Cited by 71Fatty Acid Research and HealthNatural Products and Biological ResearchNuts composition and effects

Effect of flaxseed supplementation on lipid profile: An updated systematic review and dose-response meta-analysis of sixty-two randomized controlled trials

Hadi, Amir, Askarpour, Moein, Salamat, Shekoufeh, Ghaedi, Ehsan, Symonds, Micheal E., Miraghajani, Maryam·2020·Pharmacological Research

Abstract

Raised plasma lipids are one the most important risk factors for cardiovascular disease. Flaxseed contains considerable amounts of α-linolenic acid, phenolic compounds, and lignans, which each have the capacity to reduce circulating lipid concentrations. This study aimed to systematically review current evidence to identify the potential effects of flaxseed supplementation on blood lipid profiles using a meta-analysis of randomized controlled trials (RCTs). PubMed, Scopus, Web of Science, and Google Scholar databases were searched for publications between January 1900 and May 2019. Weighted mean differences (WMDs) were analyzed using a random-effects model. The Cochrane Collaboration tool was also used to assess the risk of bias of the studies included. Sixty-two RCTs with a total of 3772 participants met the eligibility criteria. Our analysis showed that flaxseed supplementation significantly reduced total cholesterol (TC) (WMD = -5.389 mg/dL; 95% CI: -9.483, -1.295, p = 0.010), triglyceride (TG) (WMD = -9.422 mg/dL; 95% CI: -15.514, -3.330, p = 0.002), and low-density lipoprotein cholesterol (LDL-C) (WMD = -4.206 mg/dl; 95% CI: -7.260, -1.151, p = 0.007) concentrations. However, it had no effects on high-density lipoprotein cholesterol (WMD = 0.047 mg/dl; 95% CI: -0.777, 0.872, p = 0.910). This meta-analysis suggested that flaxseed supplementation improves serum TC, TG, and LDL-C, which could delay the progression of heart disease. Further studies with large-scale and better design are now needed to confirm these results.

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Crossref · 10.1016/j.phrs.2019.104622

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Authors
Hadi, A., Askarpour, M., Salamat, S., Ghaedi, E., Symonds, M. E., & Miraghajani, M.
Affiliations
  • Tehran University of Medical Sciences (IR)
  • Ahvaz Jundishapur University of Medical Sciences (IR)
  • University of Nottingham (GB)
Corresponding author
  • Ghaedi, Ehsan
  • Miraghajani, Maryam
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2020-02
Volume
152
Pages
104622
ISSN
1043-6618 (ISSN-L)
OpenAlex
W2998510612
Cited by
71
References
101
Citations by year
2026: 4 · 2025: 10 · 2024: 20 · 2023: 8 · 2022: 14 · 2021: 11 · 2020: 4
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
Keywords
flaxseed supplementation, lipid profile, total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, alpha-linolenic acid, lignans, phenolic compounds, cardiovascular risk, dose-response relationship
MeSH terms
Animals, Dose-Response Relationship, Drug, Humans, Randomized Controlled Trials as Topic, Dietary Supplements, Flax, Lipid Metabolism

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