Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis
Open accessAbstract
Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder characterized by the progressive and selective loss of both upper and lower motoneurons. The neurodegenerative process is accompanied by a sustained inflammation in the brain and spinal cord. The neuron-immune interaction, implicating resident microglia of the central nervous system and blood-derived immune cells, is highly dynamic over the course of the disease. Here, we discuss the timely controlled neuroprotective and neurotoxic cues that are provided by the immune environment of motoneurons and their potential therapeutic applications for ALS.
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Widespread and prolonged neuroinflammation exacerbates the degeneration of motor neurons.
“what can be stated is that widespread and prolonged neuroinflammation exacerbates the degeneration of motor neurons (70).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [70]
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BackgroundEarly presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis
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Self-citationMicroRNAs as Potential Circulating Biomarkers for Amyotrophic Lateral Sclerosis
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NADPH oxidase (NOX2) activity is a modifier of survival in ALS
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Self-citationGut microbiota immune cross-talk in amyotrophic lateral sclerosis
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Complex Inflammation mRNA-Related Response in ALS Is Region Dependent
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- Authors
- Bowerman, M., Vincent, T., Scamps, F., Perrin, F. E., Camu, W., & Raoul, C.
- Affiliations
- Ikerbasque (ES)
- Inserm (FR)
- Corresponding author
- Raoul, Cédric
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 214-214
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3833095
- OpenAlex
- W2149542236
- Cited by
- 46
- References
- 136
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 1 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 8
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone
- Direction de l’hospitalisation et de l’offre de Soins
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- amyotrophic lateral sclerosis, neuroimmunity, neuroinflammation, microglia, motor neurons, neuroprotection, neurotoxicity, treatment options
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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