Cited by 524Skin Diseases and DiabetesDermatology and Skin DiseasesObesity and Health Practices

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Obesity and the skin: Skin physiology and skin manifestations of obesity

Yosipovitch, Gil, DeVore, Amy, Dawn, Aerlyn·2007·Journal of the American Academy of Dermatology

DOI 10.1016/j.jaad.2006.12.004

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Abstract

Unlabelled Obesity is widely recognized as an epidemic in the Western world; however, the impact of obesity on the skin has received minimal attention. The purpose of this article is to highlight the association between obesity and dermatologic conditions. We review the impact of obesity on the skin, including skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity. Obesity is responsible for changes in skin barrier function, sebaceous glands and sebum production, sweat glands, lymphatics, collagen structure and function, wound healing, microcirculation and macrocirculation, and subcutaneous fat. Moreover, obesity is implicated in a wide spectrum of dermatologic diseases, including acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism and hirsutism, striae distensae, adiposis dolorosa, and fat redistribution, lymphedema, chronic venous insufficiency, plantar hyperkeratosis, cellulitis, skin infections, hidradenitis suppurativa, psoriasis, insulin resistance syndrome, and tophaceous gout. We review the clinical features, evidence for association with obesity, and management of these various dermatoses and highlight the profound impact of obesity in clinical dermatology.Learning objective After completing this learning activity, participants should be aware of obesity-associated changes in skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity, and be able to formulate a pathophysiology-based treatment strategy for obesity-associated dermatoses.

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Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Prevalence of obesity in the United States, 2009-2010.
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2012) · PubMed · Cited by 2,057
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022050 · Cited by 1,778
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,769
Current Estimates of the Economic Cost of Obesity in the United States
Wolf, A., & Colditz, G. A. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00322.x · Cited by 1,244
Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain
Ravussin, E., Lillioja, S., Knowler, W. C., Christin, L., Freymond, D., Abbott, W. G. H., Boyce, V., Howard, B. V., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802253180802 · Cited by 1,215
The Epidemiology of Chronic Venous Insufficiency and Varicose Veins
Beebe‐Dimmer, J., Pfeifer, J. R., Engle, J. S., & Schottenfeld, D. (2004) · Annals of Epidemiology · doi:10.1016/j.annepidem.2004.05.015 · Cited by 1,044
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
Yaswen, L. R., Diehl, N. L., Brennan, M. B., & Hochgeschwender, U. (1999) · Nature Medicine · doi:10.1038/12506 · Cited by 1,039
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038
Leptin: a review of its peripheral actions and interactions
Margetic, S., Gazzola, C., Pegg, G. G., & Hill, R. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802142 · Cited by 1,022
Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease
Klein, S., Fontana, L., Young, V. L., Coggan, A. R., Kilo, C., Patterson, B. W., & Mohammed, B. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033179 · Cited by 917
The Obesity Epidemic: Pathophysiology and Consequences of Obesity
Pi‐Sunyer, F. X. (2002) · Obesity Research · doi:10.1038/oby.2002.202 · Cited by 885
SABISTON TEXTBOOK OF SURGERY
Dries, D. J. (2008) · Shock · doi:10.1097/shk.0b013e318172f499 · Cited by 875
Clinical Management of Metabolic Syndrome: Report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association Conference on Scientific Issues Related to Management
Grundy, S. M., Hansen, B., Smith, S. C., Cleeman, J. I., Kahn, R. A., & Participants, F. C. (2004) · Circulation · doi:10.1161/01.cir.0000112379.88385.67 · Cited by 864
Asymptomatic hyperuricemia. Risks and consequences in the normative aging study
Campion, E. W., Glynn, R. J., & Delabry, L. O. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90441-4 · Cited by 851
Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ
ZURLO, F., Lillioja, S., Puente, A. E.-D., Nyomba, B. L. G., Raz, I., Saad, M. F., Swinburn, B. A., Knowler, W. C., Bogardus, C., & Ravussin, É. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.5.e650 · Cited by 709
Disease concomitance in psoriasis
Henseler, T., & Christophers, E. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)91336-x · Cited by 680
Cigarette Smoking, Body Mass Index, and Stressful Life Events as Risk Factors for Psoriasis: Results from an Italian Case–Control Study
Naldi, L., Chatenoud, L., Linder, D., Fortina, A. B., Peserico, A., Virgili, A., Bruni, P. L., Ingordo, V., Scocco, G. L., Solaroli, C., et al. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23681.x · Cited by 642
Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women
Goodpaster, B. H., Krishnaswami, S., Harris, T. B., Katsiaras, A., Kritchevsky, S. B., Simonsick, E. M., Nevitt, M., Holvoet, P., & Newman, A. B. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.777 · Cited by 637
Obesity, Weight Change, Hypertension, Diuretic Use, and Risk of Gout in Men
Choi, H. K., Atkinson, K. A., Karlson, E. W., & Curhan, G. C. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.742 · Cited by 629
Acne and sebaceous gland function
Zouboulis, C. C. (2004) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2004.03.004 · Cited by 561
Risk factors for erysipelas of the leg (cellulitis): case-control study
Dupuy, A., Benchikhi, H., Roujeau, J., Bernard, P., Vaillant, L., Chosidow, O., Sassolas, B., Guillaume, J. C., Grob, J., & Bastuji‐Garin, S. (1999) · BMJ · doi:10.1136/bmj.318.7198.1591 · Cited by 547
Impact of Obesity and Smoking on Psoriasis Presentation and Management
Herron, M. D., Hinckley, M. R., Hoffman, M. S., Papenfuss, J., Hansen, C. B., Callis, K. P., & Krueger, G. G. (2005) · Archives of Dermatology · doi:10.1001/archderm.141.12.1527 · Cited by 505
Prevalence of obesity in the United States
Baskin, M. L., Ard, J. D., Franklin, F. A., & Allison, D. B. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00165.x · Cited by 410
Impaired Microvascular Function in Obesity: Implications for Obesity-Associated Microangiopathy, Hypertension, and Insulin Resistance
de Jongh, R. T., Serné, E. H., IJzerman, R. G., de Vries, G., & Stehouwer, C. D. A. (2004) · Circulation · doi:10.1161/01.cir.0000129772.26647.6f · Cited by 407
Venous ulcer: epidemiology, physiopathology, diagnosis and treatment
Abbade, L. P. F., & Lastória, S. (2005) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2004.02456.x · Cited by 358
Effective Treatment of Lymphedema of the Extremities
Ko, D. S. C. (1998) · Archives of Surgery · doi:10.1001/archsurg.133.4.452 · Cited by 356
Plantar pressure differences between obese and non-obese adults: a biomechanical analysis
Hills, A. P., Hennig, E., McDonald, M., & Bar‐Or, O. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801785 · Cited by 351
Morbidity in patients with hidradenitis suppurativa
Werth, J. M. V. D., & Jemec, G. B. E. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04137.x · Cited by 345
Topical clindamycin versus systemic tetracycline in the treatment of hidradenitis suppurativa
Jemec, G. B. E., & Wendelboe, P. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70272-5 · Cited by 339
Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study
Dessein, P. H., Shipton, E. A., Stanwix, A. E., Joffe, B. I., & Ramokgadi, J. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.7.539 · Cited by 336
The Human Obesity Gene Map: The 2003 Update
Snyder, E. E., Walts, B., Përusse, L., Chagnon, Y. C., Weisnagel, S. J., Rankinen, T., & Bouchard, C. (2004) · Obesity Research · doi:10.1038/oby.2004.47 · Cited by 320
Obesity Due to Proopiomelanocortin Deficiency: Three New Cases and Treatment Trials with Thyroid Hormone and ACTH4–10
Krude, H., Biebermann, H., Schnabel, D., Tanšek, M. Ž., Theunissen, P., Mullis, P. E., & Grüters, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030502 · Cited by 313
Hormonal Signaling and Transcriptional Control of Adipocyte Differentiation
Morrison, R. F., & Farmer, S. R. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.3116s · Cited by 305
Hidradenitis suppurativa: pathogenesis and management
Slade, D. E. M., Powell, B. W. E. M., & Mortimer, P. S. (2003) · British Journal of Plastic Surgery · doi:10.1016/s0007-1226(03)00177-2 · Cited by 290
Diseases Associated with Psoriasis in a General Population of 159,200 Middle-Aged, Urban, Native Swedes
Lindegard, B. (2009) · Dermatologica · doi:10.1159/000249365 · Cited by 282
Cellulite: a review
Rossi, A. B., & Vergnanini, A. L. (2000) · Journal of the European Academy of Dermatology and Venereology · doi:10.1046/j.1468-3083.2000.00016.x · Cited by 276
Topical Treatment of Hidradenitis Suppurativa with Clindamycin
Clemmensen, O. J. (1983) · International Journal of Dermatology · doi:10.1111/j.1365-4362.1983.tb02150.x · Cited by 271
Subcutaneous fat in normal and diseased states
Avram, M. M., Avram, A. S., & James, W. D. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.06.022 · Cited by 269
A characterization of pH-regulated dimorphism in Candida albicans
Buffo, J., Herman, M. A., & Soll, D. R. (1984) · Mycopathologia · doi:10.1007/bf00436698 · Cited by 256
Varicose Veins and Chronic Venous Insufficiency in Brazil: Prevalence among 1755 Inhabitants of a Country Town
Maffei, F. H. A., Magaldi, C., Pinho, S., Lastória, S., Pinho, W., Yoshida, W. B., & Rollo, H. A. (1986) · International Journal of Epidemiology · doi:10.1093/ije/15.2.210 · Cited by 253
Obesity, Body Fat Distribution, Insulin Sensitivity and Islet β-Cell Function as Explanations for Metabolic Diversity
Kahn, S. E., Prigeon, R. L., Schwartz, R. S., Fujimoto, W. Y., Knopp, R. H., Brunzell, J. D., & Porte, D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.354s · Cited by 240
Incidence and Risk Factors for Gout in White Men
Roubenoff, R. (1991) · JAMA · doi:10.1001/jama.1991.03470210072035 · Cited by 237
The evaluation of plantar pressure distribution in obese and non-obese adults
Birtane, M., & Tuna, H. (2004) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2004.07.008 · Cited by 230
Necrotizing Fasciitis: Improved Survival With Early Recognition by Tissue Biopsy and Aggressive Surgical Treatment
MAJESKI, J. A., & Majeski, E. I. (1997) · Southern Medical Journal · doi:10.1097/00007611-199711000-00001 · Cited by 228
The Human Sebocyte Culture Model Provides New Insights into Development and Management of Seborrhoea and Acne
Zouboulis, C. C., Xia, L., Akamatsu, H., Seltmann, H., Fritsch, M., Hornemann, S., Rühl, R., Chen, W., Nau, H., & Orfanos, C. E. (1998) · Dermatology · doi:10.1159/000017861 · Cited by 216
Correlation Between Serum Levels of Insulin-like Growth Factor 1, Dehydroepiandrosterone Sulfate, and Dihydrotestosterone and Acne Lesion Counts in Adult Women
Cappel, M. (2005) · Archives of Dermatology · doi:10.1001/archderm.141.3.333 · Cited by 216
Hyperinsulinemic diseases of civilization: more than just Syndrome X
Cordain, L., Eades, M. R., & Eades, M. D. (2003) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(03)00011-4 · Cited by 211
Responses of Serum Androgen and Insulin Resistance to Metformin and Pioglitazone in Obese, Insulin-Resistant Women with Polycystic Ovary Syndrome
Ortega-González, C., Luna, S. L., Hernández, L., Crespo, G., Aguayo, P., Arteaga‐Troncoso, G., & Parra, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1965 · Cited by 211
Dermatological Complications of Obesity
Hidalgo, L. G. (2002) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200203070-00006 · Cited by 209
Troglitazone Improves Psoriasis and Normalizes Models of Proliferative Skin Disease
Ellis, C. N., Varani, J., Fisher, G. J., Zeigler, M. E., Pershadsingh, H. A., Benson, S. C., Chi, Y., & Kurtz, T. W. (2000) · Archives of Dermatology · doi:10.1001/archderm.136.5.609 · Cited by 208
Excess Insulin Binding to Insulin-Like Growth Factor Receptors: Proposed Mechanism for Acanthosis Nigricans
Cruz, P. D., & Hud, J. A. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12462293 · Cited by 194
The Prevalence of Cutaneous Manifestations in IDDM Patients and Their Association With Diabetes Risk Factors and Microvascular Complications
Yosipovitch, G., Hodak, E., Vardi, P., Shraga, I., Karp, M., Sprecher, E., & David, M. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.506 · Cited by 193
Self-citation
Subcutaneous fat in normal and diseased states
Avram, A. S., Avram, M. M., & James, W. D. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.015 · Cited by 188
A Classification of Facial Wrinkles
Lemperle, G., Holmes, R. E., Cohen, S. R., & Lemperle, S. M. (2001) · Plastic and Reconstructive Surgery · doi:10.1097/00006534-200111000-00050 · Cited by 184
The prevalence and descriptive epidemiology of atopic dermatitis in Singapore school children
Tay, Y. K., kong, K., KHOO, L. S. W., Goh, C.-L., & Giam, Y. C. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04566.x · Cited by 174
Role of non‐alcoholic steatohepatitis in methotrexate‐induced liver injury
Langman, G., Hall, P. D. L. Μ., & Todd, G. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02644.x · Cited by 172
Growth Hormone and Insulin-Like Growth Factors Have Different Effects on Sebaceous Cell Growth and Differentiation1
Deplewski, D., & Rosenfield, R. L. (1999) · Endocrinology · doi:10.1210/endo.140.9.6957 · Cited by 170
The Influence of Environmental Factors in Chronic Venous Insufficiency
Jawień, A. (2003) · Angiology · doi:10.1177/0003319703054001s04 · Cited by 165
Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation
Haffner, S. M. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801279 · Cited by 164
Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women
Giugliano, G., Nicoletti, G., Grella, E., Giugliano, F. M., Esposito, K., Scuderi, N., & D’Andrea, F. (2004) · British Journal of Plastic Surgery · doi:10.1016/j.bjps.2003.12.010 · Cited by 164
Prevalence and Significance of Acanthosis Nigricans in an Adult Obese Population
Hud, J. A. (1992) · Archives of Dermatology · doi:10.1001/archderm.1992.01680170073009 · Cited by 164
Acanthosis Nigricans Associated with Insulin Resistance
Hermanns‐Lê, T., Scheen, A., & rard, G. R. E. P. (2004) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200405030-00008 · Cited by 162
The Influence of Obesity on Chronic Venous Disease
Daníelsson, G., Eklöf, B., Grandinetti, A., & Kistner, R. L. (2002) · Vascular and Endovascular Surgery · doi:10.1177/153857440203600404 · Cited by 158
Leptin is an autocrine/paracrine regulator of wound healing
Murad, A. A. A., Nath, A. K., Cha, S.-T., Demir, E., Floras-Riveras, J., & Sierra-Honigmann, M. R. (2003) · The FASEB Journal · doi:10.1096/fj.03-0068fje · Cited by 157
Infliximab for hidradenitis suppurativa
Sullivan, T. P., Welsh, E. C., Kerdel, F. A., Burdick, A. E., & Kirsner, R. S. (2003) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2003.05663.x · Cited by 157
Obesity and dermatology
Scheinfeld, N. S. (2004) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2004.01.001 · Cited by 155
The Melanocortin-1 Receptor
Schaffer, J. V., & Bolognia, J. L. (2001) · Archives of Dermatology · doi:10.1001/archderm.137.11.1477 · Cited by 155
Proopiomelanocortin-Derived Peptides
BERTAGNA, X. Y. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30079-3 · Cited by 153
Hidradenitis suppurativa - characteristics and consequences
Jemec, G. B. E., Heidenheim, M., & Nielsen, N. H. (1996) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1996.tb00145.x · Cited by 147
Proopiomelanocortin Gene Product Regulation in Keratinocytes
Wintzen, M., Yaar, M., Burbach, J. P. H., & Gilchrest, B. A. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12345496 · Cited by 146
Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine
Kraus, T., Haack, M., Schuld, A., Hinze-Selch, D., Koethe, D., & Pollmächer, T. (2002) · Pharmacopsychiatry · doi:10.1055/s-2002-36390 · Cited by 144
Effects of Antidepressants on Weight and on the Plasma Levels of Leptin, TNF-α and Soluble TNF Receptors A Longitudinal Study in Patients Treated with Amitriptyline or Paroxetine
Hinze‐Selch, D. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00089-0 · Cited by 142
Implications of risk factors in necrotizing fasciitis.
Francis, K. R., Lamaute, H. R., Davis, J. M., & Pizzi, W. F. (1993) · PubMed · Cited by 140
Implications for the Role of Diet in Acne
Cordain, L. (2005) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2005.04.002 · Cited by 140
Epidemiology of Psoriasis: Clinical Issues.
Krueger, G. G., & Duvic, M. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12386079 · Cited by 138
Drug-induced weight gain
Ness-Abramof, R., & Apovian, C. M. (2005) · Drugs of today · doi:10.1358/dot.2005.41.8.893630 · Cited by 137
Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome
Romualdi, D. (2003) · Human Reproduction · doi:10.1093/humrep/deg264 · Cited by 137
Does severe venous insufficiency have a different etiology in the morbidly obese? Is it venous?
Padberg, F. T., Cerveira, J. J., Lal, B. K., Pappas, P. J., Varma, S., & Hobson, R. W. (2003) · Journal of Vascular Surgery · doi:10.1067/mva.2003.61 · Cited by 134
Acne vulgaris
Brown, S. K., & Shalita, A. R. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01046-0 · Cited by 133
Cellulite: Etiology and Purported Treatment
Draelos, Z. D., & MARENUS, K. D. (1997) · Dermatologic Surgery · doi:10.1111/j.1524-4725.1997.tb00468.x · Cited by 130
Differential effect of weight loss on insulin resistance in surgically treated obese patients
Muscelli, E., Mingrone, G., Camastra, S., Manco, M., Pereira, J. A., Pareja, J. C., & Ferrannini, E. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.08.017 · Cited by 130
Mirror, Mirror on the Wall: When the Postoperative Reflection Does Not Meet Patientsʼ Expectations
Rohrich, R. J. (2001) · Plastic and Reconstructive Surgery · doi:10.1097/00006534-200108000-00035 · Cited by 130
Effects of Rosiglitazone in Obese Women with Polycystic Ovary Syndrome and Severe Insulin Resistance
Sepilian, V., & Nagamani, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1376 · Cited by 130
Anatomy of striae
Zheng, P., Lavker, R. M., & Kligman, A. M. (1985) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1985.tb00082.x · Cited by 128
The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models
Yeo, G. S. H. (2000) · QJM · doi:10.1093/qjmed/93.1.7 · Cited by 128
Acne inversa (alias hidradenitis suppurativa)
Jansen, T., Altmeyer, P. J., & Plewig, G. (2001) · Journal of the European Academy of Dermatology and Venereology · doi:10.1046/j.1468-3083.2001.00303.x · Cited by 127
Gout and Hyperuricemia
Roubenoff, R. (1990) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(21)00887-5 · Cited by 126
Sequential gradient pneumatic compression enhances venous ulcer healing: a randomized trial.
Smith, P. C., Sarin, S., Hasty, J. H., & Scurr, J. H. (1990) · PubMed · Cited by 121
Necrotizing Fasciitis
Gozal, D. (1986) · Archives of Surgery · doi:10.1001/archsurg.1986.01400020119015 · Cited by 121
Dermatoses in 156 Obese Adults
García‐Hidalgo, L., Orozco‐Topete, R., González‐Barranco, J., Villa, A. R., Dalman, J. J., & Ortiz-Pedroza, G. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00410.x · Cited by 120
The influence of body mass index on skin susceptibility to sodium lauryl sulphate
Löffler, H., Aramaki, J. U. N., & Effendy, I. (2002) · Skin Research and Technology · doi:10.1046/j.0909-752x · Cited by 120
Wound Collagen Accumulation in Obese Hyperglycemic Mice
Goodson, W. H., & Hunt, T. K. (1986) · Diabetes · doi:10.2337/diab.35.4.491 · Cited by 117
Mast cell degranulation and elastolysis in the early stage of striae distensae
Sheu, H., Yu, H., & Chang, C. (1991) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1991.tb01376.x · Cited by 116
Treatment of Striae Rubra and Striae Alba With the 585-nm Pulsed-Dye Laser
Jimenez, G. P., Flores, F., Berman, B., & Gunja‐Smith, Z. (2003) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2003.29086.x · Cited by 115
Skin tags: a cutaneous marker for diabetes mellitus
Kahana, M., Grossman, E., Feinstein, A., Ronnen, M., Cohen, M., & Millet, M. S. (1987) · Acta Dermato Venereologica · doi:10.2340/0001555567175177 · Cited by 112
Adiposity signals, genetic and body weight regulation in humans
Cancello, R., Tounian, A., Poitou, C., & Clément, K. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70112-x · Cited by 112
The Safety and Efficacy of the 308-nm Excimer Laser for Pigment Correction of Hypopigmented Scars and Striae Alba
Alexiades, M. R., Bernstein, L. J., Friedman, P. M., & Geronemus, R. G. (2004) · Archives of Dermatology · doi:10.1001/archderm.140.8.955 · Cited by 112
Surgical treatment of hidradenitis suppurativa
Banerjee, A. K. (1992) · British journal of surgery · doi:10.1002/bjs.1800790905 · Cited by 109
Sustainable rates of sebum secretion in acne patients and matched normal control subjects
Harris, H. H., Downing, D. T., Stewart, M. E., & Strauss, J. S. (1983) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(83)70023-x · Cited by 109
Endocrine basis for the clinical presentation of hidradenitis suppurativa
Harrison, B. J., Read, G. F., & Hughes, L. E. (1988) · British journal of surgery · doi:10.1002/bjs.1800751011 · Cited by 108
Intense Pulsed Light in the Treatment of Striae Distensae
Hernández-Pérez, E., Colombo-Charrier, E., & Valencia-Ibiett, E. (2002) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2002.02111.x · Cited by 107
Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin
Rendon, M. I., Cruz, P. D., Sontheimer, R. D., & Bergstresser, P. R. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70208-5 · Cited by 105
Pentoxifylline for treatment of venous leg ulcers: a systematic review
Jull, A., Waters, J., & Arroll, B. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08513-6 · Cited by 105
Comparison of Topical Therapy for Striae Alba (20% Glycolic Acid/0.05% Tretinoin Versus 20% Glycolic Acid/ 10% L-Ascorbic Acid)
Ash, K., Lord, J., ZUKOWSKL, M., & McDaniel, D. H. (1998) · Dermatologic Surgery · doi:10.1111/j.1524-4725.1998.tb04262.x · Cited by 103
Psoriasis Remission after Laparoscopic Roux-En-Y Gastric Bypass for Morbid Obesity
Higa, G., Szomstein, S., Soto, F. C., Brasecsco, O., Cohen, C., & Rosenthal, R. J. (2004) · Obesity Surgery · doi:10.1381/0960892041975569 · Cited by 102
Skin Surface pH in Intertriginous Areas in NIDDM Patients: Possible Correlation to Candidal intertrigo
Yosipovitch, G., Tur, E., Cohen, O., & Rusecki, Y. (1993) · Diabetes Care · doi:10.2337/diacare.16.4.560 · Cited by 102
Self-citation
Alternative therapies commonly used within a population of patients with psoriasis.
Fleischer, A. B., Feldman, S. R., Rapp, Dm, R., Exum, M. L., & Ar, C. (1996) · PubMed · Cited by 101
Epidemiology of Obesity in the United States
Pender, J. R., & Pories, W. J. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2004.12.010 · Cited by 98
Selective insulin action on skin, ovary, and heart in insulin-resistant states
Geffner, M. E., & Golde, D. W. (1988) · Diabetes Care · doi:10.2337/diacare.11.6.500 · Cited by 97 · cited 1×
“The skin proliferation abnormalities in acanthosis nigricans are frequently associated with hyperinsulinemia and insulin resistance.(50) Hud et al(51) found that 74% of an obese population exhibited acanthosis nigricans along with elevated plasma insulin levels.”
Background
Necrotizing fasciitis in gynecologic and obstetric patients: A surgical emergency
Gallup, D. G., Freedman, M. A., Meguiar, R. V., Freedman, S. N., & Nolan, T. E. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.126000 · Cited by 97
Severe Hidradenitis Suppurativa Treated With Infliximab Infusion
Adams, D. R. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.12.1540 · Cited by 97
Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life
Duque, M. I., Yosipovitch, G., Chan, Y. H., Smith, R. D., & Levy, P. J. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.04.079 · Cited by 96
Self-citation
An Epidemiological Study of Varicose Veins in Indian Railroad Workers from the South and North of India, with Special Reference to the Causation and Prevention of Varicose Veins
Malhotra, S. L. (1972) · International Journal of Epidemiology · doi:10.1093/ije/1.2.177 · Cited by 88
Leptin Levels, β-Cell Function, and Insulin Sensitivity in Families with Congenital and Acquired Generalized Lipoatropic Diabetes1
Pardini, V. C., Victoria, I. M. N., Rocha, S. M. V., Andrade, D. G., Rocha, A. M., Pieroni, F. B., Milagres, G., Purisch, S., & Velho, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4567 · Cited by 86
Comparison of the 585 nm Pulse Dye Laser and the Short Pulsed CO2 Laser in the Treatment of Striae Distensae in Skin Types IV and VI
Nouri, K., Romagosa, R., Chartier, T., Bowes, L. E., & SPENCER, J. M. (1999) · Dermatologic Surgery · doi:10.1046/j.1524-4725.1999.07320.x · Cited by 85
Psoriasis risk factors: role of lifestyle practices.
Raychaudhuri, S. P., & Gross, J. (2000) · PubMed · Cited by 84
Evaluation of isotretinoin treatment of hidradenitis suppurativa
Dicken, C. H., Powell, S. T., & Spear, K. L. (1984) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(84)70199-x · Cited by 83
Analysis of Striae
Arem, A. J., & Kischer, C. W. (1980) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198001000-00005 · Cited by 82
The role of the low energy diet in psoriasis vulgaris treatment.
Ručević, I., Perl, A., Barišić-Druško, V., & Perl, M. A. (2003) · PubMed · Cited by 82
Liver injury in long‐term methotrexate treatment in psoriasis is relatively infrequent
Berends, M. A. M., Snoek, J., de Jong, E. M. G. J., van de Kerkhof, P. C. M., van Oijen, M. G. H., van Krieken, J. H., & Drenth, J. P. H. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03047.x · Cited by 82
THREE CASES OF A HITHERTO UNCLASSIFIED AFFECTION RESEMBLING IN ITS GROSSER ASPECTS OBESITY, BUT ASSOCIATED WITH SPECIAL NERVOUS SYMPTOMS—ADIPOSIS DOLOROSA
Dercum, F. X. (1892) · The American Journal of the Medical Sciences · doi:10.1097/00000441-189211000-00004 · Cited by 81
FORCES UNDER THE FOOT
Stott, J., Hutton, W. C., & Stokes, I. A. F. (1973) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.55b2.335 · Cited by 81
Infliximab for the treatment of hidradenitis suppurativa
Lebwohl, B., & Sapadin, A. N. (2003) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(03)01132-0 · Cited by 80
Pilot trial: Pioglitazone versus placebo in patients with plaque psoriasis (the P6)
Shafiq, N., Malhotra, S., Pandhi, P., Gupta, M., Kumar, B., & Sandhu, K. (2005) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2005.02504.x · Cited by 80
The role of liver biopsies in psoriatic patients receiving long-term methotrexate treatment. Improvement in liver abnormalities after cessation of treatment
Newman, M. (1989) · Archives of Dermatology · doi:10.1001/archderm.125.9.1218 · Cited by 79
Dercumʼs disease (adiposis dolorosa). Treatment of the severe pain with intravenous lidocaine
Petersen, P., & Kastrup, J. (1987) · Pain · doi:10.1016/0304-3959(87)91062-1 · Cited by 77
The metabolic syndrome
Meigs, J. B. (2003) · BMJ · doi:10.1136/bmj.327.7406.61 · Cited by 77
Subcutaneous fat in normal and diseased states
Avram, M. M., Avram, A. S., & James, W. D. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.014 · Cited by 77
Treatment of hidradenitis suppurativa with infliximab in a patient with Crohn's disease
Rosi, Y. L., Lowe, L., & Kang, S. (2005) · Journal of Dermatological Treatment · doi:10.1080/09546630410024547 · Cited by 72
Low-dose tretinoin does not improve striae distensae: a double-blind, placebo-controlled study.
Pribanich, S., Simpson, F. G., Held, B., Yarbrough, C. L., & White, S. N. (1994) · PubMed · Cited by 70
The Role of Liver Biopsies in Psoriatic Patients Receiving Long-term Methotrexate Treatment
Newman, M. (1989) · Archives of Dermatology · doi:10.1001/archderm.1989.01670210056007 · Cited by 68
Arthroscopy of the knee joint. A review of 150 cases.
Casscells, S. W. (1971) · PubMed · Cited by 66
Haploinsufficiency of the melanocortin-4 receptor: part of a thrifty genotype?
Cone, R. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10628 · Cited by 65
A prospective epidemiological study on tinea pedis and onychomycosis in Hong Kong.
Cheng, S., & Chong, L. (2002) · PubMed · Cited by 64
Hidradenitis Suppurativa
Brown, T. J., ROSEN, T., & Orengo, I. F. (1998) · Southern Medical Journal · doi:10.1097/00007611-199812000-00003 · Cited by 62
Growth Hormone and Insulin-Like Growth Factors Have Different Effects on Sebaceous Cell Growth and Differentiation
Deplewski, D. (1999) · Endocrinology · doi:10.1210/en.140.9.4089 · Cited by 62
Successful treatment of acanthosis nigricans with etretinate
Akovbian, V. A., Talanin, N. Y., Ss, A., Тухватуллина, З. Г., Musabayev, A. N., Baybekov, I. M., & Kang, M. K. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(09)80242-9 · Cited by 61
Medical treatment of hidradenitis suppurativa
Jemec, G. B. E. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.8.1767 · Cited by 61
308-nm Excimer Laser Treatment of Mature Hypopigmented Striae
Goldberg, D. J., Sarradet, D., & Hussain, M. (2003) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2003.29144.x · Cited by 60
The Impact of Liposuction on Body Fat
Matarasso, A., Kim, R. W., & Kral, J. G. (1998) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199810000-00057 · Cited by 60
Effects of Policosanol and Lovastatin in Patients with Intermittent Claudication: A Double-Blind Comparative Pilot Study
Castaño, G., Más, R., Fernández, L., Gámez, R., & Illnait, J. (2003) · Angiology · doi:10.1177/000331970305400104 · Cited by 59
Acanthosis nigricans, insulin resistance and cutaneous virilism
EARTH, J. H., Ng, L. L., WOJNAROWSKA, F. T., & Dawber, R. P. R. (1988) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1988.tb02561.x · Cited by 57
Mechanical and chemical properties of the skin and its collagen from lean and obese-hyperglycaemic (ob/ob) mice
Enser, M. B., & Avery, N. C. (1984) · Diabetologia · doi:10.1007/bf00253500 · Cited by 55
Management of Intractable Pain in Adiposis Dolorosa with Intravenous Administration of Lidocaine
IWANE, T., MARUYAMA, M., MATSUKI, M., Ito, Y., & Shimoji, K. (1976) · Anesthesia & Analgesia · doi:10.1213/00000539-197603000-00028 · Cited by 55
Population Pharmacokinetics of Efalizumab (Humanized Monoclonal Anti‐CD11a Antibody) Following Long‐Term Subcutaneous Weekly Dosing in Psoriasis Subjects
Sun, Y., Lü, J., Joshi, A., Compton, P. G., Kwon, P., & Bruno, R. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004272731 · Cited by 55
Topical tretinoin therapy for management of early striae
Kang, S. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70453-0 · Cited by 54
Treatment of Psoriasis With Troglitazone Therapy
Pershadsingh, H. A., Sproul, J. A., Benjamin, E., Finnegan, J., & Amin, N. M. (1998) · Archives of Dermatology · doi:10.1001/archderm.134.10.1304 · Cited by 53
Hidradenitis suppurativa of the anogenital region: Response to isotretinoin
Brown, C. F., Gallup, D. G., & Brown, V. M. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90766-1 · Cited by 52
Prognostic Factor Analysis for Plaque Psoriasis
Bizmark, R. S., Matsui, S., Fukushima, M., Yasuda, H., Miyauchi, H., & Miyachi, Y. (2005) · Dermatology · doi:10.1159/000086437 · Cited by 50
Determination of leptin signaling pathways in human and murine keratinocytes
Goren, I., Pfeilschifter, J. M., & Frank, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00480-7 · Cited by 48
Epidemiology of venous insufficiency in an occupational population.
Lacroix, P., Aboyans, V., Preux, P., Houles, M., & Laskar, M. (2003) · PubMed · Cited by 47
Adiposis Dolorosa (Dercumʼs Disease): 10-Year Follow-up
Brodovsky, S., Westreich, M., Leibowitz, A. N., & Schwartz, Y. (1994) · Annals of Plastic Surgery · doi:10.1097/00000637-199412000-00020 · Cited by 45
A Prospective Epidemiologic Survey on the Prevalence of Foot Disease in Hong Kong
Chan, M. K.-T., Chong, L., & _, _. (2002) · Journal of the American Podiatric Medical Association · doi:10.7547/87507315-92-8-450 · Cited by 44
Impaired skeletal muscle and skin microcirculatory function in human obesity
Agapitov, A. V., Correia, M., Sinkey, C. A., Dopp, J. M., & Haynes, W. G. (2002) · Journal of Hypertension · doi:10.1097/00004872-200207000-00027 · Cited by 44
The use of terbinafine in the treatment of onychomycosis in adults and special populations: a review of the evidence.
Gupta, A. K., Ryder, J. E., Lynch, L. E., & Tavakkol, A. (2005) · PubMed · Cited by 43
The Skinny on Psoriasis and Obesity
McGowan, J. W., Pearce, D. J., Chen, J. L., Richmond, D., Balkrishnan, R., & Feldman, S. R. (2005) · Archives of Dermatology · doi:10.1001/archderm.141.12.1601 · Cited by 42
Adiposis Dolorosa (Dercumʼs Disease)
DeFranzo, A. J., Hall, J. H., & Herring, S. M. (1990) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199002000-00022 · Cited by 41
Treatment of Acanthosis Nigricans of the Axillae Using a Long-Pulsed (5-msec) Alexandrite Laser
Rosenbach, A., & Ram, R. (2004) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2004.30346.x · Cited by 41
Acanthosis nigricans with Severe Obesity, Insulin Resistance and Hypothyroidism: Improvement by Diet Control
Kuroki, R., Sadamoto, Y., Imamura, M., Abe, Y., Higuchi, K., Kato, K., KOGA, T., & FURUE, M. (1999) · Dermatology · doi:10.1159/000018096 · Cited by 40
Treatment of mixed‐type acanthosis nigricans with topical calcipotriol
Böhm, Luger, & Metze (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.02538.x · Cited by 40
Improvement of acanthosis nigricans on isotretinoin and metformin.
Walling, H. W., MESSINGHAM, M. J., Myers, L. M., Mason, C. L., & Strauss, J. S. (2003) · PubMed · Cited by 38
KERATOTIC DISORDERS OF THE PLANTAR SKIN
Mann, R. A., & Mann, J. A. (2003) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200305000-00027 · Cited by 38
Necrotizing fasciitis in gynecologic and obstetric patients: A surgical emergency
GALLUP, D., Freedman, M., Meguiar, R. V., et al. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.126000a · Cited by 38
[Necrotizing fasciitis. Clinical criteria and risk factors].
Jc, R. (2001) · PubMed · Cited by 37
Dercum’s disease (adiposis dolorosa): a new case-report
Amine, B., Leguilchard, F., & Benhamou, C. L. (2004) · Joint Bone Spine · doi:10.1016/s1297-319x(03)00139-8 · Cited by 37
Dercum's Disease
Wortham, N. C., & Tomlinson, I. P. M. (2005) · SKINmed Dermatology for the Clinician · doi:10.1111/j.1540-9740.2005.03675.x · Cited by 37
Gout: diet and uric acid revisited
Snaith, M. L. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05745-2 · Cited by 37
Steroid Excretion in Obese Patients with Colored Abdominal Striae
Simkin, B., & Arce, R. (1962) · New England Journal of Medicine · doi:10.1056/nejm196205172662004 · Cited by 37
Leptin Levels, -Cell Function, and Insulin Sensitivity in Families with Congenital and Acquired Generalized Lipoatropic Diabetes
Pardini, V. C. (1998) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.2.503 · Cited by 37
High Body Mass Index, Dry Scaly Leg Skin and Atopic Conditions Are Highly Associated with Keratosis pilaris
Yosipovitch, G., Mevorah, B., Mashiach, J., Chan, Y. H., & David, M. (2000) · Dermatology · doi:10.1159/000018425 · Cited by 36
Self-citation
Dercum's disease: adiposis dolorosa.
Ed, P. (1981) · PubMed · Cited by 36
Influence of body mass index and age on the grade of hair growth in hirsute women of reproductive ages
Ruutiainen, K., Erkkola, R., Grönroos, M. A., & Irjala, K. M. A. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60070-5 · Cited by 33
Ecology and Epidemiology of Candida Species
Odds, F. C. (1984) · Zentralblatt für Bakteriologie Mikrobiologie und Hygiene 1 Abt Originale A Medizinische Mikrobiologie Infektionskrankheiten und Parasitologie · doi:10.1016/s0174-3031(84)80073-6 · Cited by 32
A comparison of the efficacy of oral fluconazole, 150 mg/week versus 50 mg/day, in the treatment of tinea corporis, tinea cruris, tinea pedis, and cutaneous candidosis
Nozicková, M., Koudelková, V., Kulikova, Z., Malina, L., Urbanowski, S., & Silny, W. (1998) · International Journal of Dermatology · doi:10.1046/j.1365-4362.1998.00541.x · Cited by 32
Cutaneous Angiosarcoma Complicating Morbid Obesity
Azam, M. A., Saboorian, M. H., Bieligk, S. C., Smith, T. P., & Molberg, K. H. (2001) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2001-125-0531-cacmo · Cited by 31
Complications infectieuses des lymphœdèmes
Vaillant, L., & Gironet, N. (2002) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(02)80383-6 · Cited by 31
Collagen metabolism in obesity: the effect of weight loss.
Rasmussen, M. H., Jensen, L. T., Andersen, T., Breum, L., & Hilsted, J. (1995) · PubMed · Cited by 30
Anterior abdominal wall angiosarcoma in a morbidly obese woman
Krause, K., Hebert, A. A., Sánchez, R. L., & Solomon, A. R. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70170-9 · Cited by 30
Impairment of skin vasoconstrictive response to sympathetic activation in obese patients: Influence of rheological disorders
Valensi, P. E., Smagghue, O., Pariès, J., Velayoudon, P., Lormeau, B., & Attali, J. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80034-7 · Cited by 30
Vulvar acanthosis nigricans: a marker for insulin resistance in hirsute women
Grasinger, C. C., Wild, R. A., & Parker, I. J. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55804-x · Cited by 29
Elephantiasis Nostras Verrucosa
Schissel, D. J., Hivnor, C., & Elston, D. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-37713-3.50100-x · Cited by 28
THERAPEUTIC APPROACH IN INSULIN RESISTANCE WITH ACANTHOSIS NIGRICANS
Tankova, T. I., Koev, D. J., Dakovska, L. N., & Кirilov, G. (2002) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2002.tb11327.x · Cited by 28
Risk factors for psoriasis: a retrospective study on 501 outpatients clinical records.
Marino, M. G., Carboni, I., Felice, C. D., Maurici, M., Maccari, F., & Franco, E. (2004) · PubMed · Cited by 27
Wound collagen accumulation in obese hyperglycemic mice
(1986) · Diabetes · doi:10.2337/diabetes.35.4.491 · Cited by 27
Dietary behaviour in psoriatic patients.
Zamboni, S., Zanetti, G. M. R., Grosso, G., Ambrosio, G., Gozzetti, S., & Peserico, A. (1989) · PubMed · Cited by 26
Long-term octreotide treatment reduced hyperinsulinemia, excess body weight and skin lesions in severe obesity with acanthosis nigricans
Lunetta, M., Mauro, M. D., Moli, R. L., & Burrafato, S. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03349042 · Cited by 23
Extensive Striae Distensae as a Result of Topical Corticosteroid Therapy in Psoriasis Vulgaris
Rogalski, C., & Rogalski, C. (2003) · Acta Dermato Venereologica · doi:10.1080/00015550310002747 · Cited by 22
Increased cutaneous blood flow but impaired post-ischemic response of nutritional flow in obese children
Chin, L.-C., Huang, T.-Y., Yu, C.-L., Wu, C.-H., Hsu, C.-C., & Yu, H.-S. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00135-5 · Cited by 20
Elephantiasis Nostras of the Abdominal Wall
Chernosky, M. E. (1966) · Archives of Dermatology · doi:10.1001/archderm.1966.01600300081017 · Cited by 20
Erfolgreiche symptomatische Tazarotentherapie der juvenilen Acanthosis nigricans vom familiär adipositasassoziierten Typ bei Insulinresistenz
Weißhaar, E., Bonnekoh, B., Franke, I., & Gollnick, H. P. M. (2001) · Der Hautarzt · doi:10.1007/s001050000083 · Cited by 19
Thiazolidinediones: potential as therapeutics for psoriasis and perhaps other hyperproliferative skin disease
Varani, J., Bhagavathula, N., Ellis, C. N., & Pershadsingh, H. A. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.11.1453 · Cited by 19
Book Review
Vandel, S., Sandoz, M., Vandel, B., Bonin, B., Allers, G., Volmat, R., Ananth, J., Lin, K.-M., Sanger, D. J., Joly, D., et al. (2008) · Neuropsychobiology · doi:10.1159/000118237 · Cited by 17
Weight Changes in Antidepressants: A Comparison of Amitriptyline and Trazodone
Orzack, M. H., Cole, J. O., Friedman, L., Bird, M., & McEachern, J. (2008) · Neuropsychobiology · doi:10.1159/000118283 · Cited by 16

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8 of the 226 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Commons, 2001, Large-volume liposuction: a review of 631 consecutive cases over 12 years, Plast Reconstr Surg, 108, 1753, 10.1097/00006534-200111000-00051 · DOI
Giese, 2001, Improvements in cardiovascular risk profile with large-volume liposuction: a pilot study, Plast Reconstr Surg, 108, 510, 10.1097/00006534-200108000-00036 · DOI

Sorted by citations

Human skin wounds: A major and snowballing threat to public health and the economy
Sen, C. K., Gordillo, G. M., Roy, S., Kirsner, R., Lambert, L., Hunt, T. K., Gottrup, F., Gurtner, G. C., & Longaker, M. T. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00543.x · Cited by 2,965
“Obesity is responsible for changes in skin barrier function, sebaceous glands and sebum production, sweat glands, lymphatics, collagen structure and function, wound healing, microcirculation and macrocirculation, and subcutaneous fat.(78) Obesity has a clear but not yet precisely defined effect on the immune response…”
Background
Review of Childhood Obesity
Kumar, S., & Kelly, A. S. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.09.017 · Cited by 1,421
“Other skin abnormalities include intertrigo, hidradenitis suppurativa, furunculosis, and stretch marks.(101)”
Background
Obesity: Risk factors, complications, and strategies for sustainable long‐term weight management
Fruh, S. M. (2017) · Journal of the American Association of Nurse Practitioners · doi:10.1002/2327-6924.12510 · Cited by 709
Obesity and the risk and outcome of infection
Huttunen, R., & Syrjänen, J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.62 · Cited by 595
The relationship between skin function, barrier properties, and body‐dependent factors
Dąbrowska, A., Spano, F., Derler, S., Adlhart, C., Spencer, N. D., & Rossi, R. M. (2017) · Skin Research and Technology · doi:10.1111/srt.12424 · Cited by 520

See all 524

Authors: Yosipovitch, G., DeVore, A., & Dawn, A.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Yosipovitch, Gil
ORCID: Yosipovitch, Gil
Venue: Journal of the American Academy of Dermatology
Publisher: Elsevier BV
Published: 2007-06
Volume: 56
Issue: 6
Pages: 901-916
ISSN: 0190-9622 (ISSN-L)
DOI: 10.1016/j.jaad.2006.12.004
OpenAlex: W2009476361
Semantic Scholar: b5f800df723da429743687ae8b6b272a5e4772cb
Cited by: 524
References: 226
Citations by year: 2026: 17 · 2025: 19 · 2024: 22 · 2023: 29 · 2022: 19 · 2021: 29 · 2020: 34 · 2019: 30 · 2018: 32 · 2017: 32 · 2016: 32 · 2015: 29 · 2014: 32 · 2013: 36 · 2012: 24
FWCI: 4.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of the American Academy of Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity and Health Practices
Keywords: obesity, skin barrier function, sebum production, sweat glands, collagen, wound healing, subcutaneous adipose tissue, acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism, hirsutism, striae, adiposis dolorosa, lymphedema, chronic venous insufficiency, plantar hyperkeratosis, cellulitis, skin infections, hidradenitis suppurativa, psoriasis, metabolic syndrome, tophaceous gout
MeSH terms: Acanthosis Nigricans, Adiposis Dolorosa, Animals, Chronic Disease, Elasticity, Humans, Insulin Resistance, Intertrigo, Lymphedema, Microcirculation, Obesity, Pro-Opiomelanocortin, Psoriasis, Sebaceous Glands, Skin Diseases, Venous Insufficiency, Comorbidity, Hidradenitis Suppurativa, Fasciitis, Necrotizing

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Obesity and the skin: Skin physiology and skin manifestations of obesity

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