The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker
Open accessAbstract
OBJECTIVES: This study reports on the performance of a leadless ventricular pacemaker with automated, enhanced accelerometer-based algorithms that provide atrioventricular (AV) synchronous pacing. BACKGROUND: Despite many advantages, leadless pacemakers are currently only capable of single-chamber ventricular pacing. METHODS: The prospective MARVEL 2 (Micra Atrial tRacking using a Ventricular accELerometer 2) study assessed the performance of an automated, enhanced accelerometer-based algorithm downloaded to the Micra leadless pacemaker for up to 5 h in patients with AV block. The primary efficacy objective was to demonstrate the superiority of the algorithm to provide AV synchronous (VDD) pacing versus VVI-50 pacing in patients with sinus rhythm and complete AV block. The primary safety objective was to demonstrate that the algorithm did not result in pauses or heart rates of >100 beats/min. RESULTS: Overall, 75 patients from 12 centers were enrolled; an accelerometer-based algorithm was downloaded to their leadless pacemakers. Among the 40 patients with sinus rhythm and complete AV block included in the primary efficacy objective analysis, the proportion of patients with ≥70% AV synchrony at rest was significantly greater with VDD pacing than with VVI pacing (95% vs. 0%; p < 0.001). The mean percentage of AV synchrony increased from 26.8% (median: 26.9%) during VVI pacing to 89.2% (median: 94.3%) during VDD pacing. There were no pauses or episodes of oversensing-induced tachycardia reported during VDD pacing in all 75 patients. CONCLUSIONS: Accelerometer-based atrial sensing with an automated, enhanced algorithm significantly improved AV synchrony in patients with sinus rhythm and AV block who were implanted with a leadless ventricular pacemaker. (Micra Atrial Tracking Using a Ventricular Accelerometer 2 [MARVEL 2]; NCT03752151).
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Cites
A Leadless Intracardiac Transcatheter Pacing System
Reynolds, D., Duray, G. Z., Omar, R., Soejima, K., Neuzil, P., Zhang, S., Narasimhan, C., Steinwender, C., Brugada, J., Lloyd, M., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1511643 · Cited by 933
Self-citationLamas, G. A., Orav, E. J., Stambler, B. S., Ellenbogen, K. A., Sgarbossa, E. B., Huang, S. K. S., Marinchak, R. A., Estes, N. A. M., Mitchell, G. F., Lieberman, E. H., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804163381602 · Cited by 631
Udo, E. O., Zuithoff, N. P. A., van Hemel, N. M., de Cock, C. C., Hendriks, T., Doevendans, P. A., & Moons, K. G. M. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.014 · Cited by 597
Trends in Permanent Pacemaker Implantation in the United States From 1993 to 2009
Greenspon, A. J., Patel, J. D., Lau, E., Ochoa, J. A., Frisch, D. R., Ho, R. T., Pavri, B. B., & Kurtz, S. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.017 · Cited by 478
El-Chami, M. F., Al-Samadi, F., Clementy, N., Garweg, C., Martinez-Sande, J. L., Piccini, J. P., Iacopino, S., Lloyd, M., Viñolas Prat, X., Jacobsen, M. D., et al. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.08.005 · Cited by 355
Self-citationDuray, G. Z., Ritter, P., El-Chami, M., Narasimhan, C., Omar, R., Tolosana, J. M., Zhang, S., Soejima, K., Steinwender, C., Rapallini, L., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.01.035 · Cited by 302
Self-citationAmas, A. L., Rav, E. J. O. O., Tambler, S. S., Enneth, K., Llenbogen, A. E., Garbossa, E. L. B. S., Tephen, S. H. K. S., Uang, H., Arinchak, R. O. A. M., Stes, E., et al. (1998) · Cited by 264
Nielsen, J. C., Andersen, H. R., Thomsen, P. E. B., Thuesen, L., Mortensen, P. T., Vesterlund, T., & Pedersen, A. K. (1998) · Circulation · doi:10.1161/01.cir.97.10.987 · Cited by 229
Chinitz, L., Ritter, P., Khelae, S. K., Iacopino, S., Garweg, C., Grazia-Bongiorni, M., Neuzil, P., Johansen, J. B., Mont, L., Gonzalez, E., et al. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.05.004 · Cited by 170
Self-citationEvidence Base for Pacemaker Mode Selection: From Physiology to Randomized Trials
Lamas, G. A., Ellenbogen, K. A., & With the Assistance of Charles H. Hennekens, M. (2004) · Circulation · doi:10.1161/01.cir.0000115642.05037.0e · Cited by 79
Cited by
2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab364 · Cited by 2,019
2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2022) · EP Europace · doi:10.1093/europace/euab232 · Cited by 914
A Dual-Chamber Leadless Pacemaker
Knops, R. E., Reddy, V. Y., Ip, J. E., Doshi, R., Exner, D. V., Defaye, P., Canby, R., Bongiorni, M. G., Shoda, M., Hindricks, G., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2300080 · Cited by 283
Lampert, R., Chung, E. H., Ackerman, M. J., Arroyo, A. R., Darden, D., Deo, R., Dolan, J., Etheridge, S. P., Gray, B. R., Harmon, K. G., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.05.018 · Cited by 167
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Metadata
- Authors
- Steinwender, C., Khelae, S. K., Garweg, C., Chan, J. Y. S., Ritter, P., Johansen, J. B., Sagi, V., Epstein, L. M., Piccini, J. P., Pascual, M., Mont, L., Sheldon, T., Splett, V., Stromberg, K., Wood, N., & Chinitz, L.
- Venue
- JACC: Clinical Electrophysiology
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 6
- Issue
- 1
- Pages
- 94-106
- ISSN
- 2405-500X (ISSN-L)
- OpenAlex
- W2987720593
- Cited by
- 257
- References
- 12
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Steinwender, C., Khelae, S. K., Garweg, C., Chan, J. Y. S., Ritter, P., Johansen, J. B., Sagi, V., Epstein, L. M., Piccini, J. P., Pascual, M., Mont, L., Sheldon, T., Splett, V., Stromberg, K., Wood, N., & Chinitz, L. (2020). Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker. JACC: Clinical Electrophysiology. https://doi.org/10.1016/j.jacep.2019.10.017
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