Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report
Open accessAbstract
Background: Many patients with major depressive disorder (MDD) who experience full symptomatic remission after antidepressant treatment still have residual depressive symptoms. We describe the types and frequency of residual depressive symptoms and their relationship to subsequent depressive relapse after treatment with citalopram in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Method: Participants in primary ( n =18) and psychiatric ( n =23) practice settings were openly treated with citalopram using measurement-based care for up to 14 weeks and follow-up for up to 1 year. We assessed 943 (32.8% of 2876) participants who met criteria for remission to determine the proportions with individual residual symptoms and any of the nine DSM-IV criterion symptom domains to define a major depressive episode. At each visit, the 16-item Quick Inventory of Depressive Symptomatology, Self-Report (QIDS-SR 16 ) and the self-report Frequency, Intensity, and Burden of Side Effects Rating (FIBSER) scale were used to assessed depressive symptoms and side-effects respectively. Results: More than 90% of remitters had at least one residual depressive symptom (median=3). The most common were weight increase (71.3%) and mid-nocturnal insomnia (54.9%). The most common residual symptom domains were sleep disturbance (71.7%) and appetite/weight disturbance (35.9%). Those who remitted before 6 weeks had fewer residual symptoms at study exit than did later remitters. Residual sleep disturbance did not predict relapse during follow-up. Having a greater number of residual symptom domains was associated with a higher probability of relapse. Conclusions: Patients with remission of MDD after treatment with citalopram continue to experience selected residual depressive symptoms, which increase the risk of relapse.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Less ill patients are known to have a smaller relapse risk overall.
“Less ill patients are known to have a smaller relapse risk overall (e.g. Nierenberg et al. 2010)”
From Predicting relapse after antidepressant withdrawal – a systematic review (2017) · cites this paper as Nierenberg et al. 2010
The Results report that, among patients whose depression remitted with citalopram, more residual symptom domains were associated with a greater probability of relapse. This supports the direction of the claim, but the study does not establish that less ill patients generally have a smaller relapse risk overall; its finding concerns residual symptoms in remitters. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe depression treatment cascade approach underscores the high prevalence of poor outcomes of depression in primary care, of which a significant percentage would be expected to meet criteria for TRD.
“The foregoing cascade approach - which in tegrates aspects of misdiagnosis, non- ad herence, inadequate treatment trials, as well as implementation gaps - underscores the high prevalence of poor outcomes of depression in primary care, of which a significant percentage would be expected to meet crite ria for TRD 10,30,64,71,107,108 .”
From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [71]
The Results (page unavailable) report that about 32% of evaluable participants remitted after citalopram, supporting a high rate of nonremission. The Methods say participants came from both primary-care and psychiatric settings, not primary care alone. The paper does not establish what percentage of those with poor outcomes would meet criteria for treatment-resistant depression (TRD). (LLM, conf=0.86)
Experimental — accuracy not yet measuredResidual symptom load affects relapse risk overall.
“Residual symptom load affects relapse risk overall (Nierenberg et al. 2010)”
From Predicting relapse after antidepressant withdrawal – a systematic review (2017) · cites this paper as Nierenberg et al. 2010
In the STAR*D trial, only 10% of persons 'in remission' were fully asymptomatic.
“This was highlighted in the STAR * D trial, in which it was ob served that only 10% of persons 'in re mission' were fully asymptomatic 71 .”
From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [71]
Existing TRD definitions fail to take into consideration the social, economic, anamnestic and interpersonal factors which, alone or in combinations, are known to moderate antidepressant response.
“Further drawbacks of existing TRD defi nitions are that they fail to take into consid eration the social, economic, anamnestic (e.g., adverse childhood experiences) and interpersonal factors which, alone or in combinations, are known to moderate antidepressant response 1,44,47,71,75- 81 .”
From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [71]
The Introduction and Discussion address residual depressive symptoms after citalopram treatment and their relationship to relapse, not shortcomings of treatment-resistant depression (TRD) definitions. Searches for treatment resistance and social, economic, childhood-history, and interpersonal factors found no passage in our copy establishing that these factors moderate antidepressant response or are omitted from TRD definitions. The indexed passages provide no page numbers. (LLM, conf=0.75)
Experimental — accuracy not yet measured
Sleep disturbances increase the risk for and seem to be a prodromal symptom of relapse.
“They increase the risk for [10] and seem to be a prodromal symptom of relapse [11].”
From The effects of exercise on sleep in unipolar depression: a systematic review and network meta-analysis (2021) · cites this paper as [10]
More residual symptoms are associated with a greater risk of relapse.
“A higher number of previous episodes (Berwian, Walter, Seifritz, & Huys, 2017; Kendler, Thornton, & Gardner, 2000), more residual symptoms (Berwian et al., 2017; Nierenberg et al., 2010), and failure to reach remission after acute antidepressant treatment (APA, 2010; Rush et al., 2006) are associated with a greater risk of relapse”
From Relapse prevention with levomilnacipran ER in adults with major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study (2019) · cites this paper as Nierenberg et al., 2010
Patients with residual depression symptoms despite responding to treatment have a higher risk of recurrence.
“In addition, patients who had residual depression symptoms despite responding to treatment, had higher risk of recurrence (Serafini et al., 2018; Nierenberg et al., 2010; Judd et al., 1998) [19, 24, 25].”
From Predictors of recurrence of major depressive disorder (2020) · cites this paper as Nierenberg et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410 · see citing works
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879 · see citing works
Self-citationRush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., Markowitz, J. C., Ninan, P. T., Kornstein, S., Manber, R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01866-8 · Cited by 3,829 · see citing works
Self-citationSequenced treatment alternatives to relieve depression (STAR*D): Rationale and design
Rush, A. J., Fava, M., Wisniewski, S. R., Lavori, P. W., Trivedi, M. H., Sackeim, H. A., Thase, M. E., Nierenberg, A. A., Quitkin, F. M., Kashner, T. M., et al. (2004) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00112-0 · Cited by 1,076 · see citing works
Self-citationTRIVEDI, M. H., RUSH, A. J., IBRAHIM, H. M., CARMODY, T. J., BIGGS, M. M., SUPPES, T., CRISMON, M. L., SHORES-WILSON, K., TOPRAC, M. G., DENNEHY, E. B., et al. (2004) · Psychological Medicine · doi:10.1017/s0033291703001107 · Cited by 968 · cited 2× · see citing works
“…(HAMD17 ; Hamilton, 1960, 1967) or f5 on the 16-item Quick Inventory of Depressive Symptomatology, SelfReport (QIDS-SR16 ; Rush et al. 2003, 2006a ; Trivedi et al. 2004) or response (typically defined as 50% improvement in depression rating scale scores) have been associated with continued…”
BackgroundMethodSelf-citationJudd, L. L., Akiskal, H. S., Maser, J. D., Zeller, P. J., Endicott, J., Coryell, W., Paulus, M. P., Kunovac, J. L., Leon, A. C., Mueller, T. I., et al. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.8.694 · Cited by 775 · see citing works
Report by the ACNP Task Force on Response and Remission in Major Depressive Disorder
Rush, A. J., Kraemer, H. C., Sackeim, H. A., Fava, M., Trivedi, M. H., Frank, E., Ninan, P. T., Thase, M. E., Gelenberg, A. J., Kupfer, D. J., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301131 · Cited by 707 · cited 3× · see citing works
“Remission was defined as a score f5 on the 16-item Quick Inventory of Depressive Symptomatology, Clinician-rated (QIDS-C16 ; Rush et al. 2003, 2006a ; Trivedi et al. 2004).”
BackgroundMethodSelf-citationJudd, L. L., Akiskal, H. S., Maser, J. D., Zeller, P. J., Endicott, J., Coryell, W., Paulus, M. P., Kunovac, J. L., Leon, A. C., Mueller, T. I., et al. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00138-4 · Cited by 590 · see citing works
Treatments of Depression and the Functional Capacity to Work
Mintz, J. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820100005001 · Cited by 561 · see citing works
D, M. F. M., Rush, A. J., Trivedi, M. H., Nierenberg, A. A., Thase, M. E., Sackeïm, H. A., Quitkin, F. M., Wisniewski, S. R., Lavori, P. W., Rosenbaum, J. F., et al. (2003) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(02)00107-7 · Cited by 520 · see citing works
Self-citationResidual symptoms in depressed patients who respond acutely to fluoxetine
Nierenberg, A. A., Keefe, B. R., Leslie, V. C., Alpert, J. E., Pava, J. A., Worthington, J. J., Rosenbaum, J. F., & Fava, M. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0403 · Cited by 470 · cited 6× · see citing works
“Prior studies of residual depressive symptoms have shown high rates of insomnia, fatigue, concentration and weight changes after successful treatment (Nierenberg et al. 1999 ; Fava et al. 2007).”
BackgroundInfluentialSelf-citationRush, A. J., Bernstein, I. H., Trivedi, M. H., Carmody, T. J., Wisniewski, S., Mundt, J. C., Shores-Wilson, K., Biggs, M. M., Woo, A., Nierenberg, A. A., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.022 · Cited by 385 · see citing works
Self-citationSelf-Rated Global Measure of the Frequency, Intensity, and Burden of Side Effects
Wisniewski, S. R., Rush, A. J., Balasubramani, G. K., Trivedi, M. H., & Nierenberg, A. A. (2006) · Journal of Psychiatric Practice · doi:10.1097/00131746-200603000-00002 · Cited by 288 · see citing works
Self-citationCarney, C. E., Segal, Z. V., Edinger, J. D., & Krystal, A. D. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0211 · Cited by 265 · cited 3× · see citing works
“Residual depressive symptoms (Fava et al. 2002 ; Carney et al. 2007) after remission (Nierenberg & Wright, 1999 ; Rush et al. 2006b) (typically defined as f7 on the 17-item Hamilton Depression Rating Scale (HAMD17 ; Hamilton, 1960, 1967) or f5 on the 16-item Quick Inventory of Depressive…”
BackgroundThe concept of recovery in major depression
FAVA, G. A., RUINI, C., & BELAISE, C. (2007) · Psychological Medicine · doi:10.1017/s0033291706008981 · Cited by 230 · cited 6× · see citing works
“…depression rating scale scores) have been associated with continued impaired psychosocial functioning (Mintz et al. 1992 ; Kennedy & Paykel, 2004 ; Fava et al. 2007; Zimmerman et al. 2007), a lack of feeling well (Fava et al. 2007), and an increased risk of subsequent depressive relapse and…”
BackgroundInfluentialD, M. F. M., Thase, M. E., & DeBattista, C. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0112 · Cited by 207 · see citing works
Stahl, S. M., Zhang, L., Damatarca, C., & Grady, M. M. (2003) · PubMed · Cited by 202 · see citing works
Residual symptoms at remission from depression: Impact on long-term outcome
Kennedy, N., & Paykel, E. S. (2004) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00054-5 · Cited by 199 · see citing works
DeBattista, C., Doghramji, K., Menza, M. A., Rosenthal, M. H., Fieve, R. R., & Modafinil in Depression Study Group (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0911 · Cited by 189 · see citing works
Evolution of remission as the new standard in the treatment of depression.
Nierenberg, A. A., & Wright, E. (1999) · PubMed · Cited by 161 · see citing works
Self-citationTime to recurrence after recovery from major depressive episodes and its predictors
KANAI, T., Takeuchi, H., Furukawa, T. A., Yoshimura, R., Imaizumi, T., Kitamura, T., & Takahashi, K. (2003) · Psychological Medicine · doi:10.1017/s0033291703007827 · Cited by 138 · see citing works
Residual symptoms in depression
Fava, G. A., Fabbri, S., & Sonino, N. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00226-9 · Cited by 137 · see citing works
Bockting, C., Spinhoven, P., Koeter, M. W. J., Wouters, L. F., & Schene, A. H. (2006) · PubMed · Cited by 84 · see citing works
Bockting, C., Spinhoven, P., Koeter, M. W. J., Wouters, L. F., Schene, A. H., & Depression Evaluation Longitudinal Therapy Assessment (DELTA) Study Group (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0508 · Cited by 78 · see citing works
Residual Symptoms and Impairment in Major Depression in the Community
Mojtabai, R. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1645 · Cited by 65 · see citing works
Thase, M. E., D, M. F. M., DeBattista, C., Arora, S., & Hughes, R. J. (2006) · CNS Spectrums · doi:10.1017/s1092852900010622 · Cited by 61 · see citing works
Heterogeneity among depressed outpatients considered to be in remission
Zimmerman, M., Posternak, M. A., & Chelminski, I. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.10.005 · Cited by 53 · see citing works
Leon, A. C. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050775 · Cited by 41 · see citing works
How Can We Know Whether Antidepressants Increase Suicide Risk?
Simon, G. E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1861 · Cited by 34 · see citing works
Antidepressants in Adult Suicides in New York City
Leon, A. C., Marzuk, P. M., Tardiff, K. J., Bucciarelli, A., Stajić, M., Piper, T. M., & Galea, S. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0911 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Morin, C. M., & Benca, R. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60750-2 · Cited by 976 · see citing works
McIntyre, R. S., Alsuwaidan, M., Baune, B. T., Berk, M., Demyttenaere, K., Goldberg, J. F., Gorwood, P., Ho, R., Kasper, S., Kennedy, S. H., et al. (2023) · World Psychiatry · doi:10.1002/wps.21120 · Cited by 836 · see citing works
Self-citationPiet, J., & Hougaard, E. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.05.002 · Cited by 807 · see citing works
Monoamine neurocircuitry in depression and strategies for new treatments
Hamon, M., & Blier, P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.009 · Cited by 643 · see citing works
Sanchez, C., Asin, K. E., & Artigas, F. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.07.001 · Cited by 547 · see citing works
Segal, Z. V., Bieling, P., Young, T., MacQueen, G., Cooke, R., Martin, L., Bloch, R., & Levitan, R. D. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.168 · Cited by 429 · see citing works
Williams, J. M. G., Crane, C., Barnhofer, T., Brennan, K., Duggan, D. S., Fennell, M. J. V., Hackmann, A., Krusche, A., Muse, K., Von Rohr, I. R., et al. (2014) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0035036 · Cited by 420 · see citing works
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery
Atkin, T., Comai, S., & Gobbi, G. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014381 · Cited by 400 · see citing works
Mansur, R. B., Brietzke, E. M., & McIntyre, R. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.017 · Cited by 325 · see citing works
Cognitive dysfunction in unipolar depression: Implications for treatment
Trivedi, M. H., & Greer, T. L. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.09.012 · Cited by 294 · see citing works
Self-citationLam, R. W., McIntosh, D., Wang, J., Enns, M. W., Kolivakis, T., Michalak, E. E., Sareen, J., Song, W.-Y., Kennedy, S. H., MacQueen, G. M., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659416 · Cited by 288 · see citing works
Response and remission criteria in major depression – A validation of current practice
Riedel, M. J., Möller, H., Obermeier, M., Schennach-Wolff, R., Bauer, M., Adli, M., Kronmüller, K., Nickel, T., Brieger, P., Laux, G., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.03.006 · Cited by 289 · see citing works
Carney, C. E., Edinger, J. D., Kuchibhatla, M. N., Lachowski, A. M., Bogouslavsky, O., Krystal, A. D., & Shapiro, C. M. (2017) · SLEEP · doi:10.1093/sleep/zsx019 · Cited by 212 · see citing works
McClintock, S. M., Husain, M. M., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Trivedi, M. H., Cook, I., Morris, D., Warden, D., & Rush, A. J. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31820ebd2c · Cited by 234 · see citing works
Self-citationBrain-gut-microbiota axis: challenges for translation in psychiatry
Kelly, J. R., Clarke, G. A., Cryan, J. F., & Dinan, T. G. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.02.008 · Cited by 200 · see citing works
de Zwart, P. L., Jeronimus, B. F., & de Jonge, P. (2019) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796018000227 · Cited by 189 · see citing works
Using a pharmacogenomic algorithm to guide the treatment of depression
Hall‐Flavin, D. K., Winner, J. G., Allen, J. D., Jordan, J. J., Nesheim, R. S., Snyder, K. A., Drews, M. S., Eisterhold, L. L., Biernacka, J. M., & Mrazek, D. A. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.99 · Cited by 185 · see citing works
Felger, J. C., Li, L., Marvar, P. J., Woolwine, B. J., Harrison, D. G., Raison, C. L., & Miller, A. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.010 · Cited by 176 · see citing works
Perlis, R. H., Iosifescu, D. V., Castro, V. M., Murphy, S. N., Gainer, V. S., Minnier, J., Cai, T., Goryachev, S., Zeng, Q., Gallagher, P. J., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291711000997 · Cited by 193 · see citing works
CLINICAL RELEVANCE OF FATIGUE AS A RESIDUAL SYMPTOM IN MAJOR DEPRESSIVE DISORDER
D, M. F. M., Ball, S. G., Nelson, J. C., Sparks, J., Konechnik, T. J., Classi, P. M., Dubé, S., & Thase, M. E. (2013) · Depression and Anxiety · doi:10.1002/da.22199 · Cited by 161 · see citing works
Plante, D. T., Jensen, J. E., Schoerning, L., & Winkelman, J. W. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.4 · Cited by 161 · see citing works
Segal, Z. V., Dimidjian, S., Beck, A., Boggs, J. M., Vanderkruik, R., Metcalf, C. A., Gallop, R., Felder, J. N., & Levy, J. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4693 · Cited by 159 · see citing works
Sleep Disturbances in Mood Disorders
Rumble, M. E., White, K. H., & Benca, R. M. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.006 · Cited by 143 · see citing works
Dunlop, B. W., Binder, E. B., Cubells, J. F., Goodman, M. M., Kelley, M. E., Kinkead, B., Kutner, M., Nemeroff, C. B., Newport, D. J., Owens, M. J., et al. (2012) · Trials · doi:10.1186/1745-6215-13-106 · Cited by 136 · see citing works
The Complex Role of Sleep in Adolescent Depression
Clarke, G. N., & Harvey, A. G. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.01.006 · Cited by 139 · see citing works
Psychiatric Disorders and Sleep Issues
Sutton, E. L. (2014) · Medical Clinics of North America · doi:10.1016/j.mcna.2014.06.009 · Cited by 119 · see citing works
Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression
Gómez‐Galán, M., Bundel, D. D., Eeckhaut, A. V., Smolders, I. J., & Lindskog, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.10 · Cited by 121 · see citing works
Moderators of Cognitive Behavioral Treatment for Insomnia on Depression and Anxiety Outcomes
Mirchandaney, R., Barete, R., & Asarnow, L. D. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01326-3 · Cited by 130 · see citing works
Difficult-to-treat depression: A clinical and research roadmap for when remission is elusive
Rush, A. J., Aaronson, S. T., & Demyttenaere, K. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418808585 · Cited by 120 · see citing works
Self-citationCognitive Behavioral Therapy for Insomnia in Depression
Asarnow, L. D., & Manber, R. (2019) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.01.009 · Cited by 115 · see citing works
Asarnow, L. D. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2019.12.002 · Cited by 117 · see citing works
Yeung, W., Chung, K., Tso, K., Zhang, S., Zhang, Z., & Ho, L. (2011) · SLEEP · doi:10.5665/sleep.1056 · Cited by 111 · see citing works
Li, H., Sagar, A. P., & Kéri, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.021 · Cited by 101 · see citing works
Predicting relapse after antidepressant withdrawal – a systematic review
Berwian, I. M., Walter, H., Seifritz, E., & Huys, Q. J. M. (2017) · Psychological Medicine · doi:10.1017/s0033291716002580 · Cited by 93 · see citing works
“Residual symptom load affects relapse risk overall (Nierenberg et al. 2010) and probably accounts for the impact of different definitions of remission on relapse risk (Dunlop et al. 2012).”
BackgroundInfluentialBahr, R., López, A. Q., & Rey, J. A. (2019) · PubMed Central · Cited by 102 · see citing works
Li, S. X., Lam, S. P., Chan, J. W. Y., Yu, M. W. M., & Wing, Y. K. (2012) · SLEEP · doi:10.5665/sleep.2008 · Cited by 101 · see citing works
An Open Pilot of Cognitive-Behavioral Therapy for Insomnia in Women with Postpartum Depression
Swanson, L. M., Flynn, H., Adams-Mundy, J. D., Armitage, R., & Arnedt, J. T. (2013) · Behavioral Sleep Medicine · doi:10.1080/15402002.2012.683902 · Cited by 98 · see citing works
Fatigue in Parkinson’s disease: report from a multidisciplinary symposium
Friedman, J. H., Beck, J. C., Chou, K. L., Clark, G., Fagundes, C. P., Goetz, C. G., Herlofson, K., Kluger, B. M., Krupp, L., Lang, A. E., et al. (2016) · npj Parkinson s Disease · doi:10.1038/npjparkd.2015.25 · Cited by 99 · see citing works
Webb, C. A., Cohen, Z. D., Beard, C., Forgeard, M. J. C., Peckham, A., & Björgvinsson, Þ. (2019) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000451 · Cited by 96 · see citing works
Corruble, E., de Bodinat, C., Belaïdi, C., & Goodwin, G. M. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000679 · Cited by 94 · see citing works
Insomnia and depression: clinical associations and possible mechanistic links
Vargas, I., & Perlis, M. L. (2020) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2019.11.004 · Cited by 95 · see citing works
Kang, L., Zhang, A., Sun, N., Liu, P., Yang, C., Li, G., Liu, Z., Wang, Y., & Zhang, K. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1913-6 · Cited by 94 · see citing works
Lotrich, F. E., Albusaysi, S., & Ferrell, R. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.263 · Cited by 92 · see citing works
Second-generation antipsychotics in the treatment of major depressive disorder: current evidence
Han, C., Wang, S., Kato, M., Lee, S.-J., Patkar, A. A., Masand, P. S., & Pae, C. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.811901 · Cited by 92 · see citing works
Symptoms of anxiety and depression and risk of acute myocardial infarction: the HUNT 2 study
Gustad, L. T., Laugsand, L. E., Janszky, I., Dalen, H., & Bjerkeset, O. A. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht387 · Cited by 91 · see citing works
Aripiprazole as Adjunctive Therapy for Patients with Major Depressive Disorder
Pae, C., Forbes, A., & Patkar, A. A. (2010) · CNS Drugs · doi:10.2165/11538980-000000000-00000 · Cited by 91 · see citing works
Hoorelbeke, K., den Bergh, N. V., Wichers, M., & Koster, E. H. W. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.01.007 · Cited by 91 · see citing works
Cheng, P., Casement, M. D., Kalmbach, D. A., Castelan, A. C., & Drake, C. L. (2021) · Sleep · doi:10.1093/sleep/zsaa258 · Cited by 97 · see citing works
Geschwind, N., Peeters, F., Huibers, M., van Os, J., & Wichers, M. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.104851 · Cited by 89 · see citing works
Clevenger, S. S., Malhotra, D., Dang, J., Vanle, B., & IsHak, W. W. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125317737264 · Cited by 83 · see citing works
Dimidjian, S., Beck, A., Felder, J. N., Boggs, J. M., Gallop, R., & Segal, Z. V. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.09.004 · Cited by 87 · see citing works
Residual symptoms after remission of major depressive disorder with fluoxetine and risk of relapse
Iovieno, N., van Nieuwenhuizen, A., Clain, A., Baer, L., & Nierenberg, A. A. (2011) · Depression and Anxiety · doi:10.1002/da.20768 · Cited by 98 · see citing works
Self-citationRomera, I., Pérez, V., Ciudad, A., Caballero, L., Roca, M., Polavieja, P., & Gilaberte, I. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-51 · Cited by 84 · see citing works
Culpepper, L., Muskin, P. R., & Stahl, S. M. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.07.001 · Cited by 77 · see citing works
Yohn, S. E., Collins, S. L., Contreras-Mora, H. M., Errante, E. L., Rowland, M. A., Correa, M., & Salamone, J. D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.188 · Cited by 81 · see citing works
Sakurai, H., Suzuki, T., Yoshimura, K., Mimura, M., & Uchida, H. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4634-5 · Cited by 80 · see citing works
Epperson, C. N., Rubinow, D. R., Meltzer-Brody, S. E., Deligiannidis, K. M., Riesenberg, R. A., Krystal, A. D., Bankole, K., Huang, M., Li, H., Brown, C., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.143 · Cited by 77 · see citing works
Pennybaker, S. J., Niciu, M. J., Luckenbaugh, D. A., & Zarate, C. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.10.026 · Cited by 77 · see citing works
Neurotransmitter Targeting in the Treatment of Depression
Blier, P. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12084su1c.04 · Cited by 76 · see citing works
Stahl, S. M. (2019) · CNS Spectrums · doi:10.1017/s1092852919001470 · Cited by 73 · see citing works
Paul, R., Andlauer, T. F. M., Czamara, D., Hoehn, D., Lucae, S., Pütz, B., Lewis, C. M., Uher, R., Müller‐Myhsok, B., Ising, M., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0524-4 · Cited by 69 · see citing works
MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS
Russo, M., Mahon, K., & Burdick, K. E. (2014) · Depression and Anxiety · doi:10.1002/da.22297 · Cited by 70 · see citing works
Treating insomnia in depression: insomnia related factors predict long-term depression trajectories
Bei, B., Asarnow, L. D., Krystal, A., Edinger, J. D., Buysse, D. J., & Manber, R. (2018) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000282 · Cited by 71 · see citing works
Carney, R., & Freedland, K. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182405ac4 · Cited by 86 · see citing works
Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era
Philip, N. S., Carpenter, L. L., Tyrka, A. R., & Price, L. H. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656561003614781 · Cited by 70 · see citing works
Gueorguieva, R., Chekroud, A. M., & Krystal, J. H. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30038-x · Cited by 67 · see citing works
Does insomnia treatment prevent depression?
Boland, E. M., Goldschmied, J. R., & Gehrman, P. R. (2023) · SLEEP · doi:10.1093/sleep/zsad104 · Cited by 69 · see citing works
Segal, Z. V., Anderson, A. K., Gulamani, T., Dinh Williams, L.-A., Desormeau, P., Ferguson, A., Walsh, K., & Farb, N. A. S. (2019) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000351 · Cited by 63 · see citing works
Dunlop, B. W., LoParo, D., Kinkead, B. L., Mletzko, T., Cole, S. P., Nemeroff, C. B., Mayberg, H. S., & Craighead, W. E. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18091075 · Cited by 65 · see citing works
Christensen, M. C., Wong, C. M. J., & Baune, B. T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00280 · Cited by 66 · see citing works
Predictors of recurrence in remitted late-life depression
Deng, Y., McQuoid, D. R., Potter, G. G., Steffens, D. C., Albert, K., Riddle, M., Beyer, J. L., & Taylor, W. D. (2018) · Depression and Anxiety · doi:10.1002/da.22772 · Cited by 65 · see citing works
Saragoussi, D., Touya, M., Haro, J. M., Jönsson, B., Knapp, M., Botrel, B., Florea, I., Loft, H., & Rive, B. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s136343 · Cited by 63 · see citing works
Brupbacher, G., Gerger, H., Zander-Schellenberg, T., Straus, D., Porschke, H., Gerber, M., von Känel, R., & Schmidt-Trucksäss, A. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101452 · Cited by 64 · see citing works
Identifying Difficult-to-Treat Depression
Gaynes, B. N. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.8133su1c.02 · Cited by 64 · see citing works
Recent advances in sleep and depression
Mirchandaney, R., Asarnow, L. D., & Kaplan, K. A. (2022) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000837 · Cited by 64 · see citing works
Dreimüller, N., Lieb, K., Tadić, A., Engelmann, J., Wollschläger, D., & Wagner, S. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.067 · Cited by 60 · see citing works
A critical review of pharmacotherapy for major depressive disorder.
Dupuy, J. M., Ostacher, M. J., Huffman, J., Perlis, R. H., & Nierenberg, A. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000083 · Cited by 61 · see citing works
Self-citationResting-State Functional Connectivity Impairment in Patients with Major Depressive Episode
Stoyanov, D., Khorev, V. S., Paunova, R., Kandilarova, S., Simeonova, D., Badarin, A., Kurkin, S., & Hramov, A. E. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114045 · Cited by 62 · see citing works
Does exercise improve self-reported sleep quality in non-remitted major depressive disorder?
Rethorst, C. D., Sunderajan, P., Greer, T. L., Grannemann, B. D., Nakonezny, P. A., Carmody, T. J., & Trivedi, M. H. (2012) · Psychological Medicine · doi:10.1017/s0033291712001675 · Cited by 60 · see citing works
Self-citationDisruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression
Andreescu, C., Ajilore, O., Aizenstein, H. J., Albert, K. M., Butters, M. A., Landman, B. A., Karim, H. T., Krafty, R. T., & Taylor, W. D. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.07.016 · Cited by 56 · see citing works
Meaklim, H., Saunders, W. J., Byrne, M. L., Junge, M. F., Varma, P., Finck, W. A., & Jackson, M. L. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.021 · Cited by 55 · see citing works
Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes
Penckofer, S. M., Byrn, M. A., Adams, W., Emanuele, M. A., Mumby, P. B., Kouba, J., & Wallis, D. E. (2017) · Journal of Diabetes Research · doi:10.1155/2017/8232863 · Cited by 53 · see citing works
Trajectories of individual symptoms in remitters versus non-remitters with depression
Sakurai, H., Uchida, H., Abe, T., Nakajima, S., Suzuki, T., Pollock, B. G., Sato, Y., & Mimura, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.035 · Cited by 51 · see citing works
Zimmerman, M. A., Martinez, J. H., Attiullah, N., Friedman, M. A., Toba, C., Boerescu, D. A., & Rahgeb, M. (2011) · Depression and Anxiety · doi:10.1002/da.20870 · Cited by 52 · see citing works
Bélanger, L., Harvey, A. G., Fortier-Brochu, É., Beaulieu‐Bonneau, S., Eidelman, P., Talbot, L. S., Ivers, H., Hein, K., Lamy, M., Soehner, A. M., et al. (2016) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000084 · Cited by 51 · see citing works
Carney, C. E., Harris, A. L., Friedman, J., & Segal, Z. V. (2011) · Depression and Anxiety · doi:10.1002/da.20811 · Cited by 50 · see citing works
Shariq, A. S., Rosenblat, J. D., Alageel, A. A. S., Mansur, R. B., Rong, C., Ho, R., Ragguett, R., Pan, Z., Brietzke, E. M., & McIntyre, R. S. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.008 · Cited by 50 · see citing works
Sleep and Mood Disorders Among Youth
Asarnow, L. D., & Mirchandaney, R. (2020) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2020.09.003 · Cited by 50 · see citing works
Changes in body weight during pharmacological treatment of depression
Uher, R., Mors, O. N., Hauser, J., Rietschel, M., Maier, W., Kozel, D., Henigsberg, N., Souery, D., Placentino, A., Keers, R., et al. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000933 · Cited by 49 · see citing works
Harvey, A. G., Hein, K., Dong, L., Smith, F. L., Lisman, M., Yu, S. H., Rabe‐Hesketh, S., & Buysse, D. J. (2016) · Trials · doi:10.1186/s13063-016-1690-9 · Cited by 49 · see citing works
Berntson, J., Patel, J. S., & Stewart, J. C. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.06.008 · Cited by 51 · see citing works
Multi-modality: a new approach for the treatment of major depressive disorder
Richelson, E. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001605 · Cited by 49 · see citing works
Zhang, B., Fu, W., Guo, Y., Chen, Y., Jiang, C., Li, X., & He, K. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.091 · Cited by 47 · see citing works
Dandekar, M. P., Luse, D., Hoffmann, C., Cotton, P. C., Peery, T., Ruiz, C., Hussey, C. S., Giridharan, V. V., Soares, J. C., Quevedo, J., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.074 · Cited by 47 · see citing works
Impact of psychotherapy on insomnia symptoms in patients with depression and multiple sclerosis
Baron, K. G., Corden, M. E., Jin, L., & Mohr, D. C. (2010) · Journal of Behavioral Medicine · doi:10.1007/s10865-010-9288-2 · Cited by 46 · see citing works
Xiao, L., Feng, L., Zhu, X.-Q., Feng, Y., Wu, W.-Y., Ungvari, G., Ng, C., Xiang, Y., & Wang, G. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.01.020 · Cited by 43 · see citing works
Harkness, K. L., Theriault, J. E., Stewart, J. G., & Bagby, R. M. (2013) · Depression and Anxiety · doi:10.1002/da.22177 · Cited by 45 · see citing works
Allega, O. R., Leng, X., Vaccarino, A. L., Skelly, M., Lanzini, M., Hidalgo, M. P. L., Soares, C. N., Kennedy, S. H., & Frey, B. N. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.047 · Cited by 44 · see citing works
Current Issues in the Use of fMRI-Based Neurofeedback to Relieve Psychiatric Symptoms
Fovet, T., Jardri, R., & Linden, D. E. J. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150619092540 · Cited by 43 · see citing works
- Authors
- Nierenberg, A. A., Husain, M. M., Trivedi, M. H., Fava, M., Warden, D., Wisniewski, S. R., Miyahara, S., & Rush, A. J.
- Affiliations
- Massachusetts General Hospital (US)
- The University of Texas Southwestern Medical Center (US)
- University of Pittsburgh (US)
- Corresponding author
- Nierenberg, A. A.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-05-22
- Volume
- 40
- Issue
- 1
- Pages
- 41-50
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC5886713
- OpenAlex
- W2150325627
- Cited by
- 458
- References
- 31
- Citations by year
- 2026: 24 · 2025: 23 · 2024: 23 · 2023: 32 · 2022: 35 · 2021: 23 · 2020: 26 · 2019: 34 · 2018: 26 · 2017: 24 · 2016: 25 · 2015: 31 · 2014: 28 · 2013: 34 · 2012: 30
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- Bristol-Myers Squibb
- University of Texas Southwestern Medical Center
- National Institutes of Health (n01mh90003-26-0-0)
- National Institute of Mental Health (N01 MH090003)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- major depressive disorder, residual depressive symptoms, remission, citalopram, relapse risk, sleep disorders, weight gain, antidepressant side effects, STAR*D trial, QIDS-SR16
- MeSH terms
- Adult, Major Depressive Disorder, Female, Follow-Up Studies, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Personality Inventory, Psychometrics, Recurrence, Risk Factors, Citalopram, Weight Gain, Cognitive Behavioral Therapy, Antidepressive Agents, Second-Generation, Kaplan-Meier Estimate, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
