Cited by 46Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis

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Bowerman, Melissa, Vincent, Thierry, Scamps, Frédérique, Perrin, Florence E., Camu, William, Raoul, Cédric·2013·Frontiers in Cellular Neuroscience

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder characterized by the progressive and selective loss of both upper and lower motoneurons. The neurodegenerative process is accompanied by a sustained inflammation in the brain and spinal cord. The neuron-immune interaction, implicating resident microglia of the central nervous system and blood-derived immune cells, is highly dynamic over the course of the disease. Here, we discuss the timely controlled neuroprotective and neurotoxic cues that are provided by the immune environment of motoneurons and their potential therapeutic applications for ALS.

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Crossref · 10.3389/fncel.2013.00214

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Authors
Bowerman, M., Vincent, T., Scamps, F., Perrin, F. E., Camu, W., & Raoul, C.
Affiliations
  • Ikerbasque (ES)
  • Inserm (FR)
Corresponding author
Raoul, Cédric
Venue
Frontiers in Cellular Neuroscience
Published
2013
Volume
7
Pages
214-214
ISSN
1662-5102 (ISSN-L)
OpenAlex
W2149542236
Cited by
46
References
136
Citations by year
2025: 1 · 2024: 5 · 2023: 1 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 8
FWCI
0.91
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Institut National de la Santé et de la Recherche Médicale
  • Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone
  • Direction de l’hospitalisation et de l’offre de Soins
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
amyotrophic lateral sclerosis, neuroimmunity, neuroinflammation, microglia, motor neurons, neuroprotection, neurotoxicity, treatment options

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