The DOI matches its Crossref record; 27 of the 30 references it cites were found in a registry or an index.
IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
Open accessAbstract
Background Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of TH17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear.Objective To examine differences in IL-23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets in AD.Methods Skin biopsies and peripheral blood were collected from patients with chronic AD (n = 12) and psoriasis (n = 13). Relative frequencies of CD4+ and CD8+ T-cell subsets within these 2 compartments were examined by intracellular cytokine staining and flow cytometry.Results In peripheral blood, no significant difference was found in percentages of different T-cell subsets between these diseases. In contrast, psoriatic skin had significantly increased frequencies of TH1 and TH17 T cells compared with AD, whereas TH2 T cells were significantly elevated in AD. Distinct IL-22-producing CD4+ and CD8+ T-cell populations were significantly increased in AD skin compared with psoriasis. IL-22+CD8+ T-cell frequency correlated with AD disease severity.Conclusion Our data established that T cells could independently express IL-22 even with low expression levels of IL-17. This argues for a functional specialization of T cells such that "T17" and "T22" T-cells may drive different features of epidermal pathology in inflammatory skin diseases, including induction of antimicrobial peptides for "T17" T cells and epidermal hyperplasia for "T22" T-cells. Given the clinical correlation with disease severity, further characterization of "T22" T cells is warranted, and may have future therapeutic implications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Circulating IL-22 correlates with the severity of AD and appears as a key driver in the inflammatory reaction116,119.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [116]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“IL-22 is an important part of the transcriptomic signature in AD116,117.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [116]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,886
Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells
Lowes, M. A., Kikuchi, T., Fuentes‐Duculan, J., Cardinale, I. R., Zaba, L. C., Haider, A. S., Bowman, E. P., & Krueger, J. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701213 · Cited by 1,085
Self-citationCytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3695 · Cited by 864
Nograles, K. E., Zaba, L. C., Guttman‐Yassky, E., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Cardinale, I. R., Khatcherian, A., Gonzalez, J., Pierson, K. C., White, T. R., et al. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08769.x · Cited by 816
Self-citationPossible Pathogenic Role of Th17 Cells for Atopic Dermatitis
Koga, C., Kabashima, K., Shiraishi, N., Kobayashi, M., & TOKURA, Y. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.111 · Cited by 680
Ma, H., Liang, S. C., Li, J., Napierata, L., Brown, T., Benoit, S., Senices, M., Gill, D. S., Dunussi‐Joannopoulos, K., Collins, M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33263 · Cited by 555
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
Kim, B. E., Leung, D. Y. M., Boguniewicz, M., & Howell, M. D. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.006 · Cited by 538
Flagged first, then by citations
3 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 501–600 of 626
Molecular Dissection of Psoriasis: Integrating Genetics and
Elder, B. T., Bruce, A. T., Gudjonsson, J. E., Johnston, A., Stuart, P. E., Tejasvi, T., Voorhees, J. J., & Nair, R. P. (2010) · Cited by 2
Boguniewicz, M., & Leung, D. Y. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-323-08593-9.00035-8 · Cited by 2
Theories of the psoriasis development and the role of atopy among generally accepted concepts
Barilo, A. A., & Smirnova, S. V. (2021) · Russian Journal of Clinical Dermatology and Venereology · doi:10.17116/klinderma20212003118 · Cited by 2
Effects of the dipeptide L-glutamic acid-L-tryptophan on dermatitis in mice and human keratinocytes
Shibata, S., Kuwahara, A., Sakaki‐Yumoto, M., Kawaguchi, M., Ishii, T., & Honma, Y. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e08729 · Cited by 2
Stull, C. M., Lavery, M. J., & Yosipovitch, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-33142-3_52 · Cited by 2
What Can Psoriasis Teach Us About the Genetic Basis of Cutaneous T-Cell Lymphoma?
Elder, J. T. (2010) · Clinical Lymphoma Myeloma & Leukemia · doi:10.3816/clml.2010.s.011 · Cited by 2
Arghavan, A. B., Sattari, M., Mofid, R., & Ganji, A. (2014) · International Journal of Dentistry and Oral Science · doi:10.19070/2377-8075-140005 · Cited by 2
IL-23/TH17 Pathway in Psoriasis and Inflammatory Skin Diseases
Nograles, K. E., Davidovici, B. B., & Krueger, J. G. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_25 · Cited by 2
Self-citationAryl Hydrocarbon Receptor: An Environmental Sensor in Control of Allergy Outcomes
Gargaro, M., Pirro, M., Manni, G., LUCA, A. D., Zelante, T., & Fallarino, F. (2017) · Birkhäuser advances in infectious diseases · doi:10.1007/978-3-319-69968-4_9 · Cited by 2
Inflammation of the Skin and Its Therapeutic Targets
Mathias, C. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-19922-7_5 · Cited by 2
Izuhara, K., Nunomura, S., Ohta, S., Ogawa, M., & Nanri, Y. (2017) · Springer eBooks · doi:10.1007/978-981-10-5541-6_9 · Cited by 2
Phung, T. L., Wright, T. S., Pourciau, C. Y., & Smoller, B. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-44824-4_1 · Cited by 2
Lehman, H. K., & Sabella, C. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95061-9.00039-4 · Cited by 2
Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque
Dopico, X. C., Guryleva, M. V., Mandolesi, M., Corcoran, M., Coquet, J. M., Murrell, B., & Hedestam, G. B. K. (2024) · Clinical & Translational Immunology · doi:10.1002/cti2.1508 · Cited by 2
“64,65 The largest cluster of CD8 + T cells was marked by differential expression of GZMK , GZMM , GZMB , EOMES , PRF1 , KLRG1 , KLRD1 , NKG7 and CRTAM (Figure 3g, Supplementary table 2).”
BackgroundChronic inflammation, insulin resistance, psoriasis - which have in common?
Ms, R. (2016) · Vestnik dermatologii i venerologii · doi:10.25208/0042-4609-2016-92-5-20-24 · Cited by 2
Global Journal of Endocrinological Metabolism
(2018) · Global Journal of Endocrinological Metabolism · doi:10.31031/gjem · Cited by 2
Qiu, C., Yang, L., Liu, S., Zhang, C., Zhang, Q., & Jin, Z. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109751 · Cited by 2
RetractedINTERLEUKIN-22 SERUM LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SANA'A CITY, YEMEN
El-Aghbary, D. A. (2018) · Universal Journal of Pharmaceutical Research · doi:10.22270/ujpr.v3i2.131 · Cited by 1
Takada, M., Sashikawa, M., Ohno, Y., Hossain, M. R., Xie, X., Iwabuchi, K., Komine, M., Ohtsuki, M., & Imokawa, G. (2026) · The Journal of Pathology · doi:10.1002/path.70050 · Cited by 1
Endotypes of atopic dermatitis: modern concepts and prospects
Drozhdina, M. B., Sokolovskiy, E. V., & Викторовна, С. Е. (2026) · Vestnik dermatologii i venerologii · doi:10.25208/vdv16963 · Cited by 1
Jeong, S. M., Kim, H. J., Son, C. H., Park, J. B., Suh, K. S., & Jang, M. S. (2026) · Annals of Dermatology · doi:10.5021/ad.25.194 · Cited by 1
“Asian AD is characterized by prominent Th17 and Th22 signals, with elevated IL-22 in both lesional and even non-lesional skin 5,12,18-20 .”
Insights into the Pathogenesis and Treatment of Psoriasis
Robyn, S., Mitra, A., & Hermenio, C. (2012) · InTech eBooks · doi:10.5772/25844 · Cited by 1
CsA inhibits IL-22 production by memory CD4+ T cells from patients with psoriasis
Shen, E., Yang, B., Li, Y., Lin, Q., Zou, R., Huang, H., Wu, J., Zhang, S., Zou, J., Zhou, M., et al. (2014) · Archives of Biological Sciences · doi:10.2298/abs1402775s · Cited by 1
“CD8+ T cells could also produce IL-22 in some diseases as occurs when CD8+ T cells infiltrate damaged skin in psoriasis (Nograles et al., 2009).”
BackgroundZhou, J., Koszik, F., Brunner, P. M., & Stingl, G. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.05.006 · Cited by 1
THE ROLE OF IMMUNE CELLS AND CYTOKINES IN THE DEVELOPMENT OF PSORIASIS
Pinegin, B. V., Иванов, О. Л., Pinegin, V. B., & Setchenov, I. M. (2013) · CyberLeninK (CyberLeninka) · Cited by 1
Immunology of the Asthmatic Response
Palomares, Ó., & Akdiş, C. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-29875-9.00028-8 · Cited by 1
Interleukin-1 Superfamily and Cancer
Yuzhalin, A. E., & Kutikhin, A. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801121-8.00002-6 · Cited by 1
Médecine personnalisée dans la dermatite atopique
Lefevre, M.-A., Braun, C., Vocanson, M., & Nosbaum, A. (2020) · Revue française d'allergologie · doi:10.1016/s1877-0320(20)30481-4 · Cited by 1
Mechanisms in Irritant Contact Dermatitis
Dimartino, V., Scopelliti, F., Mirisola, C., & Cavani, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-49332-5_3 · Cited by 1
Atopic Dermatitis and Allergic Contact Dermatitis
Boguniewicz, M., Fonacier, L. S., & Leung, D. Y. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-80912-2.00011-1 · Cited by 1
Sung, B., Baek, Y.-Y., Kim, Y., & You, J. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113498 · Cited by 1
“Recently, the expression of Th17 cytokines such as IL-17 and IL-22 in AD lesional skin has been reported [44,45].”
BackgroundSeethalakshmi, P. S., Hassan, S., Kiran, G. S., Bramhachari, P. V., & Selvin, J. (2023) · Springer eBooks · doi:10.1007/978-981-99-5114-7_10 · Cited by 1
Monoclonal Antibodies: Current Advancements and Future Potential for Atopic Dermatitis Therapy
Kumar, P., Ashawat, M. S., Kumar, A., Guleria, A. S., & Thakur, A. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010311098240530104530 · Cited by 2
The Roles of IL-22 and Its Related Family Members in the Pathogenesis of Psoriasis
Valdez, P. A., & Ouyang, W. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_24 · Cited by 1
Fortschritte bei der atopischen Dermatitis
Novak, N., & Bieber, T. R. M. (2012) · Der Hautarzt · doi:10.1007/s00105-011-2298-3 · Cited by 1
Veas, F., & Dubois, G. (2011) · InTech eBooks · doi:10.5772/20386 · Cited by 1
A Review of the Clinical and Immunologic Effects of Estrogen on Atopic Dermatitis
Murase, J. E. (2015) · Obstetrics & Gynecology International Journal · doi:10.15406/ogij.2015.02.00039 · Cited by 1
“However, Th 17 cells are elevated in acute AD lesions whereas Th22 cells are significantly elevated in chronic AD skin [9-11].”
BackgroundAtopic Dermatitis (or Atopic Eczema)
Ngatu, N. R., & Ikeda, M. (2018) · Springer eBooks · doi:10.1007/978-981-10-8758-5_3 · Cited by 1
Novel Insights into the Pathophysiology of Atopic Dermatitis
Niyonsaba, F., Takahashi, M., & Ikutama, R. (2020) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.2020.66.jmj20-r07 · Cited by 1
Shimoda, M., Tran, K. A., & Toda, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-84744-5.00014-0 · Cited by 1
Natural history of Atopic dermatitis-Outside-Inside-Outside Story-
Yamada, H. (2010) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.33.118 · Cited by 1
The Immune-pathogenesis of Canine Atopic Dermatitis: Skin barrier, Microbiome and Inflammation
Chermprapai, S. (2019) · Utrecht University Repository (Utrecht University) · Cited by 1
Current Drug Treatments for Allergy
Layhadi, J. A., Palmer, E. N., Sharif, H., & Shamji, M. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00236-5 · Cited by 1
Lehtimäki, S. (2012) · Työväentutkimus Vuosikirja
Epithelial Cells: Immunological Aspects
Pastore, S., Albanesi, C., & Girolomoni, G. (2015) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0001127.pub2
Treatment of psoriasis using biologics
Tada, Y., & Sato, S. (2010) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.33.126
Huber, M., & Lohoff, M. D. (2015) · Allergo Journal · doi:10.1007/s15007-015-0751-9
“Diese Tc22-Zellen lenken, vermutlich über sezerniertes IL-22, spezi sche klinische Eigenscha en der AD-Pathologie, einschließlich der Proliferation und Regulierung der endgültigen Di erenzierung von Keratinozyten [39].”
BackgroundInfluentialTh22-Zellen bei allergischen Erkrankungen
Eyerich, K., & Eyerich, S. (2015) · Allergo Journal · doi:10.1007/s15007-015-0750-x
Carvalho, S., Torres, T. R., & Selores, M. (2013) · Journal of the Portuguese Society of Dermatology and Venereology · doi:10.29021/spdv.70.3.5
Роль клеток иммунной системы и цитокинов в развитии псориаза
Pinegin, B. V., Иванов, О. Л., & Pinegin, V. B. (2012) · Российский журнал кожных и венерических болезней
The comparison of tissue IL-22 levels between Psoriasis
Albayrak, A., Cemil, B. Ç., & Yildirim, D. (2015)
Children diagnosed with both Type 1 diabetes and Celiac disease - An Immunological challenge
Faresjö, M. (2016) · Immunoendocrinology · doi:10.14800/ie.1110
“T-helper 2 cells require the transcription factors STAT6 and the zinc-finger GATA3 [5] as well as IL-4 and IL-33 for expansion and thereby produce a panel of different cytokines for example the interleukins; IL-4, IL-5, IL-6, IL-9, IL-10 and IL-13 [6].”
BackgroundInfluentialONICOMICOSE E PSORÍASE UNGUEAL
Silva, P. M. M. G. D. C., & Velho, G. (2015) · Journal of the Portuguese Society of Dermatology and Venereology · doi:10.29021/spdv.73.2.367
Yeni Tanımlanmış Bir T Hücre Alt Tipi: Th22 ve Cilt Hastalıkları
Cengiz, F. P. (2014) · Turkish Journal of Dermatology · doi:10.4274/tdd.1928
“Nograles ve arkadaşları, atopik dermatitin kronik lezyonlarında, psöriazis lezyonlarından daha yüksek oranda İL-22’nin eksprese olduğunu göstermiştir (18).”
Potential mechanism of IL-22 on microbial agents and cutaneous wound healing
Hezarjaribi, H. Z., Hafezi, N., & Ghaffarifar, F. (2016) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000069
“Also, there was a strong correlation between the frequency of CD8IL-22þ/Tc22 T cells and the atopic dermatitis severity [20,38].”
BackgroundResultNeue Wirkstoffe in der Pipeline zur Behandlung der atopischen Dermatitis
Bangert, C. (2016) · ästhetische dermatologie & kosmetologie · doi:10.1007/s12634-016-5232-1
“Anti-IL-22: Fezakinumab IL-22 wird in der Haut der AD-Patienten verstärkt von ©22Zellen produziert und scheint vor allem in der chronischen Phase der AD von Wichtigkeit zu sein [19].”
BackgroundAvaliação fenotípica e funcional de células dendríticas inflamatórias na dermatite atópica do adulto
dos Santos, V. G. (2016) · doi:10.11606/d.5.2016.tde-20052016-120809
“Andar, PAMBDermatologia CEP: 05403-000, Telefone (11) 2661-6398.”
InfluentialCzarnowicki, T., Krueger, J. G., & Guttman‐Yassky, E. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.030
Self-citationMolecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications
Yanofsky, V. R., Carucci, J. A., & Hofbauer, G. F. L. (2016) · Springer eBooks · doi:10.1007/978-3-662-47081-7_4
Mediators and receptors of chronic itch in primates and humans
Nattkemper, L. A. (2015) · TUScholarShare (Temple University)
The role of interleukin-22 in the mouse model of malaria infection, Plasmodium chabaudi
Kouassi, V. (2016) · UCL Discovery (University College London)
Systemic Therapy of Atopic Dermatitis: When, How, for How Long?
Malik, K., & Guttman‐Yassky, E. (2017) · Current Dermatology Reports · doi:10.1007/s13671-017-0176-7
Self-citationSugaya, M. (2017) · The Nishinihon Journal of Dermatology · doi:10.2336/nishinihonhifu.79.339
Papel da IL-22 na imunopatologia da asma experimental
Goulart, A. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2017.tde-06062017-162609
Characterisation of the immune cells and cytokines involved in a model of atopic dermatitis
Naidoo, K. (2018) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17067641.v1
Psoriazis ve periodontal durum arasındaki ilişkinin değerlendirilmesi
Göktürk, Ö., Yarkaç, F. U., & Oğrum, A. (2019) · Acta Odontologica Turcica · doi:10.17214/gaziaot.481136
Meena, A. (2020) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v8i2.91
Genetic and therapeutic novelties in atopic dermatitis
Universitatea de Medicină şi Farmacie „Carol Davila“, B., Stănescu, A. M. A., Grăjdeanu, I. V., Universitatea de Medicină şi Farmacie „Carol Davila“, B., Bratu, O. G., Universitatea de Medicină şi Farmacie „Carol Davila“, B., Spitalul Universitar de Urgenţă Militar Central „Dr. Carol Davila“, B., România, A. O. D. Ş. D., Iancu, M. A., Universitatea de Medicină şi Farmacie „Carol Davila“, B., et al. (2018) · Romanian Journal of Medical Practice · doi:10.37897/rjmp.2018.2.5
Generation and Characterization of Inducible Lung and Skin-Specific IL-22 Transgenic Mice
Zhou, L., Zheng, T., & Zhu, Z. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1001-5_9
Immune-Meidated Pathogenesis of Atopic Dermatitis
Park, C. O., & Kim, T. (2021) · Springer eBooks · doi:10.1007/978-981-15-8159-5_8
Coria, L. M. (2014) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Evite los problemas de entrada de GC ANTES de que le cuesten tiempo y dinero
Stenerson, K. K., & Buchanan, M. D. (2009) · Hispana
Kirchner, A., & Lake, E. P. (2022) · Journal of the Dermatology Nurses’ Association · doi:10.1097/jdn.0000000000000661
“IL-22 has been shown to be increased in patients with AD (Nograles et al., 2009), which may increase Th2 cytokine expression (Lou et al.”
BackgroundKobayashi, T., & Nagao, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-29785-9_22
Bakulev, A. L., & KRAVHCHENYA, S. S. (2012) · Vestnik dermatologii i venerologii · doi:10.25208/vdv705
Nomura, T., & Shinohara, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-55855-2_5
Chizzolini, C. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.8584956.9077054
Ghoreschi, K. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717948624.793453733
Interleukin-10 Superfamily and Cancer
Yuzhalin, A. E., & Кутихин, А. Г. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801121-8.00006-3
Immunohistological study of ovarian mature cystic teratoma with extremely elevated SCC antigen level
(2023) · European Journal of Gynaecological Oncology · doi:10.22514/ejgo.2023.030
Velasco, J. C. Z. (2023) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/61888
Babanin, V. A. (2013) · Likarska sprava · doi:10.31640/ls-2013-3-18
Biologic drugs, a new therapeutic paradigm in moderate-severe atopic dermatitis
Vignoli, C. A., & Borroni, R. G. (2023) · doi:10.37349/eaa.2023.00020
Ardern‐Jones, M. R., Flohr, C., & Reynolds, N. J. (2024) · Wiley eBooks · doi:10.1002/9781119709268.rook041
Imunoexpressão de fatores de crescimento e citocinas em lesões cutâneas da doença de Jorge Lobo.
Loureiro, W. R. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2023.tde-24042024-162944
Park, S., Lim, Y. J., Kim, H. S., Shin, H.-J., Jeong, S. Y., Cho, S., Kim, J., Baek, S., An, S., & Bae, S. (2024) · Asian Journal of Beauty and Cosmetology · doi:10.20402/ajbc.2023.0117
The Aryl Hydrocarbon Receptor and Immunity
Ehrlich, A. K., & Sulentic, C. E. W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00144-3
El‐Gendy, H., Eyada, M., Attia, F. M., & Marie, R. E. M. (2025) · Egyptian Journal of Dermatology and Venerology · doi:10.4103/ejdv.ejdv_47_24
Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin
García‐Jiménez, I., Nicolàs, L. S. S., Díez-Ribas, S., Curto‐Barredo, L., Bertolín‐Colilla, M., Vivancos-Melenchón, A., Figueras‐Nart, I., Bonfill‐Ortí, M., Ryzhkova, A., Ferrán, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1599892
Metadata
- Authors
- Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E.
- Affiliations
- Rockefeller University (US)
- Technion – Israel Institute of Technology (IL)
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 123
- Issue
- 6
- Pages
- 1244-1252.e2
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC2874584
- OpenAlex
- W2164098277
- Cited by
- 627
- References
- 30
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 21 · 2023: 23 · 2022: 28 · 2021: 39 · 2020: 39 · 2019: 28 · 2018: 25 · 2017: 49 · 2016: 49 · 2015: 51 · 2014: 52 · 2013: 34 · 2012: 47
- FWCI
- 65.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM 07739, T32GM007739)
- National Center for Research Resources (UL1RR024143)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- atopic dermatitis, IL-22, IL-17, Th17 cells, Th2 cells, Th1 cells, IL-23, psoriasis, CD4+ T cells, CD8+ T cells, disease severity, epidermal hyperplasia, antimicrobial peptides, skin inflammation
- MeSH terms
- Interleukin-22, Adult, Chronic Disease, Dermatitis, Atopic, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Middle Aged, Psoriasis, T-Lymphocyte Subsets, Interleukin-17, Interleukin-23
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
