Sleep deprivation predisposes allergic mice to neutrophilic lung inflammation
Abstract
Background Although different studies associated sleep deprivation (SD) with systemic inflammatory changes, the effect of sleep duration on the pathology of allergic chronic diseases is poorly understood.Objective We sought to evaluate the influence of SD on allergen-induced pulmonary inflammation.Methods Ovalbumin (OVA)-sensitized C57BL/6 mice were exposed to a first set of intranasal OVA challenge under SD or healthy sleep (HS) conditions, followed by a second OVA challenge, 1 week apart. Some groups were subjected to corticosteroid treatment with dexamethasone.Results OVA-sensitized mice with SD had more severe airway inflammation than the allergic group with HS. Analysis of lung parenchyma revealed that the inflammation in allergic mice with SD was marked by an influx of neutrophils (mainly) and eosinophils and secretion of IL-6, TNF-α, and IL-17 in contrast to the eosinophilic inflammation and IL-4 production observed in allergic mice with HS. The same cytokine profile was observed in ex vivo culture of cervical lymph node cells and splenocytes, indicating that in allergic mice SD favors immune responses toward a proinflammatory T H 17 profile. This idea is supported by the fact that disruption of IL-17 signaling (IL-17 receptor A-/-) prevented airway neutrophilia in allergic mice with SD. Furthermore, allergic mice with SD became refractory to corticosteroid treatment in contrast to the allergic group with HS.Conclusion Collectively, our data show that sleep quality participates in the progression of allergen-induced eosinophilic lung inflammation to corticosteroid-refractory neutrophilic manifestation.
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The perception of sleep as poor may play a critical role in WBC upregulation.
“suggesting a critical role of the perception of sleep as poor in WBC upregulation”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [403]
Increased WBC counts in a sample of over 200 male workers were associated with self-reported poor sleep, but not with sleep duration or shift work patterns.
“increased WBC counts in a sample of over 200 male workers in a manufacturing plant were associated with self-reported poor sleep (assessed by a single question), but not with sleep duration or shift work patterns”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [403]
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
- Authors
- Nunes, J. O. F., Apostolico, J. D. S., Andrade, D. A. G., Ruiz, F. S., Fernandes, E. R., Andersen, M. L., Keller, A. C., & Rosa, D. S.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Keller, Alexandre C.
- Rosa, Daniela S.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 141
- Issue
- 3
- Pages
- 1018-1027.e4
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2738221152
- Cited by
- 43
- References
- 49
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 1 · 2023: 11 · 2022: 4 · 2021: 4 · 2020: 11 · 2019: 4
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, allergic airway inflammation, neutrophilic inflammation, eosinophilic inflammation, ovalbumin sensitization, IL-17, Th17 cells, IL-17 receptor A, steroid resistance, dexamethasone, cytokine profile, sleep quality
- MeSH terms
- Animals, Disease Susceptibility, Female, Humans, Hypersensitivity, Inflammation, Pneumonia, Sleep Deprivation, Cytokines, Mice, Knockout, Mice, Th17 Cells
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