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Cited by 157Tryptophan and brain disordersStress Responses and CortisolCardiac Health and Mental Health

Depression and C-Reactive Protein: Population-Based Health 2000 Study

Elovainio, Marko, Aalto, Anna-Mari, Kivimäki, Mika, Pirkola, Sami, Sundvall, Jouko, Lönnqvist, Jouko, Reunanen, Antti·2009·Psychosomatic Medicine
DOI 10.1097/psy.0b013e31819e333a
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Abstract

OBJECTIVE: To test whether depression is independently associated with elevated levels of C-reactive protein (CRP) in a large nationwide population-based sample. METHODS: Depression and CRP were assessed in 6005 Finns aged >30 years, as part of the ongoing population-based Health 2000 Study. Depression was determined by responses to the Beck's Depression Inventory (BDI-21) and by Composite International Diagnostic Interview (CIDI). RESULTS: Higher scores on BDI-21 were related to higher CRP levels (beta = 0.12, p < .001) in men and (beta = 0.08, p < .001) in women. In men, but not in women, this relationship persisted after adjustment for a number of other known risk factors. In men, the more recent dysthymic disorder or at least moderate depressive episode defined using CIDI was related to elevated CRP levels (beta = 0.06, p = .006). CONCLUSIONS: Depressive symptoms may be partly responsible for inflammatory processes, and inflammatory processes may induce depressive symptoms in men.

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  • In men, the more recent dysthymic disorder or at least moderate depressive episode was associated with higher CRP levels, compared to females (p = 0.006).

    “Moreover, in men the more recent dysthymic disorder or at least moderate depressive episode was associated with higher CRP levels, compared to females (p = 0.006) [54].”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [54]

  • In 6005 Finns aged >30 years, higher BDI-21 scores were associated with higher CRP levels only in men (p < 0.001), even after adjustment for confounders.

    “A cross-sectional study assessed 6005 Finns aged >30 years for depression, using BDI and CIDI, and for CRP levels [54]. Higher BDI-21 scores were associated with higher CRP levels only in men (p < 0.001), even after adjustment for confounders [54].”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [54]

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Authors
Elovainio, M., Aalto, A.-M., Kivimäki, M., Pirkola, S., Sundvall, J., Lönnqvist, J., & Reunanen, A.
Affiliations
  • Finnish Institute for Health and Welfare (FI)
  • University of Helsinki (FI)
Corresponding author
Elovainio, Marko
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-05
Volume
71
Issue
4
Pages
423-430
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0b013e31819e333a
OpenAlex
W2132061072
Cited by
157
References
50
Citations by year
2026: 2 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 8 · 2020: 14 · 2019: 16 · 2018: 10 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 5 · 2013: 17 · 2012: 7
FWCI
2.64
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
  • WOS
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
depression, C-reactive protein, inflammation, depressive symptoms, sex differences, dysthymia, depressive episodes, Finns
MeSH terms
Blood Glucose, C-Reactive Protein, Depression, Depressive Disorder, Female, Finland, Health Surveys, Humans, Inflammation, Lipids, Male, Middle Aged, Obesity, Surveys and Questionnaires, Severity of Illness Index, Smoking, Socioeconomic Factors, Biomarkers, Health Behavior, Confounding Factors, Epidemiologic

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