The DOI matches its Crossref record; 218 of the 226 references it cites were found in a registry or an index.
Obesity and the skin: Skin physiology and skin manifestations of obesity
Abstract
Unlabelled Obesity is widely recognized as an epidemic in the Western world; however, the impact of obesity on the skin has received minimal attention. The purpose of this article is to highlight the association between obesity and dermatologic conditions. We review the impact of obesity on the skin, including skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity. Obesity is responsible for changes in skin barrier function, sebaceous glands and sebum production, sweat glands, lymphatics, collagen structure and function, wound healing, microcirculation and macrocirculation, and subcutaneous fat. Moreover, obesity is implicated in a wide spectrum of dermatologic diseases, including acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism and hirsutism, striae distensae, adiposis dolorosa, and fat redistribution, lymphedema, chronic venous insufficiency, plantar hyperkeratosis, cellulitis, skin infections, hidradenitis suppurativa, psoriasis, insulin resistance syndrome, and tophaceous gout. We review the clinical features, evidence for association with obesity, and management of these various dermatoses and highlight the profound impact of obesity in clinical dermatology.Learning objective After completing this learning activity, participants should be aware of obesity-associated changes in skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity, and be able to formulate a pathophysiology-based treatment strategy for obesity-associated dermatoses.
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“Obesity alters several key dermal parameters: increased dermal thickness, greater trans-epidermal water loss (TEWL), reduced capillary density, and increased depth of arteries such as the radial artery.”
From PPG-Based Heart Rate Accuracy in Hispanic Adults with Fitzpatrick III–V Skin Tones: An Evaluation of Body Composition and Skin-Tone Effects (2026) · cites this paper as [17]
In the citing paper
“Physiological changes that occur in individuals with obesity may increase the measurement uncertainties, and optical means for monitoring blood pressure will have to account for obesity-related changes to the skin optical properties12 and increased subcutaneous tissue thickness.”
From Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI) (2021) · cites this paper as [12]
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Metadata
- Authors
- Yosipovitch, G., DeVore, A., & Dawn, A.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Yosipovitch, Gil
- ORCID
- Yosipovitch, Gil
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 56
- Issue
- 6
- Pages
- 901-916
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2009476361
- Semantic Scholar
- b5f800df723da429743687ae8b6b272a5e4772cb
- Cited by
- 524
- References
- 226
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 22 · 2023: 29 · 2022: 19 · 2021: 29 · 2020: 34 · 2019: 30 · 2018: 32 · 2017: 32 · 2016: 32 · 2015: 29 · 2014: 32 · 2013: 36 · 2012: 24
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity and Health Practices
- Keywords
- obesity, skin barrier function, sebum production, sweat glands, collagen, wound healing, subcutaneous adipose tissue, acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism, hirsutism, striae, adiposis dolorosa, lymphedema, chronic venous insufficiency, plantar hyperkeratosis, cellulitis, skin infections, hidradenitis suppurativa, psoriasis, metabolic syndrome, tophaceous gout
- MeSH terms
- Acanthosis Nigricans, Adiposis Dolorosa, Animals, Chronic Disease, Elasticity, Humans, Insulin Resistance, Intertrigo, Lymphedema, Microcirculation, Obesity, Pro-Opiomelanocortin, Psoriasis, Sebaceous Glands, Skin Diseases, Venous Insufficiency, Comorbidity, Hidradenitis Suppurativa, Fasciitis, Necrotizing
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