Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation
Open accessAbstract
Objectives This study investigated the prognostic importance of measured peak oxygen intake (VO(2peak)) in women with known coronary heart disease referred for outpatient cardiac rehabilitation.Background Exercise capacity is a powerful predictor of prognosis in men with known or suspected coronary disease. Similar findings are described in women, but fewer studies have utilized measured VO(2peak), the most accurate measure of exercise capacity.Methods A single-center design took data from 2,380 women, age 59.7 +/- 9.5 years (1,052 myocardial infarctions, 620 coronary bypass procedures, and 708 with proven ischemic heart disease), who underwent cardiorespiratory exercise testing. They were followed for an average of 6.1 +/- 5 years (median 4.5 years, range 0.4 to 25 years) until cardiac and all-cause death.Results We recorded 95 cardiac deaths and 209 all-cause deaths. Measured VO(2peak) was an independent predictor of risk, values > or =13 ml/kg/min (3.7 multiples of resting metabolic rate) conferring a 50% reduction in cardiac mortality (hazard ratio [HR] 0.5, p = 0.001). Considered as a continuous variable, a 1 ml/kg/min advantage in initial VO(2peak) was associated with a 10% lower cardiac mortality. Adverse predictors were diabetes (HR 2.73, p = 0.0005) and antiarrhythmic therapy (HR 3.93, p = 0.0001).Conclusions As in men, measured VO(2peak) is a strong independent predictor of cardiac mortality in women referred for cardiac rehabilitation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cardiorespiratory fitness is one of the strongest prognostic markers in persons with and without chronic disease, including cardiovascular disease.
“Numerous studies now suggest that CRF is one of the strongest prognostic markers in persons with and without chronic disease, including CVD [13] , [14] , [15] , [16] .”
From Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise training, prescriptive methods, and special patient populations (2022) · cites this paper as [15]
The Abstract reports that peak oxygen intake strongly predicts cardiac mortality in women with coronary heart disease and notes similar prognostic relationships in men with coronary disease and healthy women. The Study limitations section confines this study's findings to women with stable coronary heart disease referred for rehabilitation. The paper does not establish the claim across persons with and without chronic disease generally. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn large populations of male and female cardiovascular patients, cardiovascular fitness (METs) has an inverse dose-response relationship with all-cause mortality, irrespective of beta-blocker use.
“recent data confirm the existence of an inverse dose-response relationship between cardiovascular fitness (evaluated by treadmill stress testing and expressed in METs) and all-cause mortality in large populations of both male and female cardiovascular patients”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [335]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Classification and Regression Trees.
Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,028 · see citing works
Classification and regression trees
Praagman, J. (1985) · European Journal of Operational Research · doi:10.1016/0377-2217(85)90321-2 · Cited by 10,053 · see citing works
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114 · see citing works
Physical Fitness and All-Cause Mortality: A Prospective Study of Healthy Men and Women
Blair, S. N. (1989) · JAMA · doi:10.1001/jama.1989.03430170057028 · Cited by 2,658 · see citing works
ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article
Gibbons, R. J., Balady, G. J., Bricker, J. T., CHAITMAN, B. R., Fletcher, G. F., Froelicher, V. F., Mark, D. B., McCallister, B. D., Mooss, A. N., O’Reilly, M. G., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034670.06526.15 · Cited by 2,606 · see citing works
Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235 · see citing works
Fletcher, G. F., Balady, G. J., Amsterdam, E. A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V. F., Leon, A. S., Piña, I. L., Rodney, R., et al. (2001) · Circulation · doi:10.1161/hc3901.095960 · Cited by 1,923 · see citing works
Gibbons, R. J., Balady, G. J., Beasley, J. W., FAAFP, Bricker, J. T., Duvernoy, W. F. C., Froelicher, V. F., Mark, D. B., Marwick, T. H., McCallister, B. D., et al. (1997) · Circulation · doi:10.1161/01.cir.96.1.345 · Cited by 1,094 · see citing works
Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation
Kavanagh, T., Mertens, D. J., Hamm, L. F., Beyene, J., Kennedy, J., Corey, P., & Shephard, R. J. (2002) · Circulation · doi:10.1161/01.cir.0000024413.15949.ed · Cited by 648 · see citing works
Self-citationGuidelines for exercise testing
Feild, M. D. J. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80208-x · Cited by 527 · see citing works
Recursive Partitioning in the Health Sciences
Zhang, H., & Singer, B. H. (1999) · Statistics in the health sciences · doi:10.1007/978-1-4757-3027-2 · Cited by 455 · see citing works
Accurate prediction of &OV0312;O2max in cycle ergometry
Storer, T. W., DAVIS, J. A., & Caiozzo, V. J. (1990) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199010000-00024 · Cited by 219 · see citing works
Comparison of the clinical profile and outcome of women and men in cardiac rehabilitation
Cannistra, L. B., Balady, G. J., O’Malley, C. J., Weiner, D. A., & Ryan, T. J. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91220-x · Cited by 215 · see citing works
Snader, C. E. P., Marwick, T. H., Pashkow, F. J., Harvey, S. A., Thomas, J. D., & Lauer, M. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00217-9 · Cited by 205 · see citing works
Prognostic significance of peak exercise capacity in patients with coronary artery disease
Vanhees, L., Fagard, R., Thijs, L., Staessen, J. A., & Amery, A. A. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90420-0 · Cited by 202 · see citing works
Prognostic Value of Treadmill Exercise Testing
Roger, V. L., Jacobsen, S. J., Pellikka, P. A., Miller, T. D., Bailey, K. R., & Gersh, B. J. (1998) · Circulation · doi:10.1161/01.cir.98.25.2836 · Cited by 193 · see citing works
Prognostic value of exercise echocardiographyin 5,798 patients: is there a gender difference?
Arruda-Olson, A. M., Juracan, E. M., Mahoney, D. W., McCully, R. B., Roger, V. L., & Pellikka, P. A. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01801-0 · Cited by 184 · see citing works
Weiner, D. A., Ryan, T. J., Parsons, L. S., Fisher, L. D., CHAITMAN, B. R., Sheffield, L. T., & Tristani, F. E. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80677-8 · Cited by 110 · see citing works
Gender-Specific Criteria and Performance of the Exercise Electrocardiogram
Okin, P. M., & Kligfield, P. (1995) · Circulation · doi:10.1161/01.cir.92.5.1209 · Cited by 83 · see citing works
Advances in Cardiopulmonary Rehabilitation
Harden, B. (2001) · Physiotherapy · doi:10.1016/s0031-9406(05)60615-3 · Cited by 19 · see citing works
Advances in Cardiopulmonary Rehabilitation
Leblanc, P., Maltais, F., & Jobin, J. (2000) · Medical Entomology and Zoology · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 22 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Storer TW, Davis JA, Caiozzo VJ. Accurate prediction of V ˙O2peak in cycle ergometry. Med Sci Sports Exerc 1990;22:704 -12.
Cited by
Sorted by citations
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490 · see citing works
European guidelines on cardiovascular disease prevention in clinical practice: executive summary
Graham, I., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm316 · Cited by 3,840 · see citing works
Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486 · see citing works
Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235 · see citing works
Balady, G. J., Arena, R., Sietsema, K., Myers, J., Coke, L., Fletcher, G. F., Forman, D., Franklin, B., Guazzi, M., Gulati, M., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181e52e69 · Cited by 1,964 · see citing works
Smith, S. C., Benjamin, E. J., Bonow, R. O., Braun, L. T., Creager, M. A., Franklin, B. A., Gibbons, R. J., Grundy, S. M., Hiratzka, L. F., Jones, D. W., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318235eb4d · Cited by 1,759 · see citing works
Graham (2007) · doi:10.1097/01.hjr.0000277983.23934.c9 · Cited by 1,647 · see citing works
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Authors/Task Force Members, Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corrà, U., Cosyns, B., et al. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316653709 · Cited by 1,409 · see citing works
Cardiac Rehabilitation and Secondary Prevention of Coronary Heart Disease
Leon, A. S., Franklin, B. A., Costa, F., Balady, G. J., Berra, K. A., Stewart, K. J., Thompson, P. D., Williams, M. A., & Lauer, M. S. (2005) · Circulation · doi:10.1161/01.cir.0000151788.08740.5c · Cited by 1,066 · see citing works
Smith, S. C., Benjamin, E. J., Bonow, R. O., Braun, L. T., Creager, M. A., Franklin, B. A., Gibbons, R. J., Grundy, S. M., Hiratzka, L. F., Jones, D. W., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.10.824 · Cited by 903 · see citing works
Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study
Merz, C. N. B., Shaw, L. J., Reís, S. E., Bittner, V., Kelsey, S. F., Olson, M. B., Johnson, B. D., Pepine, C. J., Mankad, S. V., Sharaf, B. L., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.084 · Cited by 849 · see citing works
Mitochondrial Dysfunction in Atherosclerosis
Madamanchi, N. R., & Runge, M. S. (2007) · Circulation Research · doi:10.1161/01.res.0000258450.44413.96 · Cited by 794 · see citing works
Arena, R., Myers, J., Williams, M. A., Gulati, M., Kligfield, P., Balady, G. J., Collins, E., & Fletcher, G. (2007) · Circulation · doi:10.1161/circulationaha.106.184461 · Cited by 727 · see citing works
Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study
Shaw, L. J., Merz, C. N. B., Pepine, C. J., Reís, S. E., Bittner, V., Kelsey, S. F., Olson, M. B., Johnson, B. D., Mankad, S. V., Sharaf, B. L., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.072 · Cited by 719 · see citing works
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Perk, J., Backer, G. D., Gohlke, H., Graham, I. M., Reiner, Ž., Verschuren, W. M. M., Albus, C., Benlian, P., Boysen, G., Cífková, R., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.05.007 · Cited by 693 · see citing works
Women and Ischemic Heart Disease
Shaw, L. J., Bugiardini, R., & Merz, C. N. B. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.098 · Cited by 662 · see citing works
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
Wisløff, U., Najjar, S. M., Ellingsen, Ø., Haram, P. M., Swoap, S., Al-Share, Q., Fernström, M., Rezaei, K., Lee, S. J., Koch, L. G., et al. (2005) · Science · doi:10.1126/science.1108177 · Cited by 657 · see citing works
Weiner, D. A., Ryan, T. J., McCabe, C. H., Kennedy, J. W., Schloss, M. G., Tristani, F. E., CHAITMAN, B. R., & Fisher, L. D. (1979) · New England Journal of Medicine · doi:10.1056/nejm197908023010502 · Cited by 604 · see citing works
Self-citationRognmo, Ø., Moholdt, T., Bakken, H., Hole, T., Mølstad, P., Myhr, N. E., Grimsmo, J., & Wisløff, U. (2012) · Circulation · doi:10.1161/circulationaha.112.123117 · Cited by 511 · see citing works
Cardiopulmonary Function and Age-Related Decline Across the Breast Cancer Survivorship Continuum
Jones, L. W., Courneya, K. S., Mackey, J. R., Muss, H. B., Pituskin, E., Scott, J. M., Hornsby, W., Sykes, A. D., Herndon, J. E., Douglas, P. S., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.9014 · Cited by 443 · see citing works
Nutrition, physical activity, and cardiovascular disease: An update
IGNARRO, L., Balestrieri, M. L., & Claudio Napoli, A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.030 · Cited by 443 · see citing works
Peak aerobic capacity predicts prognosis in patients with coronary heart disease
Keteyian, S. J., Brawner, C. A., Savage, P. D., Ehrman, J. K., Schairer, J. R., Divine, G., Aldred, H. A., Ophaug, K. M., & Ades, P. A. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.03.017 · Cited by 416 · see citing works
Impact of Cardiorespiratory Fitness on All-Cause and Disease-Specific Mortality: Advances Since 2009
Harber, M. P., Kaminsky, L. A., Arena, R. A., Blair, S. N., Franklin, B. A., MYERS, J. N., & Ross, R. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.03.001 · Cited by 413 · see citing works
The Importance of Cardiorespiratory Fitness in the United States: The Need for a National Registry
Kaminsky, L. A., Arena, R. A., Beckie, T. M., Brubaker, P. H., Church, T. S., Forman, D. E., Franklin, B. A., Gulati, M., Lavie, C. J., MYERS, J. N., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31827ee100 · Cited by 364 · see citing works
Swift, D. L., Lavie, C. J., Johannsen, N. M., Arena, R. A., Earnest, C. P., O’Keefe, J. H., Milani, R. V., Blair, S. N., & Church, T. S. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0007 · Cited by 356 · see citing works
Lavie, C. J., Thomas, R. J., Squires, R. W., Allison, T. G., & Milani, R. V. (2009) · Mayo Clinic Proceedings · doi:10.4065/84.4.373 · Cited by 340 · see citing works
European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012)
Perk, J., Backer, G. D., Gohlke, H., Graham, I. M., Reiner, Ž., Verschuren, W. M. M., Albus, C., Benlian, P., Boysen, G., Cífková, R., et al. (2012) · International Journal of Behavioral Medicine · doi:10.1007/s12529-012-9242-5 · Cited by 313 · see citing works
Effect of Calorie Restriction with or without Exercise on Body Composition and Fat Distribution
Redman, L. M., Heilbronn, L. K., Martin, C. K., Alfonso, A., Smith, S. R., Ravussin, E., & for the Pennington CALERIE Team (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2184 · Cited by 293 · see citing works
Maddison, R., Pfaeffli, L., Whittaker, R., Stewart, R., Kerr, A., Jiang, Y., Kira, G., Leung, W., Dalleck, L., Carter, K., et al. (2015) · European Journal of Preventive Cardiology · doi:10.1177/2047487314535076 · Cited by 268 · see citing works
Salzwedel, A., Jensen, K., Rauch, B., Doherty, P., Metzendorf, M., Hackbusch, M., Völler, H., Schmid, J., & Davos, C. H. (2020) · European Journal of Preventive Cardiology · doi:10.1177/2047487320905719 · Cited by 279 · see citing works
Church, T. S., Kuk, J. L., Ross, R., Priest, E. L., Biltoff, E., & Blair, S. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.019 · Cited by 268 · see citing works
Cancer Therapy–Induced Cardiac Toxicity in Early Breast Cancer
Khouri, M. G., Douglas, P. S., Mackey, J. R., Martín, M., Scott, J. M., Scherrer‐Crosbie, M., & Jones, L. W. (2012) · Circulation · doi:10.1161/circulationaha.112.100560 · Cited by 255 · see citing works
Ashton, R. E. M., Tew, G. A., Aning, J. J., Gilbert, S. E., Lewis, L. S., & Saxton, J. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-098970 · Cited by 254 · see citing works
High Intensity Interval Training for Maximizing Health Outcomes.
Karlsen, T., Aamot, I., Haykowsky, M., & Rognmo, Ø. (2017) · Progress in cardiovascular diseases · doi:10.1016/j.pcad.2017.03.006 · Cited by 212 · see citing works
Cardiovascular fitness and mortality after contemporary cardiac rehabilitation
Martin, B.-J., Arena, R., Haykowsky, M., Hauer, T., Austford, L. D., Knudtson, M., Aggarwal, S., & Stone, J. A. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.02.013 · Cited by 231 · see citing works
Authors/Task Force Members: Joep Perk (Chairperson) (Sweden)*, G. D. B. (. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312450228 · Cited by 863 · see citing works
Vanhees, L., Rauch, B., Piepoli, M. F., van Buuren, F., Takken, T., Börjesson, M., Bjarnason‐Wehrens, B., Doherty, P., Dugmore, D., Halle, M., et al. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312437063 · Cited by 216 · see citing works
Vigorito, C., Giallauria, F., Palomba, S., Cascella, T., Manguso, F., Lucci, R., De Lorenzo, A., Tafuri, D., Lombardi, G., Colao, A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2794 · Cited by 211 · see citing works
Aerobic Capacity in Patients Entering Cardiac Rehabilitation
Ades, P. A., Savage, P. D., Brawner, C. A., Lyon, C. E., Ehrman, J. K., Bunn, J. Y., & Keteyian, S. J. (2006) · Circulation · doi:10.1161/circulationaha.105.606624 · Cited by 205 · see citing works
Beatty, A. L., Fukuoka, Y., & Whooley, M. A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000568 · Cited by 200 · see citing works
Peak oxygen consumption and long‐term all‐cause mortality in nonsmall cell lung cancer
Jones, L. W., Watson, D. M., Herndon, J. E., Eves, N. D., Haithcock, B. E., Loewen, G., & Kohman, L. J. (2010) · Cancer · doi:10.1002/cncr.25396 · Cited by 196 · see citing works
Cardiac Rehabilitation and Exercise Training in Secondary Coronary Heart Disease Prevention
Lavie, C. J., & Milani, R. V. (2011) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2011.02.008 · Cited by 178 · see citing works
Beatty, A. L., Schiller, N. B., & Whooley, M. A. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.2198 · Cited by 174 · see citing works
South American guidelines for cardiovascular disease prevention and rehabilitation.
Herdy, A., Lopez-Jimenez, F., Terzic, C., Milani, M., Stein, R., Carvalho, T., Serra, S., ARAUJO, C. G., Zeballos, P., Anchique, C., et al. (2014) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.2014s003 · Cited by 123 · see citing works
The potential role of endogenous bacteriophages in controlling invading pathogens
Górski, A., & Weber‐Dąbrowska, B. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4403-6 · Cited by 159 · see citing works
MicroRNAs as Important Regulators of Exercise Adaptation
da Silva, G. J. J., Bye, A., el Azzouzi, H., & Wisløff, U. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.06.003 · Cited by 156 · see citing works
Myocardial Ischemia in Women: Lessons From the NHLBI WISE Study
Gulati, M., Shaw, L. J., & Merz, C. N. B. (2012) · Clinical Cardiology · doi:10.1002/clc.21966 · Cited by 145 · see citing works
Kemps, H., Kränkel, N., Dörr, M., Moholdt, T. T., Wilhelm, M., Paneni, F., Serratosa, L., Solberg, E. E., Hansen, D., Halle, M., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487318820420 · Cited by 147 · see citing works
Cardiac rehabilitation fitness changes and subsequent survival
Schutter, A. D., Kachur, S. M., Lavie, C. J., Menezes, A. R., Shum, K. K., Bangalore, S., Arena, R. A., & Milani, R. V. (2018) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcy018 · Cited by 155 · see citing works
Keteyian, S. J., Hibner, B. A., Bronsteen, K., Kerrigan, D. J., Aldred, H. A., Reasons, L. M., Saval, M. A., Brawner, C. A., Schairer, J. R., Thompson, T., et al. (2014) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000049 · Cited by 134 · see citing works
Cancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions
Hurria, A., Jones, L. W., & Muss, H. B. (2016) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_156160 · Cited by 133 · see citing works
Squires, R. W., Kaminsky, L. A., Porcari, J. P., Ruff, J. E., Savage, P. D., & Williams, M. A. (2018) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000337 · Cited by 125 · see citing works
Franklin, B. A., Eijsvogels, T. M. H., Pandey, A., Quindry, J., & Toth, P. P. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100425 · Cited by 121 · see citing works
“Numerous studies now suggest that CRF is one of the strongest prognostic markers in persons with and without chronic disease, including CVD [13 – 16].”
Skalski, J. H., Allison, T. G., & Miller, T. D. (2012) · Circulation · doi:10.1161/circulationaha.112.110460 · Cited by 119 · see citing works
Changes in cardiorespiratory fitness in cardiac rehabilitation patients: A meta-analysis
SANDERCOCK, G. R. H., Hurtado, V., & Cardoso, F. M. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.11.068 · Cited by 118 · see citing works
Franklin, B. A., Lavie, C. J., Squires, R. W., & Milani, R. V. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.03.009 · Cited by 115 · see citing works
Cardiopulmonary Exercise Testing in Systolic Heart Failure in 2014: The Evolving Prognostic Role
Corrà, U., Piepoli, M. F., Adamopoulos, S. N., Agostoni, P., Coats, A. J. S., Conraads, V. M., Lambrinou, E., Pieske, B. M., Piotrowicz, E., Schmid, J., et al. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.156 · Cited by 114 · see citing works
Goel, K., Thomas, R. J., Squires, R. W., Coutinho, T. A., Trejo-Gutiérrez, J. F., Somers, V. K., Miles, J. M., & López-Jiménez, F. A. (2011) · American Heart Journal · doi:10.1016/j.ahj.2010.12.012 · Cited by 112 · see citing works
Epidemiologic Methods in Physical Activity Studies
Lee, I. (2008) · doi:10.1093/acprof:oso/9780195183009.001.0001 · Cited by 100 · see citing works
Duscha, B. D., Piner, L. W., Patel, M. P., Craig, K. P., Brady, M., McGarrah, R. W., Chen, C., & Kraus, W. E. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.02.001 · Cited by 93 · see citing works
Ávila, A., Claes, J., Goetschalckx, K., Buys, R., Azzawi, M., Vanhees, L., & Cornelissen, V. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9943 · Cited by 96 · see citing works
A Rat Model System to Study Complex Disease Risks, Fitness, Aging, and Longevity
Koch, L. G., Britton, S. L., & Wisløff, U. (2012) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.06.007 · Cited by 94 · see citing works
Bjarnason-Wehrens, B., Grande, G., Loewel, H., Völler, H., & Mittag, O. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3280128bce · Cited by 90 · see citing works
Association of post-diagnosis cardiorespiratory fitness with cause-specific mortality in cancer
Groarke, J. D., Payne, D., Claggett, B. L., Mehra, M. R., Gong, J., Caron, J. P., Mahmood, S., Hainer, J. M., Neilan, T. G., Partridge, A. H., et al. (2020) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcaa015 · Cited by 90 · see citing works
Absence of Exercise Capacity Improvement After Exercise Training Program
Tabet, J., Meurin, P., Beauvais, F., Weber, H., Renaud, N., Thabut, G., Solal, A. C., Logeart, D., & Driss, A. B. (2008) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.775460 · Cited by 84 · see citing works
Cardiopulmonary Impairment in Young Women with Polycystic Ovary Syndrome
Orio, F., Giallauria, F., Palomba, S., Cascella, T., Manguso, F., Vuolo, L., Russo, T., Tolino, A., Lombardi, G., Colao, A., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0216 · Cited by 84 · see citing works
Prognostic Value of Exercise Capacity in Patients With Coronary Artery Disease
Hung, R. K., Al-Mallah, M. H., McEvoy, J. W., Whelton, S. P., Blumenthal, R. S., Nasir, K., Schairer, J. R., Brawner, C. A., Alam, M., Keteyian, S. J., et al. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.07.011 · Cited by 81 · see citing works
Lifestyle Modification in Secondary Prevention
Brinks, J., Fowler, A., Franklin, B. A., & Dulai, J. (2016) · American Journal of Lifestyle Medicine · doi:10.1177/1559827616651402 · Cited by 79 · see citing works
Cardiac rehabilitation and exercise therapy in the elderly: Should we invest in the aged?
Menezes Arthur, R., Lavie, C. J., Richard, V. M., Arena, R. A., & Timothy, S. (2012) · 老年心脏病学杂志：英文版 · doi:10.3724/sp.j.1263.2012.00068 · Cited by 72 · see citing works
Skeletal muscle disorders of glycogenolysis and glycolysis
Godfrey, R., & Quinlivan, R. C. M. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.75 · Cited by 73 · see citing works
Marzolini, S., Blanchard, C. M., Alter, D. A., Grace, S. L., & OH, P. I. (2015) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.115.001751 · Cited by 73 · see citing works
Nichols, S., McGregor, G., Breckon, J. D., & Ingle, L. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1198-5573 · Cited by 72 · see citing works
Cardiorespiratory fitness in breast cancer patients undergoing adjuvant therapy
Klassen, O., Schmidt, M. E., Scharhag‐Rosenberger, F., Sorkin, M., Ulrich, C. M., Schneeweiß, A., Potthoff, K., Steindorf, K., & Wiskemann, J. (2014) · Acta Oncologica · doi:10.3109/0284186x.2014.899435 · Cited by 70 · see citing works
Response to Exercise Training During Cardiac Rehabilitation Differs by Sex
Rengo, J. L., Khadanga, S., Savage, P. D., & Ades, P. A. (2020) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000536 · Cited by 66 · see citing works
Barlow, P. A., Otáhal, P., Schultz, M. G., Shing, C. M., & Sharman, J. E. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.08.029 · Cited by 64 · see citing works
Early 4-Week Cardiac Rehabilitation Exercise Training in Elderly Patients After Heart Surgery
Eder, B., Hofmann, P., von DUVILLARD, S. P., Brandt, D., Schmid, J., Pokan, R., & Wonisch, M. (2010) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e3181be7e32 · Cited by 62 · see citing works
Deutsche Leitlinie zur Rehabilitation von Patienten mit Herz-Kreislauferkrankungen (DLL-KardReha)
Bjarnason‐Wehrens, B., Held, K., Hoberg, E., Karoff, M., & Rauch, B. (2007) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-007-0001-0 · Cited by 63 · see citing works
Franklin, B. A., & McCullough, P. A. (2009) · Mayo Clinic Proceedings · doi:10.4065/84.9.776 · Cited by 91 · see citing works
Carbone, S., Kim, Y., Kachur, S. M., Billingsley, H., Kenyon, J. D., Schutter, A. D., Milani, R. V., & Lavie, C. J. (2021) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcab032 · Cited by 62 · see citing works
Rauch, B., Salzwedel, A., Bjarnason‐Wehrens, B., Albus, C., Meng, K., Schmid, J., Benzer, W., Hackbusch, M., Jensen, K., Schwaab, B., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102192 · Cited by 62 · see citing works
Exercise and type 2 diabetes: New prescription for an old problem
Bird, S. R., & Hawley, J. A. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.05.015 · Cited by 60 · see citing works
Lucía, A., Martinuzzi, A., Nogales‐Gadea, G., Quinlivan, R. C. M., Reason, S. L., Bali, D. S., Godfrey, R., Haller, R. G., Kishnani, P. S., Laforêt, P., et al. (2021) · Neuromuscular Disorders · doi:10.1016/j.nmd.2021.10.006 · Cited by 58 · see citing works
Leitlinie körperliche Aktivität zur Sekundärprävention und Therapie kardiovaskulärer Erkrankungen
Bjarnason‐Wehrens, B., Schulz, O., Gielen, S., Halle, M., Dürsch, M., Hambrecht, R., Lowis, H., Kindermann, W., Schulze, R., & Rauch, B. (2009) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-009-0078-8 · Cited by 56 · see citing works
Cardiac Rehabilitation for Women across the Lifespan
Daniels, K. M., Arena, R. A., Lavie, C. J., & Forman, D. E. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.10.028 · Cited by 57 · see citing works
Evolution of Maximal Oxygen Uptake in Children
Rowland, T. (2007) · Medicine and sport science/Medicine and sport · doi:10.1159/000101392 · Cited by 56 · see citing works
Jung, M. E., Locke, S., Bourne, J. E., Beauchamp, M. R., Lee, T., Singer, J., MacPherson, M., Barry, J., Jones, C., & Little, J. P. (2020) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-020-00933-8 · Cited by 55 · see citing works
Suri, J. S., Paul, S., Maindarkar, M. A., Puvvula, A., Saxena, S., Saba, L., Turk, M., Laird, J. R., Khanna, N. N., Višković, K., et al. (2022) · Metabolites · doi:10.3390/metabo12040312 · Cited by 58 · see citing works
KONES, R. J. (2010) · Vascular Health and Risk Management · doi:10.2147/vhrm.s7564 · Cited by 55 · see citing works
Coeckelberghs, E., Buys, R., Goetschalckx, K., Cornelissen, V., & Vanhees, L. (2015) · European Journal of Preventive Cardiology · doi:10.1177/2047487315569410 · Cited by 54 · see citing works
Ades, P. A., Savage, P. D., Lischke, S., Toth, M. J., Harvey‐Berino, J., Bunn, J. Y., Ludlow, M., & Schneider, D. J. (2011) · CHEST Journal · doi:10.1378/chest.10-3289 · Cited by 53 · see citing works
Impact of cardiorespiratory fitness on outcomes in cardiac rehabilitation
Tutor, A. W., Lavie, C. J., Kachur, S. M., Dinshaw, H. K., & Milani, R. V. (2021) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2021.11.001 · Cited by 52 · see citing works
Wallen, M. P., Hennessy, D., Brown, S. C., Evans, L., Rawstorn, J. C., Shee, A. W., & Hall, A. (2020) · European Journal of Cancer Care · doi:10.1111/ecc.13267 · Cited by 51 · see citing works
Cardiac Rehabilitation vs. Home Exercise After Coronary Artery Bypass Graft Surgery
Wu, S., Lin, Y.-W., Chen, C.-L., & Tsai, S. (2006) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/01.phm.0000228597.64057.66 · Cited by 51 · see citing works
Giallauria, F., Palomba, S., Manguso, F., Vitelli, A., Maresca, L., Tafuri, D., Lombardi, G., Colao, A., Vigorito, C., & Orio, F. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03004.x · Cited by 51 · see citing works
Smith, J. L. D., Verrill, T. A., Boura, J., Sakwa, M. P., Shannon, F. L., & Franklin, B. A. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.05.057 · Cited by 50 · see citing works
Dutcher, J., Kahn, J., Grines, C. L., & Franklin, B. A. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.08.053 · Cited by 50 · see citing works
Maddison, R., Rawstorn, J. C., Rolleston, A. K., Whittaker, R., Stewart, R., Benatar, J. R., Warren, I., Jiang, Y., & Gant, N. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-1236 · Cited by 49 · see citing works
Cirillo, P. L., Giallauria, F., Pacileo, M., Petrillo, G., D’Agostino, M., Vigorito, C., & Massimo Chiariello, A. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.11.010 · Cited by 48 · see citing works
Mytinger, M., Nelson, R. K., & Zuhl, M. (2020) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd7020015 · Cited by 51 · see citing works
- Authors
- Kavanagh, T., Mertens, D. J., Hamm, L. F., Beyene, J., Kennedy, J., Corey, P., & Shephard, R. J.
- Affiliations
- University of Toronto (CA)
- Toronto Rehabilitation Institute (CA)
- George Washington University (US)
- Corresponding author
- Kavanagh, Terence
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 42
- Issue
- 12
- Pages
- 2139-2143
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2119705713
- Cited by
- 380
- References
- 22
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 19 · 2021: 18 · 2020: 22 · 2019: 26 · 2018: 14 · 2017: 17 · 2016: 21 · 2015: 17 · 2014: 19 · 2013: 21 · 2012: 28
- FWCI
- 22.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- exercise capacity, cardiac mortality, women, coronary artery disease, cardiac rehabilitation, prognosis, all-cause mortality, diabetes mellitus, antiarrhythmic therapy, myocardial infarction, coronary artery bypass grafting
- MeSH terms
- Coronary Artery Bypass, Coronary Disease, Exercise Test, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Oxygen Consumption, Prognosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
