Cited by 524Skin Diseases and DiabetesDermatology and Skin DiseasesObesity and Health Practices

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Obesity and the skin: Skin physiology and skin manifestations of obesity

Yosipovitch, Gil, DeVore, Amy, Dawn, Aerlyn·2007·Journal of the American Academy of Dermatology

DOI 10.1016/j.jaad.2006.12.004

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Abstract

Unlabelled Obesity is widely recognized as an epidemic in the Western world; however, the impact of obesity on the skin has received minimal attention. The purpose of this article is to highlight the association between obesity and dermatologic conditions. We review the impact of obesity on the skin, including skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity. Obesity is responsible for changes in skin barrier function, sebaceous glands and sebum production, sweat glands, lymphatics, collagen structure and function, wound healing, microcirculation and macrocirculation, and subcutaneous fat. Moreover, obesity is implicated in a wide spectrum of dermatologic diseases, including acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism and hirsutism, striae distensae, adiposis dolorosa, and fat redistribution, lymphedema, chronic venous insufficiency, plantar hyperkeratosis, cellulitis, skin infections, hidradenitis suppurativa, psoriasis, insulin resistance syndrome, and tophaceous gout. We review the clinical features, evidence for association with obesity, and management of these various dermatoses and highlight the profound impact of obesity in clinical dermatology.Learning objective After completing this learning activity, participants should be aware of obesity-associated changes in skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity, and be able to formulate a pathophysiology-based treatment strategy for obesity-associated dermatoses.

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Authors: Yosipovitch, G., DeVore, A., & Dawn, A.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Yosipovitch, Gil
ORCID: Yosipovitch, Gil
Venue: Journal of the American Academy of Dermatology
Publisher: Elsevier BV
Published: 2007-06
Volume: 56
Issue: 6
Pages: 901-916
ISSN: 0190-9622 (ISSN-L)
DOI: 10.1016/j.jaad.2006.12.004
OpenAlex: W2009476361
Semantic Scholar: b5f800df723da429743687ae8b6b272a5e4772cb
Cited by: 524
References: 226
Citations by year: 2026: 17 · 2025: 19 · 2024: 22 · 2023: 29 · 2022: 19 · 2021: 29 · 2020: 34 · 2019: 30 · 2018: 32 · 2017: 32 · 2016: 32 · 2015: 29 · 2014: 32 · 2013: 36 · 2012: 24
FWCI: 4.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of the American Academy of Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity and Health Practices
Keywords: obesity, skin barrier function, sebum production, sweat glands, collagen, wound healing, subcutaneous adipose tissue, acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism, hirsutism, striae, adiposis dolorosa, lymphedema, chronic venous insufficiency, plantar hyperkeratosis, cellulitis, skin infections, hidradenitis suppurativa, psoriasis, metabolic syndrome, tophaceous gout
MeSH terms: Acanthosis Nigricans, Adiposis Dolorosa, Animals, Chronic Disease, Elasticity, Humans, Insulin Resistance, Intertrigo, Lymphedema, Microcirculation, Obesity, Pro-Opiomelanocortin, Psoriasis, Sebaceous Glands, Skin Diseases, Venous Insufficiency, Comorbidity, Hidradenitis Suppurativa, Fasciitis, Necrotizing

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Obesity and the skin: Skin physiology and skin manifestations of obesity

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