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Exercise improves cardiorespiratory fitness in people with depression: A meta-analysis of randomized control trials
Abstract
Objective Cardiorespiratory fitness (CRF) is an independent predictor of cardiovascular disease and all-cause mortality. CRF improves in response to exercise interventions, yet the effectiveness of such interventions to improve CRF among people with depression is unclear. We conducted a systematic review and meta-analysis to evaluate whether CRF improves in people with depression in exercise randomized control trials (RCTs).Method Three authors identified RCTs from a recent Cochrane review and conducted updated searches of major electronic databases. We included RCTs of exercise interventions in people with depression (including major depressive disorder (MDD) and above-threshold depressive symptoms) that reported CRF (defined as predicted maximal oxygen uptake (VO2max predicted) or peak oxygen uptake (VO2peak)) versus a control condition. A random effects meta-analysis was conducted.Results Seven unique RCTs including 8 aerobic exercise interventions for depression were eligible, including 293 people allocated to exercise (mean age=40.3 years, range=27.2-64.7 years and 35-100% female) and 205 allocated to control conditions. Across all studies exercise results in a significant increase in CRF (g=0.64, 95%CI=0.32-0.96, p<0.001) equating to a mean increase of 3.05 ml/kg/min. Results remained significant when restricted to MDD only (N=5, g=0.41, 95%CI=0.18-0.64, p<0.001) and in high quality studies (N=5, g=0.60, 95%CI=0.19-1.00, p=0.004).Conclusions People with depression can achieve clinically relevant improvements in CRF in response to exercise interventions. Targeting 'fitness' rather than 'fatness' may be another feasible intervention strategy in this population.
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“Furthermore, a review of e-Health for people with depression found that online lifestyle interventions can have positive effects on various health behaviours, including alcohol use, sleep, and physical activity.343”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [343]
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“Aerobic exercise also improves quality of life [98] and cardiorespiratory fitness in patients with depression [99].”
From The effects of exercise on sleep in unipolar depression: a systematic review and network meta-analysis (2021) · cites this paper as [99]
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544
Diagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR )
Segal, D. L. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0271 · Cited by 4,687
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322
Kodama, S. (2009) · JAMA · doi:10.1001/jama.2009.681 · Cited by 3,035
Walker, E. R., McGee, R. E., & Druss, B. G. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2502 · Cited by 2,976
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004366.pub6 · Cited by 1,834
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2014) · Advances in Psychiatric Treatment · doi:10.1192/apt.20.1.2 · Cited by 895
Fitness vs. Fatness on All-Cause Mortality: A Meta-Analysis
Barry, V., Baruth, M., Beets, M. W., Durstine, J. L., Liu, J., & Blair, S. N. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.09.002 · Cited by 716
Ioannidis, J. P. A. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.081086 · Cited by 716
Cuijpers, P., Vogelzangs, N., Twisk, J., Kleiboer, A., Li, J., & Penninx, B. W. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030325 · Cited by 677
Lee, D.-C., Sui, X., Artero, E. G., Lee, I.-M., Church, T. S., McAuley, P. A., Stanford, F. C., Kohl, H. W., & Blair, S. N. (2011) · Circulation · doi:10.1161/circulationaha.111.038422 · Cited by 572
Physical exercise intervention in depressive disorders: Meta‐analysis and systematic review
Josefsson, T., Lindwall, M., & Archer, T. (2014) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12050 · Cited by 483
Vancampfort, D., Vansteelandt, K., Correll, C. U., Mitchell, A. J., Herdt, A. D., Sienaert, P. A., Probst, M., & Binder, M. D. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12050620 · Cited by 462
Nabkasorn, C., Miyai, N., Sootmongkol, A., Junprasert, S., Yamamoto, H., Arita, M., & Miyashita, K. (2006) · European Journal of Public Health · doi:10.1093/eurpub/cki159 · Cited by 353
Blumenthal, J. A., Babyak, M. A., O’Connor, C., Keteyian, S., Landzberg, J., Howlett, J., Kraus, W., Gottlieb, S., Blackburn, G., Swank, A., et al. (2012) · JAMA · doi:10.1001/jama.2012.8720 · Cited by 305
Cuijpers, P. J., Vogelzangs, N., Twisk, J. W. R., Kleiboer, A. M., Li, J., & Penninx, B. W. J. H. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.112169 · Cited by 305
Physical exercise and clinically depressed patients: a systematic review and meta-analysis
Silveira, H., Moraes, H., Oliveira, N., Coutinho, E. S. F., Laks, J., & Deslandes, A. (2013) · Neuropsychobiology · doi:10.1159/000345160 · Cited by 279
Plescia, F., Brancato, A., Marino, R. A. M., Vita, C., Navarra, M., & Cannizzaro, C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00138 · Cited by 266
Vancampfort, D., Mitchell, A. J., De Hert, M., Sienaert, P., Probst, M., Buys, R., & Stubbs, B. (2015) · Depression and Anxiety · doi:10.1002/da.22387 · Cited by 171
Prospective study of cardiorespiratory fitness and depressive symptoms in women and men
Sui, X., Laditka, J. N., Church, T. S., Hardin, J. W., Chase, N. L., Davis, K. E., & Blair, S. N. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.08.002 · Cited by 150
Krogh, J., Saltin, B., Gluud, C. N., & Nordentoft, M. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04241 · Cited by 150
Schuch, F. B., Vasconcelos-Moreno, M. P., Borowsky, C., Zimmermann, A. B., Rocha, N. S., & Fleck, M. P. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.11.005 · Cited by 130
Danielsson, L., Papoulias, I., Petersson, E., Carlsson, J. Y., & Wærn, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.049 · Cited by 130
Krogh, J., Videbech, P., Thomsen, C. E., Gluud, C. N., & Nordentoft, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048316 · Cited by 129
Kerling, A., Tegtbur, U., Guetzlaff, E., Kück, M., Borchert, L., Ateş, Z., von Bohlen, A., Frieling, H., Hüper, K., Hartung, D., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.006 · Cited by 115
Effect of exercise intensity on depressive symptoms in women
Chu, I.-H., Buckworth, J., Kirby, T. E., & Emery, C. F. (2009) · Mental Health and Physical Activity · doi:10.1016/j.mhpa.2009.01.001 · Cited by 87
Decline in Cardiorespiratory Fitness and Odds of Incident Depression
Dishman, R. K., Sui, X., Church, T. S., Hand, G. A., Trivedi, M. H., & Blair, S. N. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.06.011 · Cited by 72
A Prospective Study of Fitness, Fatness, and Depressive Symptoms
Becofsky, K. M., Sui, X., Lee, D.-C., Wilcox, S., Zhang, J., & Blair, S. N. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwu330 · Cited by 65
Physical Fitness and Heart Rate Recovery Are Decreased in Major Depressive Disorder
Boettger, S., Wetzig, F., Puta, C., Donath, L., Müller, H.-J., Gabriel, H. H. W., & Bär, K. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a55303 · Cited by 60
Can Exercise Increase Fitness and Reduce Weight in Patients with Schizophrenia and Depression?
Krogh, J., Speyer, H., Nørgaard, H. C. B., Moltke, A., & Nordentoft, M. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00089 · Cited by 37
Physical fitness in depressive patients and impact of illness course and disability
Voderholzer, U., Dersch, R. S., Dickhut, H. H., Herter, A., Freyer, T., & Berger, T. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.028 · Cited by 27
Metabolic syndrome in first‐time hospitalized patients with depression: a 1‐year follow‐up study
Nyboe, L., Vestergaard, C. H., Lund, H., Møller, M. K., & Videbech, P. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12470 · Cited by 17
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Stubbs, B., Vancampfort, D., Hallgren, M., Firth, J., Veronese, N., Solmi, M., Brand, S., Cordes, J., Malchow, B., Gerber, M., et al. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.07.004 · Cited by 697
Gordon, B. R., McDowell, C. P., Hallgren, M., Meyer, J. D., Lyons, M., & Herring, M. P. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.0572 · Cited by 498
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Schuch, F. B., & Stubbs, B. (2019) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000620 · Cited by 298
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Schuch, F. B., & Vancampfort, D. (2021) · Trends in Psychiatry and Psychotherapy · doi:10.47626/2237-6089-2021-0237 · Cited by 251
Metadata
- Authors
- Stubbs, B., Rosenbaum, S., Vancampfort, D., Ward, P. B., & Schuch, F. B.
- Affiliations
- National Health Service (GB)
- UNSW Sydney (AU)
- KU Leuven (BE)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Stubbs, Brendon
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 190
- Pages
- 249-253
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2172569729
- Cited by
- 163
- References
- 41
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 13 · 2023: 8 · 2022: 9 · 2021: 17 · 2020: 19 · 2019: 31 · 2018: 21 · 2017: 18 · 2016: 16
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Lirias (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- cardiorespiratory fitness, depression, major depressive disorder, aerobic exercise, exercise intervention, VO2max, peak oxygen uptake, cardiovascular health
- MeSH terms
- Depression, Major Depressive Disorder, Humans, Physical Fitness, Exercise, Randomized Controlled Trials as Topic
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