Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats
Abstract
The specific systems and mechanisms affected by sleep deprivation that may perpetuate disease processes in humans still are speculative. In laboratory rats, prolonged sleep deprivation induces a state marked by abnormal control over indigenous bacteria that results in transient infections of internal tissues and eventual lethal septicemia. The present studies investigated changes in blood, serum, and bone marrow parameters that may provide diagnostic clues to immunopathology. Prolonged sleep deprivation was produced in rats by the disk-over-water method, a well-established and selective means that does not interfere with normal waking behaviors. Measurements included bone and blood differential white blood cell counts, multiple serum cytokines and chemokines, several major Ig classes and subclasses, and serum endotoxin concentrations. The results indicated mild, regenerative neutrophilia in sleep-deprived rats, initially accompanied by immature neutrophils and later by monocytosis. The corresponding serum cytokine profile revealed an evolving proinflammatory state, particularly by high incidence of interleukin-1β, implicating mononuclear phagocytes and resident tissue cells as main intermediary sources. In addition, multiple serum Ig classes were increased by sleep deprivation without experimental administration of an exogenous antigen. Despite this immune activation, there was failure to eradicate invading bacteria and toxins, suggesting competing anti-inflammatory processes or interference with immune effector functions during sleep deprivation. Nearly all of the immune-related events that emerged as responses to sleep deprivation have been implicated as etiological or provocative factors in other disease processes and may provide means by which sleep deprivation as a risk factor in disease may become understood.
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Applying the same method of sleep deprivation leads to a breakdown of host defense indicated by a systemic bacterial infection.
“a breakdown of host defense indicated by a systemic bacterial infection was reported after applying the same method of sleep deprivation (172, 175).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [172]
Cites
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,110 · see citing works
Clinical diagnosis and management by laboratory methods
Henry, J. B. (1979) · Medical Entomology and Zoology · Cited by 1,699 · see citing works
Manual of Clinical Laboratory Immunology
Rose, N. R., Hamilton, R. G., & Detrick, B. (1992) · Cited by 1,253 · see citing works
Principles and practice of infectious disease
Cann, K. (1990) · Journal of Hospital Infection · doi:10.1016/0195-6701(90)90013-e · Cited by 1,206 · see citing works
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195 · see citing works
Kleitman, N., & Eckenhoff, J. E. (1964) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196502000-00024 · Cited by 1,079 · see citing works
(2006) · Elsevier eBooks · doi:10.1016/b978-0-12-074903-4.x5000-6 · Cited by 1,073 · see citing works
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050 · see citing works
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974 · see citing works
Effect of Sleep Deprivation on Response to Immunizaton
Spiegel, K. (2002) · JAMA · doi:10.1001/jama.288.12.1469 · Cited by 633 · see citing works
Effects of sleep and circadian rhythm on human circulating immune cells
Born, J., Lange, T., Hansen, K., Mölle, M., & Fehm, H. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4454 · Cited by 611 · see citing works
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455 · see citing works
The Role of Cytokines in Physiological Sleep Regulation
Krueger, J. M., Obál, F., Fang, J., Kubota, T., & Taishi, P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05826.x · Cited by 423 · see citing works
Effect of Sleep Deprivation on Response to Immunizaton
Spiegel, K., Sheridan, J. F., & Cauter, E. V. (2002) · JAMA · doi:10.1001/jama.288.12.1471-a · Cited by 423 · see citing works
Dinges, D. F., Douglas, S. D., Zaugg, L., Campbell, D. E., McMann, J. M., Whitehouse, W. G., Orne, E. C., Kapoor, S. C., Icaza, E., & Orne, M. T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117184 · Cited by 361 · see citing works
The MCP/eotaxin subfamily of CC chemokines
Coillie, E. V., Damme, J. V., & Opdenakker, G. (1999) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00005-2 · Cited by 351 · see citing works
Sleep Enhances the Human Antibody Response to Hepatitis A Vaccination
Lange, T., Perras, B., Fehm, H. L., & Born, J. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000091382.61178.f1 · Cited by 351 · see citing works
Stress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus, M. M., Rao, B. K., Dhabhar, F. S., Ding, W., & Granstein, R. D. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01373.x · Cited by 347 · see citing works
Levitt, R. A. (1966) · Science · doi:10.1126/science.153.3731.85 · Cited by 345 · see citing works
Sleep Deprivation in the Rat: III. Total Sleep Deprivation
Everson, C. A., Bergmann, B. M., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.13 · Cited by 341 · see citing works
Self-citationBiochemical regulation of non-rapid-eye-movement sleep
Krueger, J. M. (2003) · Frontiers in Bioscience · doi:10.2741/1033 · Cited by 329 · see citing works
Small Animal Clinical Diagnosis by Laboratory Methods
(2004) · Elsevier eBooks · doi:10.1016/b0-7216-8903-5/x5001-0 · Cited by 301 · see citing works
Sustained sleep deprivation impairs host defense
Everson, C. A. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.5.r1148 · Cited by 251 · see citing works
Self-citationEffects of sleep deprivation on human immune functions
Moldofsky, H., Lue, F. A., Davidson, J. R., & Gorczynski, R. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.8.2785942 · Cited by 250 · see citing works
Systemic bacterial invasion induced by sleep deprivation
Everson, C. A., & Toth, L. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r905 · Cited by 248 · see citing works
Self-citationCoin Rubbing and Camphor Intoxication—Reply
Bächli, E., Rampini, S. K., & Schneemann, M. (2002) · JAMA · doi:10.1001/jama.288.12.1471-b · Cited by 244 · see citing works
Duncan & Prasse's veterinary laboratory medicine: clinical pathology.
Latimer, K. S. (2011) · Cited by 234 · see citing works
Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats
Everson, C. A., & Crowley, W. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2003 · Cited by 207 · see citing works
Self-citationAntioxidant defense responses to sleep loss and sleep recovery
Everson, C. A., Laatsch, C. D., & Hogg, N. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00565.2004 · Cited by 192 · see citing works
Self-citationSleep Deprivation in the Rat: V. Energy Use and Mediation
Bergmann, B. M., Everson, C. A., Kushida, C. A., Fang, V. S., Leitch, C. A., Schoeller, D. A., Refetoff, S., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.31 · Cited by 166 · see citing works
Self-citationClinical utility of the band count
Cornbleet, P. J. (2002) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(03)00069-6 · Cited by 165 · see citing works
Humoral Links between Sleep and the Immune System
Krueger, J. M., & Majde, J. A. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03133.x · Cited by 163 · see citing works
Hematology and Clinical Biochemistry
Ringler, D. H., & Dabich, L. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-074901-0.50012-5 · Cited by 154 · see citing works
Bøyum, A., Wiik, P., Gustavsson, E., Veiby, O. P., Reseland, J. E., Haugen, A.-H., & Opstad, P. K. (1996) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1996.d01-32.x · Cited by 153 · see citing works
Sleep as a Prognostic Indicator During Infectious Disease in Rabbits
Toth, L. A., Tolley, E. A., & Krueger, J. M. (1993) · Experimental Biology and Medicine · doi:10.3181/00379727-203-43590 · Cited by 153 · see citing works
Stressor exposure and immunological response in man: Interferon-producing capacity and phagocytosis
Palmblad, J. E. W., Cantell, K., Strander, H. A., Fröberg, J. E., Karlsson, C.-G., Levi, L., Granström, M., & Unger, P. (1976) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(76)90020-9 · Cited by 148 · see citing works
Sleep Deprivation in the Rat: II. Methodology
Bergmann, B. M., Kushida, C. A., Everson, C. A., Gilliland, M. A., Obermeyer, W. H., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.5 · Cited by 133 · see citing works
Self-citationDiurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures
Haack, M., Kraus, T., Schuld, A., Dalal, M. A., Koethe, D., & Pollmächer, T. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00006-9 · Cited by 113 · see citing works
Mediators of Inflammation and Their Interaction with Sleep
Mullington, J. M., Hinze‐Selch, D., & Pollmächer, T. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05825.x · Cited by 107 · see citing works
Brain-Immune interactions in sleep
Marshall, L., & Born, J. (2002) · International Review of Neurobiology · doi:10.1016/s0074-7742(02)52007-9 · Cited by 102 · see citing works
Immunology of Infectious Disease
Kaufmann, S. H. E., Sher, A., & Ahmed, R. (2002) · Medical Entomology and Zoology · Cited by 101 · see citing works
Hu, J., Chen, Z., Gorczynski, C. P., Gorczynski, L. Y., Kai, Y., Lee, L., Manuel, J., & Gorczynski, R. M. (2003) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2003.03.001 · Cited by 101 · see citing works
Everson, C., Smith, C., & Sokoloff, L. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06769.1994 · Cited by 96 · see citing works
Self-citationInterleukin-1 is involved in responses to sleep deprivation in the rabbit
Opp, M. R., & Krueger, J. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91764-7 · Cited by 93 · see citing works
Neural-immune interactions in the regulation of sleep
Opp, M. R. (2003) · Frontiers in Bioscience · doi:10.2741/1061 · Cited by 92 · see citing works
Bovill, E. G., Bild, D. E., HEISS, G. M., Kuller, L. H., Lee, M. H., Rock, R. C., & WAHL, P. W. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008687 · Cited by 92 · see citing works
Metabolic Effects of Infection on Protein and Energy Status
Powanda, M. C., & Beisel, W. R. (2003) · Journal of Nutrition · doi:10.1093/jn/133.1.322s · Cited by 89 · see citing works
Nutritional and metabolic adaptations to prolonged sleep deprivation in the rat
Everson, C. A., & Wehr, T. A. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.2.r376 · Cited by 88 · see citing works
Self-citationEffects of 48 hours sleep deprivation on human immune profile.
Öztürk, L., Pelin, Z., Karadeniz, D., Kaynak, H., Cakar, L., & Gözükırmızı, E. (1999) · PubMed · Cited by 86 · see citing works
Stress in Subjects Undergoing Sleep Deprivation
KOLLAR, E. J., SLATER, G. R., Palmer, J. O., Docter, R. F., & Mandell, A. J. (1966) · Psychosomatic Medicine · doi:10.1097/00006842-196603000-00002 · Cited by 78 · see citing works
Health effects of sleep deprivation.
Naitoh, P., Kelly, T. L., & Englund, C. E. (1989) · PsycEXTRA Dataset · doi:10.1037/e477532004-001 · Cited by 69 · see citing works
The Effect of Total Sleep Deprivation on Plasma Melatonin and Cortisol in Healthy Human Volunteers
Salín-Pascual, R. J., Ortega-Soto, H. A., Huerto‐Delgadillo, L., Camacho‐Arroyo, I., Roldán-Roldán, G., & Tamarkin, L. (1988) · SLEEP · doi:10.1093/sleep/11.4.362 · Cited by 68 · see citing works
Sleep Science: Integrating Basic Research and Clinical Practice
Schwartz, W. J. (1997) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/isbn.978-3-318-00247-8 · Cited by 68 · see citing works
(2011) · SpringerReference · doi:10.1007/springerreference_35525 · Cited by 67 · see citing works
Sleep Deprivation in the Rat: IX. Recovery
Everson, C. A., Gilliland, M. A., Kushida, C. A., Pilcher, J. J., Fang, V. S., Refetoff, S., Bergmann, B. M., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.60 · Cited by 65 · see citing works
Self-citationExperimental Immunomodulation, Sleep, and Sleepiness in Humans
Pollmächer, T., Schuld, A., Kraus, T., Haack, M., Hinze‐Selch, D., & Mullington, J. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05413.x · Cited by 61 · see citing works
Psychological, Psychophysiological, and Biochemical Correlates of Prolonged Sleep Deprivation
KOLLAR, E. J., PASNAU, R. O., Rubín, R. T., Naitoh, P., Slater, G. G., & Kales, A. (1969) · American Journal of Psychiatry · doi:10.1176/ajp.126.4.488 · Cited by 61 · see citing works
(1969) · PubMed · Cited by 58 · see citing works
Cirelli, C., & Tononi, G. (2004) · CRC Press eBooks · doi:10.1201/b14428-8 · Cited by 53 · see citing works
Mistlberger, R. E., Belcourt, J., & Antle, M. C. (2002) · Journal of Biological Rhythms · doi:10.1177/07430402017003006 · Cited by 51 · see citing works
p73, the “Assistant” Guardian of the Genome?
Melino, G. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1299.002 · Cited by 46 · see citing works
Brown, R., Price, R. J., King, M. G., & Husband, A. J. (1989) · Brain Behavior and Immunity · doi:10.1016/0889-1591(89)90031-7 · Cited by 45 · see citing works
Sleep Deprivation in the Rat: XIV. Comparison of Waking Hypothalamic and Peritoneal Temperatures
Obermeyer, W. H., Bergmann, B. M., & Rechtschaffen, A. (1991) · SLEEP · doi:10.1093/sleep/14.4.285 · Cited by 39 · see citing works
Toth, L. A., & Rehg, J. E. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00321-x · Cited by 33 · see citing works
Everson, C. A., & Reed, H. L. (1995) · Endocrinology · doi:10.1210/endo.136.4.7895653 · Cited by 32 · see citing works
Self-citationThe Complete Blood Count and Bone Marrow Examination: General Comments and Selected Techniques
Weiss, D. J., & Tvedten, H. (2004) · Elsevier eBooks · doi:10.1016/b0-72-168903-5/50006-9 · Cited by 31 · see citing works
Effect of Sleep Deprivation on Serum Influenza-Specific IgG
Renegar, K. B., Floyd, R. A., & Krueger, J. M. (1998) · SLEEP · doi:10.1093/sleep/21.1.19 · Cited by 26 · see citing works
Heiser, P., Dickhaus, B., Opper, C., Hemmeter, U., Remschmidt, H., Wesemann, W., Krieg, J.-C., & Schreiber, W. (2001) · The World Journal of Biological Psychiatry · doi:10.3109/15622970109027498 · Cited by 22 · see citing works
Sleep Deprivation in the Rat: XVI. Effects in a Light-Dark Cycle
Tsai, L., Bergmann, B. M., & Rechtschaffen, A. (1992) · SLEEP · doi:10.1093/sleep/15.6.537 · Cited by 16 · see citing works
Clinical Manifestations of Prolonged Sleep Deprivation
Everson, C. A. (1997) · KARGER eBooks · doi:10.1159/000061563 · Cited by 10 · see citing works
Self-citationEffect of Prolonged Wakefulness on the Urinary Excretion of 17-Ketosteroids.
Tyler, D. B., Marx, W., & Goodman, J. (1946) · Experimental Biology and Medicine · doi:10.3181/00379727-62-15364 · Cited by 10 · see citing works
Acquired Immunity against Bacteria
Collins, H., & Kaufmann, S. H. E. (2014) · ASM Press eBooks · doi:10.1128/9781555817978.ch15 · Cited by 7 · see citing works
Pathology and Pathogenesis of Bacterial Infections
Stenger, S., & Modlin, R. L. (2014) · ASM Press eBooks · doi:10.1128/9781555817978.ch20 · Cited by 4 · see citing works
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Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“Studies in both humans and animals did not find changes in plasma levels of IL-4 and IL-10 after sleep manipulation, although these cytokines are often below detection limits without stimulation (171, 236, 248, 480, 506, 547, 594).”
BackgroundResultInfluentialBesedovsky, L., Lange, T., & Born, J. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1044-0 · Cited by 1,153 · see citing works
Dysregulation of inflammatory responses by chronic circadian disruption
Castanon-Cervantes, O., Wu, M., Ehlen, J. C., Paul, K., Gamble, K. L., Johnson, R. L., Besing, R. C., Menaker, M., Gewirtz, A. T., & Davidson, A. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001026 · Cited by 542 · see citing works
Exploring phylogeny to find the function of sleep
Anafi, R. C., Kayser, M. S., & Raizen, D. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0098-9 · Cited by 259 · see citing works
Ferrie, J. E., Kivimaki, M., Akbaraly, T. N., Singh-Manoux, A., Miller, M. A., Gimeno, D., Kumari, M., Davey Smith, G., & Shipley, M. J. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt072 · Cited by 218 · see citing works
Effects of acute and chronic sleep loss on immune modulation of rats
Zager, A., Andersen, M. L., Ruiz, F. S., Antunes, I. B., & Tufik, S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00105.2007 · Cited by 200 · see citing works
Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats
Everson, C. A., Henchen, C. J., Szabo, A., & Hogg, N. (2014) · Sleep · doi:10.5665/sleep.4244 · Cited by 136 · see citing works
Self-citationAho, V., Ollila, H. M., Rantanen, V., Kronholm, E., Surakka, I., van Leeuwen, W. M. A., Lehto, M., Matikainen, S., Ripatti, S., Härmä, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077184 · Cited by 93 · see citing works
Palma, B. D., Gabriel, A., Colugnati, F. A. B., & Tufik, S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00186.2006 · Cited by 74 · see citing works
Sleep Deprivation After Septic Insult Increases Mortality Independent of Age
Friese, R. S., Bruns, B., & Sinton, C. M. (2009) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e318190c3a1 · Cited by 64 · see citing works
Sleep deprivation predisposes allergic mice to neutrophilic lung inflammation
Nunes, J. O. F., Apostolico, J. D. S., Andrade, D. A. G., Ruiz, F. S., Fernandes, E. R., Andersen, M. L., Keller, A. C., & Rosa, D. S. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.06.025 · Cited by 43 · see citing works
Everson, C. A., Thalacker, C. D., & Hogg, N. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90623.2008 · Cited by 35 · see citing works
Self-citationCross-Translational Studies in Human and Drosophila Identify Markers of Sleep Loss
Thimgan, M. S., Gottschalk, L., Toedebusch, C., McLeland, J., Rechtschaffen, A., Gilliland-Roberts, M., Duntley, S. P., & Shaw, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061016 · Cited by 26 · see citing works
Zager, A., Ruiz, F. S., Tufik, S., & Andersen, M. L. (2012) · Neuroimmunomodulation · doi:10.1159/000329484 · Cited by 24 · see citing works
Paradoxical sleep deprivation impairs mouse survival after infection with malaria parasites
Lungato, L., Gazarini, M. L., Paredes-Gamero, E. J., Tufik, S., & D’Almeida, V. (2015) · Malaria Journal · doi:10.1186/s12936-015-0690-7 · Cited by 21 · see citing works
- Authors
- Everson, C. A.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Everson, Carol A.
- ORCID
- Everson, Carol A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2005-10
- Volume
- 289
- Issue
- 4
- Pages
- R1054-R1063
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2109852871
- Cited by
- 141
- References
- 74
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 10 · 2014: 5 · 2013: 11 · 2012: 10
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns038733-03, 7r29hl059271-04)
- National Heart, Lung, and Blood Institute (HL59271)
- National Institute of Neurological Disorders and Stroke (NS-38733)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, differential leukocyte count, serum cytokines, serum immunoglobulins, IL-1β, neutrophilia, monocytosis, endotoxin, septicemia, bone marrow, chemokines, immune activation
- MeSH terms
- Adaptation, Physiological, Animals, Endotoxins, Immunoglobulins, Leukocyte Count, Male, Sleep Deprivation, Cytokines, Rats, Sprague-Dawley, Rats
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