The DOI matches its Crossref record; 136 of the 137 references it cites were found in a registry or an index.
Leptin Resistance
Open accessAbstract
Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to cardiovascular health. Increased circulating leptin, a marker of leptin resistance, is common in obesity and independently associated with insulin resistance and cardiovascular disease (CVD) in humans. The mechanisms of leptin resistance include genetic mutation, leptin self-regulation, limited tissue access, and cellular or circulating molecular regulation. Evidence suggests that central leptin resistance causes obesity and that obesity-induced leptin resistance injures numerous peripheral tissues, including liver, pancreas, platelets, vasculature, and myocardium. This metabolic- and inflammatory-mediated injury may result from either resistance to leptin's action in selective tissues, or excess leptin action from adiposity-associated hyperleptinemia. In this sense, the term "leptin resistance" encompasses a complex pathophysiological phenomenon. The leptin axis has functional interactions with elements of metabolism, such as insulin, and inflammation, including mediators of innate immunity, such as interleukin-6. Leptin is even purported to physically interact with C-reactive protein, resulting in leptin resistance, which is particularly intriguing, given C-reactive protein's well-studied relationship to cardiovascular disease. Given that plasma levels of leptin and inflammatory markers are correlated and also predict cardiovascular risk, it is conceivable that part of this risk may be mediated through leptin resistance-related insulin resistance, chronic inflammation, type II diabetes, hypertension, atherothrombosis, and myocardial injury. Leptin resistance and its interactions with metabolic and inflammatory factors, therefore, represent potential novel diagnostic and therapeutic targets in obesity-related cardiovascular disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The adipocyte acts as an endocrine organ, and plays a substantial role in the pathogenesis and complications of obesity (1,10).”
From Obesity and Cardiovascular Disease (2009) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
European Guidelines for Obesity Management in Adults
Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D., & Toplak, H. (2015) · Obesity Facts · doi:10.1159/000442721 · Cited by 3,432
Cited by
Sorted by citations
Items 201–300 of 516
Leptin-based adjuvants: An innovative approach to improve vaccine response
White, S. J., Taylor, M. J., Hurt, R. T., Jensen, M. D., & Poland, G. A. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.01.032 · Cited by 26
Leptin, Insulin Resistance, and Metabolic Changes 5 Years After Renal Transplantation
Nicoletto, B. B., Souza, G. C., Gonçalves, L. F. S., Costa, C. A. R., Perry, I. D. S., & Manfro, R. C. (2011) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2011.09.003 · Cited by 25
The associations of self-rated health with cardiovascular risk proteins: a proteomics approach
Bao, X., Borné, Y., Yin, S., Niu, K., Orho‐Melander, M., Nilsson, J. Å., Melander, O., & Engström, G. (2019) · Clinical Proteomics · doi:10.1186/s12014-019-9258-9 · Cited by 24
D’Elia, L., Giaquinto, A., Cappuccio, F. P., Iacone, R., Russo, O., Strazzullo, P., & Galletti, F. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01140-4 · Cited by 24
Association of Gut Hormones and Microbiota with Vascular Dysfunction in Obesity
Rovella, V., Rodia, G., Daniele, F. D., Cardillo, C., Campia, U., Noce, A., Candi, E., Della‐Morte, D., & Tesauro, M. (2021) · Nutrients · doi:10.3390/nu13020613 · Cited by 24
Plasminogen Activator Inhibitor-1 and Adiponectin Are Associated With Metabolic Syndrome Components
Vecchiola, A., García, K. K., González-Gómez, L. M., Tapia-Castillo, A., Artigas, R., Baudrand, R. F., Kalergis, A. M., Carvajal, C. A., & Fardella, C. (2021) · American Journal of Hypertension · doi:10.1093/ajh/hpab138 · Cited by 26
Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS
Смирнов, В. В., Beeraka, N. M., Butko, D. Y., Nikolenko, V. N., Bondarev, S., Achkasov, E. E., Sinelnikov, M. Y., & Vikram, P. R. H. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01013-x · Cited by 25
Reddy, V. D. K., & Jagota, A. (2014) · Biogerontology · doi:10.1007/s10522-014-9494-3 · Cited by 24
Morita, Y., Maeda, K., Kondo, T., Ishii, H., Matsudaira, K., Okumura, N., Mitsuhashi, H., Shibata, R., Murohara, T., & on behalf of the Nagoya Acute Myocardial Infarction Study (NAMIS) Group (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0251 · Cited by 24
Leptin independently predicts development of sepsis and its outcome
Jacobsson, S., Larsson, P., Johansson, G., Norberg, M., Wadell, G., Hallmans, G., Winsö, O., & Söderberg, S. (2017) · Journal of Inflammation · doi:10.1186/s12950-017-0167-2 · Cited by 24
Liberale, L., Carbone, F., Bertolotto, M. B., Bonaventura, A., Vecchié, A., Mach, F., Burger, F., Pende, A., Spinella, G., Pane, B., et al. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2017.12.066 · Cited by 24
Yang, Z., Zhao, J., Wang, J., Li, J., Ouyang, K., & Wang, W. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.110 · Cited by 24
Advanced Onset of Puberty in Gilts of Thrifty Genotype (Iberian Pig)
Gonzalez-Añover, P., Encinas, T., Gómez-Izquierdo, E., Sanz, E., Letelier, C. A., Torres-Rovira, L., Pallarés, P., Sánchez, R. S., & Gonzalez‐Bulnes, A. (2009) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2009.01476.x · Cited by 24
Saad, Y., Ahmed, A., Saleh, D. A., & Doss, W. H. (2013) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32835f2726 · Cited by 22
Becic, T., & Studenik, C. R. (2018) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.42.2.101 · Cited by 23
Navaei, N., Pourafshar, S., Akhavan, N. S., Litwin, N. S., Foley, E., George, K. S., Hartley, S. C., Elam, M. L., Rao, S., Arjmandi, B. H., et al. (2019) · Food & Function · doi:10.1039/c8fo01890a · Cited by 24
Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification
Zheng, C., Lu, K., Wu, C., Hsu, Y., & Lin, Y. (2011) · International Journal of Nephrology · doi:10.4061/2011/939613 · Cited by 23
Scrivo, R., Vasile, M., Müller‐Ladner, U., Neumann, E., & Valesini, G. (2013) · Mediators of Inflammation · doi:10.1155/2013/808125 · Cited by 25
Leptin Resistance and the Neuro-Adipose Connection
Barateiro, A. P., Mahú, I., & Domingos, A. I. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00045 · Cited by 23
Hanke, J., Romejko, K., & Niemczyk, S. (2025) · Molecules · doi:10.3390/molecules30204125 · Cited by 33
IFNγ Is a Key Link between Obesity and Th1-Mediated AutoImmune Diseases
Bae, H. R., Choi, M., Kim, S., Young, H. A., Gershwin, M. E., Jeon, S.-M., & Kwon, E.-Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010208 · Cited by 22
Muro, B. B. D., Carnevale, R. F., Leal, D. F., Almond, G. W., Monteiro, M. S., Poor, A. P., Schinckel, A. P., & Garbossa, C. A. P. (2022) · Nutrition Research Reviews · doi:10.1017/s0954422422000129 · Cited by 22
Manco, M., Fernández‐Real, J. M., Vecchio, F. M., Vellone, V. G., Moreno‐Navarrete, J. M., Tondolo, V., Bottazzo, G., Nanni, G., & Mingrone, G. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0129-8 · Cited by 22
Modulation of the cardiovascular system by leptin
Abel, E. D., & Sweeney, G. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.019 · Cited by 22
D’Elia, L., Manfredi, M., Perna, L., Iacone, R., Russo, O., Strazzullo, P., & Galletti, F. (2018) · Internal and Emergency Medicine · doi:10.1007/s11739-018-1924-9 · Cited by 22
Sweeney, T. E., Quispe, R., Das, T. M., Juraschek, S. P., Martin, S. S., & Michos, E. D. (2021) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2021.1930531 · Cited by 24
Self-citationLeptin and uric acid as predictors of metabolic syndrome in jordanian adults
Obeidat, A. A., Ahmad, M. N., Haddad, F., & Azzeh, F. S. (2016) · Nutrition Research and Practice · doi:10.4162/nrp.2016.10.4.411 · Cited by 22
Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice
Talton, O. O., Pennington, K. A., Pollock, K. E., Bates, K., Ma, L., Ellersieck, M. R., & Schulz, L. C. (2016) · Endocrinology · doi:10.1210/en.2016-1039 · Cited by 22
Kyrou, I., Mattu, H. S., Chatha, K. K., & Randeva, H. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803111-7.00007-5 · Cited by 21
Chen, W.-D., Lai, L.-J., Lee, K., Chen, T., Liu, C.-Y., & Yang, Y. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10174021 · Cited by 20
Yamazaki, Y., Emoto, M., Morioka, T., Kawano, N., Lee, E., Urata, H., Tsuchikura, S., Motoyama, K., Mori, K., Fukumoto, S., et al. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14662 · Cited by 20
Anti-inflammatory role of Leptin in glial cells through p38 MAPK pathway inhibition
Patraca, I., Martínez, N., Busquets, O., Navia, A. M., Pedrós, I., Beas‐Zárate, C., Marin, M., Ettcheto, M., Sureda, F. X., Auladell, C., et al. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.12.005 · Cited by 20
RetractedBravo, C., Cataldo, L. R., Galgani, J. E., Parada, J., & Santos, J. L. (2017) · Journal of Diabetes Research · doi:10.1155/2017/9031079 · Cited by 22
Circulating leptin levels are associated with adiposity in survivors of childhood brain tumors
Sims, E. D., Jennings, W. J., Empringham, B., Fleming, A. J., Portwine, C., Johnston, D. L., Zelcer, S. M., Rassekh, S. R., Burrow, S., Thabane, L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61520-2 · Cited by 21
The influence of polyvascular disease on the obesity paradox in vascular surgery patients.
van Kuijk, J., Flu, W., Galal, W., Chonchol, M., Goei, D., Verhagen, H., Bax, J. J., & Poldermans, D. (2011) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2010.08.048 · Cited by 18
The paradox of obesity cardiomyopathy and the potential for weight loss as a therapy
Rayner, J. J., Neubauer, S., & Rider, O. J. (2015) · Obesity Reviews · doi:10.1111/obr.12292 · Cited by 21
Migliaccio, S., Greco, E. A., Aversa, A., & Lenzi, A. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0030 · Cited by 23
Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases
Strassheim, D., Sullivan, T., Irwin, D. C., Gerasimovskaya, E. V., Lahm, T., Klemm, D. J., Dempsey, E. C., Stenmark, K. R., & Karoor, V. (2021) · Cells · doi:10.3390/cells10123347 · Cited by 21
Sadarangani, S. P., Ovsyannikova, I. G., Goergen, K. M., Grill, D. E., & Poland, G. A. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1097015 · Cited by 19
Influence of Exercise on Leptin, Adiponectin and Quality of Life in Type 2 Diabetics
Dede, N. D., İpekçi, S. H., Kebapçılar, L., Arslan, M., Kurban, S., Yıldız, M., & Gönen, M. S. (2015) · Endocrinology research and practice. · doi:10.4274/tjem.2564 · Cited by 19
Kannan, S., Srinivasan, D., Raghupathy, P. B., & Bhaskaran, R. S. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.012 · Cited by 19
Nepomuceno, R., Vallerini, B. D. F., da Silva, R. L., Corbi, S. C. T., Bastos, A. D. S., dos Santos, R. A., Takahashi, C. S., Orrico, S. R. P., & Scarel‐Caminaga, R. M. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.07.003 · Cited by 19
Melhem, S., Steven, S., Taylor, R., & Al-Mrabeh, A. H. (2021) · Nutrients · doi:10.3390/nu13051465 · Cited by 19
Metabolic syndrome in rheumatoid arthritis
Kondratyeva, L. V., Попкова, Т. В., & Насонов, Е. Л. (2013) · Rheumatology Science and Practice · doi:10.14412/1995-4484-2013-1506 · Cited by 19
Martin, S. S., Qasim, A., Rader, D. J., & Reilly, M. P. (2011) · Obesity · doi:10.1038/oby.2011.164 · Cited by 18
Self-citationBasati, G., Razavi, À. E., Abdi, S., & Sarrafzadegan, N. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.13.131 · Cited by 18
Leptin as an obesity marker in rheumatoid arthritis
Guimarães, M. F. B. D. R., de Andrade, M. V. M., Machado, C. J., Vieira, É. L. M., Pinto, M. R. D. C., Teixeira, A. L., & Kakehasi, A. M. (2018) · Rheumatology International · doi:10.1007/s00296-018-4082-5 · Cited by 18
Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
Syk, M., Isaksson, J., Rasmusson, A. J., Ekselius, L., & Cunningham, J. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-89251-y · Cited by 20
Gruzdeva, O. V., Учасова, Е. Г., Dyleva, Y. A., Евгеньевна, А. О., Каретникова, В. Н., & Барбараш, О. Л. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00324 · Cited by 18
Chrononutrition: Potential, Challenges, and Application in Managing Obesity
Fuad, S. A., Ginting, R. P., & Lee, M.-W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115116 · Cited by 16
Saâdi, S., Ghazali, H. M., Saari, N., & Abdulkarim, S. M. (2021) · Biophysical Chemistry · doi:10.1016/j.bpc.2021.106565 · Cited by 17
Impact of visceral fat on the prognosis of coronavirus disease 2019: an observational cohort study
Ogata, H., Mori, M., Jingushi, Y., Matsuzaki, H., Katahira, K., Ishimatsu, A., Enokizu‐Ogawa, A., Taguchi, K., Moriwaki, A., & Yoshida, M. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06958-z · Cited by 17
D, M. F. M., Ramey, T. S., Pickering, E. H., Kinrys, G., Boyer, S., & Altstiel, L. D. (2014) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000245 · Cited by 17
de Faria, A. P., Ritter, A. M. V., Sabbatini, A. R., Modolo, R., & Moreno, H. (2016) · Blood Pressure · doi:10.1080/08037051.2016.1192945 · Cited by 17
Shariat, A., Farhangi, M. A., & Zeinalian, R. (2019) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2019.100264 · Cited by 19
Interaction between leptin and leisure-time physical activity and development of hypertension
Asferg, C. L., Møgelvang, R., Flyvbjerg, A., Frystyk, J., Jensen, J. S., Marott, J. L., Appleyard, M., Schnohr, P., Jensen, G. B., & Jeppesen, J. (2011) · Blood Pressure · doi:10.3109/00365599.2011.586248 · Cited by 17
Calle, M. C., Vega‐López, S., Segura‐Pérez, S., Volek, J. S., & Pérez‐Escamilla, R. (2010) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000109 · Cited by 17
Association of adipokines with blood pressure in rural Chinese adolescents
Wang, H., Necheles, J., Birne, J. S., Li, Z., Xing, H., Tang, G., Christoffel, K. K., Brickman, W. J., Zimmerman, D., & Wang, X. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.64 · Cited by 17
Pathogenesis of obesity-associated cardiovascular diseases: Key role of biomolecules
Sood, S., Mittal, N., Singh, T. G., & Devi, S. (2023) · Health Sciences Review · doi:10.1016/j.hsr.2023.100098 · Cited by 17
Sokolova, R., Yankova, R. K., Abadjieva, T. I., Popova, T. A., Ivanovska, M., Murdjeva, M., Orbetzova, M. M., Dermendzhiev, S. M., & Pavlova, M. V. (2017) · Folia Medica · doi:10.1515/folmed-2017-0021 · Cited by 16
Fang, X., Chung, J., Olsen, E., Snider, I., Earls, R. H., Jeon, J. H., Park, H. J., & Lee, J. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.06.004 · Cited by 18
Serum leptin level as a diagnostic and prognostic marker in infectious diseases and sepsis
Bîrluțiu, V., & Boicean, L. C. (2021) · Medicine · doi:10.1097/md.0000000000025720 · Cited by 17
Wahba, N. S., Ghareib, S. A., Abdel-Ghany, R. H., Abdel-Aal, M., & Alsemeh, A. E. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0435 · Cited by 16
RetractedCardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism
Zhao, Y., Jia, H., Hua, X., An, T., & Song, J. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01906-6 · Cited by 19
The Cardioprotective Effects of Nutritional Ketosis: Mechanisms and Clinical Implications
Venturini, C., Mancinelli, L., Matacchione, G., Olivieri, F., & Antonicelli, R. (2024) · Nutrients · doi:10.3390/nu16234204 · Cited by 15
Ledesma, S. N. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051780 · Cited by 17
de Oliveira, R. D. V. C., Moraes, T. I., Cerda, Á., Hirata, M. H., Fajardo, C. M., Sousa, M. C., Dórea, E. L., Bernik, M. M. S., & Hirata, R. D. C. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0027-2 · Cited by 15
Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents
Mastroeni, S. S. D. B. S., Mastroeni, M. F., Gonçalves, M. D. C., Debortoli, G., da Silva, N. N., Bernal, R. T. I., Adamovski, M., Veugelers, P. J., & Rondó, P. H. D. C. (2016) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2015-0632 · Cited by 15
Nguyen, N. M., Chanh, H. Q., Tam, D. T. H., Vuong, N. L., Chau, N. T. X., Châu, N. V. V., Phong, N. T., Trieu, H. T., Tai, L. T. H., Thi, T. C., et al. (2021) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16053.2 · Cited by 15
Leoni, M. C., Valsecchi, C., Mantelli, M., Marastoni, L., Tinelli, C., Marchi, A., & Castellazzi, A. M. (2010) · Pediatric Reports · doi:10.4081/pr.2010.e19 · Cited by 15
Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice
Martineau, C., Falstrault, L., Brissette, L., & Moreau, R. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0147 · Cited by 15
Alotaiq, N., Khalifa, A. S., Youssef, A., Elnagar, E., Elwali, N. E., Habib, H. M., AlZaim, I., Eid, A. H., Bakkar, N. Z., & EL‐Yazbi, A. F. (2024) · The FASEB Journal · doi:10.1096/fj.202402470r · Cited by 14
Obesity and heart failure: exploring the cardiometabolic axis
Rayner, J. J., Abdesselam, I., Pan, J., Lewis, A., & Rider, O. J. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf090 · Cited by 15
Magnesium Intake, C-Reactive Protein, and Muscle Mass in Adolescents
Dong, Y., Chen, L., Gutin, B., Huang, Y., Dong, Y., & Zhu, H. (2022) · Nutrients · doi:10.3390/nu14142882 · Cited by 14
Genetic factors and the role of pancreatic amylase in the pathogenesis of type 2 diabetes
Abdulkareem, M. A., Owolabi, B., Saheed, E. S., Aromolaran, R. F., Bashiru, R. M., Jumah, T. A., Chijioke, D. U., Amaechi, O. J., Adeleke, F. C., Charles, O. O., et al. (2024) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-024-00505-6 · Cited by 17
Ferguson, J. F., Shah, R. Y., Shah, R., Mehta, N., Rickels, M., & Reilly, M. (2014) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2014.12.007 · Cited by 15
Self-citationde Castro, M. A., Baltar, V. T., Marchioni, D. M. L., & Fisberg, R. M. (2014) · Nutrition · doi:10.1016/j.nut.2014.09.007 · Cited by 14
Brissette, C., Jenkins, A. L., Choleva, L., & Vuksan, V. V. V. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.08.183 · Cited by 17
Increased arterial stiffness in patients with end-stage osteoarthritis: a case-control study
Tootsi, K., Märtson, A., Zilmer, M., Paapstel, K., & Kals, J. (2016) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-016-1201-x · Cited by 14
Rezaei, S., Shamsi, M. M., Mahdavi, M., Jamali, A., Prestes, J., Tibana, R. A., Navalta, J. W., & Voltarelli, F. A. (2017) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-017-0273-6 · Cited by 15
Dellas, C., Lankeit, M., Reiner, C., Schäfer, K., Hasenfuss, G. P., & Konstantinides, S. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.36 · Cited by 14
The Relationship Between Leptin and Ventilatory Control in Heart Failure
Čundrle, I., Somers, V. K., Singh, P., Johnson, B. D., Scott, C. G., & Olson, L. J. (2013) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2013.10.004 · Cited by 13
Russell, J. S., Griffith, T. A., Helman, T. J., Toit, E. F. D., Peart, J. N., & Headrick, J. P. (2019) · Experimental Physiology · doi:10.1113/ep088024 · Cited by 14
The Effects of Adiponectin and Leptin on Human Endothelial Cell Proliferation: A Live-Cell Study
Álvarez, G., Bartolomé, M. V., Miana, M., Jurado-López, R., Martín, R., Zuluaga, P., Martínez‐Martínez, E., Nieto, M. L., Alvarez-Sala, L. A., Millán, J., et al. (2012) · Journal of Vascular Research · doi:10.1159/000332332 · Cited by 14
Sharma, V., Saqib, B. Z. U., & Aran, K. R. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.008 · Cited by 13
Kazeminasab, F., Behzadnejad, N., Cerqueira, H. S. C., Santos, H. O., & Rosenkranz, S. K. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1362731 · Cited by 17
Proteomic Signature of BMI and Risk of Cardiovascular Disease
Ma, H., Wang, X., Heianza, Y., Manson, J. E., & Qi, L. (2024) · Clinical Chemistry · doi:10.1093/clinchem/hvae149 · Cited by 13
Childhood adiposity: being male is a potential cardiovascular risk factor
Pires, A., Martins, P., Pereira, A. M., Marques, M., Castela, E., Sena, C. M., & Seiça, R. M. F. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-015-2599-0 · Cited by 13
The sympathetic neuro-adipose connection and the control of body weight
Mahú, I., & Domingos, A. I. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.047 · Cited by 13
Effects of 17β-estradiol on cardiac Na+/K+-ATPase in high fat diet fed rats
Obradovic, M. M., Zafirovic, S. S., Jovanović, A., Sudar-Milovanovic, E. M., Mousa, S. A., Labudović‐Borović, M., & Isenović, E. R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.020 · Cited by 14
Gonzalez-Añover, P., Encinas, T., Torres-Rovira, L., Sanz, E., Pallarés, P., Ros, J., Gómez-Izquierdo, E., Sánchez, R. S., & Gonzalez‐Bulnes, A. (2011) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2011.01776.x · Cited by 13
Fontes‐Carvalho, R., Gonçalves, A., Severo, M., Lourenço, P., Gonçalves, F. R., Bettencourt, P., Leite-Moreira, A. F., & Azevedo, A. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.250 · Cited by 13
Lee, J. H., Jun, H., Jia, Y., Kim, W., Choi, S., & Lee, S. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202910u · Cited by 13
PPAR Gamma at the Crossroads of Health and Disease: A Masterchef in Metabolic Homeostasis
Akoum, S. E. (2014) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000126 · Cited by 13
A new therapeutic strategy against cancer: cAMP elevating drugs and leptin
Vitale, G., Dicitore, A., Mari, D., & Cavagnini, F. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.12.8937 · Cited by 13
Huang, W., Peng, H., Hu, S., & Wu, S. (2019) · Nutrients · doi:10.3390/nu11050991 · Cited by 13
Cardio-oncology: the new frontier of clinical and preventive cardiology
París, S. C., Tarantini, L., Navazio, A., & Faggiano, P. M. (2020) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2020.1348 · Cited by 13
Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity
Taheri, E., Hosseini, S., Qorbani, M., & Mirmiran, P. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-00648-8 · Cited by 13
Impairment of cellular and humoral immunity in overweight Mongolian gerbils (Meriones unguiculatus)
Xu, D., Liu, X., & Wang, D. (2011) · Integrative Zoology · doi:10.1111/j.1749-4877.2011.00259.x · Cited by 13
Metz, C. N., Xue, X., Chatterjee, P. K., Adelson, R. P., Roth, J., Brines, M. L., Tracey, K. J., Gregersen, P. K., & Pavlov, V. A. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03588-4 · Cited by 16
Metadata
- Authors
- Martin, S. S., Qasim, A., & Reilly, M. P.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Reilly, Muredach P.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 52
- Issue
- 15
- Pages
- 1201-1210
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC4556270
- OpenAlex
- W102714011
- Cited by
- 516
- References
- 137
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 19 · 2023: 21 · 2022: 18 · 2021: 35 · 2020: 32 · 2019: 23 · 2018: 26 · 2017: 34 · 2016: 31 · 2015: 37 · 2014: 34 · 2013: 38 · 2012: 31
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071224)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- leptin resistance, leptin, obesity, cardiovascular disease, insulin resistance, hyperleptinemia, chronic inflammation, interleukin-6, C-reactive protein, type 2 diabetes, hypertension, atherothrombosis, myocardial injury, energy balance, leptin signaling
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Inflammation, Obesity, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review