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Regulation of the host immune system by helminth parasites

Maizels, Rick M., McSorley, Henry J.·2016·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2016.07.007PMC PMC5010150
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Fig 1 Immune system–parasite interactions during helminth infections. A, Blockade of innate sensing and alarmin production, such as inhibiting Toll-like receptor (TLR) responses of dendritic cells, thereby impairing inflammatory TH1/TH17 development, and abrogating epithelial cell production of IL-33, thereby pre-empting the type 2 response. ILC2, Type 2 innate lymphoid cell. B, Modulation of the adaptive immune response, promoting Treg cell differentiation either directly through production of TGF-β–like mimics (TGM) or indirectly by inducing host TGF-β and retinoic acid (RA) from DCs and macrophages. C, Modification of bystander immune responses in the infected host.
Fig 1 Immune system–parasite interactions during helminth infections. A, Blockade of innate sensing and alarmin production, such as inhibiting Toll-like receptor (TLR) responses of dendritic cells, thereby impairing inflammatory TH1/TH17 development, and abrogating epithelial cell production of IL-33, thereby pre-empting the type 2 response. ILC2, Type 2 innate lymphoid cell. B, Modulation of the adaptive immune response, promoting Treg cell differentiation either directly through production of TGF-β–like mimics (TGM) or indirectly by inducing host TGF-β and retinoic acid (RA) from DCs and macrophages. C, Modification of bystander immune responses in the infected host.CC BY · PubMed Central

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Metadata

Authors
Maizels, R. M., & McSorley, H. J.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2016-09
Volume
138
Issue
3
Pages
666-675
ISSN
0091-6749
DOI
10.1016/j.jaci.2016.07.007
PMC
PMC5010150
Cited by
529
References
7
Language
en
Licence

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