The influence of body mass index on skin susceptibility to sodium lauryl sulphate
Abstract
Background: The influence of nutrition on the physiological functions of man is well studied. Numerous diseases can be exacerbated by obesity. However, it has not yet been determined whether body weight and body mass index (BMI), as an indicator of a high body fat store, can influence skin sensitivity. Objective: This study investigates the correlation between body mass index and the epidermal functions, evaluated by bioengineering methods, before and after an irritant patch test with sodium lauryl sulphate (SLS). Methods: Epidermal functions were evaluated using an evaporimeter, chromameter and laser‐Doppler‐flowmeter. Patch testing was conducted for 48 h with two different concentrations of SLS (0.25% and 0.5%) on the forearms of healthy volunteers. Measurements were performed 24 h after patch removal. Results: Obese individuals showed significantly increased transepidermal water loss (TEWL), skin blood flow and skin colour (red) as compared to a control group. However, the degree of skin sensitivity to SLS was not correlated with BMI. Conclusion: Basal biophysical parameters of the skin are primarily correlated with the BMI. This may be caused by obesity‐induced physiological changes, e.g. increased sweat gland activity, high blood pressure and physiological temperature‐regulating system. The epidermal barrier function, as evaluated after SLS patch testing is, however, not correlated with a high BMI, indicating a normal skin barrier.
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Trans-epidermal water loss is disrupted in the obese, and as BMI increases, TEWL increases, contributing to dry skin and skin irritation.
“Trans-epidermal water loss (TEWL) the process where water evaporates through the epidermis from the dermis is disruption in the obese36. As BMI increases so does TWEL66, and this effect directly contributed to dry skin and skin irritation often seen in the obese population.”
From Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI) (2021) · cites this paper as [66]
Increasing obesity is associated with changes in dermal water content, dermal blood content, dermal thickness, and increased radial artery depth.
“The significant changes to the skin which we have highlighted include changes to dermal water content66 and blood content content66 as well as dermal thickness and increased radial artery depth all with increasing levels of obesity47,48,58.”
From Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI) (2021) · cites this paper as [66]
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- Authors
- Löffler, H., Aramaki, J. U. N., & Effendy, I.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Löffler, H.
- Venue
- Skin Research and Technology
- Publisher
- Wiley
- Published
- 2002-02
- Volume
- 8
- Issue
- 1
- Pages
- 19-22
- ISSN
- 0909-752X (ISSN-L)
- 1600-0846
- OpenAlex
- W2140923242
- Cited by
- 120
- References
- 25
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 6
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Skin Research and Technology (publishedVersion)
- PubMed (publishedVersion)
- PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- body mass index, obesity, sodium dodecyl sulfate, skin irritation, transepidermal water loss, skin blood flow, skin colour, skin barrier function, skin biophysics
- MeSH terms
- Adolescent, Adult, Biophysics, Epidermis, Female, Humans, Male, Middle Aged, Obesity, Skin, Sodium Dodecyl Sulfate, Surface-Active Agents, Water, Body Mass Index, Laser-Doppler Flowmetry, Dermatitis, Irritant, Skin Irritancy Tests, Biophysical Phenomena
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