer, R., Hupperts, R., & Stinissen, P. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02690.x · Cited by 360 · see citing works

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

Chakrabarty, P., Li, A., Ceballos-Diaz, C., Eddy, J. A., Funk, C. C., Moore, B., DiNunno, N., Rosario, A. M., Cruz, P. E., Verbeeck, C., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.020 · Cited by 354 · see citing works

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

Mehling, M., Brinkmann, V., Antel, J. P., Bar‐Or, A., Goebels, N., Védrine, C., Kristofic, C., Kühle, J., Lindberg, R. L. P., & Kappos, L. (2008) · Neurology · doi:10.1212/01.wnl.0000327609.57688.ea · Cited by 344 · see citing works

CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis

Wolf, S. A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., Blankenstein, T., & Kempermann, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801218 · Cited by 329 · see citing works

IFN-γ Production by Amyloid β–Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer’s Disease

Browne, T. C., McQuillan, K., McManus, R. M., O’Reilly, J.-A., Mills, K. H. G., & Lynch, M. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200947 · Cited by 322 · see citing works

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

Benner, E. J., Mosley, R. L., Destache, C. J., Lewis, T. B., Jackson-Lewis, V. R., Gorantla, S., Nemachek, C., Green, S. R., Przedborski, S., & Gendelman, H. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400569101 · Cited by 321 · see citing works

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

Kipnis, J., Yoles, E., Porat, Z., Cohen, A., Mor, F., Sela, M., Cohen, I. R., & Schwartz, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7446 · Cited by 308 · see citing works

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD

O’Rourke, J. G., Bogdanik, L., Muhammad, A. K. M. G., Gendron, T. F., Kim, K. J., Austin, A., Cady, J., Liu, E. Y., Zarrow, J., Grant, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.027 · Cited by 298 · see citing works

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

Zhao, X., Wang, H., Sun, G., Zhang, J., Edwards, N., & Aronowski, J. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1685-15.2015 · Cited by 297 · see citing works

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

Baruch, K., Ron‐Harel, N., Gal, H., Deczkowska, A., Shifrut, E., Ndifon, W. O., Mirlas-Neisberg, N., Cardon, M., Vaknin, I., Cahalon, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211270110 · Cited by 296 · see citing works

Proinflammatory microenvironments within the intestine regulate differentiation of tissue-resident CD8 T cells responding to infection

Bergsbaken, T., & Bevan, M. (2015) · Nature Immunology · doi:10.1038/ni.3108 · Cited by 269 · see citing works

Neuroprotective autoimmunity: Naturally occurring CD4 + CD25 + regulatory T cells suppress the ability to withstand injury to the central nervous system

Kipnis, J., Mizrahi, T., Hauben, E., Shaked, I., Shevach, E. M., & Schwartz, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232565399 · Cited by 265 · see citing works

Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring

Kappos, L., Bates, D., Edan, G., Eraksoy, M., García‐Merino, A., Grigoriadis, N., Hartung, H., Havrdová, E., Hillert, J. A., Hohlfeld, R., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70149-1 · Cited by 262 · see citing works

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

Peters, O. M., Cabrera, G. T., Tran, H., Gendron, T. F., McKeon, J. E., Metterville, J., Weiss, A., Wightman, N., Salameh, J. S., Kim, J., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.11.018 · Cited by 259 · see citing works

Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia

Verjans, G. M. G. M., Hintzen, R. Q., van Dun, J. M., Poot, A. M., Milikan, J. C. M., Laman, J. D., Langerak, A. W., Kinchington, P. R., & Osterhaus, A. D. M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610847104 · Cited by 235 · see citing works

Neuronal Survival after CNS Insult Is Determined by a Genetically Encoded Autoimmune Response

Kipnis, J., Yoles, E., Schori, H., Hauben, E., Shaked, I., & Schwartz, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04564.2001 · Cited by 230 · see citing works

Autoimmune T cells as potential neuroprotective therapy for spinal cord injury

Hauben, E., Nevo, U., Yoles, E., Moalem‐Taylor, G., Agranov, E., Mor, F., AKSELROD, S., Neeman, M., Cohen, I., & Schwartz, M. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05140-5 · Cited by 213 · see citing works

Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease

Hauben, E., Agranov, E., Gothilf, A., Nevo, U., Cohen, A., Smirnov, I., Steinman, L., & Schwartz, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12837 · Cited by 208 · see citing works

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

Walsh, J. T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J. R., Gadani, S. P., Hechler, D., Gölz, G., Rosenberger, K., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76210 · Cited by 208 · see citing works

IL-4 Signaling Drives a Unique Arginase+/IL-1 + Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4R  after Traumatic Spinal Cord Injury

Fenn, A. M., Hall, J. C. E., Gensel, J. C., Popovich, P. G., & Godbout, J. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1146-14.2014 · Cited by 207 · see citing works

Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10

Xie, L., Choudhury, G. R., Winters, A., Yang, S., & Jin, K. (2015) · European Journal of Immunology · doi:10.1002/eji.201444823 · Cited by 185 · see citing works

Regulatory T Cells Accumulate and Proliferate in the Ischemic Hemisphere for up to 30 Days after MCAO

Stubbe, T., Ebner, F., Richter, D., Engel, O., Klehmet, J., Royl, G., Meisel, A., Nitsch, R., Meisel, C., & Brandt, C. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.128 · Cited by 184 · see citing works

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS

Ellwardt, E., & Zipp, F. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.02.006 · Cited by 176 · see citing works

Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity.

Jones, J. L., Anderson, J., Phuah, C., Fox, E., Selmaj, K., Margolin, D., Lake, S., Palmer, J., Thompson, S. A. J., Wilkins, A., et al. (2010) · Brain : a journal of neurology · doi:10.1093/brain/awq176 · Cited by 174 · see citing works

Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells

Cohen, H., Ziv, Y., Cardon, M., Kaplan, Z., Matar, M. A., Gidron, Y., Schwartz, M., & Kipnis, J. (2006) · Journal of Neurobiology · doi:10.1002/neu.20249 · Cited by 173 · see citing works

Involvement of Adult Hippocampal Neurogenesis in Learning and Forgetting

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Prolonged Microglial Cell Activation and Lymphocyte Infiltration following Experimental Herpes Encephalitis

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