Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine

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Network biology: understanding the cell's functional organization

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A New Initiative on Precision Medicine

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The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

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Network pharmacology: the next paradigm in drug discovery

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Five Years of GWAS Discovery

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Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations

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AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update

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Interactome Networks and Human Disease

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Deep patient: An unsupervised representation to predict the future of patients from the electronic health records

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Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases

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Phenomics: the next challenge

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Multi-target therapeutics: when the whole is greater than the sum of the parts

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Using recurrent neural network models for early detection of heart failure onset

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The productivity crisis in pharmaceutical R&D

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Decline in Rates of Death and Heart Failure in Acute Coronary Syndromes, 1999-2006

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National Human Genome Research Institute

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Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

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Deep Learning in Drug Discovery

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Social Network Analysis: Foundations and Frontiers on Advantage

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The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future

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Clinical assessment incorporating a personal genome

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Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

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Genomic Medicine — A Primer

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Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data

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Evolution of biological complexity

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Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease

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Recent trends in cardiovascular mortality in the United States and public health goals.

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The Precision Medicine Initiative

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Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges

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Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

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Identification of type 2 diabetes subgroups through topological analysis of patient similarity

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The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: The Systolic Blood Pressure Intervention Trial (SPRINT)

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Digital mammographic tumor classification using transfer learning from deep convolutional neural networks

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Shifting from the single to the multitarget paradigm in drug discovery

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Genomic Medicine — An Updated Primer

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PROLONGATION OF SURVIVAL IN CONGESTIVE CARDIOMYOPATHY BY BETA-RECEPTOR BLOCKADE

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Machine-Learning Algorithms to Automate Morphological and Functional Assessments in 2D Echocardiography

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Trimethoprim-Sulfamethoxazole Revisited

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Ensembles of Deep Learning Architectures for the Early Diagnosis of the Alzheimer’s Disease

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Big data analytics to improve cardiovascular care: promise and challenges

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Challenges and opportunities of drug repositioning

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PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability

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Unsupervised Profiling Methods for Fraud Detection

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Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance

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In silico methods for drug repurposing and pharmacology

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Coronary stents: historical development, current status and future directions

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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

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DeepChrome: deep-learning for predicting gene expression from histone modifications

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Drug repositioning for Alzheimer's disease

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Drug repurposing in oncology—patient and health systems opportunities

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Clinical Implications of Chronic Heart Failure Phenotypes Defined by Cluster Analysis

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Multi-Target Drugs: The Trend of Drug Research and Development

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Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome

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Precision medicine in cardiology

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Cost-Effectiveness of Hypertension Therapy According to 2014 Guidelines

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The Next Era: Deep Learning in Pharmaceutical Research

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Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury

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Cognitive Machine-Learning Algorithm for Cardiac Imaging

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Cardiovascular Drug Development

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GWASdb v2: an update database for human genetic variants identified by genome-wide association studies

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Sildenafil in the treatment of pulmonary hypertension

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Pleiotropic effects of statins: new therapeutic targets in drug design

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Escaping the EHR Trap — The Future of Health IT

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The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease

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Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

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Colchicine and the Heart

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Pharmaco-miR: linking microRNAs and drug effects

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UNSUPERVISED FEATURE CONSTRUCTION AND KNOWLEDGE EXTRACTION FROM GENOME-WIDE ASSAYS OF BREAST CANCER WITH DENOISING AUTOENCODERS

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Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons

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A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

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Genome-Wide Significant Loci: How Important Are They?

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Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

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The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium Excretion

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Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach

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Cyclic-GMP-Binding, Cyclic-GMP-Specific Phosphodiesterase (PDE5) Gene Expression Is Regulated during Rat Pulmonary Development

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Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization

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An Electronic Clinical Decision Support Tool to Assist Primary Care Providers in Cardiovascular Disease Risk Management: Development and Mixed Methods Evaluation

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The Pleiotropic Effects of the Hydroxy-Methyl-Glutaryl-CoA Reductase Inhibitors in Cardiovascular Disease

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Understanding Protein–Nanoparticle Interaction: A New Gateway to Disease Therapeutics

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Precision medicine in NSCLC and pathology: how does ALK fit in the pathway?

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Cardiovascular Comorbidities Relate More than Others with Disease Activity in Rheumatoid Arthritis

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Opportunities for the Cardiovascular Community in the Precision Medicine Initiative

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The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study

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Medical Student Preparedness for an Era of Personalized Medicine: Findings from One us Medical School

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Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks

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The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data

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Cholesteryl Ester Transfer Protein Inhibition Is Not Yet Dead—Pro

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Pharmacogenetics of Lipid-Lowering Agents: Precision or Indecision Medicine?

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3dswap-pred: Prediction of 3D Domain Swapping from Protein Sequence Using Random Forest Approach

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Whole Exome Sequencing Implicates an INO80D Mutation in a Syndrome of Aortic Hypoplasia, Premature Atherosclerosis, and Arterial Stiffness

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Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies

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Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study

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Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation

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DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions

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Predicting the Risk of Cardiovascular Comorbidities in Adult Cancer Survivors

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Modern Management of Acute Myocardial Infarction

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AN INTEGRATIVE PIPELINE FOR MULTI-MODAL DISCOVERY OF DISEASE RELATIONSHIPS

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Ockham’s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer

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Cholesteryl Ester Transfer Protein Inhibitors

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Pleiotropic Effects of Statins: The Role of Eicosanoid Production

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Insights into Protein Sequence and Structure-Derived Features Mediating 3D Domain Swapping Mechanism using Support Vector Machine Based Approach

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The US Cancer Moonshot initiative

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Antihypertensive Medication Classes Used among Medicare Beneficiaries Initiating Treatment in 2007–2010

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The Impact of Biochemical Markers on Major Adverse Cardiovascular Events and Contralateral Carotid Artery Stenosis Progression Following Carotid Interventions

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A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA)

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Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high-risk patients harboring neck lymph node extracapsular extension

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Multiparametric Non-Negative Matrix Factorization for Longitudinal Variations Detection in White-Matter Fiber Bundles

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Association of Soluble Fibrinogen-like Protein 2 with the Severity of Coronary Artery Disease

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Cost-Effectiveness of Hypertension Therapy According to 2014 Guidelines

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Oncology Nurses and the Cancer Moonshot 2020

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Applying Cluster Analysis to Data of Previously Published Chronic Heart Failure Trials

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Cost-Effectiveness Of A Novel Pharmacist Guided Warfarin Pharmacogenetic Service

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Artificial intelligence in cardiology

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The ‘Digital Twin’ to enable the vision of precision cardiology

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Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles

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Exploiting machine learning for end-to-end drug discovery and development

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Machine learning in cardiovascular medicine: are we there yet?

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Deep learning and the electrocardiogram: review of the current state-of-the-art

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Deep-learning cardiac motion analysis for human survival prediction

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Artificial Intelligence: Practical Primer for Clinical Research in Cardiovascular Disease

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2017 Roadmap for Innovation—ACC Health Policy Statement on Healthcare Transformation in the Era of Digital Health, Big Data, and Precision Health

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Relevance of Multi-Omics Studies in Cardiovascular Diseases

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Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4

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Using Deep-Learning Algorithms to Simultaneously Identify Right and Left Ventricular Dysfunction From the Electrocardiogram

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Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management

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Graph Representation Forecasting of Patient's Medical Conditions: Toward a Digital Twin

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The next generation of precision medicine: observational studies, electronic health records, biobanks and continuous monitoring

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The Promise of AI in Detection, Diagnosis, and Epidemiology for Combating COVID-19: Beyond the Hype

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From ‘Omics to Multi-omics Technologies: the Discovery of Novel Causal Mediators

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Up digital and personal: How heart digital twins can transform heart patient care

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Artificial Intelligence and Cardiovascular Genetics

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Machine Learning na Medicina: Revisão e Aplicabilidade

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Recent Advances in Pharmaceutical Design: Unleashing the Potential of Novel Therapeutics

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Taking Systems Medicine to Heart

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

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Mechanistic Modeling and Multiscale Applications for Precision Medicine: Theory and Practice

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Computational profiling of the gut–brain axis: microflora dysbiosis insights to neurological disorders

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Mitochondria under the spotlight: On the implications of mitochondrial dysfunction and its connectivity to neuropsychiatric disorders

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Deep Learning in Personalization of Cardiovascular Stents

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Machine learning-based long-term outcome prediction in patients undergoing percutaneous coronary intervention

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Machine Learning in Cardiology—Ensuring Clinical Impact Lives Up to the Hype

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Mapping data to virtual patients in type 1 diabetes

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Cardioinformatics: the nexus of bioinformatics and precision cardiology

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Digital Twin Models in Atrial Fibrillation: Charting the Future of Precision Therapy?

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Patient Endothelial Colony-Forming Cells to Model Coronary Artery Disease Susceptibility and Unravel the Role of Dysregulated Mitochondrial Redox Signalling

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Predicting post-contrast information from contrast agent free cardiac MRI using machine learning: Challenges and methods

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Sacubitril/Valsartan as a Therapeutic Tool Across the Range of Heart Failure Phenotypes and Ejection Fraction Spectrum

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Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases

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Artificial intelligence and its application for cardiovascular diseases in Chinese medicine

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Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System

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Transforming clinical cardiology through neural networks and deep learning: A guide for clinicians

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The Mechanics of Machine Learning: From a Concept to Value

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Big data and new information technology: what cardiologists need to know

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Generalizable Framework for Atrial Volume Estimation for Cardiac CT Images Using Deep Learning With Quality Control Assessment

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A transcriptomic model to predict increase in fibrous cap thickness in response to high-dose statin treatment: Validation by serial intracoronary OCT imaging

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Targeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery

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Precision Medicine Approaches in Cardiology and Personalized Therapies for Improved Patient Outcomes: A systematic review

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Application of Artificial Intelligence in Cardiovascular Medicine

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A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease.

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Application of Artificial Intelligence in Cardiovascular Medicine

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Multiscale Biology of Cardiovascular Risk in Psoriasis: Protocol for a Case-Control Study

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Multiomic approaches to delineate the pathogenesis of cardiac disease

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Integrative Network Analysis Linking Clinical Outcomes With Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram

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Big data y nuevas tecnologías de la información: qué necesita saber el cardiólogo

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AI in interventional cardiology: Innovations and challenges

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Cardiovascular Imaging in the Era of Precision Medicine: Insights from Advanced Technologies – A Narrative Review

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Evaluation of patient re-identification using laboratory test orders and mitigation via latent space variables

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Biobanks and Artificial Intelligence

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Modeling Clinical Trial Attrition Using Machine Intelligence: A driver analytics case study using 1,325 trials representing one million patientsPreprint

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Artificial intelligence in multi-omics analysis of heart diseases

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The Capacity of Artificial Intelligence in COVID-19 Response: A Review in Context of COVID-19 Screening and Diagnosis

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Prediction of cardiovascular events with using proportional risk models and machine learning algorithms: a systematic review

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Patient Management in Aortic Stenosis: Towards Precision Medicine through Protein Analysis, Imaging and Diagnostic Tests

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Introductory Chapter: The Modern-Day Drug Discovery

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Precision Medicine for Aortic Stenosis

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Enhanced prediction of left ventricular ejection fraction using electrocardiography with the addition of clinical metadata

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Digital Twin Technology for Precision Medicine

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Digital medicine: the next big leap advancing cardiovascular science

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AI-based diagnosis techniques for cardiac disease analysis and predictions

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A macrophage gene-regulatory network linked to clinical severity of coronary artery disease

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Clinical Research in Cardiovascular Disease using Metabolomics

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Repurposing the atypical antidepressant trazodone for atherosclerotic cardiovascular diseasePreprint

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Diagnostics and Prevention: Landscape for Technology Innovation in Precision Cardiovascular Medicine

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Outcome Prediction

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Individualized Cardiovascular Therapeutics Using Artificial Intelligence–Powered Cardiovascular Imaging

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Artificial intelligence in mitotic checkpoint modeling: transforming our understanding of cellular division through machine learning and predictive biology

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Multi-omic analysis of human PHACTR1 signaling networks

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Personalized Medicine Approaches in Metabolically Associated Fatty Liver Disease: A Comprehensive Review

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Statistical Methods for Longitudinal Cardiovascular Disease Research Design: A Narrative Review

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Echocardiographic Phenomapping in HFpEF: From Imaging Biomarkers to Precision Cardiovascular Medicine

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Artificial Intelligence in Pulmonary Hypertension: Current State and Future Prospects

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Molecular mechanisms of cardioprotection: biomarkers, signaling pathways, and emerging molecular signatures in cardiovascular disease

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Artificial Intelligence in Aortic Disease

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Artificial intelligence in interventional cardiology: present landscape and future directions

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Precision and network medicine in cardiovascular prevention and disease

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Emerging Role of Precision Medicine in Cardiovascular Disease

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Precision cardiovascular medicine: shifting the innovation paradigm

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A Comprehensive Clinical Review on Precision Medicine in Cardiovascular Diseases

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Personalizing treatments for patients based on cardiovascular phenotyping

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