Cognitive dysfunction in major depression and bipolar disorder: A ssessment and treatment options

MacQueen, Glenda M.; Memedovich, Katherine A.

doi:10.1111/pcn.12463

Cited by 172Bipolar Disorder and TreatmentTreatment of Major DepressionSchizophrenia research and treatment

Cognitive dysfunction in major depression and bipolar disorder: A ssessment and treatment options

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MacQueen, Glenda M., Memedovich, Katherine A.·2017·Psychiatry and Clinical Neurosciences

DOI 10.1111/pcn.12463

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Abstract

Cognitive dysfunction is a recognized feature of mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). Cognitive impairment is associated with poor overall functional outcome and is therefore an important feature of illness to optimize for patients’ occupational and academic outcomes. While generally people with BD appear to have a greater degree of cognitive impairment than those with MDD, direct comparisons of both patient groups within a single study are lacking. There are a number of methods for the assessment of cognitive function, but few are currently used in clinical practice. Current symptoms, past course of illness, clinical features, such as the presence of psychosis and comorbid conditions, may all influence cognitive function in mood disorders. Despite the general lack of assessment of cognitive function in clinical practice, clinicians are increasingly targeting cognitive symptoms as part of comprehensive treatment strategies. Novel pharmacological agents may improve cognitive function, but most studies of standard mood stabilizers, such as lithium and the anticonvulsants, have focused on whether or not the medications impair cognition. Non‐pharmacological strategies, such as cognitive remediation and exercise, are increasingly studied in patients with mood disorders. Despite the growing interest in strategies to manage cognitive function, there is a paucity of high‐quality trials examining either pharmacological or non‐pharmacological modes of intervention.

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Major depressive disorder involves substantial cognitive dysfunction.
“Although MDD may be considered primarily an illness of emotional/mood dysregulation, it also involves substantial cognitive dysfunction.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [63]

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Authors: MacQueen, G. M., & Memedovich, K. A.
Affiliations: University of Calgary (CA)
Corresponding author: MacQueen, Glenda M.
ORCID: MacQueen, Glenda M.
Venue: Psychiatry and Clinical Neurosciences
Publisher: Wiley
Published: 2016-11-16
Volume: 71
Issue: 1
Pages: 18-27
ISSN: 1323-1316 (ISSN-L)
1440-1819
DOI: 10.1111/pcn.12463
OpenAlex: W2528630419
Cited by: 172
References: 91
Citations by year: 2026: 6 · 2025: 15 · 2024: 25 · 2023: 16 · 2022: 19 · 2021: 18 · 2020: 18 · 2019: 21 · 2018: 17 · 2017: 17
FWCI: 2.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Psychiatry and Clinical Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: cognitive impairment, major depressive disorder, bipolar disorder, mood disorders, cognitive impairment assessment, mood stabilizers, lithium, antiepileptic drugs, cognitive remediation, physical activity, psychosis, comorbidities
MeSH terms: Bipolar Disorder, Major Depressive Disorder, Humans, Cognitive Dysfunction

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