Recurrence of major depressive disorder across different treatment settings: Results from the NESDA study
Open accessAbstract
Objective Examine time to recurrence of major depressive disorder (MDD) across different treatment settings and assess predictors of time to recurrence of MDD.Methods Data were from 375 subjects with a MDD diagnosis from the Netherlands Study of Depression and Anxiety (NESDA). The study sample was restricted to subjects with a remission of at least three months. These subjects were followed until recurrence or the end of the two year follow-up. DSM-IV based diagnostic interviews and Life Chart Interviews were used to assess time to recurrence of MDD across treatment settings. Predictors of time to recurrence were determined using Cox's proportional hazards analyses.Results Although trends indicated a slightly higher rate of and shorter time to recurrence in specialized mental health care, no significant difference in recurrence rate (26.8% versus 33.5%, p=0.23) or in time to recurrence (controlled for covariates) of MDD was found between respondents in specialized mental health care and respondents treated in primary care (average 6.6 versus 5.5 months, p=0.09). In multivariable analyses, a family history of MDD and previous major depressive episodes were associated with a shorter time to recurrence. Predictors did not differ across treatment settings.Limitations The study sample may not be representative of the entire population treated for MDD in specialized mental health care.Conclusions Health care professionals in both settings should be aware of the same risk factors since the recurrence risk and its predictors appeared to be similar across settings.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In major depressive disorder, 18-77% of patients experienced a relapse.
“Likewise, with regard to major depressive disorder (MDD), 18–77% of patients experienced a relapse [22–28].”
From Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis (2022) · cites this paper as [24]
Section 3.2 (page unavailable) reports that 26.8% of patients in primary care and 33.5% in specialized mental health care experienced a recurrence during two years. Those figures fall within the cited range, but this paper does not report its 18% or 77% endpoints, and it describes recurrence after remission rather than relapse. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSome studies have suggested that symptoms such as appetite or weight changes do not distinguish between depressed and non-depressed outside of affluent high-resource settings, as evidenced by studies in Turkey, Nigeria, and Nepal.
“To date, some studies have suggested that symptoms such as appetite or weight changes do not distinguish between depressed and nondepressed outside of affluent high-resource settings, as evidenced by studies in Turkey, Nigeria, and Nepal. 122-124”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [123]
The relapse rate in this cohort is similar to those reported in other clinical settings and in meta-analyses of RCTs, which have shown relapse rates of 21% to 49%.
“This relapse rate is similar to those reported in other clinical settings7,22 and in meta-analyses of RCTs,6,8 which have shown that those who remain on antidepressants following remission had relapse rates of 21% to 49%.”
Between one-fifth and one-half of patients in remission from a depressive episode will suffer a recurrence within 2 years.
“Studies indicate that between one-fifth to one-half of patients in remission from a depressive episode will suffer a recurrence within 2 years.4–10”
Prior research has investigated a limited range of individual predictors, many of which are related to demographics and clinical history.
“prior research has investigated a limited range of individual predictors, many of which are related to demographics and clinical history.7,9,18”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1× · see citing works
“This is largely due to its highly chronic and recurrent nature (Murray and Lopez, 1997; Vos et al., 2004).”
BackgroundWittchen, H.-U. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90036-1 · Cited by 2,348 · see citing works
Domains and Facets: Hierarchical Personality Assessment Using the Revised NEO Personality Inventory
Costa, P. T., & McCrae, R. R. (1995) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6401_2 · Cited by 2,080 · see citing works
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848 · see citing works
Wang, P. S., Aguilar-Gaxiola, S., Alonso, J., Angermeyer, M. C., Borges, G., Bromet, E. J., Bruffaerts, R., de Girolamo, G., de Graaf, R., Gureje, O., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61414-7 · Cited by 1,655 · see citing works
Brugha, T. S., Bebbington, P., Tennant, C., & Hurry, J. (1985) · Psychological Medicine · doi:10.1017/s003329170002105x · Cited by 1,108 · see citing works
The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
Penninx, B. W. J. H., Beekman, A. T. F., Smit, J. H., Zitman, F. G., Nolen, W. A., Spinhoven, P., Cuijpers, P. J., de Jong, P. J., van Marwijk, H., Assendelft, W. J., et al. (2008) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.256 · Cited by 918 · see citing works
Self-citationRecurrence after recovery from major depressive disorder during 15 years of observational follow-up
Mueller, T. I., Leon, A. C., Keller, M. B., Solomon, D. A., Endicott, J., Coryell, W., Warshaw, M., & Maser, J. D. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1000 · Cited by 897 · see citing works
Multiple recurrences of major depressive disorder
Solomon, D. A., Keller, M. B., Leon, A. C., Mueller, T. I., Lavori, P. W., Shea, M. T., Coryell, W., Warshaw, M., Turvey, C., Maser, J. D., et al. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.229 · Cited by 835 · see citing works
Piet, J., & Hougaard, E. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.05.002 · Cited by 807 · see citing works
Judd, L. L., Akiskal, H. S., Maser, J. D., Zeller, P. J., Endicott, J., Coryell, W., Paulus, M. P., Kunovac, J. L., Leon, A. C., Mueller, T. I., et al. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00138-4 · Cited by 590 · see citing works
The ESEMeD/MHEDEA 2000 investigators, Alonso, J., Angermeyer, M. C., Bernert, S., Bruffaerts, R., Brugha, T. S., Bryson, H., de Girolamo, G., de Graaf, R., Demyttenaere, K., et al. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0047.2004.00330.x · Cited by 519 · see citing works
Spijker, J., De Graaf, R., Bijl, R. V., Beekman, A. T. F., Ormel, J., & Nolen, W. A. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.181.3.208 · Cited by 514 · see citing works
Self-citationPrevalence and predictors of recurrence of major depressive disorder in the adult population
Hardeveld, F., Spijker, J., De Graaf, R., Nolen, W. A., & Beekman, A. T. F. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01519.x · Cited by 486 · see citing works
Self-citationHovens, J. G. F. M., Wiersma, J., Giltay, E. J., van Oppen, P., Spinhoven, P., Penninx, B. W. J. H., & Zitman, F. G. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01491.x · Cited by 422 · see citing works
Self-citationde Graaf, R., Bijl, R., Smit, F., Vollebergh, W., & Spijker, J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.620 · Cited by 406 · see citing works
Self-citationThe importance of childhood trauma and childhood life events for chronicity of depression in adults
Wiersma, J. E., Hovens, J. G. F. M., van Oppen, P., Giltay, E. J., van Schaik, D. J. F., Beekman, A. T. F., & Penninx, B. W. J. H. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04521 · Cited by 358 · cited 1× · see citing works
“In order to examine the role of childhood trauma, a cumulative childhood index using the NEMESIS childhood trauma interview was constructed (De Graaf et al., 2002; Wiersma et al., 2009; Hovens et al., 2010).”
MethodSelf-citationInterpersonal factors in the origin and course of affective disorders
Simpson, G. M. (1997) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/s0005-7916(97)81867-8 · Cited by 303 · see citing works
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.6.795 · Cited by 228 · see citing works
Wittchen, H.-U. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810050051009 · Cited by 219 · see citing works
The Burden of Major Depression Avoidable by Longer-term Treatment Strategies
Vos, T., Haby, M. M., Barendregt, J. J., Kruijshaar, M., Corry, J., & Andrews, G. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1097 · Cited by 213 · see citing works
Hansen, R., Gaynes, B., Thieda, P., Gartlehner, G., Deveaugh-Geiss, A., Krebs, E., & Lohr, K. (2008) · Psychiatric Services · doi:10.1176/ps.2008.59.10.1121 · Cited by 172 · see citing works
Relapse and recurrence prevention in depression: Current research and future prospects
Beshai, S., Dobson, K. S., Bockting, C. L. H., & Quigley, L. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.09.003 · Cited by 165 · see citing works
Relapse of depression in primary care: Rate and clinical predictors
Lin, E. H. B. (1998) · Archives of Family Medicine · doi:10.1001/archfami.7.5.443 · Cited by 152 · see citing works
Berger, J. S., Lala, A., Krantz, M. J., Baker, G. S., & Hiatt, W. R. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.04.006 · Cited by 144 · see citing works
Time to recurrence after recovery from major depressive episodes and its predictors
KANAI, T., Takeuchi, H., Furukawa, T. A., Yoshimura, R., Imaizumi, T., Kitamura, T., & Takahashi, K. (2003) · Psychological Medicine · doi:10.1017/s0033291703007827 · Cited by 138 · see citing works
Kaymaz, N., van Os, J., Loonen, A. J. M., & Nolan, W. A. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0910 · Cited by 135 · see citing works
Cooper, L. A., Crum, R. M., & Ford, D. E. (1994) · Medical Care · doi:10.1097/00005650-199401000-00002 · Cited by 125 · see citing works
Gopinath, S., Katon, W. J., Russo, J. E., & Ludman, E. J. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.10.023 · Cited by 111 · see citing works
Course and outcome of depressive disorders in primary care: a prospective 18-month study
Vuorilehto, M. S., Melartin, T. K., & Isometsä, E. T. (2009) · Psychological Medicine · doi:10.1017/s0033291709005182 · Cited by 105 · see citing works
Observational studies of depression in primary care: what do we know?
Gilchrist, G., & Gunn, J. M. (2007) · BMC Family Practice · doi:10.1186/1471-2296-8-28 · Cited by 82 · see citing works
Psychosocial competence of unselected young adults with sex chromosome abnormalities
Bender, B. G., Harmon, R. J., Linden, M. G., Bucher‐Bartelson, B., & Robinson, A. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990416)88:2 · Cited by 61 · see citing works
Suh, T., & Gallo, J. J. (1997) · Psychological Medicine · doi:10.1017/s0033291797005205 · Cited by 58 · see citing works
Improving Quality of Depression Care Using Organized Systems of Care
Katon, W. J., & Guico‐Pabia, C. J. (2011) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.10r01019blu · Cited by 32 · see citing works
Mood disorders: Update on prevention of recurrence.
Kupfer, D. J., Frank, E. F., & Wamhoff, J. (1996) · Cited by 31 · see citing works
Piek, E., van der Meer, K., Penninx, B. W., Verhaak, P. F., & Nolen, W. A. (2011) · BMC Family Practice · doi:10.1186/1471-2296-12-41 · Cited by 28 · see citing works
Self-citationFactors associated with recurrent depression: a prospective study in family practice
Suija, K., Aluoja, A., Kalda, R., & Maaroos, H.-I. (2010) · Family Practice · doi:10.1093/fampra/cmq076 · Cited by 23 · see citing works
Bockting, C., Kok, G. D., van der Kamp, L., Smit, F., van Valen, E., Schoevers, R., van Marwijk, H. V., Cuijpers, P., Riper, H., Dekker, J., et al. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-12 · Cited by 3 · see citing works
Flagged first, then by citations
2 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [10]10. Fyer, A.J., Weissman, M.M., 1999. Genetic linkage study of panic: clinical meth- odology and description of pedigrees. American Journal of Medical Genetics 88, 173-181.
- [23]23. Lyketsos, C.G., Nestadt, G., Cwi, J., et al., 1994. The life-chart method to describe the course of psychopathology. International Journal of Methods in Psychiatric Research 4, 143-155.
- [37]37. Wacker, H.R., Battegay, R., Mullejans, R., et al., 2006. Using the CIDI-C in the general population. In: Stefanis, C.N., Rabavilas, A.D., Soldatos, C.R. (Eds.), Psychiatry: A World Perspective. Elsevier Science Publishers, Amsterdam.
Cited by
Sorted by citations
Time for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104 · see citing works
Self-citationProspective biomarkers of major depressive disorder: A systematic review and meta-analysis
Kennis, M., Gerritsen, L., van Dalen, M., Williams, A., Cuijpers, P., & Bockting, C. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0585-z · Cited by 435 · see citing works
Buckman, J. E. J., Underwood, A., Clarke, K., Saunders, R., Hollon, S. D., Fearon, P., & Pilling, S. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.07.005 · Cited by 398 · see citing works
Association of Microvascular Dysfunction With Late-Life Depression
van Agtmaal, M. J. M., Houben, A. J. H. M., Pouwer, F., Stehouwer, C. D. A., & Schram, M. T. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0984 · Cited by 313 · see citing works
Lam, R. W., McIntosh, D., Wang, J., Enns, M. W., Kolivakis, T., Michalak, E. E., Sareen, J., Song, W.-Y., Kennedy, S. H., MacQueen, G. M., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659416 · Cited by 288 · see citing works
Bahji, A., Hawken, E. R., Sepehry, A. A., Cabrera, C. A., & Vazquez, G. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12994 · Cited by 159 · see citing works
Scholten, W. D., Batelaan, N. M., Penninx, B. W. J. H., Balkom, A. J. L. M. V., Smit, J. H., Schoevers, R. A., & Oppen, P. V. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.025 · Cited by 77 · see citing works
Self-citationSimblett, S., Matcham, F., Siddi, S., Bulgari, V., Barattieri di San Pietro, C., Hortas López, J., Ferrão, J., Polhemus, A., Haro, J. M., de Girolamo, G., et al. (2019) · JMIR mHealth and uHealth · doi:10.2196/11325 · Cited by 120 · see citing works
ten Have, M., de Graaf, R., van Dorsselaer, S., Tuithof, M., Kleinjan, M., & Penninx, B. W. J. H. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12874 · Cited by 106 · see citing works
Self-citationFeng, K., Shen, C., Ma, X., Chen, G., Zhang, M.-L., Xu, B., Liu, X., Sun, J., Zhang, X., Liu, P., et al. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.03.015 · Cited by 70 · see citing works
Hoertel, N., Blanco, C., Oquendo, M. A., Wall, M. M., Olfson, M., Falissard, B., Franco, S., Peyre, H., Lemogne, C., & Limosin, F. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.07.022 · Cited by 63 · see citing works
Temperament and character traits predict future burden of depression
Rosenström, T. H., Jylhä, P. J., Cloninger, C. R., Hintsanen, M., Elovainio, M. J., Mantere, O., Pulkki-Råbäck, L., Riihimäki, K., Vuorilehto, M. S., Keltikangas‐Järvinen, L., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.01.017 · Cited by 52 · see citing works
The Influence of Growth Mindset on the Mental Health and Life Events of College Students
Tao, W., Zhao, D., Yue, H., Horton, I., Tian, X., Xu, Z., & Sun, H. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.821206 · Cited by 51 · see citing works
van Loo, H. M., van Borkulo, C. D., Peterson, R. E., Fried, E. I., Aggen, S. H., Borsboom, D., & Kendler, K. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.038 · Cited by 50 · see citing works
Sex similarities and differences in risk factors for recurrence of major depression
van Loo, H. M., Aggen, S. H., Gardner, C. O., & Kendler, K. S. (2018) · Psychological Medicine · doi:10.1017/s0033291717003178 · Cited by 45 · see citing works
Multiple risk factors predict recurrence of major depressive disorder in women
van Loo, H. M., Aggen, S. H., Gardner, C. O., & Kendler, K. S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.045 · Cited by 45 · see citing works
Recurrence of anxiety disorders and its predictors in the general population
Scholten, W., ten Have, M., van Geel, C., van Balkom, A. J. L. M., de Graaf, R., & Batelaan, N. M. (2021) · Psychological Medicine · doi:10.1017/s0033291721002877 · Cited by 45 · see citing works
Wang, J. L., Patten, S., Sareen, J., Bolton, J., Schmitz, N., & MacQueen, G. (2014) · Depression and Anxiety · doi:10.1002/da.22215 · Cited by 43 · see citing works
Predictors of recurrence of major depressive disorder
Lye, M.-S., Tey, Y.-Y., Tor, Y.-S., Shahabudin, A. F., Ibrahim, N., Ling, K.-H., Stanslas, J., Loh, S.-P., Rosli, R., Lokman, K. A., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0230363 · Cited by 43 · see citing works
New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders
Scherma, M., Masia, P., Deidda, M. L., Fratta, W., Tanda, G., & Fadda, P. (2018) · Medicines · doi:10.3390/medicines5040107 · Cited by 41 · see citing works
Corponi, F., Anmella, G., Verdolini, N., Pacchiarotti, I., Samalin, L., Popović, D., Azorin, J., Angst, J., Bowden, C. L., Mosolov, S. N., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.03.017 · Cited by 39 · see citing works
Prognostic models for predicting relapse or recurrence of major depressive disorder in adults
Moriarty, A. S., Meader, N., Snell, K. I. E., Riley, R. D., Paton, L. W., Chew-Graham, C. A., Gilbody, S. M., Churchill, R. C., Phillips, R. S., Ali, S., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013491.pub2 · Cited by 35 · see citing works
Economic burden of relapse/recurrence in patients with major depressive disorder
Gauthier, G., Mucha, L., Shi, S., & Guerin, A. (2019) · Journal of Drug Assessment · doi:10.1080/21556660.2019.1612410 · Cited by 36 · see citing works
Blood-based immune-endocrine biomarkers of treatment response in depression
Chan, M. K., Cooper, J. D., Bot, M., Birkenhäger, T. K., Bergink, V., Drexhage, H. A., Steiner, J. H., Rothermundt, M., Penninx, B. W. J. H., & Bahn, S. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.020 · Cited by 35 · see citing works
Self-citationVerhoeven, F. E. A., Wardenaar, K. J., Ruhé, H. G. E., Conradi, H. J., & de Jonge, P. (2018) · Depression and Anxiety · doi:10.1002/da.22695 · Cited by 31 · see citing works
Dai, P., Lu, D., Shi, Y. Q., Zhou, Y. S., Xiong, T., Zhou, X., Chen, Z., Zou, B., Tang, H., Huang, Z., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.077 · Cited by 31 · see citing works
Acupuncture for Major Depressive Disorder: A Data Mining-Based Literature Study
Tu, M., Xiong, S., Lv, S., Wu, X., Hu, H., Hu, R., Fang, J., & Shao, X. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s405728 · Cited by 31 · see citing works
Positivity-approach training for depressive symptoms: A randomized controlled trial
Becker, E. S., Barth, A., Smits, J. A. J., Beisel, S., Lindenmeyer, J., & Rinck, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.042 · Cited by 31 · see citing works
Hallgren, M. Å., Nguyen, T.-T.-D., Lundin, A., Vancampfort, D., Stubbs, B., Schuch, F. B., Bellocco, R., & Lagerros, Y. T. (2018) · Preventive Medicine · doi:10.1016/j.ypmed.2018.10.009 · Cited by 27 · see citing works
Altaweel, N., Upthegrove, R., Surtees, A. D. R., Durdurak, B. B., & Marwaha, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1176355 · Cited by 24 · see citing works
van Bronswijk, S. C., Lemmens, L. H. J. M., Keefe, J. R., Huibers, M. J. H., DeRubeis, R. J., & Peeters, F. P. M. L. (2018) · Depression and Anxiety · doi:10.1002/da.22868 · Cited by 24 · see citing works
Krijnen-de Bruin, E., Scholten, W., Muntingh, A., Maarsingh, O., van Meijel, B., van Straten, A., & Batelaan, N. (2022) · PLOS ONE · doi:10.1371/journal.pone.0272200 · Cited by 23 · see citing works
Hengartner, M. P., & Plöderl, M. (2021) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253211032051 · Cited by 23 · see citing works
Wong, H., Moore, K., Angstman, K. B., & Garrison, G. M. (2019) · BMC Family Practice · doi:10.1186/s12875-019-1015-7 · Cited by 23 · see citing works
Zeeck, A., von Wietersheim, J., Weiß, H., Hermann, S., Endorf, K., Lau, I., & Hartmann, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00147 · Cited by 22 · see citing works
Park, C., Zhu, J., Ho, R., Rosenblat, J. D., Iacobucci, M., Gill, H., Mansur, R. B., & McIntyre, R. S. (2020) · Annals of Clinical Psychiatry · doi:10.1177/104012372003200109 · Cited by 21 · see citing works
Rehospitalization of Postpartum Depression and Psychosis After Electroconvulsive Therapy
Rönnqvist, I., Brus, O., Hammar, Å., Landén, M., Lundberg, J., Nordanskog, P., & Nordenskjöld, A. (2019) · Journal of Ect · doi:10.1097/yct.0000000000000578 · Cited by 20 · see citing works
A review of new insights into existing major depressive disorder biomarkers
Rimti, F. H., Shahbaz, R., Bhatt, K., & Xiang, A. J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18909 · Cited by 19 · see citing works
Martínez, P., Rojas, G., Rosemarie Fritsch, M., Martínez, V., Vöhringer, P. A., & Castro, A. (2017) · Revista médica de Chile · doi:10.4067/s0034-98872017000100004 · Cited by 17 · see citing works
Data mining algorithm predicts a range of adverse outcomes in major depression
van Loo, H. M., Bigdeli, T. B., Milaneschi, Y., Aggen, S. H., & Kendler, K. S. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.098 · Cited by 16 · see citing works
Tan, Y., Lattie, E. G., Qiu, Y., Teng, Z., Wu, C., Tang, H., & Chen, J. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100475 · Cited by 16 · see citing works
Polygenic heterogeneity in antidepressant treatment and placebo response
Nøhr, A. K., Forsingdal, A., Moltke, I., Howes, O. D., Vitezic, M., Albrechtsen, A., & Dalby, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02221-4 · Cited by 16 · see citing works
Dijkstra-Kersten, S. M. A., Sitnikova, K., Terluin, B., Penninx, B. W. J. H., Twisk, J. W. R., van Marwijk, H. W. J., van der Horst, H. E., & van der Wouden, J. C. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.04.015 · Cited by 15 · see citing works
Self-citationMuntingh, A., Hoogendoorn, A. W., van Schaik, A., van Straten, A., Stolk, E. A., van Balkom, A. J. L. M., & Batelaan, N. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219588 · Cited by 17 · see citing works
Chan, M. K., Cooper, J. D., Bot, M., Steiner, J. H., Penninx, B. W. J. H., & Bahn, S. (2015) · Neuroendocrinology · doi:10.1159/000442208 · Cited by 14 · see citing works
Self-citationNuggerud-Galeas, S., Oliván Blázquez, B., Perez Yus, M. C., Valle-Salazar, B., Aguilar-Latorre, A., & Magallón Botaya, R. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01230 · Cited by 13 · see citing works
Parami, S., Tapak, L., Poorolajal, J., Moghimbeigi, A., & Ghaleiha, A. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03559-7 · Cited by 15 · see citing works
Greeven, A., van Balkom, A. J. L. M., & Spinhoven, P. (2014) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000133 · Cited by 12 · see citing works
Agomelatina: fallo hepático fulminante en paciente con hígado graso
Gruz, F., Raffa, S., Santucci, C., Papale, R. M., Videla, M. G., Fernández, M. G., Yantorno, S. E., & Descalzi, V. (2013) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2013.04.008 · Cited by 12 · see citing works
Dai, P., Shi, Y. Q., Lu, D., Zhou, Y. S., Luo, J., He, Z., Chen, Z., Zou, B., Tang, H., Huang, Z., et al. (2024) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2024.108114 · Cited by 11 · see citing works
Frick, A., Thinnes, I., & Stangier, U. (2020) · Trials · doi:10.1186/s13063-019-3815-4 · Cited by 12 · see citing works
Zhou, J., Wang, X., Yang, J., Zhu, X., Xiao, L., Feng, L., & Wang, G. (2022) · Trials · doi:10.1186/s13063-022-06295-9 · Cited by 10 · see citing works
Path analysis of the chronicity of depression using the comprehensive developmental model framework
Fandiño‐Losada, A., Bangdiwala, S. I., Lavebratt, C., & Forsell, Y. (2016) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2015.1134651 · Cited by 9 · see citing works
Wu, Y., Li, S., Hu, K., & Yang, J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.06.023 · Cited by 9 · see citing works
Dahrendorff, J., Currier, G. W., & Uddin, M. (2024) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32985 · Cited by 8 · see citing works
Gender differences on functioning in depressive patients
Gili, M., Castro, A., Navarro, C., Molina, R., Magallón-Botaya, R. M., Garcı́a-Toro, M., & Roca, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.030 · Cited by 8 · see citing works
Gorham, L. S., Sadeghi, N., Eisner, L., Taigman, J., Haynes, K. T., Qi, K., Camp, C., Fors, P. Q., Rodriguez, D., McGuire, J., et al. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13547 · Cited by 7 · see citing works
Constantino, J. L., van Dalfsen, J. H., Massetti, S., Kamphuis, J., & Schoevers, R. A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111251 · Cited by 8 · see citing works
Lam, R. W., Rnic, K., Nunez, J.-J., Ho, K., LeMoult, J., Nunes, A., Chakrabarty, T., Foster, J. A., Frey, B. N., Harkness, K. L., et al. (2025) · The Canadian Journal of Psychiatry · doi:10.1177/07067437251337603 · Cited by 6 · see citing works
Eckley, D., Allen, A., Millear, P. M. R., Rune, K. T., & Mason, J. (2023) · Cognitive Therapy and Research · doi:10.1007/s10608-023-10403-7 · Cited by 6 · see citing works
Bruin, E. K.-D., Muntingh, A., Hoogendoorn, A. W., van Straten, A., Batelaan, N. M., Maarsingh, O. R., van Balkom, A. J. L. M., & van Meijel, B. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2034-6 · Cited by 6 · see citing works
Measuring Primary Health Care Clinicians’ Skills for Depression Management
Martínez, P., Rojas, G., Martínez, V., Marín, R., Cornejo, J. P., & Gómez, V. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00570 · Cited by 6 · see citing works
Nunes, A., Pavlova, B., Cunningham, J. E. A., Nuñez, J.-J., Quilty, L. C., Foster, J. A., Harkness, K. L., Ho, K., Lam, R. W., Li, Q. S., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.06.023 · Cited by 5 · see citing works
Symptom network connectivity indices as predictors of relapse in major depressive disorder
Nunes, A., Pavlová, B., Nuñez, J.-J., Quilty, L. C., Foster, J. A., Harkness, K. L., Ho, K. T., Lam, R. W. M., Li, Q. S., Milev, R. V., et al. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116562 · Cited by 5 · see citing works
Pang, J., Xu, J., Chen, L., Teng, H.-M., Su, C., Zhang, Z., Gao, L., Zhang, R., Liu, G., Chen, Y., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03409-0 · Cited by 6 · see citing works
Bockting, C., Breedvelt, J., & Brouwer, M. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818697-8.00224-7 · Cited by 5 · see citing works
EEG-Based Depression Detection with a Synthesis-Based Data Augmentation Strategy
Wei, X., Chen, M., Wu, M., Zhang, X., & Hu, B. (2021) · Lecture notes in computer science · doi:10.1007/978-3-030-91415-8_41 · Cited by 4 · see citing works
Bruin, E. K.-D., Muntingh, A., Bourguignon, E., Hoogendoorn, A., Maarsingh, O., van Balkom, A. V., Batelaan, N., van Straten, A., & van Meijel, B. (2022) · JMIR Mental Health · doi:10.2196/25441 · Cited by 4 · see citing works
Rnic, K., LeMoult, J., Torres, I. J., Chakrabarty, T., Foster, J., Frey, B. N., Harkness, K. L., Ho, K., Li, Q. S., Milev, R., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115606 · Cited by 3 · see citing works
Dahrendorff, J., Pages, K. P., Currier, G. W., Sarker, M. H., Graham, Z., Louis‐Jacques, A. F., Dagne, G. A., & Uddin, M. (2025) · BMC Medical Genomics · doi:10.1186/s12920-025-02240-2 · Cited by 3 · see citing works
Wang, P., Zheng, Y., Sun, L., Xiao, Y., Zang, X., Wang, J., Wang, J., & Xue, S. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121409 · Cited by 3 · see citing works
Impact of personality style changes on CBT and PDT treatment responses in major depression.
Norman, U. A., Truijens, F., Desmet, M., Smet, M. D., & Meganck, R. (2024) · Acta Psychologica · doi:10.1016/j.actpsy.2024.104295 · Cited by 4 · see citing works
Riiser, S., Smith‐Sivertsen, T., Baste, V., Haukenes, I., Hetlevik, Ø., & Ruths, S. (2025) · BMC Family Practice · doi:10.1186/s12875-025-02825-x · Cited by 2 · see citing works
Barros, B. R., Schacht, A., Happich, M., Televantou, F., Berggren, L., Walker, D. J., & Dueñas, H. (2014) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.14m01661 · Cited by 2 · see citing works
Yao, S., & Hu, J. S. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120302 · Cited by 1 · see citing works
Rich-club connections dynamics are associated with long-term outcomes in major depressive disorder
Yang, L., Yang, Y., Wang, J., Xu, F., Yu, Y., Zhang, S., & Xu, Y. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121584 · Cited by 1 · see citing works
Torgersen, K. S., Dammen, T., Klungsøyr, O., Wilberg, T., Bringager, C. B., Evensen, J. H., Løvgren, A., Malkomsen, A., Osnes, K., Ulberg, R., et al. (2026) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2026.2648291 · Cited by 1 · see citing works
Altaweel, N., Upthegrove, R., & Marwaha, S. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.08.190 · Cited by 1 · see citing works
Department of Psychology, W. U. T., & Sălăgean, N. (1999) · Romanian Journal of Applied Psychology · doi:10.24913/rjap.19.1.03
Terluin, B., & Spijker, J. (2018) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2174-2_8
Self-citationEarly effects of antidepressants on emotional processing
Komulainen, E. (2019) · Työväentutkimus Vuosikirja
Kruisdijk, F. R. (2020) · Pure Amsterdam UMC
Trends in pharmacotherapy of unipolar depression
Novák, T. (2017) · Psychiatrie pro praxi · doi:10.36290/psy.2017.022
Personalized treatment strategies for depression
van Bronswijk, S. C. (2020) · doi:10.26481/dis.20201211sb
Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs
Braný, D., Dvorská, D., Lockwood, L. E., Strnádel, J., & Youssef, N. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00011-3
Dijkstra‐Kersten, S. M. A., Sitnikova, K., Terluin, B., Penninx, B. W. J. H., Twisk, J. W. R., van Marwijk, H., van der Horst, H., & van der Wouden, J. C. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.03.231
Self-citationTsai, S., Hsu, J.-W., Huang, K., Bai, Y., Su, T., Chen, T., & Chen, M. (2023) · CNS Spectrums · doi:10.1017/s1092852922001213 · Cited by 1 · see citing works
Positive Effects of Botulinum Toxin On Patients Suffering From Depression
Łapińsk, U., Łapiński, R., Machała-Ćwikła, E., Machała, D., Ćwikła, P., Machała, K., & Zdziebło, P. (2024) · International Journal of Current Research and Review · doi:10.31782/ijcrr.2024.161302
Chiang, H., & Chen, M. (2024) · Studies in big data · doi:10.1007/978-3-031-66842-5_6
Ibáñez, D., Condominas, E., Haro, J. M., Giné-Vázquez, I., RADAR-MDD-Spain, Bailón, R., Pagès, E. G., Kontaxis, S., Peñarrubia‐María, M. T., Arranz, B., et al. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1436611
Self-citationO’Shields, J., Slavich, G. M., & Mowbray, O. P. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106190
Parami, S., Tapak, L., Poorolajal, J., Moghimbeigi, A., & Ghaleiha, A. (2021) · Figshare · doi:10.6084/m9.figshare.16916673
Park, C., Zhu, J., Man, R. H. C., Rosenblat, J. D., Iacobucci, M., Gill, H., Mansur, R. B., & McIntyre, R. S. (2019) · Annals of Clinical Psychiatry · doi:10.1177/154733251903100409
Cao, Y., Li, P.-F., Zhu, L., Li, K., & He, K. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.v16.i2.113037
- Authors
- Hardeveld, F., Spijker, J., De Graaf, R., Hendriks, S. M., Licht, C. M. M., Nolen, W. A., Penninx, B. W. J. H., & Beekman, A. T. F.
- Affiliations
- Pro Persona (NL)
- Amsterdam Public Health (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Hardeveld, Florian
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 147
- Issue
- 1-3
- Pages
- 225-231
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2096329254
- Cited by
- 95
- References
- 42
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 2
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, recurrence, time to recurrence, treatment setting, specialized mental health care, primary care, predictors of recurrence, family history of depression, remission, NESDA
- MeSH terms
- Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Mental Health Services, Netherlands, Primary Health Care, Recurrence, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
