The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A Moderate Serving of High-Quality Protein Maximally Stimulates Skeletal Muscle Protein Synthesis in Young and Elderly Subjects
Open accessAbstract
Ingestion of sufficient dietary protein is a fundamental prerequisite for muscle protein synthesis and maintenance of muscle mass and function. The elderly are often at increased risk for protein-energy malnutrition, sarcopenia and a diminished quality of life. This study sought to compare changes in muscle protein synthesis and anabolic efficiency in response to a single moderate (113 g; 220 kcal; 30 g protein) or large serving (340 g; 660 kcal; 90 g protein) of 90% lean beef. Venous blood and vastus lateralis muscle biopsy samples were obtained during a primed, constant infusion (0.08 μmol/kg/min) of L-[ring-13C6] phenylalanine in healthy young (n=17; 34±3yrs) and elderly (n=17; 68±2yrs) individuals. Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive period and for 5 h following meal ingestion. Data were analysed using a two-way repeated measures ANOVA with Tukey's pair-wise comparisons. A 113 g serving of lean beef increased muscle protein synthesis by approximately 50% in both young and older volunteers. Despite a 3-fold increase in protein and energy content, there was no further increase in protein synthesis following ingestion of 340 g of lean beef in either age group. Ingestion of more than 30 g of protein in a single meal does not further enhance the stimulation of muscle protein synthesis in young and elderly.
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Cites
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Slow and fast dietary proteins differently modulate postprandial protein accretion
Boirie, Y., Dangin, M., Gachon, P., Vasson, M.-P., Maubois, J.-L., & Beaufrère, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14930 · Cited by 1,453
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · cited 2×
“Although a blunted protein-anabolic response to a small, mixed-nutrient meal may, over time, contribute to the development of sarcopenia (25), there is no age-related discrepancy in muscle protein synthesis after ingestion of a higher total amino acid load ( 12 ,14,26,27).”
BackgroundInfluentialVolpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Self-citationProtein, weight management, and satiety
Paddon-Jones, D., Westman, E., Mattes, R. D., Wolfe, R. R., Astrup, A., & Westerterp-Plantenga, M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1558s · Cited by 549
Amino acid ingestion improves muscle protein synthesis in the young and elderly
Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467 · cited 3×
“Although a blunted protein-anabolic response to a small, mixed-nutrient meal may, over time, contribute to the development of sarcopenia (25), there is no age-related discrepancy in muscle protein synthesis after ingestion of a higher total amino acid load (12, 14 ,26,27).”
BackgroundResultInfluentialSelf-citationVolpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464
Self-citationThe Rate of Protein Digestion affects Protein Gain Differently during Aging in Humans
Dangin, M., Guillet, C., Garcia‐Rodenas, C., Gachon, P., Bouteloup‐Demange, C., Reiffers‐Magnani, K., Fauquant, J., Ballèvre, O., & Beaufrère, B. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.036897 · Cited by 395
High protein intake sustains weight maintenance after body weight loss in humans
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Paddon-Jones, D., Sheffield-Moore, M., Katsanos, C. S., Zhang, X.-J., & Wolfe, R. R. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.006 · Cited by 223 · cited 3×
“The data presented in this study represent a practical extension of previous proof-of-concept research that has largely focused on amino acid or whey protein supplementation ( 13 ,14,24,28).”
BackgroundResultInfluentialSelf-citationThe Recommended Dietary Allowance of Protein: A Misunderstood Concept
Wolfe, R. R., & Miller, S. L. (2008) · JAMA · doi:10.1001/jama.299.24.2891 · Cited by 107
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Protein content and amino acid composition of commercially available plant-based protein isolates
Gorissen, S. H. M., Crombag, J. J. R., Senden, J. M. G., Waterval, W. A. H., Bierau, J., Verdijk, L. B., & van Loon, L. J. C. (2018) · Amino Acids · doi:10.1007/s00726-018-2640-5 · Cited by 1,169
The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption
van Vliet, S., Burd, N. A., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.204305 · Cited by 651
Witard, O. C., Jackman, S. R., Breen, L., Smith, K., Selby, A., & Tipton, K. D. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.055517 · Cited by 517
Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults
Mamerow, M. M., Mettler, J. A., English, K. L., Casperson, S. L., Arentson-Lantz, E., Sheffield-Moore, M., Layman, D. K., & Paddon-Jones, D. (2014) · The Journal of Nutrition · doi:10.3945/jn.113.185280 · Cited by 438
Self-citationPromoting perioperative metabolic and nutritional care
Gillis, C., & Carli, F. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000795 · Cited by 350
Metadata
- Authors
- Symons, T. B., Sheffield-Moore, M., Wolfe, R. R., & Paddon-Jones, D.
- Venue
- Journal of the American Dietetic Association
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 109
- Issue
- 9
- Pages
- 1582-1586
- ISSN
- 0002-8223 (ISSN-L)
- OpenAlex
- W2065285042
- Cited by
- 353
- References
- 11
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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