The DOI matches its Crossref record; 27 of the 30 references it cites were found in a registry or an index.
IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
Open accessAbstract
Background Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of TH17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear.Objective To examine differences in IL-23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets in AD.Methods Skin biopsies and peripheral blood were collected from patients with chronic AD (n = 12) and psoriasis (n = 13). Relative frequencies of CD4+ and CD8+ T-cell subsets within these 2 compartments were examined by intracellular cytokine staining and flow cytometry.Results In peripheral blood, no significant difference was found in percentages of different T-cell subsets between these diseases. In contrast, psoriatic skin had significantly increased frequencies of TH1 and TH17 T cells compared with AD, whereas TH2 T cells were significantly elevated in AD. Distinct IL-22-producing CD4+ and CD8+ T-cell populations were significantly increased in AD skin compared with psoriasis. IL-22+CD8+ T-cell frequency correlated with AD disease severity.Conclusion Our data established that T cells could independently express IL-22 even with low expression levels of IL-17. This argues for a functional specialization of T cells such that "T17" and "T22" T-cells may drive different features of epidermal pathology in inflammatory skin diseases, including induction of antimicrobial peptides for "T17" T cells and epidermal hyperplasia for "T22" T-cells. Given the clinical correlation with disease severity, further characterization of "T22" T cells is warranted, and may have future therapeutic implications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Circulating IL-22 correlates with the severity of AD and appears as a key driver in the inflammatory reaction116,119.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [116]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“IL-22 is an important part of the transcriptomic signature in AD116,117.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [116]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,886
Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells
Lowes, M. A., Kikuchi, T., Fuentes‐Duculan, J., Cardinale, I. R., Zaba, L. C., Haider, A. S., Bowman, E. P., & Krueger, J. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701213 · Cited by 1,085
Self-citationCytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3695 · Cited by 864
Nograles, K. E., Zaba, L. C., Guttman‐Yassky, E., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Cardinale, I. R., Khatcherian, A., Gonzalez, J., Pierson, K. C., White, T. R., et al. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08769.x · Cited by 816
Self-citationPossible Pathogenic Role of Th17 Cells for Atopic Dermatitis
Koga, C., Kabashima, K., Shiraishi, N., Kobayashi, M., & TOKURA, Y. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.111 · Cited by 680
Ma, H., Liang, S. C., Li, J., Napierata, L., Brown, T., Benoit, S., Senices, M., Gill, D. S., Dunussi‐Joannopoulos, K., Collins, M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33263 · Cited by 555
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
Kim, B. E., Leung, D. Y. M., Boguniewicz, M., & Howell, M. D. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.006 · Cited by 538
Cited by
Sorted by citations
Weidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,520
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I., Nalawade, S. A., Eagar, T. N., & Forsthuber, T. G. (2014) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,240
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
Boguniewicz, M., & Leung, D. Y. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01027.x · Cited by 1,100
“In addition, IL-17 expression was induced in the skin as well as in the airways in a murine epicutaneous antigen challenge model analogous to human AD (88).”
BackgroundInfluentialSonnenberg, G. F., Fouser, L. A., & Artis, D. (2011) · Nature Immunology · doi:10.1038/ni.2025 · Cited by 1,083
Trifari, S., Kaplan, C. D., Tran, E. H., Crellin, N. K., & Spits, H. (2009) · Nature Immunology · doi:10.1038/ni.1770 · Cited by 1,021
Gittler, J. K., Shemer, A., Suárez-Fariñas, M., Fuentes-Duculan, J., Gulewicz, K. J., Wang, C. Q. F., Mitsui, H., Cardinale, I., de Guzman Strong, C., Krueger, J. G., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.012 · Cited by 981
“%] in chronic AD skin) are within the psoriasis field, with few exceptions, including S100A7 and S100A8, which are synergistically induced by IL-17 and IL-22.”
BackgroundInfluentialSelf-citationInterleukin-22: Immunobiology and Pathology
Dudakov, J. A., Hanash, A. M., & van den Brink, M. R. M. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112123 · Cited by 939
“Initial studies regarding the effects of IL-22 in pathologies of the skin demonstrated that IL-22 levels were increased in T cell dermatoses, such as psoriasis and atopic dermatitis (23, 53).”
BackgroundMechanisms of allergen-specific immunotherapy
Akdiş, C. A., & Akdis, M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.030 · Cited by 829
Davidovici, B. B., Sattar, N. A., Prinz, J. C., Puig, L., Emery, P., Barker, J. N., van de Kerkhof, P., Ståhle, M., Nestle, F. O., Girolomoni, G., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.103 · Cited by 717
Self-citationGuttman‐Yassky, E., Bissonnette, R., Ungar, B., Suárez‐Fariñas, M., Ardeleanu, M., Esaki, H., Suprun, M., Estrada, Y. D., Xu, H., Peng, X., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.08.022 · Cited by 715
“Although dupilumab’s effects have proved that the type 2 pathway is central to AD pathogenesis, previous studies have shown that the TH22 and TH17 pathways can also play contributory roles in the AD phenotype and its epidermal pathology.(1,3-5,7,20,51,53,129,130) However, consistent robust efficacy in patients with AD…”
ResultSelf-citationTh2 Cytokines and Atopic Dermatitis
Brandt, E. B. (2011) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000110 · Cited by 658
“The presence of IL-22 producing cells was increased in AD compared to psoriasis [69], and a recent study showed that IL-22 down regulates filaggrin expression in keratinocytes [70].”
ResultThe immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies
Brunner, P. M., Guttman‐Yassky, E., & Leung, D. Y. M. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.01.011 · Cited by 662
Self-citationCirculating Th17, Th22, and Th1 Cells Are Increased in Psoriasis
Kagami, S., Rizzo, H. L., Lee, J. J. Y., Koguchi, Y., & Blauvelt, A. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.399 · Cited by 645
“Th22 cells are recently described inflammatory CD4þ T cells that produce IL-22, but do not express IL-17A or IFN-g (Duhen et al., 2009; Liu et al., 2009; Nograles et al., 2009; Trifari et al., 2009).”
Pathophysiology of atopic dermatitis: Clinical implications
Kim, J., Kim, B. E., & Leung, D. Y. M. (2019) · Allergy and Asthma Proceedings · doi:10.2500/aap.2019.40.4202 · Cited by 655
Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
Bieber, T. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00266-6 · Cited by 623
The Roles of CD8+ T Cell Subsets in Antitumor Immunity
Paul, M. S., & Ohashi, P. S. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.06.003 · Cited by 635
Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
Werfel, T., Allam, J., Biedermann, T., Eyerich, K., Gilles, S., Guttman‐Yassky, E., Hoetzenecker, W., Knol, E. F., Simon, H., Wollenberg, A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.010 · Cited by 603
“Although AD is established in adults as a disease with polarized T H 2 and T H 22 cytokine activation in both skin and blood, 36,49,50 early-onset AD begins as a T H 2 disease.”
Self-citationTherapeutic opportunities of the IL-22–IL-22R1 system
Sabat, R., Ouyang, W., & Wolk, K. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4176 · Cited by 588
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis
Kobayashi, T., Glatz, M., Horiuchi, K., Kawasaki, H., Akiyama, H., Kaplan, D. H., Kong, H. H., Amagai, M., & Nagao, K. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.014 · Cited by 566
“In addition to Th1 and Th2 responses in AD, emerging reports demonstrate the contributions of Th17 and Th22 (Gittler et al., 2012; Koga et al., 2008; Nograles et al., 2009; Suárez-Fariñas et al., 2013), suggesting that immune responses in AD are complex.”
ResultHe, H., Suryawanshi, H., Morozov, P. S., Gay-Mimbrera, J., DUCA, E. D., Kim, H. J., Kameyama, N., Estrada, Y. D., Der, E. B., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.01.042 · Cited by 510
Self-citationThe Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma
Zheng, T. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000202 · Cited by 520
“The importance of the role of IL-22 in human AD has become clearer as recent studies have demonstrated the frequency of IL-22–producing T cells in AD skin positively correlates with disease severity and the newly identified IL-13/IL-22– coproducing CD4+ T cells carrying cutaneous lymphocyte antigen contribute to the p…”
BackgroundSuárez-Fariñas, M., Dhingra, N., Gittler, J., Shemer, A., Cardinale, I., de Guzman Strong, C., Krueger, J. G., & Guttman-Yassky, E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.046 · Cited by 483
Self-citationThe Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
Weaver, C. T., Elson, C. O., Fouser, L. A., & Kolls, J. K. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130318 · Cited by 462
Suárez‐Fariñas, M., Tintle, S. J., Shemer, A., Chiricozzi, A., Nograles, K. E., Cardinale, I. R., Duan, S., Bowcock, A. M., Krueger, J. G., & Guttman‐Yassky, E. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.1124 · Cited by 469
Self-citationPerera, G. K., Meglio, P. D., & Nestle, F. O. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132448 · Cited by 480
Immunity against Staphylococcus aureus cutaneous infections
Miller, L. S., & Cho, J. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3010 · Cited by 439
Duhen, T., Duhen, R., Lanzavecchia, A., Sallusto, F., & Campbell, D. J. (2012) · Blood · doi:10.1182/blood-2011-11-392324 · Cited by 413
Furue, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155382 · Cited by 419
The multifunctional role of filaggrin in allergic skin disease
McAleer, M. A., & Irvine, A. D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.668 · Cited by 426
Atopic dermatitis: A practice parameter update 2012
Schneider, L. C., Tilles, S. A., Lio, P., Boguniewicz, M., Beck, L. A., LeBovidge, J., Novak, N., Bernstein, D., Blessing-Moore, J., Khan, D. A., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.672 · Cited by 420
Role of Treg in immune regulation of allergic diseases
Palomares, Ó., Yaman, G., Azkur, A. K., Akkoç, T., Akdiş, M., & Akdiş, C. A. (2010) · European Journal of Immunology · doi:10.1002/eji.200940045 · Cited by 402
The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside
Liu, T., Li, S., Ying, S., Tang, S., Ding, Y., Li, Y., Qiao, J., & Fang, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594735 · Cited by 406
Contrasting pathogenesis of atopic dermatitis and psoriasis—Part I: Clinical and pathologic concepts
Guttman‐Yassky, E., Nograles, K. E., & Krueger, J. G. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.053 · Cited by 400
Self-citationIL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis
Krueger, J. G., Fretzin, S., Suárez‐Fariñas, M., Haslett, P. A. J., Phipps, K. M., Cameron, G. S., McColm, J., Katcherian, A., Cueto, I., White, T. R., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.04.024 · Cited by 384
Self-citationEnvironmental risk factors and their role in the management of atopic dermatitis
Kantor, R. W., & Silverberg, J. I. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1212660 · Cited by 387
“plasia and disturbed terminal differentiation in AD [21].”
BackgroundThe concept of psoriasis as a systemic inflammation: implications for disease management
Reich, K. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04410.x · Cited by 361
Kabashima, K. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.02.001 · Cited by 360
“IL-22CD8 T-cell frequency correlated with AD disease severity [58].”
BackgroundMechanisms of allergen-specific immunotherapy and immune tolerance to allergens
Akdiş, C. A., & Akdiş, M. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-015-0063-2 · Cited by 372
“strated in T cells that independently express IL-22 with low expression levels of IL-17 and play a role in atopic dermatitis [94].”
BackgroundBiomarkers in atopic dermatitis—a review on behalf of the International Eczema Council
Renert-Yuval, Y., Thyssen, J. P., Bissonnette, R., Bieber, T., Kabashima, K., Hijnen, D., & Guttman-Yassky, E. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.01.013 · Cited by 350
Self-citationGuilloteau, K., Paris, I., Pedretti, N., Boniface, K., Juchaux, F., Huguier, V., Guillet, G., Bernard, F.-X., Lecron, J.-C., & Morel, F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902464 · Cited by 353
“Our data indirectly show that Th17 or even more specialized T cells, such as T17 or T22, can generate the inflammatory environment required to strongly modify the keratinocyte biological program (41).”
BackgroundRes, P. C. M., Pişkin, G., de Boer, O. J., van der Loos, C. M., Teeling, P., Bos, J. D., & Teunissen, M. B. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014108 · Cited by 335
Immunology of atopic eczema: overcoming the Th1/Th2 paradigm
Eyerich, K., & Novak, N. (2013) · Allergy · doi:10.1111/all.12184 · Cited by 329
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
Furue, M., Chiba, T., Tsuji, G., Ulzii, D., Kido‐Nakahara, M., Nakahara, T., & Kadono, T. (2017) · Allergology International · doi:10.1016/j.alit.2016.12.002 · Cited by 324
Molecular Dissection of Psoriasis: Integrating Genetics and Biology
Elder, J. T., Bruce, A. T., Gudjonsson, J. E., Johnston, A., Stuart, P. E., Tejasvi, T., Voorhees, J. J., Abecasis, G. R., & Nair, R. P. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.319 · Cited by 325
“More recently, we and others (Nograles et al., 2009) have made similar observations for IL-22.”
Skin Barrier Disruption: A Requirement for Allergen Sensitization?
Benedetto, A. D., Kubo, A., & Beck, L. A. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.435 · Cited by 320
“…humans where there is a remarkable paucity of tissue neutrophils in AD skin biopsies, despite modest expression of prototypic Th17 cytokines, suggesting that Th2 inflammation dampens the functional Th17 response (Guttman-Yassky et al., 2011a, b; Nograles et al., 2009; Suarez-Farinas et al., 2011).”
BackgroundResultGuttman‐Yassky, E., Nograles, K. E., & Krueger, J. G. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.054 · Cited by 316
Self-citationTargeting IL-10 Family Cytokines for the Treatment of Human DiseasesPreprint
Wang, X., Wong, K., Ouyang, W., & Rutz, S. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028548 · Cited by 316
“In contrast to psoriasis, the expression of IL-22 in AD ismainly derived fromTh22 cells and from IL-22-producing CD8 cells (Nograles et al. 2009).”
BackgroundResultBoisson, B., Wang, C., Pedergnana, V., Wu, L., Cypowyj, S., Rybojad, M., Belkadi, A., Picard, C., Abel, L., Fieschi, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.002 · Cited by 293
“result, at least in part, from the expansion of the IL-22 T cell population, as suggested by findings in humans (Nograles et al., 2009) and mice (Wang et al.”
Dhingra, N., Shemer, A., Correa da Rosa, J., Rozenblit, M., Fuentes-Duculan, J., Gittler, J. K., Finney, R., Czarnowicki, T., Zheng, X., Xu, H., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.009 · Cited by 305
“Quantitative real-time PCR and gene-array analysis RNA was extracted for real-time (RT)-PCR with EZ-PCR Core Reagents (Life Technologies, Grand Island, NY), and custom primers were generated.(36-43) Expression values were normalized to hARP.”
MethodSelf-citationHijnen, D., Knol, E. F., Gent, Y. Y. J., Giovannone, B., Beijn, S. J. P., Kupper, T. S., Bruijnzeel-Koomen, C. A. F. M., & Clark, R. A. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.456 · Cited by 288
Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis
Guttman-Yassky, E., Suárez-Fariñas, M., Chiricozzi, A., Nograles, K. E., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Lin, P., Bergman, R., Bowcock, A. M., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.031 · Cited by 268
Self-citationLiu, H., Archer, N. K., Dillen, C. A., Wang, Y., Ashbaugh, A. G., Ortines, R. V., Kao, T., Lee, S. K., Cai, S. S., Miller, R. J., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.006 · Cited by 263
Tibbitt, C. A., Stark, J. M., Martens, L., Ma, J., Mold, J. E., Deswarte, K., Oliynyk, G., Feng, X., Lambrecht, B. N., Bleser, P. D., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.014 · Cited by 261
Human Langerhans cells induce distinct IL-22-producing CD4 + T cells lacking IL-17 production
Fujita, H., Nograles, K. E., Kikuchi, T., Gonzalez, J., Carucci, J. A., & Krueger, J. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911472106 · Cited by 267
“Indeed, psoriasis skin lesions contain a population of T cells that cosynthesize IL-17 and IL-22, but the majority of IL-22-producing T cells are neither Th17, Th1, nor Th2 (6).”
BackgroundMethodInfluentialSelf-citationTh17 and Th22 cells in psoriatic arthritis and psoriasis
Benham, H., Norris, P. G., GOODALL, J. C., Wechalekar, M. D., FitzGerald, O., Szentpétery, Á., Smith, M., Thomas, R., & Gaston, H. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4317 · Cited by 254
“These T cells, subsequently termed Th22 cells, produce IL-22 without IL-17 or interferon γ (IFNγ) and are characterized by the expression of certain chemokine receptors, including chemokine receptor 4 (CCR4) and CCR6, which can influence homing to skin and joints [12].”
BackgroundGittler, J. K., Krueger, J. G., & Guttman‐Yassky, E. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.06.048 · Cited by 248
Self-citationGutowska‐Owsiak, D., Schaupp, A., Salimi, M., Selvakumar, T. A., McPherson, T., Taylor, S., & Ogg, G. S. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01412.x · Cited by 235
The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
Facheris, P., Jeffery, J., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00992-4 · Cited by 255
“The Th22 pathway The Th22 axis is directly involved in AD pathogenesis: both Th22 cells and Tc22 cells have a pathogenetic role and are present in increased numbers in skin samples from patients with AD compared to healthy controls [107].”
BackgroundSelf-citationIL-17 and IL-22: siblings, not twins
Eyerich, S., Eyerich, K., Cavani, A., & Schmidt‐Weber, C. B. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.06.004 · Cited by 242
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F., Odorisio, T., Traidl-Hoffmann, C., Behrendt, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40202 · Cited by 1,052
Rojahn, T. B., Vorstandlechner, V., Krausgruber, T., Bauer, W. M., Alkon, N., Bangert, C., Thaler, F. M., Sadeghyar, F., Fortelny, N., Fife, V. E. R., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.041 · Cited by 233
CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire
de Jong, A., Peña‐Cruz, V., Cheng, T., Clark, R. A., Rhijn, I. V., & Moody, D. B. (2010) · Nature Immunology · doi:10.1038/ni.1956 · Cited by 243
“Determining the relative contribution of CD1a and MHC antigen presenting molecules in T H 22 cell activation will be important for understanding and intervening in skin immunopathology caused by IL-22 in psoriasis and other skin diseases 46, 49 .”
InfluentialWitte, E., Witte, K., Warszawska, K., Sabat, R., & Wolk, K. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.08.002 · Cited by 243
“Actually, the expression of IL-22 in atopic skin was even slightly higher when compared to lesional psoriatic skin, which may rely on the observation that the majority of IL-22-producing cells in atopic skin are Th22 cells, whereas in psoriatic skin there is a shift to a rather equal presence of IL-22-producing Th22,…”
ResultMutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema
Eyerich, S., Onken, A. T., Weidinger, S., Franke, A., Nasorri, F., Pennino, D., Grosber, M., Pfab, F., Schmidt‐Weber, C. B., Mempel, M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1104200 · Cited by 233
Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis
He, H., Bissonnette, R., Wu, J., Diaz, A., Proulx, É. S., Maari, C., Jack, C. S., Louis, M., Estrada, Y. D., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.048 · Cited by 237
Self-citationCzarnowicki, T., Gonzalez, J., Shemer, A., Malajian, D., Xu, H., Zheng, X., Khattri, S., Gilleaudeau, P., Sullivan-Whalen, M. M., Suárez‐Fariñas, M., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.020 · Cited by 226
Self-citationEsaki, H., Ewald, D. A., Ungar, B., Rozenblit, M., Zheng, X., Xu, H., Estrada, Y. D., Peng, X., Mitsui, H., Litman, T., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.037 · Cited by 220
“However, in bulk genomic profiling we could not determine which compartments are responsible for individual gene expression or locate their cellular sources.(4,12,27) Furthermore, because of a dilution effect in bulk tissues, which are composed of functionally heterogeneous cells, many genes linked to AD pathogenesis…”
BackgroundSelf-citationTintle, S. J., Shemer, A., Suárez‐Fariñas, M., Fujita, H., Gilleaudeau, P., Sullivan-Whalen, M. M., Johnson-Huang, L. M., Chiricozzi, A., Cardinale, I. R., Duan, S., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.05.042 · Cited by 224
Self-citationTsoi, L. C., Rodríguez, E., Stölzl, D., Wehkamp, U., Sun, J., Gerdes, S., Sarkar, M. K., Hübenthal, M., Zeng, C., Uppala, R., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.11.047 · Cited by 226
The Role of Helper T Cells in Psoriasis
Hu, P., Wang, M., Gao, H., Zheng, A., Li, J., Mu, D., & Tong, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.788940 · Cited by 216
“discovered a new subtype of T cells by analyzing the T cell subsets in skin biopsies and peripheral blood collected from psoriatic patients by intracellular cytokine staining and flow cytometry, and these cells were called Th22 cells (43).”
BackgroundEfficacy and safety of ustekinumab treatment in adults with moderate‐to‐severe atopic dermatitis
Khattri, S., Brunner, P. M., Garcet, S., Finney, R., Cohen, S. R., Oliva, M., Dutt, R., Fuentes‐Duculan, J., Zheng, X., Li, X., et al. (2016) · Experimental Dermatology · doi:10.1111/exd.13112 · Cited by 213
“Recent data suggest that AD is primarily immune-driven, like psoriasis, showing dense cellular infiltrates (1) and over-expression of certain cytokines in skin lesions (2).”
BackgroundSelf-citationInterleukin-12: Functional activities and implications for disease
Zundler, S., & Neurath, M. F. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.003 · Cited by 225
Keratinocytes: innate immune cells in atopic dermatitis
Chieosilapatham, P., Kiatsurayanon, C., Umehara, Y., Trujillo-Paez, J. V., Peng, G., Yue, H., Nguyen, L. T. H., & Niyonsaba, F. (2021) · Clinical and Experimental Immunology · doi:10.1111/cei.13575 · Cited by 217
Czarnowicki, T., Esaki, H., Gonzalez, J., Malajian, D., Shemer, A., Noda, S., Talasila, S., Berry, A., Gray, J., Becker, L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.049 · Cited by 211
Self-citationThe Role of Th17-Related Cytokines in Atopic Dermatitis
Sugaya, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041314 · Cited by 204
“When examining skin samples from AD, psoriasis, and healthy controls, IL-17 expression level was increased in AD skin compared to normal skin, although it was much lower than that in psoriasis skin [18].”
BackgroundCytokines IL-17 and IL-22 in the host response to infection
Valeri, M., & Raffatellu, M. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw111 · Cited by 202
“CD4+, CCR4+, CCR6+, CCR10+ Human Eyerich et al. (2009); Trifari et al. (2009) Tc22 IL-22 Unknown CD4+, CD8+, IL-21R+ Human Nograles et al. (2009) Tc17 IL-17 Unknown CD8+, CD45RB+, CD38+, CD103+, CCR6+ Mouse Yen et al. (2009) γ δ cells IL-17, IL-22 AP1 CD27−, CD28−, NKP80+, CD45RA+, CD158+ Human and mouse Peng et al. (…”
BackgroundInfluentialBrunner, P. M., Pavel, A. B., Khattri, S., Leonard, A., Malik, K., Rose, S., On, S. C. J., Vekaria, A. S., Traidl‐Hoffmann, C., Singer, G., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.07.028 · Cited by 204
“The fact that treatment effects were restricted to patients with high IL-22 baseline expression underscores disease heterogeneity,5,66,67 which perhaps necessitates different therapeutic approaches in different patient subsets59-61,63,68 or use of broader inhibitors, such as Janus kinase antagonists,69 to achieve comp…”
InfluentialSelf-citationT cell pathology in skin inflammation
Sabat, R., Wolk, K., Loyal, L., Döcke, W., & Ghoreschi, K. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00742-7 · Cited by 207
“At the chronic disease stage, the T22 mediator IL-22 is also of relevance [84, 85].”
BackgroundRebane, A., Runnel, T., Aab, A., Maslovskaja, J., Rückert, B., Zimmermann, M., Plaas, M., Kärner, J., Treis, A., Pihlap, M., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.022 · Cited by 200
Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A
Besnard, A., Sabat, R., Dumoutier, L., Renauld, J., Willart, M. A. M., Lambrecht, B. N., Teixeira, M. M., Charron, S., Fick, L., Erard, F., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201008-1383oc · Cited by 212
New Insights in the Immunologic Basis of Psoriasis
Nograles, K. E., Davidovici, B. B., & Krueger, J. G. (2010) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2010.03.001 · Cited by 200
Self-citationThe role of IL-22 and Th22 cells in human skin diseases
Fujita, H. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.04.028 · Cited by 197
“It is also of particular interest that the number of CD8 T cells producing IL-22 correlated with disease activity score of AD (scoring atopic dermatitis; SCORAD), and the vast majority of the IL-22-producing CD8 T cells are unique Tc22 cells that do not produce IFN-g, IL-4, or IL-17 [20].”
BackgroundInfluentialAkdiş, M., Palomares, Ó., van de Veen, W., van Splunter, M. E., & Akdiş, C. A. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.003 · Cited by 201
Ramirez, J., Brembilla, N. C., Sorg, O., Chicheportiche, R., Matthes, T., Dayer, J., Saurat, J. ‐., Roosnek, E. E., & Chizzolini, C. (2010) · European Journal of Immunology · doi:10.1002/eji.201040461 · Cited by 200
Human skin dendritic cells in health and disease
Haniffa, M., Gunawan, M., & Jardine, L. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.08.012 · Cited by 187
“cytokines also feature in AD lesions, and their production can be stimulated by pDCs [83,84].”
BackgroundThe interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis
Otsuka, A., Nomura, T., Rerknimitr, P., Seidel, J. A., Honda, T., & Kabashima, K. (2017) · Immunological Reviews · doi:10.1111/imr.12545 · Cited by 188
Gomez‐Lopez, N., Galaz, J., Miller, D., Farías, M., Liu, Z., Arenas‐Hernandez, M., Garcia‐Flores, V., Shaffer, Z., Greenberg, J. M., Theis, K. R., et al. (2022) · Reproduction · doi:10.1530/rep-22-0046 · Cited by 194
Khattri, S., Shemer, A., Rozenblit, M., Dhingra, N., Czarnowicki, T., Finney, R., Gilleaudeau, P., Sullivan-Whalen, M. M., Zheng, X., Xu, H., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.003 · Cited by 181
“IL-22 has been linked to many aspects of epidermal pathology in patients with AD, including inhibition of epidermal differentiation, induction of hyperplasia, and upregulation of S100s, and has been strongly correlated with disease activity.(33,40,46) IL-4 and IL-13 have been reported to inhibit differentiation, produ…”
Self-citationBiedermann, T., Skabytska, Y., Kaesler, S., & Volz, T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00353 · Cited by 183
“Accumulation of Th22 cells was demonstrated in acute and chronic lesions of AD (36, 37) as were IL-22-producing CD8+ T cells (33, 36).”
BackgroundCzarnowicki, T., Krueger, J. G., & Guttman‐Yassky, E. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.03.006 · Cited by 184
Self-citationTruchetet, M., Brembilla, N. C., Montanari, E., Allanore, Y., & Chizzolini, C. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3486 · Cited by 180
“For instance, the frequency of IL-22+ T cells in skin derived T-cell lines from psoriasis, atopic eczema and allergic contact dermatitis was significantly higher than in the peripheral blood [17,37-39].”
BackgroundSonnenberg, G. F., Fouser, L. A., & Artis, D. (2010) · Advances in immunology · doi:10.1016/b978-0-12-381300-8.00001-0 · Cited by 180
IL-22 Induces an Acute-Phase Response
Liang, S. C., Nickerson‐Nutter, C. L., Pittman, D. D., Carrier, Y., Goodwin, D. G., Shields, K. M., Lambert, A.-J., Schelling, S. H., Medley, Q. G., Ma, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904091 · Cited by 175
Th17 Cells and Activated Dendritic Cells Are Increased in Vitiligo Lesions
Wang, C. Q. F., Cruz‐Inigo, A. E., Fuentes‐Duculan, J., Moussai, D., Gulati, N., Sullivan-Whalen, M. M., Gilleaudeau, P., Cohen, J. A., & Krueger, J. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018907 · Cited by 169
“In the skin, for instance, psoriasis contains a prominent Th17 population [19,22], but atopic dermatitis has a very minimal Th17 component [48].”
BackgroundSelf-citationGutowska-Owsiak, D., Schaupp, A. L., Salimi, M., Taylor, S., & Ogg, G. S. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10400.x · Cited by 168
Renert-Yuval, Y., Del Duca, E., Pavel, A. B., Fang, M., Lefferdink, R., Wu, J., Diaz, A., Estrada, Y. D., Canter, T., Zhang, N., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.01.001 · Cited by 168
Self-citationInnate and adaptive immune responses against Staphylococcus aureus skin infections
Krishna, S. M., & Miller, L. S. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0292-6 · Cited by 168
Immunologic, microbial, and epithelial interactions in atopic dermatitis
Brunner, P. M., Leung, D. Y. M., & Guttman‐Yassky, E. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.09.055 · Cited by 166
Self-citation
Metadata
- Authors
- Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E.
- Affiliations
- Rockefeller University (US)
- Technion – Israel Institute of Technology (IL)
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 123
- Issue
- 6
- Pages
- 1244-1252.e2
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC2874584
- OpenAlex
- W2164098277
- Cited by
- 627
- References
- 30
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 21 · 2023: 23 · 2022: 28 · 2021: 39 · 2020: 39 · 2019: 28 · 2018: 25 · 2017: 49 · 2016: 49 · 2015: 51 · 2014: 52 · 2013: 34 · 2012: 47
- FWCI
- 65.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM 07739, T32GM007739)
- National Center for Research Resources (UL1RR024143)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- atopic dermatitis, IL-22, IL-17, Th17 cells, Th2 cells, Th1 cells, IL-23, psoriasis, CD4+ T cells, CD8+ T cells, disease severity, epidermal hyperplasia, antimicrobial peptides, skin inflammation
- MeSH terms
- Interleukin-22, Adult, Chronic Disease, Dermatitis, Atopic, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Middle Aged, Psoriasis, T-Lymphocyte Subsets, Interleukin-17, Interleukin-23
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
