The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Hypolipidemia is associated with the severity of COVID-19
Open accessAbstract
Background Many patients with coronavirus disease 2019 (COVID-19) suffer multiple organ dysfunctions. However, whether patients develop dyslipidemia is unknown. Objective In this study, we aimed to investigate the pathological alterations of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and total cholesterol (TC) in COVID-19 patients and their relationships with the disease severity. Methods A retrospective study was performed to examine serum levels of LDL-c, HDL-c, and TC on 597 COVID-19 patients (mild: 394; severe, 171; critical: 32) who were hospitalized in our center between February 1 and March 3, 2020. Age- and gender-matched normal subjects (n = 50) who had routine laboratory lipid tests between October 1 and November 1, 2019 in our center were included as the control group. Results LDL-c and TC levels were significantly lower in COVID-19 patients as compared with normal subjects (P < .001). There were significant and gradual decreases in levels of LDL-c (median (IQR) in mg/dL, mild: 91 (76, 104); severe: 86 (69, 102); critical: 69 (48, 81); P < .02) and TC (mild: 173 (148, 203); severe: 167 (138, 197); critical: 125 (95, 162); P < .05) across all three groups. HDL-c levels only decreased significantly in critical cases as compared with levels in mild and severe cases. LDL-c and TC levels inversely correlated with C-reactive protein and interleukin-6, and positively correlated with the number of lymphocytes in patients. Conclusions Development of hypolipidemia begins in patients with mild symptoms. It progressively becomes worse in an association with the disease severity.
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Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V., & Fendt, S.-M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.013 · Cited by 758
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases
Song, Y., Liu, J., Zhao, K., Gao, L., & Zhao, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.09.001 · Cited by 322
Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19
Aparisi, Á., Iglesias-Echeverría, C., Ybarra-Falcón, C., Cusácovich, I., Uribarri, A., García-Gómez, M., Ladrón, R., Fuertes, R., Candela, J., Tobar, J., et al. (2021) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.06.016 · Cited by 48
Guild-Level Microbiome Signature Associated with COVID-19 Severity and Prognosis
Guo, M., Wu, G., Tan, Y., Li, Y., Jin, X., Qi, W., Guo, X., Zhang, C., Zhu, Z., & Zhao, L. (2023) · mBio · doi:10.1128/mbio.03519-22 · Cited by 19
Metadata
- Authors
- Wei, X., Zeng, W., Su, J., Wan, H., Yu, X., Cao, X., Tan, W., & Wang, H.
- Venue
- Journal of Clinical Lipidology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 14
- Issue
- 3
- Pages
- 297-304
- ISSN
- 1876-4789 (ISSN-L)
- 1933-2874
- OpenAlex
- W3022331416
- Cited by
- 355
- References
- 25
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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