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Cited by 16Circadian rhythm and melatoninDietary Effects on HealthNutrition, Genetics, and Disease

Chrononutrition: Potential, Challenges, and Application in Managing Obesity

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Fuad, Siti Aisyah, Ginting, Rehna Paula, Lee, Min-Woo·2025·International Journal of Molecular Sciences
DOI 10.3390/ijms26115116PMC PMC12154423
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Abstract

The circadian clock orchestrates nearly every aspect of physiology, aligning metabolic processes with environmental cues, such as light and food intake. While the central pacemaker in the suprachiasmatic nucleus synchronizes peripheral clocks across key metabolic tissue, feeding behavior emerges as the dominant cue for peripheral clock alignment. This interaction reveals a crucial link between circadian biology and metabolism. Disruption of these processes, whether from shift work, irregular eating patterns or lifestyle misalignment, has been strongly associated with metabolic disorders, including obesity, insulin resistance and cardiometabolic diseases. Within the field of chrononutrition, strategies, such as time-restricted feeding (TRF), have gained attention for their potential to restore circadian alignment and improve metabolic health. However, translational gaps persist, as most mechanistic insights are derived from nocturnal murine models, limiting their applicability to diurnal human physiology. Moreover, human studies are confounded by interindividual variability in chronotype, behavioral patterns, and dietary compliance. This review explores the molecular underpinnings of zeitgeber signals and critically assesses the translational barriers to implementing chrononutrition across species. By integrating insights from both preclinical and clinical research, we aim to refine the potential of circadian-based dietary interventions for metabolic disease prevention and personalized nutrition.

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  • Incorporating chrononutritional variables, meal timing, sleep patterns, and lifestyle behaviors provides a more accurate understanding of microbiota-mediated influences on nutritional health.

    “Incorporating chrononutritional variables, meal timing, sleep patterns, and lifestyle behaviors provides a more accurate understanding of microbiota-mediated influences on nutritional health [100-103].”

    From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [101]

    Section 7 links nutrient timing to gut-microbiota rhythms and metabolic outcomes, while section 6.4 says sleep quality and other lifestyle factors affect responses to meal timing. The paper does not say that incorporating all these variables provides a more accurate understanding of microbiota-mediated influences on nutritional health. The indexed passages provide section labels but no page numbers. (LLM, conf=0.78)

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Cited by

Sorted by citations

Authors
Fuad, S. A., Ginting, R. P., & Lee, M.-W.
Affiliations
Soonchunhyang University (KR)
Corresponding author
Lee, Min-Woo
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2025-05-26
Volume
26
Issue
11
Pages
5116
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms26115116
PMC
PMC12154423
OpenAlex
W4410833302
Cited by
16
References
20
Citations by year
2026: 11 · 2025: 5
FWCI
1.80
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea (NRF-RS-2019-NR040068, NRF-RS-2024-00338026)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
chrononutrition, circadian clock, obesity, time-restricted feeding, feeding behavior, suprachiasmatic nucleus, peripheral clocks, insulin resistance, cardiometabolic disease, chronotype, personalized nutrition, translational barriers, circadian misalignment
MeSH terms
Animals, Circadian Rhythm, Feeding Behavior, Humans, Obesity, Circadian Clocks

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