The effectiveness of vortioxetine on neurobiochemical metabolites and cognitive of major depressive disorders patients: A 8-week follow-up study
Abstract
Objective Vortioxetine has been shown to improve cognitive performance in people with depression. This study will look at the changes in neurobiochemical metabolites that occur when vortioxetine improves cognitive performance in MDD patients, with the goal of determining the neuroimaging mechanism through which vortioxetine improves cognitive function. Methods 30 depressed patients and 30 demographically matched healthy controls (HC) underwent MCCB cognitive assessment and 1H-MRS. After 8 weeks of vortioxetine medication, MCCB and 1H-MRS tests were retested in the MDD group. Before and after therapy, changes in cognitive performance, NAA/Cr, and Cho/Cr were examined in the MDD group. Results Compared with the HC group, the MDD group had significant reduced in verbal learning, social cognition, and total cognition (all p < 0.05). And the MDD group had lower NAA/Cr in Right thalamus and Left PFC; the Cho/Cr in Right thalamus was lower than HC; the Cho/Cr in Left ACC had significantly increase (all p < 0.05). The MDD group showed significant improvements in the areas of verbal learning, attention/alertness, and total cognitive function before and after Vortioxetine treatment (all p < 0.05). The NAA/Cr ratio of the right PFC before and after treatment (t = 2.338, p = 0.026) showed significant changes. Conclusions Vortioxetine can enhance not just the depression symptoms of MDD patients in the initial period, but also their verbal learning, social cognition, and general cognitive capacities after 8 weeks of treatment. Furthermore, vortioxetine has been shown to enhance cognitive function in MDD patients by altering NAA/Cr and Cho/Cr levels in the frontal-thalamic-ACC.
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Vortioxetine has been shown to enhance cognition in MDD patients by affecting brain metabolites, including altering neurobiochemical metabolites levels in the frontal lobe-thalamus-cingulate gyrus loop.
“Besides, Vortioxetine has been shown to enhance cognition in MDD patients by affecting brain metabolites, including altering neurobiochemical metabolites levels in the frontal lobe-thalamus-cingulate gyrus loop.32”
The MCCB has been widely used to assess cognitive functions in clinical trials and shown stable internal consistency and reliability in Chinese patients with MDD of different ages.
“Studies have showed that MCCB has been widely used to assess cognitive functions in clinical trials and shown stable internal consistency and reliability in Chinese patients with MDD of different ages.28–32”
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Retracted
- Authors
- Zhang, Y., Lai, S., Zhang, J., Wang, Y., Zhao, H., He, J., Huang, D., Chen, G., Qi, Z., Chen, P., Yan, S., Huang, X., Lu, X., Zhong, S., & Jia, Y.
- Affiliations
- First Affiliated Hospital of Jinan University (CN)
- Corresponding author
- Zhong, Shuming
- Jia, Yanbin
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2024-04
- Volume
- 351
- Pages
- 799-807
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W4391513150
- Cited by
- 11
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- vortioxetine, major depressive disorder, cognitive function, N-acetylaspartate, choline, thalamus, prefrontal cortex, anterior cingulate cortex, verbal learning, social cognition, 1H NMR
- MeSH terms
- Vortioxetine, Cognition, Major Depressive Disorder, Depressive Disorder, Major, Follow-Up Studies, Humans, Motivation
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