The Preeminent Role of Childhood Abuse and Neglect in Vulnerability to Major Psychiatric Disorders: Toward Elucidating the Underlying Neurobiological Mechanisms
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Components of biological embedding and their consequences are now recognized as chief neurobiological mechanisms underlying a host of cognitive and emotional processes that contribute to psychiatric disorders.
“Owing in part to these advanced theoretical models of how CM confers risk for maldevelopment, the components of biological embedding and their consequences are now recognized as chief neurobiological mechanisms underlying a host of cognitive and emotional processes that contribute to psychiatric disorders (Nemeroff & Binder 2014).”
From Child Sexual Abuse as a Unique Risk Factor for the Development of Psychopathology: The Compounded Convergence of Mechanisms (2021) · cites this paper as Nemeroff & Binder 2014
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- Authors
- Nemeroff, C. B., & Binder, E.
- Affiliations
- University of Miami (US)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Nemeroff, Charles B.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 53
- Issue
- 4
- Pages
- 395-397
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2056684699
- Cited by
- 60
- References
- 23
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 7 · 2017: 2 · 2016: 9 · 2015: 6 · 2014: 2
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- childhood abuse, child neglect, childhood adversity, psychiatric vulnerability, neurobiological mechanisms, hypothalamic-pituitary-adrenal axis, stress response, corticotropin-releasing factor, monoamines, substance P, inflammatory cytokines, amygdala, hippocampus, limbic system, depression, post-traumatic stress disorder, schizophrenia, bipolar disorder, anxiety disorders, neurogenesis, adverse childhood experiences
- MeSH terms
- Child Abuse, Depression, Female, Humans, Male, Neoplasm Proteins, Nerve Tissue Proteins, Stress, Psychological, Receptors, N-Methyl-D-Aspartate, Epigenesis, Genetic, Inhibitor of Differentiation Proteins
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