Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

Savitz, Jonathan B.; Price, Joseph L.; Drevets, Wayne C.

doi:10.1016/j.neubiorev.2014.02.008

Cited by 145Bipolar Disorder and TreatmentSchizophrenia research and treatmentTreatment of Major Depression

Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

Savitz, Jonathan B., Price, Joseph L., Drevets, Wayne C.·2014·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2014.02.008

Open this paper in CoChat — free account

Abstract

The question of whether BD is primarily a developmental disorder or a progressive, neurodegenerative disorder remains unresolved. Here, we review the morphometric postmortem and neuroimaging literature relevant to the neuropathology of bipolar disorder (BD). We focus on the medial prefrontal cortex (mPFC) network, a key system in the regulation of emotional, behavioral, endocrine, and innate immunological responses to stress. We draw four main conclusions: the mPFC is characterized by (1) a decrease in volume, (2) reductions in neuronal size, and/or changes in neuronal density, (3) reductions in glial cell density, and (4) changes in gene expression. These data suggest the presence of dendritic atrophy of neurons and the loss of oligodendroglial cells in BD, although some data additionally suggest a reduction in the cell counts of specific subpopulations of GABAergic interneurons. Based on the weight of the postmortem and neuroimaging literature discussed herein, we favor a complex hypothesis that BD primarily constitutes a developmental disorder, but that additional, progressive, histopathological processes also are associated with recurrent or chronic illness. Conceivably BD may be best conceptualized as a progressive neurodevelopmental disorder.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2014.02.008

Cites

208 of 208 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

There is evidence of vmPFC gray matter loss in mood disorders.
“There is evidence of vmPFC gray matter loss in mood disorders7,115,116, which implies dendritic atrophy.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [116]

From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health
Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.11.009 · Cited by 3,224 · see citing works
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Self-citation
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Self-citation
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Self-citation
Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder
Guidotti, A., Auta, J., Davis, J. M., Gerevini, V. D. G., Dwivedi, Y., Grayson, D. R., Impagnatiello, F., Pandey, G. N., Pesold, C., Sharma, R. P., et al. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1061 · Cited by 1,203 · see citing works
The subgenual anterior cingulate cortex in mood disorders
Drevets, W. C., Savitz, J., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900013754 · Cited by 1,109 · see citing works
Self-citation
Structural Brain Changes in Aging: Courses, Causes and Cognitive Consequences
Fjell, A. M., & Walhovd, K. B. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.3.187 · Cited by 1,085 · see citing works
NMDA receptor hypofunction model of schizophrenia
Olney, J. W., Newcomer, J. W., & Farber, N. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00029-1 · Cited by 1,020 · see citing works
Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting
Liston, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968 · see citing works
A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder
Robinson, L. J., Thompson, J. M., Gallagher, P., Goswami, U., Young, A. H., Ferrier, I. N., & Moore, P. B. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.02.016 · Cited by 962 · see citing works
Architectonic subdivision of the human orbital and medial prefrontal cortex
Öngür, D., Ferry, A. T., & Price, J. L. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10609 · Cited by 944 · see citing works
Self-citation
Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.
Tkachev, D., Mimmack, M., Ryan, M. M., Wayland, M., Freeman, T., Jones, P., Starkey, M., Webster, M., Yolken, R., & Bahn, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14289-4 · Cited by 940 · see citing works
Reciprocal regulation of the neural and innate immune systems
Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910 · see citing works
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works
The orbitofrontal cortex and beyond: From affect to decision-making
Rolls, E. T., & Fabian Grabenhorst, B. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.001 · Cited by 808 · see citing works
Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791 · see citing works
Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder
Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766 · see citing works
Chronic stress alters dendritic morphology in rat medial prefrontal cortex
Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 750 · see citing works
Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives
Arts, B. M. G., Jabben, N., A, L. K. M., & van Os, J. (2007) · Psychological Medicine · doi:10.1017/s0033291707001675 · Cited by 709 · see citing works
Neural correlates of heart rate variability during emotion
Lane, R. D., Kateri Mcrae, A., Reiman, E. M., Chen, K., Ahern, G. L., & Thayer, J. F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.056 · Cited by 687 · see citing works
Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659 · see citing works
Lithium-induced increase in human brain grey matter
Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G., & Menji, H. K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02793-8 · Cited by 649 · see citing works
Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634 · see citing works
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
The prefrontal cortex as a key target of the maladaptive response to stress
Cerqueira, J. J., Mailliet, F., Almeida, O. F. X., Jay, T. M., & Sousa, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4372-06.2007 · Cited by 599 · see citing works
Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome
Martínez‐Arán, A., Vieta, E., Colom, F., Torrent, C., Sánchez‐Moreno, J., Reinares, M., Benabarre, A., Goikolea, J. M., Brugué, E., Daban, C., et al. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00111.x · Cited by 587 · see citing works
Cholinergic control of inflammation
Rosas‐Ballina, M., & Tracey, K. J. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02098.x · Cited by 582 · see citing works
Depression, the autonomic nervous system, and coronary heart disease
Carney, R. M., Freedland, K. E., & Veith, R. C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000162254.61556.d5 · Cited by 582 · see citing works
Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572 · see citing works
Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus
Sklar, P. B., Gabriel, S., McInnis, M. G., Bennett, P., Lim, Y.-M., Tsan, G., Schaffner, S. F., Kirov, G., Jones, I. R., Owen, M. J., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001058 · Cited by 563 · see citing works
Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494 · see citing works
Self-citation
Preterm Birth and Psychiatric Disorders in Young Adult Life
Nosarti, C., Reichenberg, A., Murray, R. M., Cnattingius, S., Lambe, M. P., Yin, L., MacCabe, J. H., Rifkin, L., & Hultman, C. M. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1374 · Cited by 467 · see citing works
Depression, Comorbid Anxiety Disorders, and Heart Rate Variability in Physically Healthy, Unmedicated Patients: Implications for Cardiovascular Risk
Kemp, A. H., Quintana, D. S., Felmingham, K. L., Matthews, S. T., & Jelinek, H. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030777 · Cited by 447 · see citing works
Functioning and Disability in Bipolar Disorder: An Extensive Review
Sánchez‐Moreno, J., Martínez‐Arán, A., Tabarés‐Seisdedos, R., Torrent, C., Vieta, E., & Ayuso‐Mateos, J. L. (2009) · Psychotherapy and Psychosomatics · doi:10.1159/000228249 · Cited by 446 · see citing works
Cognitive Impairment in Euthymic Bipolar Patients With and Without Prior Alcohol Dependence
van Gorp, W. G., Altshuler, L. L., Theberge, D. C., Wilkins, J. N., & Dixon, W. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.41 · Cited by 413 · see citing works
Is Schizophrenia a Progressive Neurodevelopmental Disorder? Toward a Unitary Pathogenetic Mechanism
Woods, B. T. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.12.1661 · Cited by 413 · see citing works
Density of Glutamic Acid Decarboxylase 67 Messenger RNA–ContainingNeurons That Express the N-Methyl-D-AspartateReceptor Subunit NR2A in the Anterior Cingulate Cortex in Schizophreniaand Bipolar Disorder
Woo, T.-U. W., Walsh, J. P., & Benes, F. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.649 · Cited by 411 · see citing works
Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment
Czéh, B., Keuker, J. I. H., Ryguła, R., Abumaria, N., Hiemke, C., Domenici, E., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301275 · Cited by 397 · see citing works
Effects of medication on neuroimaging findings in bipolar disorder: an updated review
Hafeman, D. M., Chang, K. D., Garrett, A. S., Sanders, E. M., & Phillips, M. L. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01023.x · Cited by 379 · see citing works
Association of Genetic Risks for Schizophrenia and Bipolar DisorderWith Specific and Generic Brain Structural Endophenotypes
McDonald, C., Bullmore, E. T., Sham, P. C., Chitnis, X., Wickham, H., Bramon, E., & Murray, R. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.10.974 · Cited by 379 · see citing works
Lateralized Effects of Medial Prefrontal Cortex Lesions on Neuroendocrine and Autonomic Stress Responses in Rats
Sullivan, R. M., & Gratton, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02834.1999 · Cited by 377 · see citing works
Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Beasley, C. L., Zhang, Z. J., Patten, I., & Reynolds, G. P. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01360-4 · Cited by 374 · see citing works
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 374 · see citing works
Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder
Nunes, P. V., Forlenza, O. V., & Gattaz, W. F. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.029868 · Cited by 369 · see citing works
Cognitive function in euthymic Bipolar I Disorder
Zubieta, J., Huguelet, P., Lajiness-O'Neill, R. R., & Giordani, B. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00242-6 · Cited by 356 · see citing works
Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic–depressive illness
Manji, H. K., Moore, G. J., & Chen, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00979-3 · Cited by 352 · see citing works
Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders
Drevets, W. C., Öngür, D., & Price, J. L. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000370 · Cited by 352 · see citing works
Self-citation
A Discriminating Messenger RNA Signature for Bipolar Disorder Formed by an Aberrant Expression of Inflammatory Genes in Monocytes
Padmos, R. C., Hillegers, M. H. J., Knijff, E. M., Vonk, R., Bouvy, A., Staal, F. J. T., de Ridder, D., Kupka, R. W., Nolen, W. A., & Drexhage, H. A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.395 · Cited by 336 · see citing works
Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder
Lewandowski, K. E., Cohen, B. M., & Öngür, D. (2010) · Psychological Medicine · doi:10.1017/s0033291710001042 · Cited by 335 · see citing works
The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects
Benes, F. M., Vincent, S. L., & Todtenkopf, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01084-8 · Cited by 327 · see citing works
Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress
RADLEY, J., ROCHER, A., JANSSEN, W., HOF, P., MCEWEN, B., & MORRISON, J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.008 · Cited by 323 · see citing works
The neuropathology of primary mood disorder
Harrison, P. J. (2002) · Brain · doi:10.1093/brain/awf149 · Cited by 321 · see citing works
Tissue pH as an indicator of mRNA preservation in human post-mortem brain
Kingsbury, A. E., Foster, O. J. F., Nisbet, A. P., Cairns, N. J., Bray, L., Eve, D. J., Lees, A. J., & MARSDEN, C. D. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00219-5 · Cited by 320 · see citing works
Elevated Left and Reduced Right Orbitomedial Prefrontal Fractional Anisotropy in Adults With Bipolar Disorder Revealed by Tract-Based Spatial Statistics
Versace, A., Almeida, J., Hassel, S., Walsh, N., Novelli, M., Klein, C. R., Kupfer, D. J., & Phillips, M. L. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.9.1041 · Cited by 315 · see citing works
Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group
Simonsen, C., Sundet, K. S., Vaskinn, A., Birkenaes, A. B., Engh, J. A., Færden, A., Jónsdóttir, H., Ringen, P. A., Opjordsmoen, S., Melle, I., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp034 · Cited by 306 · see citing works
Regional cerebral cortical thinning in bipolar disorder
Lyoo, I. K., Sung, Y. H., Dager, S. R., Friedman, S. D., Lee, J., Kim, S. J., Kim, N., Dünner, D. L., & Renshaw, P. F. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00284.x · Cited by 303 · see citing works
Subgenual Cingulate Cortex Volume in First-Episode Psychosis
Hirayasu, Y., Shenton, M. E., Salisbury, D. F., Kwon, J. S., Wible, C. G., Fischer, I. A., Yurgelun-Todd, D., Zarate, C., Kikinis, R., Jolesz, F. A., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1091 · Cited by 301 · see citing works
Cognitive impairment in the euthymic phase of affective disorder
Kessing, L. V. (1998) · Psychological Medicine · doi:10.1017/s0033291798006862 · Cited by 292 · see citing works
Greater Cortical Gray Matter Density in Lithium-Treated Patients with Bipolar Disorder
Bearden, C. E., Thompson, P. M., Dalwani, M., Hayashi, K. M., Lee, A. D., Nicoletti, M., Trakhtenbroit, M., Glahn, D. C., Brambilla, P., Sassi, R. B., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.027 · Cited by 289 · see citing works
Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania.
Cavanagh, J., Beck, M. V., Muir, W., & Blackwood, D. (2002) · The British journal of psychiatry : the journal of mental science · doi:10.1192/bjp.180.4.320 · Cited by 277 · see citing works
White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
Sussmann, J. E., Lymer, G. K. S., McKirdy, J. W., Moorhead, T. W. J., Maniega, S. M., Job, D. E., Hall, J., Bastin, M. E., Johnstone, E. C., Lawrie, S. M., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00646.x · Cited by 273 · see citing works
Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania
Öngür, D., Jensen, J. E., Prescot, A. P., Stork, C., Lundy, M. Y., Cohen, B. M., & Renshaw, P. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.014 · Cited by 272 · see citing works
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1
Veldić, M., Guidotti, A., Maloku, E., Davis, J. M., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409665102 · Cited by 269 · see citing works
Lithium Treatment and Risk of Dementia
Kessing, L. V., Søndergård, L., Forman, J. L., & Andersen, P. K. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1331 · Cited by 267 · see citing works
Clinical implications of a staging model for bipolar disorders
Kapczinski, F. P., Dias, V. V., Kauer‐Sant’Anna, M., Frey, B. N., Grassi‐Oliveira, R., Colom, F., & Berk, M. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.31 · Cited by 263 · see citing works
Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins
Eastwood, S. L., & Harrison, P. J. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00530-5 · Cited by 262 · see citing works
Effect of Chronic Antipsychotic Exposure on Astrocyte and Oligodendrocyte Numbers in Macaque Monkeys
Konopaske, G. T., Dorph‐Petersen, K., Sweet, R. A., Pierri, J. N., Zhang, W., Sampson, A. R., & Lewis, D. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.018 · Cited by 260 · see citing works
White Matter Tractography in Bipolar Disorder and Schizophrenia
McIntosh, A. M., Maniega, S. M., Lymer, G. K. S., McKirdy, J. W., Hall, J., Sussmann, J. E., Bastin, M. E., Clayden, J. D., Johnstone, E. C., & Lawrie, S. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.026 · Cited by 259 · see citing works
Frontotemporal Alterations in Pediatric Bipolar Disorder
Dickstein, D. P., Milham, M. P., Nugent, A. C., Drevets, W. C., Charney, D. S., Pine, D. S., & Leibenluft, E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.734 · Cited by 255 · see citing works
Self-citation
Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density
Chana, G., Landau, S., Beasley, C. L., Everall, I., & Cotter, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00114-8 · Cited by 245 · see citing works
The Neurocognitive Signature of Psychotic Bipolar Disorder
Glahn, D. C., Bearden, C. E., Barguil, M., Barrett, J., Reichenberg, A., Bowden, C. L., Soares, J. C., & Velligan, D. I. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.001 · Cited by 241 · see citing works
Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder
Wang, F., Kalmar, J. H., He, Y., Jackowski, M., Chepenik, L. G., Edmiston, E. K., Tie, K., Gong, G., Shah, M. P., Jones, M., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.023 · Cited by 236 · see citing works
A Longitudinal Study of the Effects of Lithium Treatment on Prefrontal and Subgenual Prefrontal Gray Matter Volume in Treatment-Responsive Bipolar Disorder Patients
Moore, G. J., Cortese, B. M., Glitz, D. A., Zajac-Benitez, C., Quiroz, J. A., Uhde, T. W., Drevets, W. C., & Manji, H. K. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.07m03745 · Cited by 234 · see citing works
Self-citation
Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders
Vostrikov, V. M., Uranova, N. A., & Orlovskaya, D. D. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.04.014 · Cited by 233 · see citing works
Alteration of cardiac autonomic functions in patients with major depression: A study using heart rate variability measures
Udupa, K., Sathyaprabha, T. N., Thirthalli, J., Kishore, K., Lavekar, G. S., Raju, T. R., & Gangadhar, B. N. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.10.007 · Cited by 231 · see citing works
Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder
Pennington, K., Beasley, C. L., Dicker, P., Fagan, A., English, J., Pariante, C. M., Wait, R., Dunn, M. J., & Cotter, D. R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002098 · Cited by 227 · see citing works
Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence
López‐Jaramillo, C., Lopera-Vásquez, J. P., Gallo, A., Ospina‐Duque, J., Bell, V., Torrent, C., Martínez‐Arán, A., & Vieta, E. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00835.x · Cited by 223 · see citing works
Diagnosis-Related Regional Gray Matter Loss Over Two Years in First Episode Schizophrenia and Bipolar Disorder
Farrow, T. F. D., Whitford, T. J., Williams, L. M., Gomes, L. J., & Harris, A. W. F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.033 · Cited by 222 · see citing works
Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides
Torres-Platas, S. G., Hercher, C., Davoli, M. A., Maussion, G., Labonté, B., Turecki, G., & Mechawar, N. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.154 · Cited by 221 · see citing works
Birth Weight, Schizophrenia, and Adult Mental Disorder
Abel, K. M., Wicks, S., Susser, E., Dalman, C., Pedersen, M. G., Mortensen, P. B., & Webb, R. T. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.100 · Cited by 219 · see citing works
Imaging phenotypes of major depressive disorder: genetic correlates
Savitz, J. B., & Drevets, W. C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.082 · Cited by 216 · see citing works
Self-citation
Longitudinal neuroimaging and neuropsychological changes in bipolar disorder patients: Review of the evidence
Lim, C. S., Baldessarini, R. J., Vieta, E., Yücel, M., Bora, E., & Sim, K. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.003 · Cited by 214 · see citing works
Evidence of White Matter Pathology in Bipolar Disorder Adolescents Experiencing Their First Episode of Mania: A Diffusion Tensor Imaging Study
Adler, C. M., Adams, J., DelBello, M. P., Holland, S. K., Schmithorst, V. J., Levine, A. D., Jarvis, K., & Strakowski, S. M. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.322 · Cited by 214 · see citing works
The density and spatial distribution of gabaergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Cotter, D., Landau, S., Beasley, C. L., Stevenson, R. N., Chana, G., MacMillan, L., & Everall, I. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01243-4 · Cited by 211 · see citing works
Neural Response to Catecholamine Depletion in Unmedicated Subjects With Major Depressive Disorder in Remission and Healthy Subjects
Hasler, G., Fromm, S., Carlson, P. J., Luckenbaugh, D. A., Waldeck, T., Geraci, M., Roiser, J. P., Neumeister, A., Meyers, N., Charney, D. S., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.521 · Cited by 209 · see citing works
Self-citation
Specific and Generalized Neuropsychological Deficits: A Comparison of Patients With Various First-Episode Psychosis Presentations
Zanelli, J., Reichenberg, A., Morgan, K. D., Fearon, P., Kravariti, E., Dazzan, P., Morgan, C., Zanelli, C., Demjaha, A., Jones, P. B., et al. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09010118 · Cited by 209 · see citing works
Anterior cingulate cortex pathology in schizophrenia and bipolar disorder
Bouras, C., Kövari, E., Hof, P. R., Riederer, B. M., & Giannakopoulos, P. (2001) · Acta Neuropathologica · doi:10.1007/s004010100392 · Cited by 208 · see citing works
Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
Cecil, K. M., DelBello, M. P., Morey, R., & Strakowski, S. M. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.02235.x · Cited by 207 · see citing works
Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia
Webster, M. J., O’Grady, J., Kleinman, J. E., & Weickert, C. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.037 · Cited by 206 · see citing works
Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
Nugent, A. C., Milham, M. P., Bain, E. E., Mah, L., Cannon, D. M., Marrett, S., Zarate, C. A., Pine, D. S., Price, J. L., & Drevets, W. C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.029 · Cited by 206 · see citing works
Self-citation
Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses
Haznedar, M. M., Roversi, F., Pallanti, S., Rossi, N. B., Schnur, D. B., LiCalzi, E. M., Tang, C. Y., Hof, P. R., Hollander, E., & Buchsbaum, M. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.002 · Cited by 202 · see citing works
Heart rate variability in bipolar mania and schizophrenia
Henry, B. L., Minassian, A., Paulus, M. P., Geyer, M. A., & Perry, W. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.07.011 · Cited by 197 · see citing works
Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play
Savitz, J. B., Rauch, S. L., & Drevets, W. C. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.25 · Cited by 189 · see citing works
Self-citation
Voxel-based morphometry in adolescents with bipolar disorder: first results
Wilke, M., Kowatch, R. A., DelBello, M. P., Mills, N. P., & Holland, S. K. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.01.004 · Cited by 189 · see citing works
Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention
Berk, M., Brnabic, A. J. M., Dodd, S., Kelin, K., Tohen, M. F., Malhi, G. S., Berk, L., Conus, P., & McGorry, P. D. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00889.x · Cited by 187 · see citing works
Neuroprogression in bipolar disorder
Schneider, M. R., DelBello, M. P., McNamara, R. K., Strakowski, S. M., & Adler, C. M. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01024.x · Cited by 186 · see citing works
Decreased glutamic acid decarboxylase67 mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders
Thompson, M., Weickert, C. S., Wyatt, E. J., & Webster, M. J. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.02.005 · Cited by 185 · see citing works
Neuropsychological dysfunction in bipolar affective disorder: a critical opinion
Savitz, J. B., Solms, M., & Ramesar, R. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00203.x · Cited by 182 · see citing works
Self-citation
Habenula Volume in Bipolar Disorder and Major Depressive Disorder: A High-Resolution Magnetic Resonance Imaging Study
Savitz, J. B., Nugent, A. C., Bogers, W., Roiser, J. P., Bain, E., Neumeister, A., Zarate, C. A., Manji, H. K., Cannon, D. M., Marrett, S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.027 · Cited by 182 · see citing works
Self-citation
The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar disorder I and its clinical correlates.
Frangou, S., Donaldson, S., Hadjulis, M., Landau, S., & Goldstein, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.056 · Cited by 180 · see citing works
White matter abnormalities in children with and at risk for bipolar disorder
Frazier, J. A., Breeze, J. L., Papadimitriou, G., Kennedy, D. N., Hodge, S. M., Moore, C. M., Howard, J. D., Rohan, M. P., Caviness, V. S., & Makris, N. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00482.x · Cited by 178 · see citing works
Myelin staining of deep white matter in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and unipolar major depression
Regenold, W. T., Phatak, P., Marano, C. M., Gearhart, L., Viens, C. H., & Hisley, K. C. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.12.019 · Cited by 178 · see citing works
A Cross-Sectional and Longitudinal Magnetic Resonance Imaging Study of Cingulate Gyrus Gray Matter Volume Abnormalities in First-Episode Schizophrenia and First-Episode Affective Psychosis
Koo, M.-S., Levitt, J. J., Salisbury, D. F., Nakamura, M., Shenton, M. E., & McCarley, R. W. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.7.746 · Cited by 175 · see citing works
Glial Cell Loss in the Hippocampus of Alcoholics
Korbo, L. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04039.x · Cited by 174 · see citing works
Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex
Houenou, J., Wessa, M., Douaud, G., Leboyer, M., Chanraud, S., Perrin, M., Poupon, C., Martinot, J., & Paillère-Martinot, M. L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002010 · Cited by 172 · see citing works
Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure
Selemon, L. D., Lidow, M. S., & Goldman, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00113-4 · Cited by 166 · see citing works
Cortical Brain Development in Nonpsychotic Siblings of Patients With Childhood-Onset Schizophrenia
Gogtay, N., GREENSTEIN, D. K., Lenane, M., CLASEN, L. S., Sharp, W. S., Gochman, P., Butler, P., Evans, A. C., & Rapoport, J. L. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.772 · Cited by 165 · see citing works
Long-Term Outcome of Cognitive Impairment in Bipolar Disorder
Torrent, C., Martínez‐Arán, A., Bonnín, C. D. M., Reinares, M., Daban, C., Solé, B., Rosa, A. R., Tabarés‐Seisdedos, R., Popović, D., Salamero, M., et al. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07471 · Cited by 164 · see citing works
Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
Gogtay, N., Ordóñez, A. E., Herman, D. H., Hayashi, K. M., GREENSTEIN, D. K., Vaituzis, C., Lenane, M., CLASEN, L. S., Sharp, W. S., Giedd, J. N., et al. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01747.x · Cited by 163 · see citing works
Decreased N-Acetylaspartate in children with familial bipolar disorder
Chang, K., Adleman, N. E., Dienes, K., Barnea‐Goraly, N., Reiss, A. L., & Ketter, T. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01744-4 · Cited by 162 · see citing works
Meta-analytic review of neurocognition in bipolar II disorder
Bora, E., Yücel, M., Pantelis, C., & Berk, M. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01638.x · Cited by 161 · see citing works
The potential utility of a staging model as a course specifier: A bipolar disorder perspective
Berk, M., Hallam, K. T., & McGorry, P. D. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.03.007 · Cited by 158 · see citing works
Association Between Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism and Progressive Brain Volume Changes in Schizophrenia
Ho, B., Andreasen, N. C., Dawson, J. D., & Wassink, T. H. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.05111903 · Cited by 158 · see citing works
Neurocognitive Impairment in Bipolar Patients With and Without History of Psychosis
Martínez‐Arán, A., Torrent, C., Tabarés‐Seisdedos, R., Salamero, M., Daban, C., Balanzá‐Martínez, V., Sánchez‐Moreno, J., Goikolea, J. M., Benabarre, A., Colom, F., et al. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0209 · Cited by 157 · see citing works
Cortical White Matter Microstructural Abnormalities in Bipolar Disorder
Beyer, J. L., Taylor, W. D., MacFall, J. R., Kuchibhatla, M. N., Payne, M. E., Provenzale, J. M., Cassidy, F., & Krishnan, K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300802 · Cited by 155 · see citing works
Neurocognitive markers of psychosis in bipolar disorder: A meta-analytic study
Bora, E., Yücel, M., & Pantelis, C. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.02.117 · Cited by 154 · see citing works
Persistent Cognitive Dysfunctions in Bipolar I Disorder and Schizophrenic Patients: A 3-Year Follow-Up Study
Balanzá‐Martínez, V., Tabarés‐Seisdedos, R., Selva‐Vera, G., Martínez‐Arán, A., Torrent, C., Salazar-Fraile, J., Cercós, C. L., Vieta, E., & Gómez-Beneyto, M. (2005) · Psychotherapy and Psychosomatics · doi:10.1159/000083170 · Cited by 152 · see citing works
Stereological Approaches to Identifying Neuropathology in Psychosis
Dorph‐Petersen, K., & Lewis, D. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.030 · Cited by 151 · see citing works
Heart rate variability is a trait marker of major depressive disorder: evidence from the sertraline vs. electric current therapy to treat depression clinical study
Brunoni, A. R., Kemp, A. H., Dantas, E. M., Goulart, A. C., Nunes, M. A., Boggio, P. S., Mill, J. G., Lotufo, P. A., Fregni, F., & Benseñor, I. M. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000497 · Cited by 149 · see citing works
Chapter 28 The glutamate synapse in neuropsychiatric disorders: Focus on schizophrenia and Alzheimer's disease
Farber, N. B., Newcomer, J. W., & Olney, J. W. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)60453-7 · Cited by 148 · see citing works
Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities
Savitz, J., Frank, M. B., Victor, T., Bebak, M., Marino, J. H., Bellgowan, P. S. F., McKinney, B. A., Bodurka, J., Kent Teague, T., & Drevets, W. C. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.007 · Cited by 146 · see citing works
Self-citation
Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis
Gigante, A. D., Young, L. T., Yatham, L. N., Andreazza, A. C., Nery, F. G., Grinberg, L. T., Heinsen, H., & Lafer, B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571000146x · Cited by 143 · see citing works
Cingulate Cortex Anatomical Abnormalities in Children and Adolescents With Bipolar Disorder
Kaur, S., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Monkul, E. S., Hatch, J. P., Keshavan, M. S., Ryan, N. D., Birmaher, B. B., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1637 · Cited by 143 · see citing works
Rostral Anterior Cingulate Cortex Volume Correlates with Depressed Mood in Normal Healthy Children
Boes, A. D., McCormick, L. M., Coryell, W. H., & Nopoulos, P. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.018 · Cited by 139 · see citing works
Evidence for orbitofrontal pathology in bipolar disorder and major depression, but not in schizophrenia
Cotter, D., Hudson, L., & Landau, S. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00230.x · Cited by 133 · see citing works
The effect of previous psychotic mood episodes on cognitive impairment in euthymic bipolar patients
Bora, E., Vahip, S., Akdeniz, F., Gönül, A. S., Eryavuz, A., Ogut, M., & Alkan, M. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00469.x · Cited by 132 · see citing works
Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study
Mahon, K., Burdick, K. E., Wu, J., Ardekani, B. A., & Szeszko, P. R. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.00984.x · Cited by 131 · see citing works
Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
Kim, S., & Webster, M. J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.99 · Cited by 127 · see citing works
Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder
Pillai, J. J., Friedman, L., Stuve, T. A., Trinidad, S., Jesberger, J. A., Lewin, J. S., Findling, R. L., Swales, T. P., & Schulz, S. C. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00129-9 · Cited by 126 · see citing works
The longitudinal course of cognition in older adults with bipolar disorder
Gildengers, A. G., Mulsant, B. H., Begley, A. E., Mazumdar, S., Hyams, A. V., Reynolds, C. F., Kupfer, D. J., & Butters, M. A. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00739.x · Cited by 126 · see citing works
The Effects of Tryptophan Depletion on Neural Responses to Emotional Words in Remitted Depression
Roiser, J. P., Levy, J., Fromm, S. J., Nugent, A. C., Talagala, S. L., Hasler, G., Henn, F. A., Sahakian, B. J., & Drevets, W. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.002 · Cited by 123 · see citing works
Self-citation
Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia
Woo, T.-U. W., Kim, A. M., & Viscidi, E. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.092 · Cited by 122 · see citing works
Lower Orbital Frontal White Matter Integrity in Adolescents With Bipolar I Disorder
Kafantaris, V., Kingsley, P. B., Ardekani, B. A., Saito, E., Lencz, T., Lim, K. O., & Szeszko, P. R. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181900421 · Cited by 119 · see citing works
Changes in density of calcium‐binding‐protein‐immunoreactive GABAergic neurons in prefrontal cortex in schizophrenia and bipolar disorder
Sakai, T., Oshima, A., Nozaki, Y., Ida, I., Haga, C., Akiyama, H., Nakazato, Y., & Mikuni, M. (2008) · Neuropathology · doi:10.1111/j.1440-1789.2007.00867.x · Cited by 118 · see citing works
Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder
Matsuo, K., Walss‐Bass, C., Nery, F. G., Nicoletti, M., Hatch, J. P., Frey, B. N., Monkul, E. S., Zunta‐Soares, G. B., Bowden, C. L., Escamilla, M. A., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.23 · Cited by 115 · see citing works
Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging
Wang, F., Jackowski, M. P., Kalmar, J. H., Chepenik, L. G., Tie, K., Qiu, M., Gong, G., Pittman, B. P., Jones, M. M., Shah, M. P., et al. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.048793 · Cited by 115 · see citing works
Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia
Beneyto, M., & Meador‐Woodruff, J. H. (2006) · Synapse · doi:10.1002/syn.20329 · Cited by 113 · see citing works
Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication‐free individuals with bipolar disorder: an in vivo1H MRS study
Frey, B. N., Stanley, J. A., Nery, F. G., Monkul, E. S., Nicoletti, M., Chen, H., Hatch, J. P., Caetano, S. C., Ortíz, O., Kapczinski, F. P., et al. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00454.x · Cited by 113 · see citing works
Neurocognitive Function in Pediatric Bipolar Disorder: 3-Year Follow-up Shows Cognitive Development Lagging Behind Healthy Youths
Pavuluri, M. N., West, A. E., Hill, S. K., Jindal, K., & Sweeney, J. A. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318196b907 · Cited by 110 · see citing works
White matter microstructure in untreated first episode bipolar disorder with psychosis: comparison with schizophrenia
Lu, L. H., Zhou, X. J., Keedy, S., Reilly, J. L., & Sweeney, J. A. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00958.x · Cited by 109 · see citing works
Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia
Williams, M. R., Hampton, T., Pearce, R. K. B., Hirsch, S. R., Ansorge, O., Thom, M., & Maier, M. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0328-5 · Cited by 109 · see citing works
Glutamate decarboxylase65-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain
Benes, F. M., Todtenkopf, M. S., Logiotatos, P., & Williams, M. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00105-8 · Cited by 109 · see citing works
Preliminary Study of Magnetic Resonance Imaging Characteristics in 8− to 16-Year-Olds with Mania
Botteron, K. N., Vannier, M. W., Geller, B., Todd, R. D., & Lee, B. C. P. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199506000-00014 · Cited by 109 · see citing works
Are BPI and BPII suicide attempters distinct neuropsychologically?
Harkavy‐Friedman, J., Keilp, J. G., Grunebaum, M. F., Sher, L., PRINTZ, D. J., Burke, A. K., MANN, J., & OQUENDO, M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.04.010 · Cited by 109 · see citing works
Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication
Savitz, J. B., Nugent, A. C., Bogers, W., Liu, A., Sills, R., Luckenbaugh, D. A., Bain, E., Price, J. L., Zarate, C. A., Manji, H. K., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.025 · Cited by 109 · see citing works
Self-citation
A 2-year naturalistic study on cognitive functioning in bipolar disorder
Arts, B. M. G., Jabben, N., A, L. K. M., & van Os, J. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01601.x · Cited by 109 · see citing works
Investigation of Cortical Thickness Abnormalities in Lithium-Free Adults With Bipolar I Disorder Using Cortical Pattern Matching
Foland‐Ross, L. C., Thompson, P. M., Sugar, C. A., Madsen, S. K., Shen, J. K., Penfold, C., Ahlf, K., Rasser, P. E., Fischer, J., Yang, Y., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10060896 · Cited by 104 · see citing works
Progressive neurostructural changes in adolescent and adult patients with bipolar disorder
Lisy, M. E., Jarvis, K., DelBello, M. P., Mills, N. P., Weber, W. A., Fleck, D. E., Strakowski, S. M., & Adler, C. M. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00927.x · Cited by 103 · see citing works
Longitudinal analysis of cognitive performances and structural brain changes in late‐life bipolar disorder
Delaloye, C., Moy, G., de Bilbao, F., Weber, K., Baudois, S., Haller, S., Xekardaki, A., Canuto, A., Giardini, U., Lövblad, K., et al. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2683 · Cited by 103 · see citing works
Reduced NAA Levels in the Dorsolateral Prefrontal Cortex of Young Bipolar Patients
Sassi, R. B., Stanley, J. A., Axelson, D., Brambilla, P., Nicoletti, M., Keshavan, M. S., Ramos, R. T., Ryan, N. D., Birmaher, B. B., & Soares, J. C. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.2109 · Cited by 101 · see citing works
Neuropsychological functions in patients with bipolar I and bipolar II disorder
Hsiao, Y.-L., Wu, Y., Wu, J. Y., Hsu, M., Chen, H., Lee, S.-Y., Lee, I., Yeh, T. L., Yang, Y. K., Ko, H., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00723.x · Cited by 100 · see citing works
Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders
Dean, B., Gibbons, A. S., Tawadros, N., Brooks, L., Everall, I., & Scarr, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.95 · Cited by 99 · see citing works
Brain lithium, N‐acetyl aspartate and myo‐inositol levels in older adults with bipolar disorder treated with lithium: a lithium‐7 and proton magnetic resonance spectroscopy study
Forester, B. P., Finn, C. T., Berlow, Y. A., Wardrop, M., Renshaw, P. F., & Moore, C. M. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00627.x · Cited by 98 · see citing works
Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder
MacDonald, M. L., Naydenov, A. V., Chu, M. S., Matzilevich, D., & Konradi, C. L. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00302.x · Cited by 92 · see citing works
Dysregulation of GABAergic Neurotransmission in Mood Disorders
Bielau, H., Steiner, J. H., Mawrin, C., Trübner, K., Brisch, R., Meyer-Lotz, G., Brodhun, M., Dobrowolny, H., Baumann, B., Gos, T., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.081 · Cited by 90 · see citing works
Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression?
Gildengers, A. G., Chisholm, D., Butters, M. A., Anderson, S. J., Begley, A., Holm, M., Rogers, J. C., Reynolds, C. F., & Mulsant, B. H. (2013) · Psychological Medicine · doi:10.1017/s0033291712001614 · Cited by 89 · see citing works
Cingulate White Matter Neurons in Schizophrenia and Bipolar Disorder
Connor, C., Guo, Y., & Akbarian, S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.032 · Cited by 87 · see citing works
Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder
Fornito, A., Malhi, G. S., Lagopoulos, J., Ivanovski, B., Wood, S. J., Saling, M. M., Pantelis, C., & Yücel, M. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.06.004 · Cited by 83 · see citing works
Magnetic Resonance Spectroscopy: Neurochemistry and Treatment Effects in Affective Disorders
Moore, G. J., PhD, Galloway, A. M. P., & PhD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4220 · Cited by 82 · see citing works
Structural brain and neuropsychometric changes associated with pediatric bipolar disorder with psychosis
James, A. C., Hough, M., James, S., Burge, L., Winmill, L., Nijhawan, S., Matthews, P. M., & Zarei, M. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00891.x · Cited by 81 · see citing works
Preventative Strategies for Early-Onset Bipolar Disorder
McNamara, R. K., Nandagopal, J. J., Strakowski, S. M., & DelBello, M. P. (2010) · CNS Drugs · doi:10.2165/11539700-000000000-00000 · Cited by 79 · see citing works
Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
Kalmar, J. H., Wang, F., Spencer, L., Edmiston, E. K., Lacadie, C., Martin, A., Constable, R. T., Duncan, J. S., Staib, L. H., Papademetris, X., et al. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709090584 · Cited by 79 · see citing works
Illness duration and total brain gray matter in bipolar disorder: Evidence for neurodegeneration?
Frey, B. N., Zunta-Soares, G. B., Caetano, S. C., Nicoletti, M. A., Hatch, J. P., Brambilla, P., Mallinger, A. G., & Soares, J. C. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.04.015 · Cited by 79 · see citing works
MRI subcortical signal hyperintensities in Mania at first hospitalization
Strakowski, S. M., Woods, B. T., Tohen, M. F., Wilson, D. R., Douglas, A. W., & Stoll, A. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90140-9 · Cited by 78 · see citing works
Brain blood-flow change with acute vagus nerve stimulation in treatment-refractory major depressive disorder
Conway, C. R., Sheline, Y. I., Chibnall, J. T., Bucholz, R. D., Price, J. L., Gangwani, S., & Mintun, M. A. (2011) · Brain stimulation · doi:10.1016/j.brs.2011.03.001 · Cited by 77 · see citing works
Self-citation
Anterior cingulate volume in pediatric bipolar disorder and autism
Chiu, S., Widjaja, F., Bates, M. E., Voelbel, G. T., Pandina, G., Marble, J., Blank, J., Day, J., Brule, N., & Hendren, R. L. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.04.019 · Cited by 75 · see citing works
The Maudsley Bipolar Disorder Project
Frangou, S. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.463005.x · Cited by 74 · see citing works
Association of clinical symptoms and neurocognitive performance in bipolar disorder: a longitudinal study
Chaves, O. C., Lombardo, L., Bearden, C. E., Woolsey, M. D., Martinez, D., Barrett, J. A., Miller, A. L., Velligan, D. I., & Glahn, D. C. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00888.x · Cited by 74 · see citing works
Low Levels of N -Acetyl Aspartate in the Left Dorsolateral Prefrontal Cortex of Pediatric Bipolar Patients
Olvera, R. L., Caetano, S. C., Fonseca, M., Nicoletti, M., Stanley, J. A., Chen, H. H., Hatch, J. P., Hunter, K., Pliszka, S. R., & Soares, J. C. (2007) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2007.0102 · Cited by 73 · see citing works
Neuropsychological functioning in early-onset first-episode psychosis: comparison of diagnostic subgroups
Zabala, A., Rapado‐Castro, M., Arango, C., Robles, O., de la Serna, E., González, C., Rodríguez-Sánchez, J. M., Andrés, P., Mayoral, M., & Bombín, I. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0046-9 · Cited by 73 · see citing works
Perinatal factors and the risk of bipolar disorder in Finland
Chudal, R., Sourander, A., Polo‐Kantola, P., Hinkka‐Yli‐Salomäki, S., Lehti, V., Sucksdorff, D., Gissler, M., & Brown, A. S. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.026 · Cited by 69 · see citing works
Anterior cingulate subregion volumes and executive function in bipolar disorder
Zimmerman, M. E., DelBello, M. P., Getz, G. E., Shear, P. K., & Strakowski, S. M. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00298.x · Cited by 69 · see citing works
Clinical staging in severe mental disorder: evidence from neurocognition and neuroimaging
Lin, A. P., Reniers, R. L. E. P., & Wood, S. J. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.119156 · Cited by 68 · see citing works
Anterior cingulate pyramidal neurons display altered dendritic branching in depressed suicides.
Hercher, C., Canetti, L., Turecki, G., & Mechawar, N. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.011 · Cited by 64 · see citing works
Neuropsychological status of bipolar I disorder: impact of psychosis
Savitz, J. B., van der Merwe, L., Stein, D. J., Solms, M., & Ramesar, R. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.052001 · Cited by 63 · see citing works
Self-citation
Personality: is it a viable endophenotype for genetic studies of bipolar affective disorder?
Savitz, J. B., & Ramesar, R. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00309.x · Cited by 61 · see citing works
Self-citation
Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder
Molina, V., Sánchez, J. C., Sanz, J., Reig, S., Benito, C., Leal, I. G. B., Sarramea, F., Rebolledo, R., Palomo, T., & Desco, M. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.07.006 · Cited by 60 · see citing works
The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depression
Law, A. J., & Harrison, P. J. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00075-x · Cited by 60 · see citing works
Anterior cingulate volumes associated with trait impulsivity in individuals with bipolar disorder
Matsuo, K., Nicoletti, M., Peluso, M. A. M., Hatch, J. P., Nemoto, K., Watanabe, Y., Nery, F. G., Monkul, E. S., Zunta‐Soares, G. B., Bowden, C. L., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00732.x · Cited by 60 · see citing works
Neurocognitive Function as an Endophenotype for Genetic Studies of Bipolar Affective Disorder
Savitz, J. B., Solms, M., & Ramesar, R. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:4:275 · Cited by 59 · see citing works
Self-citation
Differential alterations of kainate receptor subunits in inhibitory interneurons in the anterior cingulate cortex in schizophrenia and bipolar disorder
Woo, T.-U. W., SHRESTHA, K., AMSTRONG, C., Minns, M., WALSH, J., & Benes, F. M. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.06.023 · Cited by 58 · see citing works
A magnetic resonance imaging study of mood stabilizer‐ and neuroleptic‐naïve first‐episode mania
Yatham, L. N., Lyoo, I. K., Liddle, P. F., Renshaw, P. F., Wan, D. D. C., Lam, R. W. M., & Hwang, J. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00414.x · Cited by 57 · see citing works
Changes in Gyrification Over 4 Years in Bipolar Disorder and Their Association with the Brain-Derived Neurotrophic Factor Valine66 Methionine Variant
Mirakhur, A., Moorhead, T. W. J., Stanfield, A. C., McKirdy, J. W., Sussmann, J. E., Hall, J., Lawrie, S. M., Johnstone, E. C., & McIntosh, A. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.006 · Cited by 55 · see citing works
Type 2 Diabetes Mellitus: A Potentially Modifiable Risk Factor for Neurochemical Brain Changes in Bipolar Disorders
Hájek, T., Calkin, C., Blagdon, R. A., Slaney, C., & Alda, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.007 · Cited by 55 · see citing works
Dorsolateral and dorsomedial prefrontal gray matter density changes associated with bipolar depression
Brooks, J. O., Bonner, J. C., Rosen, A. C., Wang, P. W., Hoblyn, J. C., Hill, S. J., & Ketter, T. A. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.06.007 · Cited by 55 · see citing works
Heart rate variability during motor and cognitive tasks in females with major depressive disorder
Nugent, A. C., Bain, E. E., Thayer, J. F., Sollers, J. J., & Drevets, W. C. (2011) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.08.013 · Cited by 54 · see citing works
Self-citation
Cortical and subcortical white matter abnormalities in adults with remitted first‐episode mania revealed by Tract‐Based Spatial Statistics
Chan, W., Yang, G., Chia, M., Woon, P., Lee, J., Keefe, R. S. E., Sitoh, Y., Nowinski, W. L., & Sim, K. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00829.x · Cited by 54 · see citing works
N-Methyl-D-Aspartate Receptor and Calbindin-Containing Neurons in the Anterior Cingulate Cortex in Schizophrenia and Bipolar Disorder
Woo, T.-U. W., Shrestha, K., Lamb, D., Minns, M., & Benes, F. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.034 · Cited by 54 · see citing works
Body Mass Index–Related Regional Gray and White Matter Volume Reductions in First-Episode Mania Patients
Bond, D. J., Ha, T. H., Lang, D. J., Su, W., Torres, I. J., Honer, W. G., Lam, R. W. M., & Yatham, L. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.030 · Cited by 54 · see citing works
Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia
O’Connor, J. A., & Hemby, S. E. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.09.022 · Cited by 53 · see citing works
Neurocognitive features in subgroups of bipolar disorder
Aminoff, S. R., Hellvin, T., Lagerberg, T. V., Berg, A. O., Andreassen, O. A., & Melle, I. S. (2013) · Bipolar Disorders · doi:10.1111/bdi.12061 · Cited by 50 · see citing works
Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder
Bearden, C. E., Glahn, D. C., Caetano, S. C., Olvera, R. L., Fonseca, M., Najt, P., Hunter, K., Pliszka, S. R., & Soares, J. C. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00453.x · Cited by 50 · see citing works
Vagal nerve activity as a moderator of brain-immune relationships
Ohira, H., Matsunaga, M., Osumi, T., Fukuyama, S., Shinoda, J., Yamada, J., & Gidron, Y. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.04.011 · Cited by 47 · see citing works
Assessing the potential to use neurocognition to predict who is at risk for developing bipolar disorder: a review of the literature
Olvet, D., Burdick, K., & Cornblatt, B. (2012) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2012.724193 · Cited by 40 · see citing works
Increased nuclear Olig1-expression in the pregenual anterior cingulate white matter of patients with major depression: A regenerative attempt to compensate oligodendrocyte loss?
Mosebach, J., Keilhoff, G., Gos, T., Schiltz, K., Schoeneck, L., Dobrowolny, H., Mawrin, C., Müller, S., Schroeter, M. L., Bernstein, H., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.03.018 · Cited by 40 · see citing works
Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder
Haukvik, U. K., McNeil, T. F., Lange, E. H., Melle, I. S., Dale, A. M., Andreassen, O. A., & Agartz, I. (2013) · Psychological Medicine · doi:10.1017/s0033291713001529 · Cited by 39 · see citing works

Flagged first, then by citations

3 of the 211 references couldn’t be matched to a known paper.

Sorted by citations

Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752 · see citing works
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Réus, G. Z., Fries, G. R., Stertz, L., Badawy, M., Passos, I. C., Barichello, T., Kapczinski, F., & Quevedo, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.018 · Cited by 594 · see citing works
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Steullet, P., Cabungcal, J.-H., Coyle, J., Didriksen, M., Gill, K., Grace, A. A., Hensch, T. K., LaMantia, A.-S., Lindemann, L., Maynard, T. M., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.47 · Cited by 360 · see citing works
The Emerging Neurobiology of Bipolar Disorder
Harrison, P. J., Geddes, J. R., & Tunbridge, E. M. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.006 · Cited by 235 · see citing works
Executive function impairments in depression and bipolar disorder: association with functional impairment and quality of life
Cotrena, C., Branco, L. D., Shansis, F. M., & Fonseca, R. P. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.007 · Cited by 227 · see citing works
Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder
Savitz, J. B., Drevets, W. C., Wurfel, B. E., Ford, B. N., Bellgowan, P. S. F., Victor, T. A., Bodurka, J., Teague, T. K., & Dantzer, R. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.007 · Cited by 207 · see citing works
Self-citation
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder
Meier, T. B., Drevets, W. C., Wurfel, B. E., Ford, B. N., Morris, H. M., Victor, T. A., Bodurka, J., Teague, T. K., Dantzer, R., & Savitz, J. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.003 · Cited by 175 · see citing works
Self-citation
Neuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165 · see citing works
Self-citation
Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression
Barbosa, I. G., Bauer, M. E., Machado‐Vieira, R., & Teixeira, A. L. (2014) · Neural Plasticity · doi:10.1155/2014/360481 · Cited by 148 · see citing works
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder
Hoseth, E. Z., Krull, F., Dieset, I., Mørch, R. H., Hope, S., Gardsjord, E. S., Steen, N. E., Melle, I. S., Brattbakk, H.-R., Steen, V. M., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0102-1 · Cited by 141 · see citing works
Mood disorders in the elderly: prevalence, functional impact, and management challenges
Forlenza, O. V., Valiengo, L., & Stella, F. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s94643 · Cited by 129 · see citing works
Manic episodes are related to changes in frontal cortex: a longitudinal neuroimaging study of bipolar disorder 1
Abé, C., Ekman, C. J., Sellgren, C. M., Petrović, P., Ingvar, M., & Landén, M. (2015) · Brain · doi:10.1093/brain/awv266 · Cited by 128 · see citing works
Cortical thickness, volume and surface area in patients with bipolar disorder types I and II
Abé, C., Ekman, C. J., Sellgren, C. M., Petrović, P., Ingvar, M., & Landén, M. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150093 · Cited by 124 · see citing works
Neurodevelopmental pathways in bipolar disorder
Kloiber, S., Rosenblat, J. D., Husain, M. I., Ortiz, A., Berk, M., Quevedo, J., Vieta, E., Maes, M., Birmaher, B., Soares, J. C., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.005 · Cited by 122 · see citing works
Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells
Bauer, M. E., & Teixeira, A. L. (2021) · NeuroImmunoModulation · doi:10.1159/000515594 · Cited by 125 · see citing works
Depression of Excitatory Synapses onto Parvalbumin Interneurons in the Medial Prefrontal Cortex in Susceptibility to Stress
Perova, Z., Delevich, K. M., & Li, B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2670-14.2015 · Cited by 116 · see citing works
The Gut Microbiota Links Dietary Polyphenols With Management of Psychiatric Mood Disorders
Westfall, S., & Pasinetti, G. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01196 · Cited by 108 · see citing works
Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group
Abé, C., Ching, C. R. K., Liberg, B., Lebedev, A. V., Agartz, I., Akudjedu, T. N., Alda, M., Alnæs, D., Alonso-Lana, S., Benedetti, F., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.09.008 · Cited by 103 · see citing works
Abnormal cerebellum-DMN regions connectivity in unmedicated bipolar II disorder.
Chen, G.-M., Zhao, L.-P., Jia, Y.-B., Zhong, S.-M., Chen, F., Luo, X., Qiu, S., Lai, S.-K., Qi, Z.-Z., Huang, L., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.076 · Cited by 81 · see citing works
Resting-state functional connectivity of emotion regulation networks in euthymic and non-euthymic bipolar disorder patients
Rey, G., Piguet, C., Benders, A., Favre, S., Eickhoff, S. B., Aubry, J., & Vuilleumier, P. O. (2016) · European Psychiatry · doi:10.1016/j.eurpsy.2015.12.005 · Cited by 88 · see citing works
A unified model of the pathophysiology of bipolar disorder
Magioncalda, P., & Martino, M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01091-4 · Cited by 88 · see citing works
Lithium-induced neuroprotection is associated with epigenetic modification of specific BDNF gene promoter and altered expression of apoptotic-regulatory proteins
Dwivedi, T., & Zhang, H. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00457 · Cited by 82 · see citing works
DTI and Myelin Plasticity in Bipolar Disorder: Integrating Neuroimaging and Neuropathological Findings
Bellani, M., Boschello, F., Delvecchio, G., Dusi, N., Altamura, C. A., Ruggeri, M., & Brambilla, P. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00021 · Cited by 74 · see citing works
The neuropathology of bipolar disorder: systematic review and meta-analysis
Harrison, P. J., Colbourne, L., & Harrison, C. H. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0213-3 · Cited by 72 · see citing works
Investigating the mechanism(s) underlying switching between states in bipolar disorder
Young, J. W., & Dulcis, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.019 · Cited by 68 · see citing works
DNA Damage in Major Psychiatric Diseases
Raza, M. U., Tufan, T., Wang, Y., Hill, C. P., & Zhu, M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9621-9 · Cited by 67 · see citing works
Longitudinal Cortical Thickness Changes in Bipolar Disorder and the Relationship to Genetic Risk, Mania, and Lithium Use
Abé, C., Liberg, B., Song, J., Bergen, S. E., Petrović, P., Ekman, C. J., Sellgren, C. M., Ingvar, M., & Landén, M. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.015 · Cited by 66 · see citing works
Assessing intracortical myelin in the living human brain using myelinated cortical thickness
Rowley, C. D., Bazin, P., Tardif, C. L., Sehmbi, M., Hashim, E., Zaharieva, N., Minuzzi, L., Frey, B. N., & Bock, N. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00396 · Cited by 61 · see citing works
Neural ECM in addiction, schizophrenia, and mood disorder
Lubbers, B. R., Smit, A. B., Spijker, S., & van den Oever, M. C. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00012-8 · Cited by 60 · see citing works
Theory of Mind in Bipolar Disorder, with Comparison to the Impairments Observed in Schizophrenia
Mitchell, R. L. C., & Young, A. H. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00188 · Cited by 59 · see citing works
Distinctive Neuroanatomical Substrates for Depression in Bipolar Disorder versus Major Depressive Disorder
Matsuo, K., Harada, K., Fujita, Y., Okamoto, Y., Ota, M., Narita, H., Mwangi, B., Gutierrez, C. A., Okada, G., Takamura, M., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx319 · Cited by 58 · see citing works
N‐acetylaspartate normalization in bipolar depression after lamotrigine treatment
Croarkin, P. E., Thomas, M. A., Port, J. D., Baruth, J. M., Choi, D., Abulseoud, O. A., & Frye, M. A. (2014) · Bipolar Disorders · doi:10.1111/bdi.12285 · Cited by 54 · see citing works
Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder
Magioncalda, P., Martino, M., Conio, B., Piaggio, N., Teodorescu, R., Escelsior, A., Marozzi, V., Rocchi, G., Roccatagliata, L., Northoff, G., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.050 · Cited by 51 · see citing works
Attenuated Notch signaling in schizophrenia and bipolar disorder
Hoseth, E. Z., Krull, F., Dieset, I., Mørch, R. H., Hope, S., Gardsjord, E. S., Steen, N. E., Melle, I. S., Brattbakk, H.-R., Steen, V. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23703-w · Cited by 52 · see citing works
Bipolar disorder: Functional neuroimaging markers in relatives
Piguet, C., Fodoulian, L., Aubry, J., Vuilleumier, P. O., & Houenou, J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.015 · Cited by 48 · see citing works
Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder
Bernstein, H., Meyer-Lotz, G., Dobrowolny, H., Bannier, J., Steiner, J. H., Walter, M., & Bogerts, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00273 · Cited by 48 · see citing works
Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence
Abé, C., Liberg, B., Klahn, A. L., Petrović, P., & Landén, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02073-4 · Cited by 47 · see citing works
Altered prefrontal cortex activity during working memory task in Bipolar Disorder: A functional Magnetic Resonance Imaging study in euthymic bipolar I and II patients
Dell’Osso, B. M., Cinnante, C. M., Giorgio, A. D., Cremaschi, L., Palazzo, C., Cristoffanini, M., Fazio, L., Dobrea, C., Avignone, S., Triulzi, F. M., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.026 · Cited by 46 · see citing works
Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex
Zhang, B., Yang, X., Ye, L., Liu, R., Ye, B., Du, W., Shen, F., Li, Q., Guo, F., Liu, J., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108382 · Cited by 45 · see citing works
Role of astrocytic glutamate transporter in alcohol use disorder
Ayers-Ringler, J. R., Jia, Y., Qiu, Y., & Choi, D. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i1.31 · Cited by 43 · see citing works
Bipolar disorder type I and II show distinct relationships between cortical thickness and executive function
Abé, C., Rolstad, S., Petrović, P., Ekman, C. J., Sparding, T., Ingvar, M., & Landén, M. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12922 · Cited by 42 · see citing works
Coping with Stress During Aging: The Importance of a Resilient Brain
Sampedro-Piquero, P., Alvarez-Suarez, P., & Begega, A. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170915141610 · Cited by 41 · see citing works
Deficits in auditory and visual steady-state responses in adolescents with bipolar disorder
Wang, X., Gu, M., & Khaleghi, A. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.04.041 · Cited by 39 · see citing works
Glial Pathology in Bipolar Disorder: Potential Therapeutic Implications
Dong, X., & Zhen, X. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12390 · Cited by 39 · see citing works
Structural and functional correlates of serum soluble IL-6 receptor level in patients with bipolar disorder
Tu, P., Li, C., Lin, W.-C., Chen, M., Su, T., & Bai, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.036 · Cited by 38 · see citing works
From the microscope to the magnet: Disconnection in schizophrenia and bipolar disorder
Ji, E., Lejuste, F., Sarrazin, S., & Houenou, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.005 · Cited by 38 · see citing works
Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons
Sampedro‐Piquero, P., Castilla‐Ortega, E., Zancada-Menéndez, C., Santín, L. J., & Begega, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.032 · Cited by 36 · see citing works
From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation
Krasner, H., Ong, C. V., Hewitt, P., & Vida, T. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073219 · Cited by 36 · see citing works
Effects of illness duration on cognitive performances in bipolar depression are mediated by white matter microstructure
Melloni, E. M. T., Poletti, S., Vai, B., Bollettini, I., Colombo, C., & Benedetti, F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.015 · Cited by 34 · see citing works
Reduced interhemispheric resting‐state functional connectivity in unmedicated bipolar II disorder
Wang, Y., Zhong, S., Jia, Y., Zhou, Z., Zhou, Q., & Huang, L. J. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12429 · Cited by 34 · see citing works
Neuroinflammation: The Role of Anthocyanins as Neuroprotectants
Banji, O. J. F., Banji, D., Makeen, H. A., Alqahtani, S. S., & Alshahrani, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220119140835 · Cited by 31 · see citing works
Aberrant brain network topology in fronto‐limbic circuitry differentiates euthymic bipolar disorder from recurrent major depressive disorder
Dvorak, J., Hilke, M., Trettin, M., Wenzler, S., Hagen, M., Ghirmai, N., Müller, M., Kraft, D., Reif, A., & Oertel, V. (2019) · Brain and Behavior · doi:10.1002/brb3.1257 · Cited by 32 · see citing works
A platform for stereological quantitative analysis of the brain-wide distribution of type-specific neurons
Zhang, C., Yan, C., Ren, M., Li, A., Quan, T., Gong, H., & Yuan, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-14699-w · Cited by 28 · see citing works
Neuroimaging of bipolar disorder
Phillips, M. L., & Drevets, W. C. (2020) · doi:10.1093/med/9780198713005.003.0071 · Cited by 29 · see citing works
Self-citation
Brain oscillations in bipolar disorder and lithium-induced changes
Atagün, M. İ. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s100597 · Cited by 29 · see citing works
Inflammation as a Mechanism of Bipolar Disorder Neuroprogression
Barichello, T., Giridharan, V. V., Bhatti, G. S., Sayana, P., Doifode, T., Macêdo, D. S., & Quevedo, J. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_173 · Cited by 27 · see citing works
Prenatal immune activation alters hippocampal place cell firing characteristics in adult animals
Wolff, A. R., & Bilkey, D. K. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.012 · Cited by 26 · see citing works
Night sleep influences white matter microstructure in bipolar depression
Benedetti, F., Melloni, E. M. T., Dallaspezia, S., Bollettini, I., Locatelli, C., Poletti, S., & Colombo, C. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.008 · Cited by 26 · see citing works
Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function
Rathje, M., Waxman, H., Benoit, M., Tammineni, P., Leu, C., Loebrich, S., & Nedivi, E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0314-z · Cited by 23 · see citing works
Association between resting-state functional connectivity of amygdala subregions and peripheral pro-inflammation cytokines levels in bipolar disorder
Gong, J., Chen, G., Chen, F., Zhong, S., Chen, P., Zhong, H., Lai, S., Tang, G., Wang, J., Luo, Z., et al. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00636-7 · Cited by 22 · see citing works
Altered behavior and neural activity in conspecific cagemates co-housed with mouse models of brain disorders
Yang, H. J., Jung, S., Seo, J., Khalid, A., Yoo, J.-S., Park, J., Kim, S., Moon, J., Lee, S., Jung, K., et al. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.031 · Cited by 21 · see citing works
Decreased medial prefrontal cortex activation during self-referential processing in bipolar mania
Herold, D., Usnich, T., Spengler, S., Sajonz, B., Bauer, M., & Bermpohl, F. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.065 · Cited by 21 · see citing works
Chronic mild stress disrupts mitophagy and mitochondrial status in rat frontal cortex
Ulecia-Morón, C., Bris, Á. G., MacDowell, K. S., Madrigal, J. L. M., García‐Bueno, B., Leza, J. C., & Caso, J. R. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06604-1 · Cited by 20 · see citing works
Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway
Ni, R., 四川大学华西医院精神医学研究室和精神卫生中心, 四. 成., Gao, T.-H., Wang, Y., Tian, Y., Wei, J., Zhao, L., Ni, P., Ma, X., Li, T., et al. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.278 · Cited by 20 · see citing works
Association of the plasma complement system with brain volume deficits in bipolar and major depressive disorders
Yu, H., Ni, P., Tian, Y., Zhao, L., Li, M., Li, X., Wei, W., Wei, J., Du, X., Wang, Q., et al. (2022) · Psychological Medicine · doi:10.1017/s0033291722003282 · Cited by 20 · see citing works
iPSC-derived cerebral organoids reveal mitochondrial, inflammatory and neuronal vulnerabilities in bipolar disorder
Sabbagh, D. E. S. E., Machado, A. K., Pappis, L., Beroncal, E. L., Ji, D., Nader, G., Chander, P. R., Choi, J., Duong, A., Jeong, H., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03529-7 · Cited by 19 · see citing works
Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits
Pinsonneault, J. K., Frater, J. T., Kompa, B., Mascarenhas, R., Wang, D., & Sadée, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179020 · Cited by 20 · see citing works
Abnormal brain activation during emotion processing of euthymic bipolar patients taking different mood stabilizers
Li, L., Ji, E., Tang, F., Qiu, Y., Han, X., Zhang, S., Zhang, Z., & Yang, H. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9915-z · Cited by 17 · see citing works
The Emerging Neurobiology of Bipolar Disorder
Harrison, P. J., Geddes, J. R., & Tunbridge, E. M. (2019) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.17309 · Cited by 17 · see citing works
Biological Psychiatry and Psychopharmacology
Fountoulakis, K. N., Nimatoudis, I., & Stahl, S. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-18323-3_13 · Cited by 17 · see citing works
Abnormal Connectivity Within Anterior Cortical Midline Structures in Bipolar Disorder: Evidence From Integrated MRI and Functional MRI
Yang, J., Pu, W., Ouyang, X., Tao, H., Chen, X., Huang, X., & Liu, Z. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00788 · Cited by 15 · see citing works
Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus
Liu, J., Fan, W., Jia, Y., Su, X., Wu, W., Long, X., Sun, X., Liu, J., Sun, W., Zhang, T., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00045 · Cited by 15 · see citing works
Ingestion of dried-bonito broth ( dashi ) facilitates PV-parvalbumin-immunoreactive neurons in the brain, and affects emotional behaviors in mice
Jargalsaikhan, U., Nishimaru, H., Matsumoto, J., Takamura, Y., Nakamura, T., Hori, E., Kondoh, T., Ono, T., & Nishijo, H. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1208429 · Cited by 15 · see citing works
Hypersexuality and Neuroimaging Personality, Social Cognition, and Character
Absher, J. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800935-2.00001-4 · Cited by 14 · see citing works
Transcranial temporal interference stimulation for treating bipolar disorder with depressive episodes: a feasibility Study
Zhou, H., Wang, M., Qi, S., Chen, Q., Lai, J., Wu, Z., Liu, R., Wang, L., Zhou, H., Zhang, S., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03292-7 · Cited by 13 · see citing works
Widespread white matter microstructural abnormalities and cognitive impairment in schizophrenia, bipolar disorder, and major depressive disorder: Tract-based spatial statistics study
Yamada, S., Takahashi, S., Ohoshi, Y., Ishida, T., Tsuji, T., Shinosaki, K., Terada, M., & Ukai, S. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111045 · Cited by 13 · see citing works
Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder
Duong, A., Che, Y., Ceylan, D., Pinguelo, A., Andreazza, A. C., Young, L. T., & Berk, M. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.12.015 · Cited by 12 · see citing works
A Brain on a Roller Coaster: Can the Dopamine Reward System Act as a Protagonist to Subdue the Ups and Downs of Bipolar Disorder?
Arjmand, S., Behzadi, M., Stephens, G. J., Ezzatabadipour, S., Seifaddini, R., Arjmand, S., & Shabani, M. (2017) · The Neuroscientist · doi:10.1177/1073858417714226 · Cited by 10 · see citing works
Genetic and symptomatic risks associated with longitudinal brain morphometry in bipolar disorder
Lu, W., Wu, J., Shao, R., Zou, W., Zhang, R., Li, X., Kong, J., Zheng, D., Tian, X., Gao, Y., et al. (2024) · Nature Mental Health · doi:10.1038/s44220-023-00194-x · Cited by 9 · see citing works
Circulating cytotoxic immune cell composition, activation status and toxins expression associate with white matter microstructure in bipolar disorder
Aggio, V., Fabbella, L., Poletti, S., Lorenzi, C., Finardi, A., Colombo, C., Zanardi, R., Furlan, R., & Benedetti, F. (2023) · Scientific Reports · doi:10.1038/s41598-023-49146-6 · Cited by 9 · see citing works
Homogeneous magnetic resonance imaging of brain abnormalities in bipolar spectrum disorders comorbid with Wilson's disease
Carta, M. G., Saba, L., Moro, M. F., Demelia, E., Sorbello, O., Pintus, M., Pintus, E., Simavorian, T., Akiskal, H. H., & Demelia, L. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.01.006 · Cited by 9 · see citing works
An Integrative Computational Approach to Evaluate Genetic Markers for Bipolar Disorder
Xu, Y. J., Wang, J., Rao, S., Ritter, M. L., Manor, L. C., Backer, R., Cao, H., Cheng, Z., Liu, S., Liu, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05846-4 · Cited by 8 · see citing works
Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis
Kuang, L., Gao, W., Long, Z., Cao, W., Cui, D., Guo, Y., Jiao, Q., Qiu, J., Su, L., & Lu, G. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.750798 · Cited by 8 · see citing works
A fatal alliance: Glial connexins, myelin pathology and mental disorders
Zlomuzica, A., Plank, L., Kodzaga, I., & Dere, E. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.008 · Cited by 8 · see citing works
Exploring Signatures of Neurodegeneration in Early-Onset Older-Age Bipolar Disorder and Behavioral Variant Frontotemporal Dementia
Sanabria, F. C., Reyes, P. A., Triviño, C., Garcia, D. M., Carmassi, C., Pardo, R., & Matallana, D. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.713388 · Cited by 7 · see citing works
Neuroprotective Role of Ketamine in Reducing Neuroinflammation and Enhancing Neuroplasticity Against a Cortisol-Induced In Vitro Stress Model
Santos¹, L. F. D. S., Petry, F. D. S., Girardi, C. S., Hansen, J., Martins, D., Fröhlich, N. T., Possa, L. D. R., Mendes, L. F. B., Farias, H. R., Silva, A. M., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05114-x · Cited by 6 · see citing works
Gut microbiota modulates synaptic plasticity, connectivity, and dopamine transmission in the VTA-mPFC pathway in bipolar depression
Tang, A., Chen, Y., Si, K., Lai, J., Gong, W., & Hu, S. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03398-y · Cited by 7 · see citing works
Utilidad de la tomografía de coherencia óptica en la evaluación de los pacientes con trastorno bipolar
Gavin, A., García‐Martín, E., García‐Campayo, J., Viladés, E., Orduna, E., & Satué, M. (2020) · Archivos de la Sociedad Española de Oftalmología · doi:10.1016/j.oftal.2020.07.022 · Cited by 5 · see citing works
Changes in the medial prefrontal cortex metabolites after 6 months of medication therapy for patients with bipolar disorder: A 1H ‐ MRS study
Li, H., Gao, J., Song, H., Yang, X., Li, C., Zhang, Y., Wang, J., Liu, Y., Wang, D., & Li, H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70048 · Cited by 5 · see citing works
Chronic LiCl pretreatment suppresses thrombin‐stimulated intracellular calcium mobilization through TRPC 3 in astroglioma cells
Uemura, T., Green, M., & Warsh, J. J. (2016) · Bipolar Disorders · doi:10.1111/bdi.12447 · Cited by 5 · see citing works
Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study
Lee, J., Choi, S., Kang, J. C., Won, E., Tae, W., Lee, M.-S., & Ham, B. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.09.013 · Cited by 4 · see citing works
Executive functioning of older adults with bipolar disorder
Omer, E., Braw, Y., Amiaz, R., & Ravona‐Springer, R. (2020) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5402 · Cited by 4 · see citing works
An Overview of Machine Learning Applications in Mood Disorders
Topolski, N., Jeong, S. H., & Mwangi, B. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.017 · Cited by 4 · see citing works
Magnetic Resonance Spectroscopy in Bipolar Disorder
Vecera, C. M., Chong, A. C., Ruiz, A. C., Rong, C., Jones, G. H., Machado‐Vieira, R., & Soares, J. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00030-8 · Cited by 4 · see citing works
Affective Disorders
Ellenbroek, B. A., & Youn, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801657-2.00007-0 · Cited by 4 · see citing works
Serotonin 2C Receptor as a Superhero: Diversities and Talents in the RNA Universe for Editing, Variant, Small RNA and Other Expected Functional RNAs
Tohda, M. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r06cr · Cited by 4 · see citing works
Convergence between behavioral, neural, and self-report measures of cognitive control: The Frontal Systems Behavior Scale in bipolar disorder
Wong, K. S., Chou, T., Peters, A. T., Ellard, K. K., Nierenberg, A. A., Dougherty, D. D., & Deckersbach, T. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.053 · Cited by 3 · see citing works
Abordagens terapêuticas do episódio de mania no transtorno bipolar
Conde, A. G., Fagundes, M. L. M., & Mendes-Gomes, J. (2022) · Brazilian Journal of Health Review · doi:10.34119/bjhrv5n4-167 · Cited by 3 · see citing works
Biomarkers for bipolar disorder: current insights
Scola, G., Duong, A., & Syed, B. (2015) · Current Biomarker Findings · doi:10.2147/cbf.s79138 · Cited by 4 · see citing works

Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572 · see citing works
406. Prefrontal cell pathology distinguishes bipolar disorder from schizophrenia
Rajkowska, G., Halaris, A., & Selemon, L. D. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00676-4 · Cited by 2 · see citing works
Neuropathology of bipolar disorder
Vawter, M. P., Freed, W. J., & Kleinman, J. E. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00978-1 · Cited by 149 · see citing works
Neuroimaging and Neuropathological Findings in Bipolar Disorder
Savitz, J. B., & Drevets, W. C. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_68 · Cited by 7 · see citing works
Self-citation
773. Neuroimaging Abnormalities Identify Neuroprogressive Course of Bipolar Disorder
Soares, J. C. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.840 · Cited by 1 · see citing works

Authors: Savitz, J. B., Price, J. L., & Drevets, W. C.
Affiliations: Laureate Institute for Brain Research (US)
Washington University in St. Louis (US)
Corresponding author: Savitz, Jonathan B.
ORCID: Savitz, Jonathan B.
Drevets, Wayne C.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2014-05
Volume: 42
Pages: 132-147
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2014.02.008
OpenAlex: W1968616230
Cited by: 145
References: 211
Citations by year: 2026: 5 · 2025: 9 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 29 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 13 · 2016: 18 · 2015: 21 · 2014: 6
FWCI: 2.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: bipolar disorder, medial prefrontal cortex, neuropathology, neurodevelopmental disorders, neurodegeneration, neuron size, glial cell density, dendritic atrophy, GABAergic interneurons, gene expression, stress response, chronic disease
MeSH terms: Animals, Bipolar Disorder, Humans, Neural Pathways, Neuroglia, Neurons, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks