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IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
Open accessAbstract
Background Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of TH17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear.Objective To examine differences in IL-23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets in AD.Methods Skin biopsies and peripheral blood were collected from patients with chronic AD (n = 12) and psoriasis (n = 13). Relative frequencies of CD4+ and CD8+ T-cell subsets within these 2 compartments were examined by intracellular cytokine staining and flow cytometry.Results In peripheral blood, no significant difference was found in percentages of different T-cell subsets between these diseases. In contrast, psoriatic skin had significantly increased frequencies of TH1 and TH17 T cells compared with AD, whereas TH2 T cells were significantly elevated in AD. Distinct IL-22-producing CD4+ and CD8+ T-cell populations were significantly increased in AD skin compared with psoriasis. IL-22+CD8+ T-cell frequency correlated with AD disease severity.Conclusion Our data established that T cells could independently express IL-22 even with low expression levels of IL-17. This argues for a functional specialization of T cells such that "T17" and "T22" T-cells may drive different features of epidermal pathology in inflammatory skin diseases, including induction of antimicrobial peptides for "T17" T cells and epidermal hyperplasia for "T22" T-cells. Given the clinical correlation with disease severity, further characterization of "T22" T cells is warranted, and may have future therapeutic implications.
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“Circulating IL-22 correlates with the severity of AD and appears as a key driver in the inflammatory reaction116,119.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [116]
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“IL-22 is an important part of the transcriptomic signature in AD116,117.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [116]
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Cites
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,886
Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells
Lowes, M. A., Kikuchi, T., Fuentes‐Duculan, J., Cardinale, I. R., Zaba, L. C., Haider, A. S., Bowman, E. P., & Krueger, J. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701213 · Cited by 1,085
Self-citationCytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3695 · Cited by 864
Nograles, K. E., Zaba, L. C., Guttman‐Yassky, E., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Cardinale, I. R., Khatcherian, A., Gonzalez, J., Pierson, K. C., White, T. R., et al. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08769.x · Cited by 816
Self-citationPossible Pathogenic Role of Th17 Cells for Atopic Dermatitis
Koga, C., Kabashima, K., Shiraishi, N., Kobayashi, M., & TOKURA, Y. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.111 · Cited by 680
Ma, H., Liang, S. C., Li, J., Napierata, L., Brown, T., Benoit, S., Senices, M., Gill, D. S., Dunussi‐Joannopoulos, K., Collins, M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33263 · Cited by 555
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
Kim, B. E., Leung, D. Y. M., Boguniewicz, M., & Howell, M. D. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.006 · Cited by 538
Cited by
Sorted by citations
Items 201–300 of 626
Atopic Dermatitis: Collegium Internationale Allergologicum (CIA) Update 2019
Simon, D., Wollenberg, A., Renz, H. E., & Simon, H. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000497383 · Cited by 65
Makowska, K., Nowaczyk, J., Blicharz, L., Waśkiel-Burnat, A., Czuwara, J., Olszewska, M., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010781 · Cited by 63
“, in Asians), albeit not as prominently as in other inflammatory dermatoses such as psoriasis [13,21].”
BackgroundCritical role of the interleukin‐23//T‐helper 17 cell axis in the pathogenesis of psoriasis
Nakajima, K. (2012) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2011.01458.x · Cited by 60
CCR6 as a possible therapeutic target in psoriasis
Hedrick, M. N., Lonsdorf, A. S., Hwang, S. T., & Farber, J. M. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.504716 · Cited by 64
“Recently, a subset of skinhoming CD4+ T cells that produce IL-22, but not IL-17A, so-called Th22 cells, have been described in humans [17, 18], and cells of this phenotype have been found in inflammatory diseases of the skin, including psoriasis [19, 20].”
BackgroundProstaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis
Robb, C. T., McSorley, H. J., Lee, J., Aoki, T., Yu, C., Crittenden, S., Astier, A., Felton, J. M., Parkinson, N., Ayele, A., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.045 · Cited by 68
Self-citationThe role of keratinocytes in defense against infection
Schröder, J.-M. (2010) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328335b004 · Cited by 61
Diagnosis and Management of Psoriasis in Children
Tollefson, M. M. (2014) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2013.11.003 · Cited by 60
“Activation of several T cells, Th-1, Th-17, and Th-22, resulting in production of specific cytokines, such as interferon-g, tumor necrosis factor, IL-17, IL-22, and IL-23, has recently been discovered to play an important role in the development of the disease.(1,2) These cytokines then activate keratinocytes, leading…”
BackgroundWhat’s New in Atopic Dermatitis
Renert‐Yuval, Y., & Guttman‐Yassky, E. (2019) · Dermatologic Clinics · doi:10.1016/j.det.2018.12.007 · Cited by 61
Self-citationOur evolving understanding of the functional role of filaggrin in atopic dermatitis
Leung, D. Y. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.041 · Cited by 60
Mulcahy, M. E., Leech, J. M., Renauld, J.-C., Mills, K. H., & McLoughlin, R. M. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.24 · Cited by 58
Tyler, C. J., McCarthy, N. E., Lindsay, J. O., Stagg, A. J., Moser, B., & Eberl, M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700003 · Cited by 59
“meostasis and inflammation at epithelial barriers in multiple organs (6, 13, 39, 40).”
BackgroundRole of IL‐17 in atopy—A systematic review
Hofmann, M. A., Fluhr, J. W., Ruwwe‐Glösenkamp, C., Stevanovic, K., Bergmann, K., & Zuberbier, T. (2021) · Clinical and Translational Allergy · doi:10.1002/clt2.12047 · Cited by 61
“Furthermore, the number of circulating Th17‐cells correlated with the clinical severity of atopic eczema.29 In a small study with AD and psoriasis patients, Nograles et al.30 showed that Th17 cells were significantly decreased in AD skin specimens compared to psoriatic skin, but in peripheral blood there was no differ…”
Endotypes of atopic dermatitis
Fyhrquist, N., Yang, Y., Karisola, P., & Alenius, H. T. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.02.029 · Cited by 65
Anti-cytokine therapies for psoriasis
Nograles, K. E., & Krueger, J. G. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.01.024 · Cited by 58
Self-citationCirculating CLA+T cells in atopic dermatitis and their possible role as peripheral biomarkers
Czarnowicki, T., Santamaria‐Babí, L. F., & Guttman‐Yassky, E. (2016) · Allergy · doi:10.1111/all.13080 · Cited by 57
“Our blood phenotyping in young children of less than 5 years old with disease duration up to 6 months showed that early pediatric AD is characterized by a skin-selective Th1/Th2 imbalance and that Th22/ IL-22 expansion in blood is solely a feature of long-standing, chronic disease in adults with AD (27, 52).”
BackgroundSelf-citationLeyva-Castillo, J. M., Sun, L., Wu, S.-Y., Rockowitz, S., Piotr Sliz, A., & Geha, R. S. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.03.002 · Cited by 57
Chuah, L., Loo, H. L., Goh, C. F., Fu, J., & Ng, S. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01307-w · Cited by 61
Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model
Choi, E., Iwasa, M., Han, K.-I., Kim, W.-J., Tang, Y., Hwang, Y., Chae, J., Han, W. C., Shin, Y.-S., & Kim, E. (2016) · Nutrients · doi:10.3390/nu8030146 · Cited by 56
Cytokine-Based Therapy in Psoriasis
Mitra, A., Fallen, R. S., & Lima, H. (2012) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-012-8306-2 · Cited by 55
“IL-17, some T cells express IL-22 [97].”
The adaptive immune system in atopic dermatitis and implications on therapy
Roesner, L. M., Werfel, T., & Heratizadeh, A. (2016) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2016.1165093 · Cited by 55
“For IgE sensitization to SEB, a correlation with the severity of AD has been demonstrated [58].”
BackgroundMari, O. D. A., Uchi, H., Morino‐Koga, S., & Furue, M. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.02.014 · Cited by 53
Baba, N., Rubio, M., Kenins, L., Regairaz, C., Woisetschlager, M., Carballido, J. M., & Sarfati, M. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.05.002 · Cited by 52
Significant correlation of serum IL-22 levels with CCL17 levels in atopic dermatitis
Hayashida, S., Uchi, H., Takeuchi, S., Esaki, H., Moroi, Y., & Furue, M. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.08.013 · Cited by 52
Kärner, J., Wawrzyniak, M., Tankov, S., Runnel, T., Aints, A., Kisand, K. E., Altraja, A., Kingo, K., Akdiş, C. A., Akdiş, M., et al. (2016) · Allergy · doi:10.1111/all.12907 · Cited by 52
“Th22 cells are involved in the regulation of immune responses and epidermal remodeling in atopic dermatitis (AD) (5, 6).”
BackgroundNew insights in the pathogenesis of atopic dermatitis
Ong, P. Y. (2013) · Pediatric Research · doi:10.1038/pr.2013.196 · Cited by 52
“Increased expression of IL-22 has been found consistently in both psoriatic and AD lesions (46,47).”
BackgroundJusta, S., Zhou, X., & Sarkar, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093279 · Cited by 55
“presence of IL-22 producing cells which are distinct from IL-17 producing cells [24,25,26,27].”
BackgroundBiochemical markers of psoriasis as a metabolic disease
Gerkowicz, A., Pietrzak, A., Szepietowski, J. C., Radej, S., & Chodorowska, G. (2012) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.2012.0025 · Cited by 49
“[22] revealed the presence of Th 22 lymphocytes in the skin of patients with psoriasis.”
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin
Malhotra, N., Yoon, J., Leyva-Castillo, J. M., Galand, C., Archer, N. K., Miller, L. S., & Geha, R. S. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.001 · Cited by 51
Impaired Expression of Tim-3 on Th17 and Th1 Cells in Psoriasis
Kanai, Y., Satoh, T., Igawa, K., & Yokozeki, H. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1285 · Cited by 51
Association of chronic periodontitis and psoriasis: periodontal status with severity of psoriasis
Sharma, A., Raman, A., & Pradeep, A. (2014) · Oral Diseases · doi:10.1111/odi.12271 · Cited by 50
Past, present, and future for biologic intervention in atopic dermatitis
Howell, M. D., Parker, M. L., Mustelin, T., & Ranade, K. (2015) · Allergy · doi:10.1111/all.12632 · Cited by 51
New therapies for atopic dermatitis: Additional treatment classes
Vakharia, P. P., & Silverberg, J. I. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.12.024 · Cited by 51
The role of Langerhans cells in pathologies of the skin
Rajesh, A., Wise, L. M., & Hibma, M. H. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12253 · Cited by 50
“The T-cell response is skewed toward T helper (Th) 2 and Th22 cell pathways in this disease in mice(85) and humans.(86) Th2 cytokines lead to IgE class switching and induce eosinophils and mast cells.”
BackgroundNew insights into T cells and their signature cytokines in atopic dermatitis
Wang, A., & Xu, N. (2015) · IUBMB Life · doi:10.1002/iub.1405 · Cited by 49
“Th22 cells are found to reside in the inflammatory lesions of AD and the Th22 cells count is correlated with the AD disease activity as defined by the Scoring of AD (SCORAD) index (31).”
BackgroundLio, P., Lee, M. S., LeBovidge, J., Timmons, K. G., & Schneider, L. C. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.02.015 · Cited by 48
“Newer data reveal that IL-22 is released in AD skin from Th17 cells and a class of T helper cells called Th22 cells, first identified in patients with AD.(13,14) IL-22 production stimulated by epidermal Langerhans and dendritic cells results in the epidermal hyperplasia observed in AD and psoriasis, and is intensified…”
BackgroundImmunomodulating properties of protein hydrolysates for application in cow's milk allergy
Kiewiet, M. B. G., Gros, M., van Neerven, R. J. J., Faas, M. M., & de Vos, P. (2015) · Pediatric Allergy and Immunology · doi:10.1111/pai.12354 · Cited by 48
Carretero, M., Guerrero‐Aspizua, S., Illera, N., Gálvez, V., Navarro, M., Garcia‐García, F., Dopazo, J., Jorcano, J. L., Larcher, F., & Río, M. D. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.362 · Cited by 49
New and emerging targeted systemic therapies: a new era for atopic dermatitis
Lee, D. E., Clark, A. K., Tran, K. A., & Shi, V. Y. (2017) · Journal of Dermatological Treatment · doi:10.1080/09546634.2017.1373736 · Cited by 48
“Additionally, Th22 cells produce IL-22, which promotes chronic phase of AD and skin barrier dysfunction by inhibiting terminal differentiation and, at the same time, inducing epidermal hyperplasia (6,25,30).”
BackgroundIL-22 promotes allergic airway inflammation in epicutaneously sensitized mice
Leyva-Castillo, J. M., Yoon, J., & Geha, R. S. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.05.032 · Cited by 51
Efficacy of biologics in atopic dermatitis
Wu, J., & Guttman-Yassky, E. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1722998 · Cited by 46
Self-citationThe evolving landscape of biologic therapies for atopic dermatitis: Present and future perspective
David, E., Ungar, B., Renert‐Yuval, Y., Facheris, P., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Clinical & Experimental Allergy · doi:10.1111/cea.14263 · Cited by 49
Self-citationKumar, P., Rajasekaran, K., Palmer, J. M., Thakar, M. S., & Malarkannan, S. (2013) · Journal of Cancer · doi:10.7150/jca.5048 · Cited by 47
“IL-22 also enhances the pathogenesis of atopic dermatitis (66;67).”
BackgroundImmunological mechanisms for desensitization and tolerance in food allergy
Rachid, R. A., & Umetsu, D. T. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0333-9 · Cited by 47
“IL-22 levels are also increased in the skin of patients with atopic dermatitis [56].”
Bachmann, M., Horn, K., Rudloff, I., Goren, I., Holdener, M., Christen, U., Darsow, N., Hunfeld, K., Koehl, U., Kind, P., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001144 · Cited by 47
“These cells in part belong to the memory CD4 T cell subset and have been introduced as Th22 [23] or T22 cells [25].”
BackgroundTh22 cells in allergic disease
Eyerich, K., & Eyerich, S. (2015) · Allergo Journal International · doi:10.1007/s40629-015-0039-3 · Cited by 61
“is is due to a considerably elevated proportion of 22 cells in AE [39].”
BackgroundInterleukin 22 Signaling Promotes Cell Growth in Mantle Cell Lymphoma
Gélébart, P., Zak, Z., Bard, J. D., Anand, M., & Lai, R. L. (2011) · Translational Oncology · doi:10.1593/tlo.10172 · Cited by 46
Nomura, T., & Kabashima, K. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.022 · Cited by 47
Anti‐inflammatory therapies in atopic dermatitis
Heratizadeh, A., & Werfel, T. (2016) · Allergy · doi:10.1111/all.13065 · Cited by 45
“Activated Th22 cells could be observed in the circulation of patients with AD and, moreover, increased numbers of skinhoming Th22 cells have been detected in inflamed skin lesions (34, 35).”
BackgroundTh22 and related cytokines in inflammatory and autoimmune diseases
Tian, T., Yu, S., & Ma, D. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.736497 · Cited by 49
“In summary, the novel subsets of Th22 and Tc22 T cells contribute to the increased IL-22 expression in chronic AD skin, and support a Th2/T22 immune polarization in chronic AD [25].”
BackgroundInfluentialThe Pathogenesis and Genetics of Psoriasis
Puig, L., Julià, A., & Marsal, S. (2014) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2014.05.013 · Cited by 45
“A marked expansion of cytotoxic T lymphocytes, which independently express IL-17 and IL-22 in the psoriatic epidermis, has been reported.(16,17) The expansion of Th1 lymphocytes feeds back into this process by stimulating synthesis of IL-12 and IL-23 by antigen-presenting cells through production of IFN- .”
BackgroundTh22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival
Lullo, G. D., Marcatti, M., Heltai, S., Brunetto, E., Tresoldi, C., Bondanza, A., Bonini, C., Ponzoni, M., Tonon, G., Ciceri, F., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1005460 · Cited by 45
Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22
Abikhair, M., Mitsui, H., Yanofsky, V. R., Roudiani, N., Ovits, C., Bryan, T., Oberyszyn, T. M., Tober, K. L., Gonzalez, J., Krueger, J. G., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.86434 · Cited by 45
Self-citationIL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function
Paul, M. S., Saibil, S. D., Lien, S. C., Han, S., Sayad, A., Mulder, D. T., Garcia-Batres, C. R., Elford, A. R., Israni-Winger, K., Robert-Tissot, C., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0521 · Cited by 44
“This may explain why Tc22s were detected in human inflammatory skin lesions in high numbers with >20% of infiltrating CD8þ T cells being Tc22s in some patients (24), as exposure of tryptophan toUV rays from sunlight can induce the AhR ligand FICZ (67).”
BackgroundSicherer, S. H., & Leung, D. Y. M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.024 · Cited by 45
The ‘omics’ revolution: redefining the understanding and treatment of allergic skin diseases
Oliva, M., Renert‐Yuval, Y., & Guttman‐Yassky, E. (2016) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000306 · Cited by 46
Self-citationBrembilla, N. C., Ramirez, J., Chicheportiche, R., Sorg, O., Saurat, J. ‐., & Chizzolini, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018741 · Cited by 45
“Th22 cells have been shown to be involved in skin disease such as psoriasis and atopic dermatitis [21,22,23] which molecular pathology is very different from the dioxin-induced skin lesions, historically called ‘‘chloracne’’ and now defined as ‘‘metabolizing acquired dioxin induced skin hamartomas’’ which primarily in…”
BackgroundIL‐22‐producing CD4+ T cells: Middle‐men between the immune system and its environment
Trifari, S., & Spits, H. (2010) · European Journal of Immunology · doi:10.1002/eji.201040848 · Cited by 43
Psoriasis: bases genéticas y patogenéticas
Puig, L., Julià, A., & Marsal, S. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2012.11.006 · Cited by 43
Skin immunity and its dysregulation in atopic dermatitis, hidradenitis suppurativa and vitiligo
Campione, E., Lanna, C., Diluvio, L., Cannizzaro, M. V., Grelli, S., Galluzzo, M., Talamonti, M., Annicchiarico‐Petruzzelli, M., Mancini, M., Melino, G., et al. (2020) · Cell Cycle · doi:10.1080/15384101.2019.1707455 · Cited by 45
“In active AD, IL-17 levels are high, while in chronic AD, are low, or even undetectable [42].”
BackgroundAltered Transforming Growth Factor-Beta Signaling in a Murine Model of Thoracic Aortic Aneurysm
Jones, J. A., Barbour, J. R., Stroud, R. E., Bouges, S., Stephens, S. L., Spinale, F. G., & Ikonomidis, J. S. (2008) · Journal of Vascular Research · doi:10.1159/000127437 · Cited by 43
Immunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update
Wang, D., & Beck, L. A. (2016) · American Journal of Clinical Dermatology · doi:10.1007/s40257-016-0205-5 · Cited by 44
“keratinocytes and leads to epidermal thickening characteristic of chronic AD [46, 73, 76].”
BackgroundThe roles of T cells in psoriasis
Zhang, P., Su, Y., Li, S., Chen, H., Wu, R., & Wu, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1081256 · Cited by 44
IL-13/IL-22–coproducing T cells, a novel subset, are increased in atopic dermatitis
Teraki, Y., Sakurai, A., & Izaki, S. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.07.029 · Cited by 41
Understanding the squamous cell carcinoma immune microenvironment
Saeidi, V., Doudican, N. A., & Carucci, J. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1084873 · Cited by 40
Ding, W., Manni, M., Stohl, L. L., Zhou, X. K., Wagner, J. A., & Granstein, R. D. (2012) · European Journal of Immunology · doi:10.1002/eji.201141958 · Cited by 40
“Th22 cells are recently described human inflammatory CD4+ T cells that produce IL-22 but not IL-17A or IFN-γ [61–63].”
BackgroundAn increased proportion of circulating Th22 and Tc22 cells in psoriasis
Li, L., Ding, Y., Han, S., Zhang, Z., & Liu, X. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.06.007 · Cited by 39
Nakagawa, R., Yoshida, H., Asakawa, M., Tamiya, T., Inoue, N., Morita, R., Inoue, H., Nakao, A., & Yoshimura, A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100649 · Cited by 40
“Under more ordinary circumstances, IL-17 production is lower in AD patients than in psoriasis patients; specifically, less IL-17 is secreted (50).”
BackgroundNew and Emerging Therapies for Pediatric Atopic Dermatitis
Nguyen, H. L., Anderson, K., & Tollefson, M. M. (2019) · Pediatric Drugs · doi:10.1007/s40272-019-00342-w · Cited by 41
Batista, M. D., Tincati, C., Milush, J. M., Ho, E. L., Ndhlovu, L. C., York, V. A., Kallas, E. G., Kalil, J. E., Keating, S. M., Norris, P. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052144 · Cited by 38
“IL-22 induces multiple anti-apoptotic and proliferative pathways through the Stat3 cascade and has the capacity of inducing keratinocyte proliferation through the down-regulation of keratinocyte differentiation genes, such as keratin 1 and fillagrin [34,35].”
Successful use of ustekinumab therapy in refractory severe atopic dermatitis
Shroff, A., & Guttman‐Yassky, E. (2014) · JAAD Case Reports · doi:10.1016/j.jdcr.2014.10.007 · Cited by 38
“AD is increasingly recognized as a Th2- and Th22-centered disease with some contributions of Th17 and Th1 axes.(4) IL-23 is believed to promote expansion of Th17 and Th22 T cells, and Th17 T cells have been reported recently to play a role in acute AD lesions.”
Self-citationGros, E., Petzold, S., Maintz, L., Bieber, T. R. M., & Novak, N. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.05.043 · Cited by 38
T‐helper 22 cells as a new player in chronic inflammatory skin disorders
Mirshafiey, A., Simhag, A., Rouby, N. M. E., & Azizi, G. (2015) · International Journal of Dermatology · doi:10.1111/ijd.12883 · Cited by 40
Kong, Q., Wu, W., Yang, F., Liu, Y., Xue, Y., Gao, M., Lai, W., Pan, X., Yuluan, Y., Pang, Y., et al. (2012) · Virology Journal · doi:10.1186/1743-422x-9-232 · Cited by 38
“Demonstrated by emerging literature in kinds of diseases such as rheumatoid arthritis, atopic dermatitis, systemic sclerosis, human immunodeficiency virus (HIV) infection, Th22 cells were considered providing a unique contribution to tissue inflammation, virus infection and immune responses [13-16].”
BackgroundStaphylococcus aureus enterotoxins modulate IL-22-secreting cells in adults with atopic dermatitis
Orfali, R. L., Oliveira, L. M. D. S., de Lima, J. F., de Carvalho, G. C., Ramos, Y. Á. L., Pereira, N. Z., Pereira, N. V., Zaniboni, M. C., Sotto, M. N., Duarte, A. J. D. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25125-0 · Cited by 37
The Role of Genetics, the Environment, and Epigenetics in Atopic Dermatitis
Mu, Z., & Zhang, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3449-2_4 · Cited by 39
Novel Targeted Biological Agents for the Treatment of Atopic Dermatitis
Yang, N., Chen, Z., Zhang, X., & Shi, Y. (2021) · BioDrugs · doi:10.1007/s40259-021-00490-x · Cited by 37
Xu, X., Tang, Y., Guo, S., Zhang, Y., Tian, Y., Ni, B., & Wang, H. (2014) · Pancreas · doi:10.1097/mpa.0000000000000055 · Cited by 37
Interleukin-17-producing T-helper cells and related cytokines in human airways exposed to endotoxin
Glader, P., Smith, M. E., Malmhäll, C., Balder, B., Sjöstrand, M., Qvarfordt, I., & Lindén, A. (2010) · European Respiratory Journal · doi:10.1183/09031936.00170609 · Cited by 37
Target-oriented therapy: Emerging drugs for atopic dermatitis
Lauffer, F., & Ring, J. (2016) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2016.1146681 · Cited by 36
Immunomodulatory Role of Staphylococcus aureus in Atopic Dermatitis
Chung, E. J.-C., Luo, C.-H., Thio, C. L., & Chang, Y. (2022) · Pathogens · doi:10.3390/pathogens11040422 · Cited by 37
“Transcript levels of IL-22 and IL-22-expressing CD4+ and CD8+ T cells were found to be increased in the skin of AD patients [64].”
BackgroundGene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress
Li, X., Chen, J., Yue, G.-X., Liu, Y., Zhao, X., Guo, X.-L., Liu, Q., Jiang, Y.-M., & Bai, M.-H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057621 · Cited by 37
der Lee, A. J., Rutten, V. P. M. G., Bruijn, J., Willemse, T., & Broere, F. (2014) · Veterinary Dermatology · doi:10.1111/vde.12140 · Cited by 37
IL-17E but not IL-17A is associated with allergic sensitization: results from the LISA study
Herberth, G., Daegelmann, C., Röder, S. W., Behrendt, H., Krämer, U., Borte, M., Heinrich, J., Herbarth, O., Lehmann, I., & for the LISAplus study group (2010) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2010.01033.x · Cited by 36
“Furthermore, high frequencies of IL-17A-producing cells were observed in psoriatic skin lesions but not in atopic dermatitis lesions, and no frequency difference was observed in peripheral blood (15).”
BackgroundVelasco, J. C. Z., Reinoso, R., Armentia, A., Enríquez‐de‐Salamanca, A., & Corell, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.911022 · Cited by 36
“These cells have been shown to be related to skin diseases and may be increased in atopy (dermatitis and psoriasis) (22).”
BackgroundNiccolai, E., Taddei, A., Ricci, F., Rolla, S., D’Elios, M. M., Benagiano, M., Bechi, P., Bencini, L., Ringressi, M. N., Pini, A., et al. (2015) · Clinical Science · doi:10.1042/cs20150437 · Cited by 36
Cutaneous dendritic cells in allergic inflammation
Gros, E., & Novak, N. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.03964.x · Cited by 36
Mechanisms of Aeroallergen Immunotherapy
Özdemir, C., Küçüksezer, U. C., Akdiş, M., & Akdiş, C. A. (2015) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2015.08.003 · Cited by 35
“have been shown to produce IL-22 together with low levels of IL-4, and their contribution to atopic diseases especially in atopic dermatitis has been revealed.(28) Additionally, Th17 cells express IL-17A, IL-17F, IL-6, IL-8, tumor necrosis factor-a, IL-22, and IL-26 and are shown to contribute to some autoimmune patho…”
Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression
Weiss, D., Schaschinger, M., Ristl, R., Gruber, R. W., Kopp, T., Stingl, G., & Bangert, C. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.07.047 · Cited by 35
The Roles of IL-22 and Its Receptor in the Regulation of Inflammatory Responses in the Brain
Lee, D., Jo, H., Go, C., Jang, Y., Chu, N., Bae, S., Kang, D., Kim, Y., & Kang, J. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020757 · Cited by 35
“Previous studies have examined IL-22Rα expression at the cellular level and in non-hematopoietic tissues such as the skin and pancreas [9,11].”
BackgroundActivation of human T cells by CD 1 and self‐lipids
de Jong, A. (2015) · Immunological Reviews · doi:10.1111/imr.12322 · Cited by 38
T cells and their function in the immune response to viruses
Beňová, K., Hancková, M., Koči, K., Kúdelová, M., & Betáková, T. (2020) · Acta Virologica · doi:10.4149/av_2020_203 · Cited by 36
Tosti, N., Cremonesi, E., Governa, V., Basso, C., Kancherla, V., Coto‐Llerena, M., Amicarella, F., Weixler, B., Däster, S., Sconocchia, G., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0934 · Cited by 34
“IL22 is a cytokine of the IL10 family produced by different cell types of the innate immune system, including group 3 innate lymphoid cells (ILC3), and of the adaptive immune system, including Th17, na€ ve CD4þT cells polarized upon exposure toTNFa and IL6, also known as Th22 cells (8), and CD8þ T cells (9, 10).”
BackgroundCytokine Effects Induced by the Human Autoallergen α-NAC
Hradetzky, S., Roesner, L. M., Balaji, H., Heratizadeh, A., Mittermann, I., Valenta, R., & Werfel, T. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.25 · Cited by 33
Atopic dermatitis keratinocytes exhibit normal TH17 cytokine responses
Nograles, K. E., Suárez‐Fariñas, M., Shemer, A., Fuentes‐Duculan, J., Chiricozzi, A., Cardinale, I. R., Zaba, L. C., Kikuchi, T., Ramon, M., Bergman, R., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.934 · Cited by 33
Self-citationCheung, L. K., Fisher, R. M., Kuzmina, N., Li, D., Li, X., Werngren, O., Blomqvist, L., Ståhle, M., & Xu, N. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.12.008 · Cited by 33
“Psoriasis is a prototypical Th-1, Th-17, and Th-22 inflammatory disease of the skin (Lowes et al., 2008; Nograles et al., 2009).”
BackgroundJin, M., & Yoon, J. (2018) · Immune Network · doi:10.4110/in.2018.18.e42 · Cited by 33
“Moreover, the number of Th22 cells and IL-22+CD8+ T-cell positively correlates with AD disease severity (31), and IL-22, highly expressed in the affected skin of patients suffering from AD, is deeply involved in epidermal hyperplasia and barrier defects (57,59).”
BackgroundInfluentialMegna, M., Caiazzo, G., Parisi, M., Ruggiero, A., Capasso, G., Mascolo, M., Russo, D., Gallo, L., Fabbrocini, G., Napolitano, M., et al. (2021) · Clinical and Experimental Dermatology · doi:10.1111/ced.15052 · Cited by 33
The Role of Interleukins in the Pathogenesis of Dermatological Immune-Mediated Diseases
Turchin, I., & Bourcier, M. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02241-y · Cited by 37
“IL-22 producing CD4? and CD8? T cells were significantly increased in AD skin lesions compared to psoriatic lesions, and correlated with AD disease severity [77].”
BackgroundInsights into atopic dermatitis pathogenesis lead to newly approved systemic therapies
Trier, A. M., & Kim, B. (2022) · British Journal of Dermatology · doi:10.1093/bjd/ljac016 · Cited by 32
Pathways to managing atopic dermatitis: consensus from the experts.
Lebwohl, M., Rosso, J. Q. D., Abramovits, W., Berman, B., Cohen, D. E., Guttman, E., Mancini, A. J., & Schachner, L. A. (2013) · Europe PMC (PubMed Central) · Cited by 33
Metadata
- Authors
- Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E.
- Affiliations
- Rockefeller University (US)
- Technion – Israel Institute of Technology (IL)
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 123
- Issue
- 6
- Pages
- 1244-1252.e2
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC2874584
- OpenAlex
- W2164098277
- Cited by
- 627
- References
- 30
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 21 · 2023: 23 · 2022: 28 · 2021: 39 · 2020: 39 · 2019: 28 · 2018: 25 · 2017: 49 · 2016: 49 · 2015: 51 · 2014: 52 · 2013: 34 · 2012: 47
- FWCI
- 65.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM 07739, T32GM007739)
- National Center for Research Resources (UL1RR024143)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- atopic dermatitis, IL-22, IL-17, Th17 cells, Th2 cells, Th1 cells, IL-23, psoriasis, CD4+ T cells, CD8+ T cells, disease severity, epidermal hyperplasia, antimicrobial peptides, skin inflammation
- MeSH terms
- Interleukin-22, Adult, Chronic Disease, Dermatitis, Atopic, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Middle Aged, Psoriasis, T-Lymphocyte Subsets, Interleukin-17, Interleukin-23
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