Cited by 627Dermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

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IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells

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Nograles, Kristine E., Zaba, Lisa C., Shemer, Avner, Fuentes-Duculan, Judilyn, Cardinale, Irma, Kikuchi, Toyoko, Ramon, Michal, Bergman, Reuven, Krueger, James G., Guttman-Yassky, Emma·2009·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2009.03.041PMC PMC2874584

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Abstract

Background Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of TH17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear.Objective To examine differences in IL-23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets in AD.Methods Skin biopsies and peripheral blood were collected from patients with chronic AD (n = 12) and psoriasis (n = 13). Relative frequencies of CD4+ and CD8+ T-cell subsets within these 2 compartments were examined by intracellular cytokine staining and flow cytometry.Results In peripheral blood, no significant difference was found in percentages of different T-cell subsets between these diseases. In contrast, psoriatic skin had significantly increased frequencies of TH1 and TH17 T cells compared with AD, whereas TH2 T cells were significantly elevated in AD. Distinct IL-22-producing CD4+ and CD8+ T-cell populations were significantly increased in AD skin compared with psoriasis. IL-22+CD8+ T-cell frequency correlated with AD disease severity.Conclusion Our data established that T cells could independently express IL-22 even with low expression levels of IL-17. This argues for a functional specialization of T cells such that "T17" and "T22" T-cells may drive different features of epidermal pathology in inflammatory skin diseases, including induction of antimicrobial peptides for "T17" T cells and epidermal hyperplasia for "T22" T-cells. Given the clinical correlation with disease severity, further characterization of "T22" T cells is warranted, and may have future therapeutic implications.

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Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054
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Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,886
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Lowes, M. A., Kikuchi, T., Fuentes‐Duculan, J., Cardinale, I. R., Zaba, L. C., Haider, A. S., Bowman, E. P., & Krueger, J. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701213 · Cited by 1,085
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Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3695 · Cited by 864
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Self-citation
Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis
Koga, C., Kabashima, K., Shiraishi, N., Kobayashi, M., & TOKURA, Y. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.111 · Cited by 680
IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation
Ma, H., Liang, S. C., Li, J., Napierata, L., Brown, T., Benoit, S., Senices, M., Gill, D. S., Dunussi‐Joannopoulos, K., Collins, M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33263 · Cited by 555
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
Kim, B. E., Leung, D. Y. M., Boguniewicz, M., & Howell, M. D. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.006 · Cited by 538

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Impaired Toll-like receptor 2-mediated Th1 and Th17/22 cytokines secretion in human peripheral blood mononuclear cells from patients with atopic dermatitis
Yu, Y., Zhang, Y., Zhang, J., Dou, X., Yang, H. S., Shao, Y., Wang, K., Yu, B., Zhang, W., & Lau, H. Y. A. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0744-1 · Cited by 15
“On the other hand, the number of IL-22+CD8+T-cell is correlated with chronic AD disease severity [32].”
Background
Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
Ma, X., Ru, Y., Luo, Y., Kuai, L., Chen, Q., Bai, Y. C., Liu, Y., Chen, J., Luo, Y. Y., Song, J., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.942838 · Cited by 14
“With the further identification of adaptive immunity in AD, acute lesions are always driven by the TH2/TH22 dominant allergic responses, while chronic lesions are driven by a TH1 response (Nograles et al., 2009; Lou et al., 2017).”
Background
Efficacy and anti-inflammatory properties of low-molecular-weight fucoidan in patients with atopic dermatitis: a randomized double-blinded placebo-controlled trial
Shih, H.-L., Wang, P.-H., Shih, I., Hu, S., Lin, J., Hsu, P.-Y., & Yang, S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2292472 · Cited by 15
“[32,47] Another study showed that IgG of AD patients can stimulate IL-17 and IL-10 production in infant intrathymic CD4 and CD8 cells.”
Advances in the Diagnosis and Therapeutic Management of Atopic Dermatitis
Vestergaard, C., & Deleuran, M. S. (2014) · Drugs · doi:10.1007/s40265-014-0219-3 · Cited by 14
The role of heterodimer IL 17A/F in atopic dermatitis
Krzysiek, J., Lesiak, A., Szybka, M., Michalak, A., Pastuszak‐Lewandoska, D., Grzegorczyk, J. Ł., Ciążyńska, M. A., & Narbutt, J. (2022) · Advances in Dermatology and Allergology · doi:10.5114/ada.2022.122604 · Cited by 14
“It was discovered that IL-17 was significantly increased in AD skin in contrast to non-lesional skin but it was lower than in psoriatic plaque [27, 28].”
Background
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+T cell responses against a HBV DNA vaccine in mice
Wu, B., Zou, Q., Hu, Y., & Wang, B. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.26047 · Cited by 14
Genetic Basis of Irritant Susceptibility in Health Care Workers
Yücesoy, B., Talzhanov, Y. A., Barmada, M. M., Johnson, V. J., Kashon, M. L., Baron, E. D., Wilson, N. W., Frye, B. L., Wang, W., Fluharty, K. L., et al. (2016) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000784 · Cited by 14
“38 Interestingly, atopic dermatitis is known to be worsened by alkaline pH, and NaOH is a very alkaline irritant.”
T helper type 2 signatures in atopic dermatitis
Furue, M. (2018) · Journal of Cutaneous Immunology and Allergy · doi:10.1002/cia2.12023 · Cited by 14
“anti–IL‐4 receptor α antibody dupilumab and the anti–IL‐22 antibody fezakinumab(45,46) Although a potential role for the IL‐17–producing Th17 cells has been proposed in AD,(47,48) conflicting results have been reported.(49,50) Despite a low phylogenetic homology of the IL‐31 gene in mammals, administration of IL‐31 ca…”
Background
The efficacy and immunological effects of upadacitinib in the treatment of moderate-to-severe Chinese atopic dermatitis patients
Li, L., Wu, N., Liu, T., Yu, G., Wang, Y., He, T., Mao, R., Yang, L., Li, Y., Shen, C., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111193 · Cited by 13
Preventing NLRP3 inflammasome activation: Therapeutic atrategy and challenges in atopic dermatitis
Sun, Y., Zhou, Y., Peng, T., Huang, Y., Lü, H., Ying, X., Kang, M., Jiang, H., Wang, J., Zheng, J., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113696 · Cited by 14
Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases
Zhang, M., Miura, T., Suzuki, S., Chiyotanda, M., Tanaka, S., Sugiyama, K., Kawashima, H., & Hirano, T. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b20-00079 · Cited by 13
IL-22 Downregulates Peptidylarginine Deiminase-1 in Human Keratinocytes: Adding Another Piece to the IL-22 Puzzle in Epidermal Barrier Formation
Padhi, A., Srivastava, A., Ramesh, A., Ehrström, M., Simon, M., Sonkoly, E., Eidsmo, L., Bergman, P., & Lysell, J. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.07.155 · Cited by 13
Anti-inflammatory and immunomodulatory effects of polysaccharide extracted from Wuguchong (maggot) on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice
Peng, F., Zong, J., Zhao, T., Shi, P., Lu, M., Qu, X., Han, X., Zhao, L., Jia, Z., & Wang, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1119103 · Cited by 12
“IL-22 plays vital roles in AD initiation, development, and severity, partly by inducing epithelial Th2 cytokines production and the GRP pathway activation (Nograles et al., 2009; Lou et al., 2017).”
Background
Topical delgocitinib for the treatment of chronic hand eczema
Abdelhalim, A., Yilmaz, O., Berair, M. E., & Torres, T. R. (2025) · Journal of Dermatological Treatment · doi:10.1080/09546634.2025.2479126 · Cited by 12
“Elevated IL-22 levels further disrupt the skin barrier in AD (29).”
IL-6 Negatively Regulates IL-22RαExpression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis
Frempah, B., Luckett‐Chastain, L. R., & Gallucci, R. M. (2019) · Journal of Immunology Research · doi:10.1155/2019/6276254 · Cited by 12
“IL-22 also promotes epidermal barrier disruption and pruritus and has been reported to play a role in the pathogenesis of atopic dermatitis [5, 16].”
Background
Topical and systemic JAK inhibitors in hand eczema – a narrative review
Zalewski, A., & Szepietowski, J. C. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2174526 · Cited by 12
“function IL-22 expression is found to be upregulated in AD patients skin biopsies [38].”
Background
Phenotypic analysis of perennial airborne allergen‐specific CD4+ T cells in atopic and non‐atopic individuals
Crack, L. R., Chan, H., McPherson, T., & Ogg, G. S. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03819.x · Cited by 12
Investigation of the role of IL18, IL-1β and NLRP3 inflammasome in reducing expression of FLG-2 protein in Psoriasis vulgaris skin lesions
Akhlaghi, M., Karrabi, M., Atabti, H., Raoofi, A., & Khaneghah, A. M. (2021) · Biotechnic & Histochemistry · doi:10.1080/10520295.2021.1954692 · Cited by 12
“Nograles et al. (2009) reported that epidermal barrier proteins are impaired in psoriasis.”
Background
Effect of Enterococcus faecalis EF-2001 on experimentally induced atopic eczema in mice
Choi, E., Iwasa, M., Han, K.-I., Kim, W.-J., Tang, Y., Han, W. C., Kim, E., & Park, Z. (2016) · Food Science and Biotechnology · doi:10.1007/s10068-016-0175-7 · Cited by 12
Induction of skin-pathogenic Th22 cells by epicutaneous allergen exposure
Glocova, I., Brück, J., Geisel, J., Müller‐Hermelink, E., Widmaier, K., Yazdi, A. S., Röcken, M., & Ghoreschi, K. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.06.006 · Cited by 13
Epithelial-Mesenchymal Transition in Atopy: A Mini-Review
Anderson, E. D., Alishahedani, M. E., & Myles, I. A. (2020) · Frontiers in Allergy · doi:10.3389/falgy.2020.628381 · Cited by 11
Predictive biomarker modeling of pediatric atopic dermatitis severity based on longitudinal serum collection
Engle, S., Chang, C.-Y., Ulrich, B. J., Satterwhite, A., Hayes, T. A., Robling, K., Sissons, S. E., Schmitz, J., Tepper, R. S., Kaplan, M. H., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab009 · Cited by 11
“Analytes described as drivers of adult AD, such as IL-22 and IL-17A [7, 22], did not possess strong correlations to disease severity within these pediatric AD samples.”
BackgroundInfluential
Child with atopic dermatitis
Kanchongkittiphon, W., Gaffin, J. M., & Phipatanakul, W. (2014) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2014.08.016 · Cited by 11
The importance of cytokines for the atopic dermatitis pathogenesis
Varlamov, E. E., Pampura, A. N., & Sukhorukov, V. S. (2018) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2018-63-1-28-33 · Cited by 11
“У пациентов с тяжелым дерматитом выявлена положительная корреляция между количеством продуцирующих ИЛ-22 клеток и уровнем IgE и индексом SCORAD [42].”
The role of IL-22 in the pathogenesis of skin diseases
Fujita, H. (2012) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.35.168 · Cited by 11
Monoclonal Antibodies for Atopic Dermatitis: Progress and Potential
Vakharia, P. P., & Silverberg, J. I. (2017) · BioDrugs · doi:10.1007/s40259-017-0241-6 · Cited by 10
T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T‐cell costimulator
Jiao, Q., Qian, Q., Liu, C., Luo, Y., Fang, F., Wang, M., Ji, J. H., Qian, H., Zhang, X., & Maurer, M. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18040 · Cited by 10
Personalized Management of Atopic Dermatitis: Beyond Emollients and Topical Steroids
Bieber, T. R. M. (2015) · Springer eBooks · doi:10.1007/978-3-662-45840-2_5 · Cited by 10
Depletion of IL-22 during culture enhanced antigen-driven IFN-γ production by CD4+T cells from patients with active TB
Qiu, Y., Huang, Y., Chen, J., Qiao, D., Zeng, G., & Cai, J. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.12.008 · Cited by 10
Cat Allergy as a Source Intensification of Atopic Dermatitis in Adult Patients
Jaworek, A., Szafraniec, K., Jaworek, M., Doniec, Z., Zalewski, A., Kurzawa, R., Wojas‐Pelc, A., & Pokorski, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_451 · Cited by 10
A Staphylococcus epidermidis strain inhibits the uptake of Staphylococcus aureus derived from atopic dermatitis skin into the keratinocytes
Numata, T., Iwamoto, K., Matsunae, K., Miyake, R., Suehiro, M., Yanagida, N., Kan, T., Takahagi, S., Hide, M., & Tanaka, A. (2024) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2024.01.006 · Cited by 9
The Future of Atopic Dermatitis Treatment
Patel, N., & Strowd, L. C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-64804-0_15 · Cited by 9
Emerging drugs for the treatment of chronic pruritic diseases
Fourzali, K. M., Golpanian, R. S., & Yosipovitch, G. (2020) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2020.1801632 · Cited by 9
Association between Serum IL-16 Levels and the Degree of Sensitization in Patients with Atopic Dermatitis
Nagy, G., Gáspár, K., Irinyi, B., Gál, M., Tumpek, J., Gyimesi, E., Sipka, S., Remenyik, É., Szodoray, P., & Szegedi, A. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000321959 · Cited by 9
HSP: Bystander Antigen in Atopic Diseases?
Aalberse, J. A., Prakken, B. J., & Kapitein, B. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00139 · Cited by 9
MicroRNAs in atopic dermatitis: a review
Bhardwaj, N. (2017) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2017.01 · Cited by 9
“High levels of chemokine ligand (CCL) 27 can be found in chronic AD lesions([13]).”
Background
Assessment of Periodontal status in Patients with Psoriatic Arthritis: A retrospective, case-control study
Mishra, S. K., Johnson, L. A., Agrawal, S., & Rajput, S. (2021) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.58125 · Cited by 9
“The crosstalk between the innate and adaptive immunity that sustain chronic inflammation, resulting in dysregulation and excessive production of various pro-inflammatory cytokines like TNF-α, IL-17, IL-1β, IL-22 and IL-2316, (40,41) suggesting a possible link between PsA and periodontitis.”
Background
p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice
Lee, J., Son, S.-H., Kim, N., & Im, D. (2022) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2022.024 · Cited by 9
“Although TH2 helper cells are crucial in the acute phase of AD, TH1/TH17/TH22 helper cells play fundamental roles in the chronic phase of AD pathogenesis (Spergel et al., 1999; Chen et al., 2004; Koga et al., 2008; Nograles et al., 2009; Souwer et al., 2010).”
Background
[Interleukin-17 as a therapeutic target in psoriasis].
Torres, T. R., & Filipe, P. (2014) · PubMed · Cited by 9
The Newly Identified T Helper 22 Cells Lodge in Leukemia.
Azizi, G., Rastegari‐Pouyani, M., Navabi, S. S., Yazdani, R., Kiaee, F., & Mirshafiey, A. (2015) · Europe PMC (PubMed Central) · Cited by 9
Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis
Kumar, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188788 · Cited by 12
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Singh, P., Gáspár, K., Szegedi, A., Sajtos, L., Baráth, S., & Hevessy, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063486 · Cited by 8
“Significantly higher amounts of IL-22-producing T cells are distinct in AD patients [30].”
Background
Emerging treatments for atopic dermatitis
Katoh, N. (2020) · The Journal of Dermatology · doi:10.1111/1346-8138.15504 · Cited by 8
Recent advances on the role of cytotoxic T lymphocytes in the pathogenesis of spondyloarthritis
Tang, M., & Inman, R. D. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00846-z · Cited by 8
Immunohistopathological Analysis of Immunoglobulin E-Positive Epidermal Dendritic Cells with House Dust Mite Antigens in Naturally Occurring Skin Lesions of Adult and Elderly Patients with Atopic Dermatitis
Tanei, R., & Hasegawa, Y. (2021) · Dermatopathology · doi:10.3390/dermatopathology8030045 · Cited by 8
“In the present immunohistopathological studies with double-immunofluorescence staining techniques for adult and elderly patients with IgE-allergic AD and HDM allergy, we confirmed that along with T-cell infiltration, IgE-bearing IDECs (CD11c+ and CD206+ cells) infiltrated and aggregated in the central area of the spon…”
Background
Different cytokine profiles of skin-derived T cell cultures from patients with atopic dermatitis and psoriasis
Martel, B. C., Dyring‐Andersen, B., Skov, L., Thestrup‐Pedersen, K., Skov, S., Skak, K., & Poulsen, L. K. (2015) · Inflammation Research · doi:10.1007/s00011-015-0912-z · Cited by 8
“Psoriasis is an inflammatory skin disease considered to be partially divergent from AD with regard to the T cell subsets involved in their underlying immune response, with Th17 and Th1 cytokines dominating psoriatic lesions [7].”
Background
Th17 cells and skin diseases
TOKURA, Y. (2012) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.35.388 · Cited by 8
Cytokines et différenciation lymphocytaire T au cours de la sclérodermie systémique
Trad, S., Granel, B., Parizot, C., Dorgham, K., Hanslik, T., Marié, I., & Amoura, Z. (2010) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2010.07.015 · Cited by 9
Pemphigus foliaceus patients (Fogo Selvagem) treated with kinesiotherapy presented lower levels of proinflammatory cytokines
Timóteo, R. P., Sales‐Campos, H., da Silva, M. V., da Silva, D. A. A., Catarino, J. D. S., de Sousa, M. A. D., Rodrigues, V., Andrade-Silva, L. E., Bittencourt, A. C. S., Carneiro, É. M., et al. (2019) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1938146.073 · Cited by 8
“Different studies have demonstrated a positive correlation between higher levels of IL-22 and inflammatory disorders in skin, such as psoriasis (Benham et al., 2013) and atopic dermatitis (Nograles et al., 2009).”
Background
Bath Psoralen Plus UVA Therapy Suppresses Keratinocyte-Derived Chemokines in Pathogenetically Relevant Cells
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“, 2010) and skin lesions (Nograles et al., 2009) of patients with psoriasis.”
Background
The Aryl Hydrocarbon Receptor and Immunity
Sulentic, C. E. W., Snyder, A. D., & Salisbury, R. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64231-9 · Cited by 8
Inflammasome pathways in atopic dermatitis: insights into inflammatory mechanisms and therapeutic targets
Ramos, Y. Á. L., Pietrobon, A. J., Teixeira, F. M. E., Aoki, V., Sato, M. N., & Orfali, R. L. (2025) · Anais Brasileiros de Dermatologia · doi:10.1016/j.abd.2025.501136 · Cited by 7
Suppression of IL-17A-induced CCL20 production by cytokine inducible SH2-containing protein 1 in epidermal keratinocytes
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IL-17 family cytokines in inflammatory or autoimmune skin diseases
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Patho‐immunological mechanisms of atopic dermatitis: The role of the three major human microbiomes
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“83 In contrast, the elevation of IL-22 levels in psoriasis is caused by polarization to a Th1/Th17 phenotype, and the majority of IL-22 is produced by Th17 cells.”
ACTUAL CONCEPTION OF ALLERGEN-SPECIFIC IMMUNOTHERAPY MECHANISMS, POTENTIAL BIOMARKERS OF EFFICACY AND WAYS OF ENHANCEMENT
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Increased Interleukin-36β Expression Promotes Angiogenesis in Japanese Atopic Dermatitis
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“The expression of IL-22, mainly produced by Th17 cells and Th22 cells, is elevated in AD patients [10] and fezakinumab, an antibody to IL-22, was effective for severe AD in the clinical trial [11].”
Background
News from dendritic cells in atopic dermatitis
Schäkel, K., & Hänsel, A. (2011) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32834a977a · Cited by 7
The enigmatic role of IL-22 in asthma
Manni, M. L., & Alcorn, J. F. (2016) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2016.1174580 · Cited by 7
“[34,38], hepatitis [39,40], psoriasis [41], atopic dermatitis [20], rheumatoid arthritis [42], inflammatory bowel diseases [43– 46], and asthma (as discussed herein).”
Background
Emerging systemic therapies for atopic dermatitis: biologics
Nusbaum, K. B., Nguyen, C., & Fleischer, A. B. (2020) · Journal of Dermatological Treatment · doi:10.1080/09546634.2020.1836314 · Cited by 7
Atopic Eczema (Atopic Dermatitis)
Ardern‐Jones, M. R., Flohr, C., Reynolds, N. J., & Holden, C. A. (2016) · doi:10.1002/9781118441213.rtd0042 · Cited by 7
Comparison of CD30L and OX40L Reveals CD30L as a Promising Therapeutic Target in Atopic Dermatitis
Gupta, R. K., Figueroa, D. S., Ay, F., Causton, B., Abdollahi, S., & Croft, M. (2024) · Allergy · doi:10.1111/all.16412 · Cited by 6
A translational approach to improve therapeutics in atopic dermatitis and beyond
Liu, D., Patel, D., Lau, M., Largen, J., Hu, B., He, H., & Guttman‐Yassky, E. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf049 · Cited by 7
Self-citation
Biologic Therapy for Psoriatic Arthritis or Moderate to Severe Plaque Psoriasis: Systematic Review with Pairwise and Network Meta-Analysis
Peruzzi, M., Colombo, D., FALCO, E. D., Chimenti, I., Abbate, A., Frati, G., & Biondi‐Zoccai, G. (2014) · International Journal of Statistics in Medical Research · doi:10.6000/1929-6029.2014.03.02.1 · Cited by 6
“Biologics belong to four broad categories, which correspond to the main inflammation mechanisms involved in this condition [16-19].”
Background
The use of biopharmaceuticals in the treatment of psoriasis
Partyka, A., Czopek, A., Stanisz‐Wallis, K., & Zagórska, A. (2018) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0012.2026 · Cited by 7
CD4+ T cell depletion changes the cytokine environment from a TH1/TH2 response to a TC17-like response in a murine model of atopic dermatitis
Christensen, G. B., Hvid, M., Kvist, P. H., Deleuran, B. W., Deleuran, M. S., Vestergaard, C., & Kemp, K. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.04.010 · Cited by 6
“However, Nograles et al have recently reported an increased level of IL-22 in both CD4 and CD8 cells within the skin lesions of AD patients, which further supports our data [27].”
Result
Evaluation of the cutaneous expression of IL-17, IL-22, IL-31, and their receptors in canine atopic dermatitis
Shiomitsu, S., Gillen, J., Frasca, S., & Santoro, D. (2021) · Research in Veterinary Science · doi:10.1016/j.rvsc.2020.12.015 · Cited by 6
Treatment of Atopic Dermatitis Using JAK Inhibitors: A Systematic Review
Siedlikowski, S. T., Sandhu, V. K., & Lynde, C. W. (2019) · EMJ Dermatology · doi:10.33590/emjdermatol/10312649 · Cited by 6
Interleukin‐22‐producing T cells: a specialized population involved in skin inflammation?
Yssel, H., & Pène, J. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.68 · Cited by 6
Peripherally induced RORγt + skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy
Zhang, K., Kim, S. M., Kwon, H., Kim, S. H., Kim, T., Sun, Z., Kim, H. L., Tyo, A., Kim, J. H., Kim, R. G., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.ado1375 · Cited by 5
Clinical characteristics and management of dupilumab-associated ocular surface disease in Japan
Shoji, J., & Ebihara, N. (2025) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-025-01299-9 · Cited by 5
“Th22 cells in the skin lesions of patients with AD are more frequent than in those of patients with psoriasis [69].”
Psoriasis Treatments: A Review of the Current Research Pipeline
Golant, A., & Guttman‐Yassky, E. (2011) · Psoriasis Forum · doi:10.1177/247553031117a00102 · Cited by 5
Self-citation
Interleukin antagonists for atopic dermatitis: a new era of therapy
Tsiogka, A., Paschou, E., Koumaki, D., Vakirlis, E., & Gregoriou, S. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2347294 · Cited by 5
“Activation of IL-22 signaling has been associated with upregulation of antimicrobial peptides in the epidermis, promotion of keratinocyte proliferation and inhibition of their terminal differentiation, contributing significantly in skin barrier dysfunction and epidermal hyperplasia [47–50].”
Background
The atopic skin‐like microenvironment modulates the T ‐cell‐polarising cytokine production of myeloid dendritic cells, as determined by laser scanning cytometry
Nagy, G., Doan‐Xuan, Q., Gáspár, K., Mócsai, G., Kapitány, A., Törőcsik, D., Bacsó, Z., Gyimesi, E., Remenyik, É., Bı́ró, T., et al. (2014) · Experimental Dermatology · doi:10.1111/exd.12342 · Cited by 5
Lipid Nutrition and the Epidermal Barrier: The Connection Between Immune-Mediated Inflammatory Diseases and Peroxisome Proliferator-Activated Receptors, a New Therapeutic Target in Psoriasis and Atopic Dermatitis
Villarrubia, V. G., Vidal‐Asensi, S., Bañasco, V. P., Santos, J. C., & Cisterna-Cáncer, R. (2010) · Actas Dermo-Sifiliográficas · doi:10.1016/s1578-2190(10)70681-8 · Cited by 5
Adaptive Immunantworten und damit verbundene Triggerfaktoren bei atopischer Dermatitis
Heratizadeh, A., Werfel, T., & Rösner, L. M. (2014) · Der Hautarzt · doi:10.1007/s00105-014-3559-8 · Cited by 5
Rotavirus regulates the gut microhabitat immune response through the IL-22/pSTAT3/RegIIIγ signaling pathway, leading to lactose intolerance
Shen, J., Xiao, Y., Hui-juan, B., Guo, R., Qu, M., Ding, R., Zhang, X., Li, H., Han, M., & Huang, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114275 · Cited by 4
A specific molecular signature for psoriasis and eczema.
Coimbra, S., & Santos‐Silva, A. (2015) · PubMed Central · doi:10.3978/j.issn.2305-5839.2015.01.24 · Cited by 4
“However, other authors defend that activation of Th2 cells and of the Th22 pathway results in reactive epidermal hyperplasia (4).”
Background
Atopic Dermatitis and Allergic Contact Dermatitis
Leung, D. Y. M., & Boguniewicz, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37579-5.00011-8 · Cited by 4
Atopic and Contact Dermatitis
Boguniewicz, M., Fonacier, L. S., & Leung, D. Y. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-7020-6896-6.00044-2 · Cited by 4
Phenotypes and endotypes of atopic dermatitis: Clinical implications
Kim, M., & Kim, J. (2020) · Allergy Asthma & Respiratory Disease · doi:10.4168/aard.2020.8.1.9 · Cited by 4
Predicting Favorable Conditions for the Determination of Initial Use of Janus Kinase Inhibitors in Patients with Moderate to Severe Atopic Dermatitis
Park, J. H., Oh, S., Park, J., Choi, Y., & Lee, J. H. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124312 · Cited by 3
House Dust Mites Confer a Distinct Immunological Feature among Dermatitis.
Barış, S., Ozen, A. O., Akdeniz, F. T., Karakoç-Aydıner, E., Aydın, Ö., Sarıçoban, H. E., Öğülür, İ., Çamcıoğlu, Y., Cengizlier, R., Demirkesen, C., et al. (2016) · PubMed · Cited by 3
Emerging Targeted Treatments
Lee, G. R., Lee, D. E., & Shi, V. Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-84744-5.00023-1 · Cited by 3
Possible involvement of interleukin‐22‐producing CD103 + CD8 + T cells in the epidermal hyperplasia of atopic dermatitis
Kurihara, K., Fujiyama, T., TOKURA, Y., & Honda, T. (2022) · The Journal of Dermatology · doi:10.1111/1346-8138.16382 · Cited by 3
Exploratory analyses of biomarkers in blood and stratum corneum in patients with atopic dermatitis
Maruyama, A., Tamagawa‐Mineoka, R., Nishigaki, H., Masuda, K., & Katoh, N. (2022) · Medicine · doi:10.1097/md.0000000000031267 · Cited by 3
“Received: 14 September 2022 / Accepted: 19 September 2022 http://dx.doi.org/10.1097/MD.0000000000031267 chemokine (TARC),[15,16] CCL22/macrophage-derived chemokine,[17,18] and the Th22-related cytokine IL-22[17,19] in the blood and skin.”
BackgroundInfluential
Role of IL-22 in acute asthma mouse model
Kim, K. Y., Hur, J., Lee, H. Y., & Lee, S. Y. (2022) · Journal of Asthma · doi:10.1080/02770903.2022.2155186 · Cited by 3
“Moreover, the frequency of the IL-22-producing CD8+ T-cells is positively correlated with the severity of AD (10); IL-22, which is highly expressed in patients with AD, is deeply involved in epidermal hyperplasia and barrier defects (11,12).”
Background
Oral exposure to citrinin significantly exacerbates the pathophysiology of a mouse model of imiquimod‐induced psoriasis via direct activation of dendritic cell
Yamaguchi, H., Ando, M., Iwashita, N., Takagi, Y., Kushiro, M., & Fukuyama, T. (2023) · Journal of Applied Toxicology · doi:10.1002/jat.4462 · Cited by 3
“As a result of dendritic proliferation and TNFα secretion, differentiation and activation of Th17 and ILC17 cells are promoted (Nograles et al., 2009).”
Background
Skin repair and immunoregulatory effects of myeloid suppressor cells from human cord blood in atopic dermatitis
Kim, C., Hong, S.-M., Kim, S., Yu, J. I., Jung, S., Bang, C. H., Lee, J. H., & Kim, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1263646 · Cited by 3
The interaction between NK cells and ILC cells and their subsets in atopic dermatitis patients with and without dupilumab therapy
Boudková, P., Čermáková, E., Krejsek, J., & Čelakovská, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112327 · Cited by 3
Revisiting immunotherapeutic strategies for the management of atopic dermatitis
Siwe, G. T., Fajemisin, E. A., Mugeri, M., Naran, K., & Barth, S. (2024) · doi:10.37349/eaa.2024.00052 · Cited by 4
Elevation of Circulating Th17/Th22 Cells Exposed to Low-Level Formaldehyde and Its Relevance to Formaldehyde-Induced Occupational Allergic Contact Dermatitis
Mai, W., Liu, X., Su, G., Zhou, W., Wen, Z., & Lu, D. (2017) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001074 · Cited by 3
Interleukin (IL)‐13/IL‐22/IL‐31 skewing within the skin‐homing T‐cell population in papuloerythroderma
Takamura, S., & Teraki, Y. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15937 · Cited by 3
Expression and Function of CCL17 in Atopic Dermatitis
Stutte, S., Gerbitzki, N., Novak, N., & Frster, I. (2012) · InTech eBooks · doi:10.5772/25704 · Cited by 4
“In psoriasis, Th17 cells act together with Th1 cells in disease pathogenesis (Lowes et al., 2008; Nograles et al., 2009).”
BackgroundResult
Barrera epidérmica y nutrición lipídica. La conexión PPAR e inmunopatología inflamatoria como nuevas dianas de tratamiento en dermatitis atópica y psoriasis
Villarrubia, V. G., Vidal‐Asensi, S., Bañasco, V. P., Santos, J. C., & Cisterna-Cáncer, R. (2010) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2010.03.005 · Cited by 3
Contribution of IL-22 to Experimental Skin Inflammation
Lecron, J., Paris, I., Bernard, F., & Morel, F. (2012) · Springer eBooks · doi:10.1007/978-3-0348-0522-3_22 · Cited by 3
“Not specific of psoriasis, Th22 is also increased in lesional skin of atopic dermatitis [54].”
Background
Expression of interleukin-22 and its significance in the pathogenesis of chronic rhinosinusitis.
Wang, X., Gao, M., Xu, Y., Guo, H., & Zhao, C. (2014) · PubMed Central · Cited by 3
Cytokines and Chemokines
Turner, M. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-29785-9_15 · Cited by 5
Editorial update on emerging treatments of atopic dermatitis
Ong, P. Y. (2012) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2012.668884 · Cited by 3
“IL-22 expression is increased in AD lesions and contributes to the pathology of AD [9-11].”
Background
Identification of disease-specific regulatory networks in prurigo nodularis versus atopic dermatitis through ATAC/RNA single-nucleus profiling
Wu, Y., Wasikowski, R., Patrick, M. T., Gharaee‐Kermani, M., Xing, X., Billi, A. C., Kahlenberg, J. M., Julia, V., Gudjonsson, J. E., & Tsoi, L. C. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.08.026 · Cited by 3

Authors: Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E.
Affiliations: Rockefeller University (US)
Technion – Israel Institute of Technology (IL)
ORCID: Zaba, Lisa C.
Shemer, Avner
Krueger, James G.
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2009-06
Volume: 123
Issue: 6
Pages: 1244-1252.e2
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2009.03.041
PMC: PMC2874584
OpenAlex: W2164098277
Cited by: 627
References: 30
Citations by year: 2026: 13 · 2025: 17 · 2024: 21 · 2023: 23 · 2022: 28 · 2021: 39 · 2020: 39 · 2019: 28 · 2018: 25 · 2017: 49 · 2016: 49 · 2015: 51 · 2014: 52 · 2013: 34 · 2012: 47
FWCI: 65.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (GM 07739, T32GM007739)
National Center for Research Resources (UL1RR024143)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: atopic dermatitis, IL-22, IL-17, Th17 cells, Th2 cells, Th1 cells, IL-23, psoriasis, CD4+ T cells, CD8+ T cells, disease severity, epidermal hyperplasia, antimicrobial peptides, skin inflammation
MeSH terms: Interleukin-22, Adult, Chronic Disease, Dermatitis, Atopic, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Middle Aged, Psoriasis, T-Lymphocyte Subsets, Interleukin-17, Interleukin-23

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IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells

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