The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Coronary Arterial 18F-Sodium Fluoride Uptake
Open accessAbstract
OBJECTIVES With combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of active plaque calcification and inflammation, respectively. BACKGROUND The noninvasive assessment of coronary artery plaque biology would be a major advance particularly in the identification of vulnerable plaques, which are associated with specific pathological characteristics, including micro-calcification and inflammation. METHODS We prospectively recruited 119 volunteers (72 ± 8 years of age, 68% men) with and without aortic valve disease and measured their coronary calcium score and 18F-NaF and 18F-FDG uptake. Patients with a calcium score of 0 were used as control subjects and compared with those with calcific atherosclerosis (calcium score >0). RESULTS Inter-observer repeatability of coronary 18F-NaF uptake measurements (maximum tissue/background ratio) was excellent (intra-class coefficient 0.99). Activity was higher in patients with coronary atherosclerosis (n = 106) versus control subjects (1.64 ± 0.49 vs. 1.23 ± 0.24; p = 0.003) and correlated with the calcium score (r = 0.652, p < 0.001), although 40% of those with scores >1,000 displayed normal uptake. Patients with increased coronary 18F-NaF activity (n = 40) had higher rates of prior cardiovascular events (p = 0.016) and angina (p = 0.023) and higher Framingham risk scores (p = 0.011). Quantification of coronary 18F-FDG uptake was hampered by myocardial activity and was not increased in patients with atherosclerosis versus control subjects (p = 0.498). CONCLUSIONS 18F-NaF is a promising new approach for the assessment of coronary artery plaque biology. Prospective studies with clinical outcomes are now needed to assess whether coronary 18F-NaF uptake represents a novel marker of plaque vulnerability, recent plaque rupture, and future cardiovascular risk. (An Observational PET/CT Study Examining the Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis; NCT01358513).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Quantification of coronary artery calcium using ultrafast computed tomography
Agatston, A. S., Janowitz, W. R., Hildner, F. J., Zusmer, N. R., Viamonte, M., & Detrano, R. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90282-t · Cited by 7,786
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,533
Pathology of the Vulnerable Plaque
Virmani, R., Burke, A. P., Farb, A., & Kolodgie, F. D. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.065 · Cited by 2,315
Rudd, J. H. F., Warburton, E. A., Fryer, T. D., Jones, H. A., Clark, J. C., Antoun, N., Johnström, P., Davenport, A. P., Kirkpatrick, P. J., Arch, B. N., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020548.60110.76 · Cited by 1,226
Self-citationMultislice Computed Tomographic Characteristics of Coronary Lesions in Acute Coronary Syndromes
Motoyama, S., Kondo, T., Sarai, M., Sugiura, A., Harigaya, H., Sato, T., Inoue, K., Okumura, M., Ishii, J., Anno, H., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.044 · Cited by 1,026
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.9.1512 · Cited by 965
Tawakol, A., Migrino, R. Q., Bashian, G. G., Bedri, S., Vermylen, D., Cury, R. C., Yates, D., LaMuraglia, G. M., Furie, K., Houser, S., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.076 · Cited by 915
Taylor, A. J., Cerqueira, M., Hodgson, J. M., Mark, D., Min, J., O'Gara, P., & Rubin, G. D. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.07.005 · Cited by 894
Even‐Sapir, E., Metser, U., Mishani, E., Lievshitz, G., Lerman, H., & Leibovitch, I. (2006) · PubMed · Cited by 795
Cited by
Madhavan, M. V., Tarigopula, M., Mintz, G. S., Maehara, A., Stone, G. W., & Généreux, P. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.017 · Cited by 579
Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography
Irkle, A., Vesey, A. T., Lewis, D. Y., Skepper, J. N., Bird, J. L. E., Dweck, M. R., Joshi, F. R., Gallagher, F. A., Warburton, E. A., Bennett, M. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms8495 · Cited by 468
Self-citationJaminon, A., Reesink, K., Kroon, A., & Schurgers, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225694 · Cited by 305
Dweck, M. R., Jenkins, W. S. A., Vesey, A. T., Pringle, M. A. H., Chin, C. W. L., Malley, T. S., Cowie, W. J. A., Tsampasian, V., Richardson, H., Fletcher, A., et al. (2014) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.113.001508 · Cited by 260
Self-citationGating Approaches in Cardiac PET Imaging
Lassen, M. L., Kwiecinski, J., & Slomka, P. J. (2019) · PET Clinics · doi:10.1016/j.cpet.2018.12.008 · Cited by 38
Metadata
- Authors
- Dweck, M. R., Chow, M. W. L., Joshi, N. V., Williams, M. C., Jones, C., Fletcher, A. M., Richardson, H., White, A., McKillop, G., van Beek, E. J. R., Boon, N. A., Rudd, J. H. F., & Newby, D. E.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 59
- Issue
- 17
- Pages
- 1539-1548
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W121634664
- Cited by
- 488
- References
- 41
- FWCI
- 26.48
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Coronary Arterial 18F-Sodium Fluoride Uptake. https://app.cochat.ai/papers/10.1016/j.jacc.2011.12.037
- The paper
- Dweck, M. R., Chow, M. W. L., Joshi, N. V., Williams, M. C., Jones, C., Fletcher, A. M., Richardson, H., White, A., McKillop, G., van Beek, E. J. R., Boon, N. A., Rudd, J. H. F., & Newby, D. E. (2012). Coronary Arterial 18F-Sodium Fluoride Uptake. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2011.12.037
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
