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Leptin Resistance
Open accessAbstract
Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to cardiovascular health. Increased circulating leptin, a marker of leptin resistance, is common in obesity and independently associated with insulin resistance and cardiovascular disease (CVD) in humans. The mechanisms of leptin resistance include genetic mutation, leptin self-regulation, limited tissue access, and cellular or circulating molecular regulation. Evidence suggests that central leptin resistance causes obesity and that obesity-induced leptin resistance injures numerous peripheral tissues, including liver, pancreas, platelets, vasculature, and myocardium. This metabolic- and inflammatory-mediated injury may result from either resistance to leptin's action in selective tissues, or excess leptin action from adiposity-associated hyperleptinemia. In this sense, the term "leptin resistance" encompasses a complex pathophysiological phenomenon. The leptin axis has functional interactions with elements of metabolism, such as insulin, and inflammation, including mediators of innate immunity, such as interleukin-6. Leptin is even purported to physically interact with C-reactive protein, resulting in leptin resistance, which is particularly intriguing, given C-reactive protein's well-studied relationship to cardiovascular disease. Given that plasma levels of leptin and inflammatory markers are correlated and also predict cardiovascular risk, it is conceivable that part of this risk may be mediated through leptin resistance-related insulin resistance, chronic inflammation, type II diabetes, hypertension, atherothrombosis, and myocardial injury. Leptin resistance and its interactions with metabolic and inflammatory factors, therefore, represent potential novel diagnostic and therapeutic targets in obesity-related cardiovascular disease.
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“The adipocyte acts as an endocrine organ, and plays a substantial role in the pathogenesis and complications of obesity (1,10).”
From Obesity and Cardiovascular Disease (2009) · cites this paper as [10]
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Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
European Guidelines for Obesity Management in Adults
Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D., & Toplak, H. (2015) · Obesity Facts · doi:10.1159/000442721 · Cited by 3,432
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Items 101–200 of 516
Phenotypic and genetic variation in leptin as determinants of weight regain
Erez, G., Tirosh, A., Rudich, A., Meiner, V., Schwarzfuchs, D., Sharon, N., Shpitzen, S., Blüher, M., Stümvoll, M., Thiery, J., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.217 · Cited by 58
How to Estimate Fat Mass in Overweight and Obese Subjects
Donini, L. M., Poggiogalle, E., del Balzo, V., Lubrano, C., Faliva, M. A., Opizzi, A., Perna, S., Pinto, A., & Rondanelli, M. (2013) · International Journal of Endocrinology · doi:10.1155/2013/285680 · Cited by 55
Adipokines and Cardiovascular Risk in Cushing’s Syndrome
Valassi, E., Biller, B. M. K., Klibanski, A., & Misra, M. (2011) · Neuroendocrinology · doi:10.1159/000330416 · Cited by 54
Inflammatory markers in children and adolescents with type 2 diabetes mellitus
Reinehr, T. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.07.006 · Cited by 53
Morel, O., Luca, F., Grunebaum, L., Jesel, L., Meyer, N., Desprez, D., Robert, S., Dignat‐George, F., Toti, F., Simon, C., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.19 · Cited by 53
TSP-1 (Thrombospondin-1) Deficiency Protects ApoE −/− Mice Against Leptin-Induced Atherosclerosis
Ganguly, R., Khanal, S., Mathias, A., Gupta, S., Lallo, J., Sahu, S., Ohanyan, V., Patel, A., Storm, K., Datta, S., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314962 · Cited by 52
Cardiovascular disease risk in rheumatoid arthritis: Progress, debate, and opportunity
Kramer, H. R., & Giles, J. T. (2010) · Arthritis Care & Research · doi:10.1002/acr.20386 · Cited by 53
de Oliveira, R. D. V. C., Cerda, Á., Genvigir, F. D. V., Sampaio, M. F., Armaganijan, D., Bernik, M. M. S., Dórea, E. L., Hirata, M. H., Hinuy, H. M., & Hirata, R. D. C. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000900002 · Cited by 52
Sears, B., & Ricordi, C. (2012) · PubMed · Cited by 53
Leptin as a Key between Obesity and Cardiovascular Disease
Kang, K., Ok, M., & Lee, S. (2020) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20120 · Cited by 53
Obesity, inflammation, and cancer in dogs: Review and perspectives
Marchi, P. H., Vendramini, T. H. A., Perini, M. P., Zafalon, R. V. A., Amaral, A. R., Ochamotto, V. A., da Silveira, J. C., Dagli, M. L., & Brunetto, M. A. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1004122 · Cited by 69
Leptin and its cardiovascular effects: Focus on angiogenesis
Khazaei, M., & Tahergorabi, Z. (2015) · Advanced Biomedical Research · doi:10.4103/2277-9175.156526 · Cited by 54
Diabetes type 2 pandemic in 21st century
GINTER, E., & Simko, V. (2010) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03657340 · Cited by 50
Huang, Q., Fang, C., Chen, Y., Wu, X., Ye, T., Lin, Y., & Dong, S. (2012) · Environmental Science and Pollution Research · doi:10.1007/s11356-012-1034-6 · Cited by 51
Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes
Morioka, T., Emoto, M., Yamazaki, Y., Kawano, N., Imamura, S., Numaguchi, R., Urata, H., Motoyama, K., Mori, K., Fukumoto, S., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-10 · Cited by 50
Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
Wang, J., Ge, J., Cao, H., Zhang, X., Guo, Y., Li, X., Xia, B., Yang, G., & Shi, X. (2019) · Cells · doi:10.3390/cells8040372 · Cited by 50
Gonzalez‐Bulnes, A., Óvilo, C., López-Bote, C. J., Astiz, S., Ayuso, M., Perez-Solana, M., Sánchez, R. S., & Torres-Rovira, L. (2012) · Reproduction · doi:10.1530/rep-12-0105 · Cited by 53
Balsan, G. A., Pellanda, L. C., Sausen, G., Galarraga, T., Zaffari, D., Pontin, B., & Portal, V. L. (2019) · Nutrition Journal · doi:10.1186/s12937-018-0426-y · Cited by 53
The obesity paradox and diabetes
Gravina, G., Ferrari, F., & Nebbiai, G. (2020) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-01015-1 · Cited by 52
Fortuño, A., Bidegain, J., Baltanás, A., Moreno, M. U., Montero, L., Landecho, M. F., Beloqui, Ó., Dı́ez, J., & Zalba, G. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833c21af · Cited by 49
Leptin signaling and leptin resistance
Liu, J., Lai, F., Hou, Y., & Zheng, R. (2022) · Medical Review · doi:10.1515/mr-2022-0017 · Cited by 61
Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly
Rajagopalan, P., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2012) · Neuroreport · doi:10.1097/wnr.0b013e32835c5254 · Cited by 46
Direct and indirect effects of obesity on the kidney.
Alicic, R. Z., Patakoti, R., & Tuttle, K. R. (2013) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2012.12.006 · Cited by 43
Khosravi-Largani, M., Nojomi, M., Aghili, R., Otaghvar, H. A., Tanha, K., Seyedi, S. H. S., & Mottaghi, A. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3550-z · Cited by 48
Gonzalez-Añover, P., Encinas, T., Torres-Rovira, L., Pallarés, P., Muñoz-Frutos, J., Gómez-Izquierdo, E., Sánchez, R. S., & Gonzalez‐Bulnes, A. (2010) · Theriogenology · doi:10.1016/j.theriogenology.2010.07.009 · Cited by 48
Treatment of Insulin Resistance by Acupuncture: A Review of Human and Animal Studies
Martinez, B., & Peplow, P. V. (2016) · Acupuncture in Medicine · doi:10.1136/acupmed-2016-011074 · Cited by 47
Impact of treating the metabolic syndrome on chronic kidney disease
Agrawal, V., Shah, A., Rice, C., Franklin, B. A., & McCullough, P. A. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.114 · Cited by 62
The role of leptin and low testosterone in obesity
Khodamoradi, K., Khosravizadeh, Z., Seetharam, D., Mallepalli, S. K. R., Farber, N., & Arora, H. (2022) · International Journal of Impotence Research · doi:10.1038/s41443-022-00534-y · Cited by 49
Herrick, J. E., Panza, G. S., & Gollie, J. M. (2016) · Journal of Obesity · doi:10.1155/2016/8375828 · Cited by 46
Obesity and Cardiometabolic Defects in Heart Failure Pathology
Halade, G. V., & Kain, V. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170011 · Cited by 47
Paltoglou, G., Schoina, M., Valsamakis, G., Salakos, N., Avloniti, A. A., Chatzinikolaou, A., Margeli, A., Skevaki, C. L., Papagianni, M., Kanaka‐Gantenbein, C., et al. (2017) · Endocrine · doi:10.1007/s12020-017-1227-3 · Cited by 46
Ding, W., Cheng, H., Chen, F., Yan, Y., Zhang, M., Zhao, X., Hou, D., & Mi, J. (2017) · Journal of Epidemiology · doi:10.2188/jea.je20160141 · Cited by 45
Rehman, K., Munawar, S. M., Akash, M. S. H., Buabeid, M. A., Chohan, T. A., Tariq, M., Jabeen, K., & Arafa, E. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227637 · Cited by 45
Guglielmi, V., Colangeli, L., D’Adamo, M., & Sbraccia, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063183 · Cited by 45
Adipokines: Novel Players in Resistant Hypertension
de Faria, A. P., Modolo, R., Fontana, V., & Moreno, H. (2014) · Journal of Clinical Hypertension · doi:10.1111/jch.12399 · Cited by 44
Protective Effects of Melatonin against Obesity‐Induced by Leptin Resistance
Suriyagandhi, V., & Nachiappan, V. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113598 · Cited by 44
Folch, J., Patraca, I., Martínez, N., Pedrós, I., Petrov, D., Ettcheto, M., Abad, S., Marin, M., Beas-Zarate, C., & Camins, A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.002 · Cited by 48
Thromboxane Production in Morbidly Obese Subjects
Graziani, F., Biasucci, L. M., Cialdella, P., Liuzzo, G., Giubilato, S., Bona, R. D., Pulcinelli, F. M., Iaconelli, A., Mingrone, G., & Crea, F. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.01.053 · Cited by 44
Shawky, N. M., Pichavaram, P., Shehatou, G. S. G., Suddek, G. M., Gameil, N. M., Jun, J. Y., & Segar, L. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.01.009 · Cited by 43
Vinke, P. C., Aidy, S. E., & van Dijk, G. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00034 · Cited by 43
Adipokines in neurovascular diseases
Opatřilová, R., Čaprnda, M., Kubatka, P., Valentová, V., Uramova, S., Nosáľ, V., Gašpar, Ľ., Zachar, L., Mozos, I. M., Petrovič, D., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.074 · Cited by 43
Williams, G. P. (2010) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e328338f7d2 · Cited by 42
Gonzalez, M. A., Lind, L., & Söderberg, S. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.03.018 · Cited by 42
Galletti, F., D’Elia, L., Palma, D. D., Russo, O., Barba, G., Siani, A., Miller, M. A., Cappuccio, F. P., Rossi, G., Zampa, G., et al. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.05.007 · Cited by 42
Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases
Abedpoor, N., Taghian, F., & Hajibabaie, F. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151844 · Cited by 42
Molecular regulation of DNA damage and repair in female infertility: a systematic review
Xu, X., Wang, Z., Lv, L., Liu, C., Wang, L., Sun, Y., Zhao, Z., Shi, B., Li, Q., & Hao, G. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01273-z · Cited by 49
Al-Mrabeh, A. H. (2021) · Biomedicines · doi:10.3390/biomedicines9020226 · Cited by 43
Current progress in the hypoglycemic mechanisms of natural polysaccharides
Tang, C., Zhou, R., Cao, K., Liu, J., Kan, J., Qian, C., & Jin, C. (2023) · Food & Function · doi:10.1039/d3fo00991b · Cited by 45
Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss
Dâmaso, A. R., de Piano, A., Sanches, P. D. L., Corgosinho, F. C., Tock, L., Oyama, L. M., Tock, L., do Nascimento, C. M. O., Tufik, S., & de Mello, M. T. (2011) · Peptides · doi:10.1016/j.peptides.2011.04.025 · Cited by 39
Di-(2-ethylhexyl)-phthalate induces glucose metabolic disorder in adolescent rats
Xu, J., Zhou, L., Wang, S., Zhu, J. H., Liu, T., Jia, Y., Sun, D., Chen, H., Wang, Q., Xu, F., et al. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0738-z · Cited by 40
Obesity: the 'huge' problem in cardiovascular diseases.
Ashraf, M. J., & Baweja, P. S. (2013) · Europe PMC (PubMed Central) · Cited by 39
Muneyuki, T., Nakajima, K., Aoki, A., Yoshida, M., Fuchigami, H., Munakata, H., Ishikawa, S., Sugawara, H., Kawakami, M., Momomura, S., et al. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-80 · Cited by 40
Yahia, S., El-Farahaty, R. M., El-Hawary, A. K., El-Hussiny, M. A.-B., Abdel-Masseih, H. M., El‐Dahtory, F., & El‐Gilany, A. (2012) · BMC Endocrine Disorders · doi:10.1186/1472-6823-12-22 · Cited by 37
Pokusa, M., & Trancikova, A. K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8210734 · Cited by 37
Cao, J., Xiuliang, Y., Deng, Z., Pan, Y., Zhang, B., Tsao, R., & Li, H. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05137 · Cited by 38
Wilhelmsen, A., Tsintzas, K., & Jones, S. W. (2021) · GeroScience · doi:10.1007/s11357-021-00322-4 · Cited by 42
Vavruch, C., Länne, T., Fredrikson, M. G., Lindström, T., Östgren, C. J., & Nyström, F. H. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0208-1 · Cited by 38
Motawi, T. K., Salman, T. M., Shaker, O. G., & Abdelhamid, A. M. (2015) · PubMed Central · doi:10.5114/aoms.2015.54848 · Cited by 36
Yang, Z., Miyahara, H., Takeo, J., Hatanaka, A., & Katayama, M. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-189 · Cited by 38
Pang, L., Cai, Y., Tang, E. H. C., Irwin, M. G., Ma, H., & Xia, Z. (2016) · Journal of Diabetes Research · doi:10.1155/2016/1324347 · Cited by 36
Lee, H. S., Lee, Y. J., Chung, Y. H., Nam, Y., Kim, S. T., Park, E. S., Hong, S. M., Yang, Y. K., Kim, H., & Jeong, J. H. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3259 · Cited by 36
Yeon, J., Kim, H., & Sung, M. (2011) · Preventive Medicine · doi:10.1016/j.ypmed.2011.12.026 · Cited by 35
Leptin Signaling in Adipose Tissue
Singh, P., Peterson, T. E., Kuniyoshi, F. H. S., Glenn, J. A., Davison, D. E., Romero‐Corral, A., Pusalavidyasagar, S. S., Jensen, M. D., & Somers, V. K. (2012) · Circulation Research · doi:10.1161/circresaha.112.273656 · Cited by 35
Fontes‐Carvalho, R., Pimenta, J. M., Bettencourt, P., Leite-Moreira, A. F., & Azevedo, A. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1019468 · Cited by 35
Li, D., Wu, H., & Dou, H. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1578640 · Cited by 34
Lejawa, M., Osadnik, K., Czuba, Z. P., Osadnik, T., & Pawlas, N. (2021) · Life · doi:10.3390/life11121350 · Cited by 35
Metabolic Syndrome and Heart Failure—The Risk, Paradox, and Treatment
Gaddam, K. K., Ventura, H. O., & Lavie, C. J. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0179-x · Cited by 35
The macrophage at the intersection of immunity and metabolism in obesity
Samaan, M. C. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-29 · Cited by 34
Leptin Resistance: A Possible Interface Between Obesity and Pulmonary-Related Disorders
Khan, A. R., & Awan, F. R. (2016) · Intern J Endocrinol Metab · doi:10.5812/ijem.32586 · Cited by 33
Ghosh, S., Sinha, J. K., Muralikrishna, B., Putcha, U. K., & Raghunath, M. (2017) · BioFactors · doi:10.1002/biof.1350 · Cited by 34
Kumaran, K. R., Yunusa, S., Perimal, E. K., Wahab, H. A., Müller, C. P., & Hassan, Z. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220666 · Cited by 39
Leptin upregulates caveolin-1 expression: Implications for development of atherosclerosis
Singh, P., Peterson, T. E., Kuniyoshi, F. H. S., Jensen, M. D., & Somers, V. K. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.10.012 · Cited by 33
Reshidan, N. H., Muid, S. A., & Mamikutty, N. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2627-0 · Cited by 33
Association between interleukin-1 beta polymorphism (+3953) and obesity
Mânica-Cattani, M. F., Bittencourt, L., da Rocha, M. I. D. U. M., Algarve, T. D., Bodanese, L. C., Rech, R. L., Machado, M. M., Santos, G., Gottlieb, M. G. V., Schwanke, C. H. A., et al. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.029 · Cited by 33
Yu, D., Yu, Z., Sun, Q., Sun, L., Li, H., Song, J., Mi, M., Wu, H., Lu, L., Liu, C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016818 · Cited by 32
Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
Bottasso, O. A., Bay, M. L., Besedovsky, H. O., & del Rey, A. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.11.002 · Cited by 32
Pathophysiology and emerging biomarkers of cardiovascular-renal-hepato-metabolic syndrome
Nzobokela, J., Muchaili, L., Mwambungu, A., Masenga, S. K., & Kirabo, A. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1661563 · Cited by 36
Serum Leptin Levels and the Risk of Stroke
Saber, H., Himali, J. J., Shoamanesh, A., Beiser, A., Pikula, A., Harris, T. B., Roubenoff, R., Romero, J. R., Kase, C. S., Vasan, R. S., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.009463 · Cited by 31
Type 2 diabetes and metabolic syndrome – adipokine levels and effect of drugs
Farooq, R., Amin, S., Bhat, M. H., Malik, R. A., Wani, H. A., & Majid, S. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1207165 · Cited by 31
Orabi, S. H., sabbagh, E. A., Khalifa, H. K., Mohamed, M. A. E.-G., Elhamouly, M., Gad-Allah, S. M., Abdel‐Daim, M. M., & Eldaim, M. A. A. (2020) · Nutrients · doi:10.3390/nu12030803 · Cited by 31
The Influence of Antioxidants on Oxidative Stress-Induced Vascular Aging in Obesity
Sharebiani, H., Keramat, S., Chavoshan, A., Fazeli, B., & Stanek, A. (2023) · Antioxidants · doi:10.3390/antiox12061295 · Cited by 32
Understanding the Role of Adipokines in Cardiometabolic Dysfunction: A Review of Current Knowledge
Datta, S., Koka, S., & Boini, K. M. (2025) · Biomolecules · doi:10.3390/biom15050612 · Cited by 33
Resistance to acute NO-mimetic and EDHF-mimetic effects of leptin in the metabolic syndrome
Bełtowski, J., Wójcicka, G., Jamróz-Wiśniewska, A., & Marciniak, A. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.08.002 · Cited by 30
CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance
Drori, A., Gammal, A., Azar, S., Hinden, L., Hadar, R., Wesley, D., Nemirovski, A., Szanda, G., Salton, M., Tirosh, B., et al. (2020) · eLife · doi:10.7554/elife.60771 · Cited by 30
Esteghamati, A., Noshad, S., Rabizadeh, S., Ghavami, M., Zandieh, A., & Nakhjavani, M. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2012.12.005 · Cited by 30
Endothelial function and weight loss: Comparison of low‐carbohydrate and low‐fat diets
Mohler, E. R., Sibley, A. A., Stein, R. I., Dávila‐Román, V. G., Wyatt, H. R., Badellino, K. O., Rader, D. J., Klein, S., & Foster, G. D. (2013) · Obesity · doi:10.1002/oby.20055 · Cited by 31
Navarro, P., de Dios, O., Gavela‐Pérez, T., Jois, A., Garcés, C., & Soriano‐Guillén, L. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.08.020 · Cited by 30
Vauzour, D., Rodríguez‐Ramiro, I., Rushbrook, S., Ipharraguerre, I. R., Bevan, D., Davies, S. E., Tejera, N., Mena, P. R., de Pascual‐Teresa, S., Rio, D. D., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.10.002 · Cited by 30
Leptin but not adiponectin is related to type 2 diabetes mellitus in obese adolescents
Reinehr, T., Woelfle, J., Wiegand, S., Karges, B., Meißner, T., Nagl, K., & Holl, R. W. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12276 · Cited by 29
Medici, V., Ali, M., Seo, S., Aoki, C. A., Rossaro, L., Kim, K., Fuller, W. D., Vidovszky, T. J., Smith, W., Jiang, J. X., et al. (2010) · Obesity · doi:10.1038/oby.2010.95 · Cited by 29
Sanches, P. D. L., de Mello, M. T., Elías, N., Fonseca, F. A. H., Campos, R. M. D. S., Carnier, J., de Piano, A., Masquio, D. C. L., da Silva, P. L., Oyama, L. M., et al. (2013) · Inflammation · doi:10.1007/s10753-013-9709-9 · Cited by 29
Takasu, T., & Takakura, S. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.051 · Cited by 29
Benefits of resistance exercise in lean women with fibromyalgia: involvement of IGF-1 and leptin
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Gonzalez‐Bulnes, A., Torres-Rovira, L., Óvilo, C., Astiz, S., Gómez-Izquierdo, E., Gonzalez-Añover, P., Pallarés, P., Perez-Solana, M., & Sánchez, R. S. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.12.038 · Cited by 28
Effects of fetal genotype and sex on developmental response to maternal malnutrition
Cogollos, L., García-Contreras, C., Vázquez-Gómez, M., Astiz, S., Sánchez, R. S., Gómez‐Fidalgo, E., Óvilo, C., Isabel, B., & Gonzalez‐Bulnes, A. (2016) · Reproduction Fertility and Development · doi:10.1071/rd15385 · Cited by 31
Cardiovascular Implications of Antihyperglycemic Therapies for Type 2 Diabetes
Ovalle, F. (2011) · Clinical Therapeutics · doi:10.1016/j.clinthera.2011.04.006 · Cited by 28
Migliaccio, S., Bimonte, V. M., Besharat, Z. M., Sabato, C., Crescioli, C., Lenzi, A., & Ferretti, E. (2021) · Biomolecules · doi:10.3390/biom12010044 · Cited by 27
Assessment of leptin and resistin levels in patients with chronic obstructive pulmonary disease
Kumor‐Kisielewska, A., Kierszniewska‐Stępień, D., Pietras, T., Kroczyńska‐Bednarek, J., Kurmanowska, Z., Antczak, A. J., & Górski, P. (2013) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1724 · Cited by 27
Leptin is essential in maintaining normal vascular compliance independent of body weight
Sikka, G., Yang, R., Reid, S., Benjo, A. M., Koitabashi, N., Camara, A., Baraban, E. G., O'Donnell, C. P., Berkowitz, D. E., & Barouch, L. A. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.208 · Cited by 26
Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease
Liu, R., He, B., Gao, F., Liu, Q., & Yi, Q. (2012) · Translational research · doi:10.1016/j.trsl.2012.01.013 · Cited by 26
Metadata
- Authors
- Martin, S. S., Qasim, A., & Reilly, M. P.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Reilly, Muredach P.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 52
- Issue
- 15
- Pages
- 1201-1210
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC4556270
- OpenAlex
- W102714011
- Cited by
- 516
- References
- 137
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 19 · 2023: 21 · 2022: 18 · 2021: 35 · 2020: 32 · 2019: 23 · 2018: 26 · 2017: 34 · 2016: 31 · 2015: 37 · 2014: 34 · 2013: 38 · 2012: 31
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071224)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- leptin resistance, leptin, obesity, cardiovascular disease, insulin resistance, hyperleptinemia, chronic inflammation, interleukin-6, C-reactive protein, type 2 diabetes, hypertension, atherothrombosis, myocardial injury, energy balance, leptin signaling
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Inflammation, Obesity, Leptin
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