Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples
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BACKGROUND: Studies of psychiatric populations have reported associations between childhood adversity and volumes of stress-related brain structures. This meta-analysis investigated these associations in non-clinical samples and therefore independent of the effects of severe mental health difficulties and their treatment. METHODS: The MEDLINE database was searched for magnetic resonance imaging studies measuring brain structure in adults with and without childhood adversity. Fifteen eligible papers (1781 participants) reporting hippocampal volumes and/or amygdala volumes were pooled using a random effects meta-analysis. RESULTS: = 0.124). This association differed depending on whether studies included participants with some psychopathology, though this may be due to differences in the type of adversity these studies examined. There was no strong evidence of any differences in amygdala volume. DISCUSSION: Childhood adversity may have only a modest impact on stress-related brain structures in those without significant mental health difficulties.
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A meta-analysis of 1781 people documented significantly decreased hippocampal volumes following ELA, with weaker evidence of increased amygdala volumes.
“A meta-analysis of 1781 people documented significantly decreased hippocampal volumes following ELA, with weaker evidence of increased amygdala volumes [128].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [128]
A history of ELA can have a sustained impact on the integrity and function of the brain, with brain regions associated with emotional regulation, cognitive modulation and feeding behaviours frequently implicated.
“Evidence from neuroimaging studies suggests that a history of ELA can have a sustained impact on the integrity and function of the brain 9, 10, 11, 12, with brain regions associated with emotional regulation, cognitive modulation and feeding behaviours frequently implicated 12, 13, 14, 15, 16.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [14]
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- Authors
- Calem, M., Bromis, K., McGuire, P., Morgan, C., & Kempton, M. J.
- Affiliations
- King's College London (GB)
- National Technical University of Athens (GR)
- Corresponding author
- Kempton, Matthew J
- Venue
- NeuroImage Clinical
- Publisher
- Elsevier BV
- Published
- 2017
- Volume
- 14
- Pages
- 471-479
- ISSN
- 2213-1582 (ISSN-L)
- PMC
- PMC5331153
- OpenAlex
- W2590133125
- Cited by
- 171
- References
- 74
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 21 · 2023: 26 · 2022: 25 · 2021: 16 · 2020: 22 · 2019: 19 · 2018: 11 · 2017: 2
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- NeuroImage Clinical (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIHR CLAHRC South London Fee Support Award (NIHR CLAHRC-2013-10022)
- MRC Career Development Award (MR/J008915/1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- childhood adversity, hippocampal volume, amygdala volume, non-clinical population, general population, psychopathology, brain structure, neuroimaging
- MeSH terms
- Amygdala, Child, Child Abuse, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Poverty, Sex Characteristics, MEDLINE
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